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Entry version 48 (02 Jun 2021)
Sequence version 1 (11 Oct 2005)
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Protein
Submitted name:

Inositol 1,4,5,-triphosphate receptor n-2

Gene

IP3Rn-2

Organism
Paramecium tetraurelia
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.3.2.7, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Inositol 1,4,5,-triphosphate receptor n-2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IP3Rn-2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiParamecium tetraureliaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5888 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2515 – 2536HelicalSequence analysisAdd BLAST22
Transmembranei2557 – 2577HelicalSequence analysisAdd BLAST21
Transmembranei2583 – 2611HelicalSequence analysisAdd BLAST29
Transmembranei2631 – 2653HelicalSequence analysisAdd BLAST23
Transmembranei2708 – 2727HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini149 – 202MIRInterPro annotationAdd BLAST54
Domaini209 – 276MIRInterPro annotationAdd BLAST68
Domaini344 – 416MIRInterPro annotationAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2820 – 2840DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1024 – 1048Sequence analysisAdd BLAST25
Coiled coili1250 – 1277Sequence analysisAdd BLAST28
Coiled coili2346 – 2366Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014821, Ins145_P3_rcpt
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR035910, RyR/IP3R_RIH_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF08454, RIH_assoc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909, SSF100909, 2 hits
SSF82109, SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50919, MIR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3SDX7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEIIKIGSIV SISHLQDDDA LIGGDGFIKN AVILKGMSPL NKLDTKDFNI
60 70 80 90 100
SYFSQMNIPN CLFVVCPRTS NGKKVEVAKI FPQRKKKPFG SINDDVTDQK
110 120 130 140 150
SEVTPVRSQI KSVTHSVQPL LSEKQVRDNQ MNLFNEFKFN VDGFEKEKGN
160 170 180 190 200
YVKYEEPIQL LHLASSKWLC SLLDEAKFEN QNFKLALSDY TSDETLFKIV
210 220 230 240 250
ATYKYQKEGD QIVYSQEIVR IMRMIPFLGK PTYLHCSGEI PQKAIKEYRE
260 270 280 290 300
NSEVKIQKRE INASLEESTS WKINLFAEEL PIDGDLVWIH HSETCSQLAV
310 320 330 340 350
DYERDLNRAK ISVFQTDLSE LSFDNYSGNA YSMWIIEGED YKKGGPYLYS
360 370 380 390 400
NNYRLKHFHT GLYLACVRVI PKEQEDIKID PYGKKKVIIP KSKKVPATFA
410 420 430 440 450
LQVQPNKDSL FRFEPLKSVN KDEIQSDFIQ IRSVTQGKYL DVINKFHQDE
460 470 480 490 500
NTLKPVILNQ KNEHAVFKIF RANKQETQEV LFLDSCTKQL RKYQFYINLL
510 520 530 540 550
FKFEQNQMYQ SLSDDVELLK IKTKKLATAQ RCIQNLDDFL RQKIYNSSPS
560 570 580 590 600
QKYGFISPKR QKLLKDQHFF DVLLQILTST VTKQELEIWS NKKGNLKALE
610 620 630 640 650
QPSMTEKNQR KQQTISEKDK LELSNSKVEV CNMIFVLLQT SVINNTSNQL
660 670 680 690 700
YLFERLPDYQ HYCKYLPQTI NFLIEMVKSN EKILINLCNN LKIEFDYIKK
710 720 730 740 750
QEIEDDLKNK VKVLINFYEK DAGIQQDVSI PVKVHDRIIT RPINIIQYFF
760 770 780 790 800
NLIIDDTAKN NEHYLRFLRH ICRYKNNAIS INQENLFKLY KKYNKQTKLL
810 820 830 840 850
QIETNNGCII DKEISFQYEL LQFFSEVSYG RNYLWQAELS PLFEKDILIN
860 870 880 890 900
QIWNPNQVEG NQIDDKLRSY WCRLSRTLYI DQQPFQYLIV PNFCRLYSPY
910 920 930 940 950
QDQLKNRNDE EIEKQFKLKK MFKYIKTKRS EVYEAIASRA SSDLLNDELV
960 970 980 990 1000
YNAADQILTM LQLDIMPNKY YNKIIKYMSE MFIYDRKNLD YLNAAVKSYQ
1010 1020 1030 1040 1050
KTVTERKSKK SIVINQFGNV FSGMKDLIQL KQEDKEEIAE EEEDEEINLY
1060 1070 1080 1090 1100
DQPKLFLNPI MKGFMAMSNQ LEGLITLPKS QQEIEFKLKV CSILDHFLDR
1110 1120 1130 1140 1150
RQNFLISNIL LFFLKYQYTN DDLSDEDDDQ TIKAAPKIFN NNYKTLIPTI
1160 1170 1180 1190 1200
ARTGIDEIDE PEDTTQDFLQ MAVKKPPTFT NYFQQYNIKS EDEFQELDYY
1210 1220 1230 1240 1250
LSQAQKFDNN ERLSEDQLKE KQVASLLPYL MSTYFLVKDQ VLEERCLNVI
