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Protein

Ribose 1,5-bisphosphate phosphokinase PhnN

Gene

phnN

Organism
Thiobacillus denitrificans (strain ATCC 25259)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).UniRule annotation

Catalytic activityi

ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Ribose 1,5-bisphosphate phosphokinase PhnN (phnN)
This subpathway is part of the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II), the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis and in Metabolic intermediate biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTDEN292415:G1G56-2316-MONOMER
UniPathwayiUPA00087; UER00175

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose 1,5-bisphosphate phosphokinase PhnNUniRule annotation (EC:2.7.4.23UniRule annotation)
Alternative name(s):
Ribose 1,5-bisphosphokinaseUniRule annotation
Gene namesi
Name:phnNUniRule annotation
Ordered Locus Names:Tbd_2289
OrganismiThiobacillus denitrificans (strain ATCC 25259)
Taxonomic identifieri292415 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesThiobacillaceaeThiobacillus
Proteomesi
  • UP000008291 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004128021 – 190Ribose 1,5-bisphosphate phosphokinase PhnNAdd BLAST190

Interactioni

Protein-protein interaction databases

STRINGi292415.Tbd_2289

Structurei

3D structure databases

ProteinModelPortaliQ3SGK8
SMRiQ3SGK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribose 1,5-bisphosphokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105MFQ Bacteria
COG3709 LUCA
HOGENOMiHOG000037637
KOiK05774
OMAiMARLIWL
OrthoDBiPOG091H0H09

Family and domain databases

HAMAPiMF_00836 PhnN, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR012699 PhnN
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR02322 phosphon_PhnN, 1 hit
PROSITEiView protein in PROSITE
PS50052 GUANYLATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3SGK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEGKLFYVI GPSGSGKDSL MRYGRERLAG DPGVVFAHRY ITRPVELHGE
60 70 80 90 100
NHVALTEDEF DARLATGLFA LHWDSHGLRY GIGREINLWL AKGCNVVLNG
110 120 130 140 150
SREYLPEARR RYPGLTAILV NVSPEVLAER LRARGRETED QISRRVARAK
160 170 180 190
QFMHPEGRLE VIANDAELHV AGERLVQLLS DADASKRAFA
Length:190
Mass (Da):21,260
Last modified:October 11, 2005 - v1
Checksum:iD6A3A138FCD7980E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000116 Genomic DNA Translation: AAZ98242.1
RefSeqiWP_011312801.1, NC_007404.1

Genome annotation databases

EnsemblBacteriaiAAZ98242; AAZ98242; Tbd_2289
KEGGitbd:Tbd_2289

Similar proteinsi

Entry informationi

Entry nameiPHNN_THIDA
AccessioniPrimary (citable) accession number: Q3SGK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: October 11, 2005
Last modified: February 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health