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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processQueuosine biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciNWIN323098:G1G55-1854-MONOMER
UniPathwayiUPA00392

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:Nwi_1796
OrganismiNitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255)
Taxonomic identifieri323098 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
Proteomesi
  • UP000002531 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002313511 – 360S-adenosylmethionine:tRNA ribosyltransferase-isomeraseAdd BLAST360

Proteomic databases

PRIDEiQ3SRN4

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi323098.Nwi_1796

Structurei

3D structure databases

ProteinModelPortaliQ3SRN4
SMRiQ3SRN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2N Bacteria
COG0809 LUCA
HOGENOMiHOG000004401
KOiK07568
OMAiYSYGDGM
OrthoDBiPOG091H00ZG

Family and domain databases

HAMAPiMF_00113 QueA, 1 hit
InterProiView protein in InterPro
IPR003699 QueA
IPR036100 QueA_sf
PANTHERiPTHR30307 PTHR30307, 1 hit
PfamiView protein in Pfam
PF02547 Queuosine_synth, 1 hit
SUPFAMiSSF111337 SSF111337, 1 hit
TIGRFAMsiTIGR00113 queA, 1 hit

Sequencei

Sequence statusi: Complete.

Q3SRN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTDLFDFEL PAGSIALRPA SPRDSARMLV VQPGSGVRDQ QVSDLPEWLR
60 70 80 90 100
PGDQLVVNDT RVIAAQLHGR RIGREAEPRI DATLIKRLDG SRWSALVRPA
110 120 130 140 150
RKLMAGDIVR LGNEGRVCFL GHLDARVESK GEEGEVTFAF SFHGPMLDQA
160 170 180 190 200
IAELGSTPLP PYIASKRAPD DRDASDYQTM FATHEGAVAA PTAGLHFTPE
210 220 230 240 250
IETALRGRGV GLHRITLHVG AGTFLPVKVD DTAGHRMHSE WGAISTETAD
260 270 280 290 300
ALNAARSRGG RIVAVGTTSL RLLESAADDD GRIKPFTGET AIFITPGHRF
310 320 330 340 350
RAVDILMTNF HLPRSTLFML VSAFSGLETM KQAYAHAISA GYRFYSYGDA
360
CLLFPERAGA
Length:360
Mass (Da):39,098
Last modified:October 11, 2005 - v1
Checksum:iEAEB0182478678A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000115 Genomic DNA Translation: ABA05057.1
RefSeqiWP_011315053.1, NC_007406.1

Genome annotation databases

EnsemblBacteriaiABA05057; ABA05057; Nwi_1796
KEGGinwi:Nwi_1796

Similar proteinsi

Entry informationi

Entry nameiQUEA_NITWN
AccessioniPrimary (citable) accession number: Q3SRN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 11, 2005
Last modified: July 18, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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