Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 75 (31 Jul 2019)
Sequence version 1 (11 Oct 2005)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Dicer-like ribonuclease with mutated helicase and Rnase III domains

Gene

Dcr2

Organism
Paramecium tetraurelia
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicaseImported, Hydrolase, RNA-bindingPROSITE-ProRule annotation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dicer-like ribonuclease with mutated helicase and Rnase III domainsImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dcr2Imported
ORF Names:GSPATT00033115001Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiParamecium tetraureliaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5888 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000600 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5888.CAK63262

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini118 – 315Helicase ATP-bindingInterPro annotationAdd BLAST198
Domaini561 – 705Helicase C-terminalInterPro annotationAdd BLAST145
Domaini744 – 840Dicer dsRNA-binding foldInterPro annotationAdd BLAST97

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili79 – 99Sequence analysisAdd BLAST21
Coiled coili157 – 177Sequence analysisAdd BLAST21
Coiled coili560 – 587Sequence analysisAdd BLAST28

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. Dicer subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0701 Eukaryota
COG1111 LUCA

KEGG Orthology (KO)

More...
KOi
K11592

Identification of Orthologs from Complete Genome Data

More...
OMAi
FPITQQN

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.160.380, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR036389 RNase_III_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF04851 ResIII, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3SE28-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYELPADDKK LENMDLQHNS FDVKLIEDDD EEDKSQISQF LQNVIKQPEE
60 70 80 90 100
NLFDLDISES QEQQNEPKDS LSSLVDQMLS SISNNQEILN NKVNLLEEDD
110 120 130 140 150
TIVDTIEEFE FRDYQIELYE KGIGKNSIIY LETGLGKTLV IIMLMWDRLF
160 170 180 190 200
KYPDKKIVFL ANTVQLVEQQ AQQIKQKLPR VAELISDDDS MIVKAKEIGS
210 220 230 240 250
KLNVLHGSKC TDIWNQIMWQ IILEESKILV MTTQIFLNIL RKGLVKISNF
260 270 280 290 300
SFIAMDECHN AIQDHPYNYI LKEFYLKTKF QSDNQFLPQI VGATASPVMN
310 320 330 340 350
SKSVSNNQLL QELLQLSANM DSQYLHIDAQ NLKKHIKEAQ IVPIYYKMLF
360 370 380 390 400
NDPDIQKVID LKASLTNCEK NENKALDVMR RNSYLTEFFQ IKQTLENFKK
410 420 430 440 450
KYSYDLQTKI LIAQIEKQVL INGFQMYLEL GQYLFVLLVE YVIIKLNDFL
460 470 480 490 500
TIKRPPNQAA CLDILKSIST ILKDAKLRYS NVQQSSTPKV QVLFELIRKA
510 520 530 540 550
YSQGDDNSRI LIFVKQRLTA FFLNRLIEEY LASERINIVS NFIIGHCSSM
560 570 580 590 600
VRKQNNSIMI NVIESNKEDQ EELIKKLYAE LQNDQSKFSI EQLKDQVNRL
610 620 630 640 650
NIFAYRISST VQNDIINKFR QGKIKILIST SVAEEGIDIP MCNYVIGFNP
660 670 680 690 700
ISSSKAYVQM KGRARKENSQ FMIFMVDKLQ QAQVQSHQQV QNNIKQIIEE
710 720 730 740 750
LTAPQRQQML NKAMQTLQSK TYENTYFDSF EIEGSGALIN TNWSCQLIQQ
760 770 780 790 800
LCQKFNQKDA DKTQPKYAIY QLHGNAQTNQ QFIAFLLLPI SMKSFIFYGK
810 820 830 840 850
LAPSSKDAKA SAAFEASVQL YQKGYIDDNL QICFDSDLGQ HIGADQDDSQ
860 870 880 890 900
IMMTREQWQI ACKYSQRLVQ SQSTMGGKVN SQKRYYTNLF KTLFQTKDQE
910 920 930 940 950
GQFEDFLLYE CLFQNEKILL AFPKQMLPQI SKSENTLQAL GIQFQSMQKI
960 970 980 990 1000
SKSQYEGHYK KYVETIIKEE NLQQWRDDIY AIINQKCQIR IKSESNSNLL
1010 1020 1030 1040 1050
LILKGSVKSK FTLSQIINQF ALRFKVDLFQ DKIKEQLIQK IQIIPQNIKP
1060 1070 1080 1090 1100
HINEVLNSTS KYIKYLTSLQ YCYQNELDSL QLNFIHYSVS DVVLNFDVKD
1110 1120 1130 1140 1150
RLDEILFKSL DLSSHKYNEL LLGHQYYKFL IAVVLYANYF ENDINITRAK
1160 1170 1180 1190 1200
YKTFTRSTYV RNCLLESYLF LYLHKNDLND ITTQFIGLEK FQDNFDMMME
1210 1220 1230 1240 1250
QLILDDFSVA KRKSQRNTIK NKIHISNQEF FQFIQNSLFL IQQNDQDLVN
1260 1270 1280 1290 1300
GLNWLRTFRI MTSMKIHVNS SQCLQEFLPG FVPLSEQTRK IKRVFSSLEY
1310 1320 1330 1340 1350
KIKYQFKHFE LLFQAMTDIS FKFVINNKLK FKYYEQFQKK EEFQGMIQEQ
1360 1370 1380 1390 1400
QWIEFKSQFE CMNETDQNNY ENSLLAMLGK ALWNYLTIKI LNENNLDCFA
1410 1420 1430 1440 1450
IKIVGKILSK TPFLAYLAIQ LGLQQYLNSI YSTILLNLAS EVEKCKDSSL
1460 1470 1480 1490 1500
AFKIGKIQKS IHTQCLETAF FALVGAIYLD SNCSSNIVMQ WATLILDNVQ
1510 1520 1530 1540 1550
VQQFYSPDFI KRQPKYQFYQ WYQSNIGNPF NFNLIKIPHQ DYRRVSQGDK
1560 1570 1580 1590
LFIPYDMLEA QIVNIKKDKY YEISQLHIYA KSKEKAWEKL YEMIDY
Length:1,596
Mass (Da):187,068
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF89CA26600A63D7D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR932271 Genomic DNA Translation: CAI39097.1
CT868024 Genomic DNA Translation: CAK63262.1

NCBI Reference Sequences

More...
RefSeqi
XP_001430660.1, XM_001430623.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAK63262; CAK63262; GSPATT00033115001

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5016444

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ptm:GSPATT00033115001

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR932271 Genomic DNA Translation: CAI39097.1
CT868024 Genomic DNA Translation: CAK63262.1
RefSeqiXP_001430660.1, XM_001430623.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi5888.CAK63262

Genome annotation databases

EnsemblProtistsiCAK63262; CAK63262; GSPATT00033115001
GeneIDi5016444
KEGGiptm:GSPATT00033115001

Phylogenomic databases

eggNOGiKOG0701 Eukaryota
COG1111 LUCA
KOiK11592
OMAiFPITQQN

Family and domain databases

Gene3Di3.30.160.380, 1 hit
InterProiView protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF04851 ResIII, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 1 hit
PROSITEiView protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ3SE28_PARTE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3SE28
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: July 31, 2019
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again