1260 1270 1280 1290 1300
MRVFNQREEL RENMKKLQIL FDDDNIKIYE FVEHLQKDLR VMVEKTEIWL
1310 1320 1330 1340 1350
TQFRAGYDVE ELDKCAQIIR QLTLCMRQGV QVNDRELVVE VVNKEINDSE
1360 1370 1380 1390 1400
KQSIMTFLKI HEIVINLIQN GMAHFISVLN DEFIKIERKE QLLLLFSNAF
1410 1420 1430 1440 1450
KFLICYCTNN KGNQLILYQY LEIYLQFIQY DVGQCKLLIE IFRDNPRLLN
1460 1470 1480 1490 1500
TGVKSLVQRL IEIIEREGRQ VKFVEILLNL ISIAGQYLLE NQILILNTFL
1510 1520 1530 1540 1550
PMRSLKETEQ RLLYAEGSQQ KDLRFYFDDQ FLEPEENLIK QLEAIDWKDC
1560 1570 1580 1590 1600
YRDEPFLYHS KILDLLLQTS LIDNTVREYN PSLMPTDNFN ISVFKLKKMI
1610 1620 1630 1640 1650
KPSYLLEILR LDDDMVSLKQ RLARMPTQFI KGQASQYQDE QFNKKKGYTA
1660 1670 1680 1690 1700
LKPIVCEFLR LVHIVSEKNN AQEGLLSQLS RQFIHFVEFE SKKLEFVAAG
1710 1720 1730 1740 1750
TDYQNCYVDY IIGQVIPLIL CYHQRVLSVQ QEDVKNALIE FSSQFAQALC
1760 1770 1780 1790 1800
STFYQKLTKY EQLEIISKLR EYYQNEYYEP AYRQEGEQSI LHLQHMQFQL
1810 1820 1830 1840 1850
EDGEDLQQPI EEQHVQSIQK KSQSKSKNLL SQFASLNLSL INKTSKHKRG
1860 1870 1880 1890 1900
DLTPIKLQEQ WKRFAEELFR SPKLEEQIDI EKEALADAII GIDKLIQEPC
1910 1920 1930 1940 1950
EIKPSLESIL KKFITFLQTA VLQQDNKGTI VILLKIMSKI IEKQDSDEKK
1960 1970 1980 1990 2000
EYYQKLFDNL GATRMVLNVI TDYSKLLSNE MLYYLISFIN VLLRNGNSQV
2010 2020 2030 2040 2050
QNTIFTFCQT QQKSEVMFQT FAKYLEIAAT SGRDKNEDKE EAEVQKQIVN
2060 2070 2080 2090 2100
CILKFFQNCT EGHYQDMQNY IRYQYNSRAS KDLINLVADL FKNYDRTKQN
2110 2120 2130 2140 2150
FSNLMCCLDT LNELVQGPCA ENQLAVADSK FFDVVQEMFP LRKGAVSQQK
2160 2170 2180 2190 2200
AVKSAATKRI SVLPSQSVSN LLTRGMKAQL QNKILVLVLS LLENREIKGK
2210 2220 2230 2240 2250
NSIIKRIMRV LPMNVLERHL SKIYKKWFNK YTGDYNMQAF ELLKIDAMDL
2260 2270 2280 2290 2300
DEESQEFKDC EIIIQNGFYI MFLICYYMES DEEIDSVFMG YNKQYLKSQI
2310 2320 2330 2340 2350
QQNSLFDPNS TLGQLFALGM ELYEMSLLKT QQMFNELNKT RKDDPEFILE
2360 2370 2380 2390 2400
QQKRKQEEKK KRLKKAFMFF RARTAHIEVV RDDQIELVFF PLLPFSKLNK
2410 2420 2430 2440 2450
DEKQSFQQTV DRSSAKSKVQ DLMEKSPELI QIMRHEEEMN RFYKQYKLIG
2460 2470 2480 2490 2500
FFANYIQLWK DLAFYLTLII NTMIIASFSH QSDPDRPKED VSSEALDEYV
2510 2520 2530 2540 2550
FFRKDEWTQA QTKELISALG YAMMVCSLFV VLFVLARIAP LIIKKALQRK
2560 2570 2580 2590 2600
PLLEGQGMIK LLINWLAKFF FVLFYCLQDF QLVYYLGYGA LSVIGTLVHP
2610 2620 2630 2640 2650
FFFCFHLTVI LIRYPTLSNV VRAVTMPWQQ LVLTLLLIII ITYIFTLIAF
2660 2670 2680 2690 2700
YALQDPFGLD CKEVSICFLQ IFDKNFKIPG GIGGDITNNN PSPTYEIFRY
2710 2720 2730 2740 2750
LYDQINNLLL VIIMVSIASG IIIDTFGQLR EDENKMNSDI KDKCFICGQE
2760 2770 2780 2790 2800
NIIFERSSDG SSGGFKNHIR QNHYMWNYLY YIAYLQWKDP QDYSGIESYV
2810 2820 2830 2840 2850
DKKIKDTDLS WIPFGRAREL DKGEDESEKQ AKQMEQSSSN IASLLTHSSD
2860 2870 2880
IIQALKEKKE KRKQHFTQQT QPTQYKEQIL SQQSMALL
Length:2,888
Mass (Da):339,535
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D234137D4626095
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR932322 Genomic DNA Translation: CAI39148.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR932322 Genomic DNA Translation: CAI39148.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi1.A.3.2.7, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

Family and domain databases

InterProiView protein in InterPro
IPR014821, Ins145_P3_rcpt
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR035910, RyR/IP3R_RIH_dom_sf
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF08454, RIH_assoc, 1 hit
SUPFAMiSSF100909, SSF100909, 2 hits
SSF82109, SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50919, MIR, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ3SDX7_PARTE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3SDX7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: June 2, 2021
This is version 48 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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