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Entry version 97 (12 Aug 2020)
Sequence version 1 (11 Oct 2005)
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Protein

T-box transcription factor TBX2

Gene

tbx2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi104 – 277T-boxPROSITE-ProRule annotationAdd BLAST174

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
T-box transcription factor TBX2
Short name:
T-box protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tbx2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-1018115, tbx2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002624661 – 685T-box transcription factor TBX2Add BLAST685

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3SA48

PRoteomics IDEntifications database

More...
PRIDEi
Q3SA48

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed ventrally in early gastrulae (stage 10.5) and is expressed most strongly in the outer layer of ectodermal cells. At the late gastrula stage (stage 12), expression appears to be up-regulated consistently in a small group of cells clustered around the ventral edge of the closing blastopore. At the early neurula stage (stage 13), four regions of ectodermal expression are clearly detected. At stage 19 (late neurula), expression persists in the cement gland, the ventral epidermis, the proctodeal region, the lens placodes, and in a broad placodal area caudal to the eye anlagen. In addition, expression also detected in the dorsal root ganglia of the future spinal cord. At stage 21/22, expression seen in a wishbone-shaped group of cells situated dorsal and caudal to each developing optic vesicle corresponding to the cranial (profundal and trigeminal) ganglia. Expression persists in these cells through tail bud and into early tadpole stages. From stage 21/22 onward, the bilateral expression in the ectodermal placodes becomes restricted primarily to the otic placode and the developing otic vesicles. At stage 24, also observed in the precursors of the hypaxial muscles and the pronephric duct in the trunk, in the developing branchial arches and in the primordium of the heart. In stage 29 embryos, expression detected in the frontonasal process and continues to be expressed in the same regions of the embryo at stage 33, although its expression becomes clearly regionalized in the looping heart. A higher level of expression seen in the ventricle as compared with the atrium.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSXETG00000020557, Expressed in mesonephros and 33 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000044410

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3SA48

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili652 – 676Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi559 – 567Poly-Ala9

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3585, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_023038_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3SA48

KEGG Orthology (KO)

More...
KOi
K10176

Identification of Orthologs from Complete Genome Data

More...
OMAi
EHHSNHK

Database of Orthologous Groups

More...
OrthoDBi
301173at2759

TreeFam database of animal gene trees

More...
TreeFami
TF106341

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00182, TBOX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008967, p53-like_TF_DNA-bd
IPR036960, T-box_sf
IPR022582, TBX
IPR002070, TF_Brachyury
IPR001699, TF_T-box
IPR018186, TF_T-box_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11267, PTHR11267, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00907, T-box, 1 hit
PF12598, TBX, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00938, BRACHYURY
PR00937, TBOX

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00425, TBOX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49417, SSF49417, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01283, TBOX_1, 1 hit
PS01264, TBOX_2, 1 hit
PS50252, TBOX_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q3SA48-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRDPAFPGAA MAYHPFHAPR PADFPMSAFL AAAQPSFFPA LTLPPAALGK
60 70 80 90 100
PLSDPSLAGA AEAGLHVSAL GHHHQAAHLR SLKSLEPEEE VEDDPKVTLE
110 120 130 140 150
AKELWDQFHK LGTEMVITKS GRRMFPPFKV RVSGLDKKAK YILLMDIVAA
160 170 180 190 200
DDCRYKFHNS RWMVAGKADP EMPKRMYIHP DSPATGEQWM AKPVAFHKLK
210 220 230 240 250
LTNNISDKHG FTILNSMHKY QPRFHIVRAN DILKLPYSTF RTYVFPETDF
260 270 280 290 300
IAVTAYQNDK ITQLKIDNNP FAKGFRDTGN GRREKRKQLS LPSLRMYEEQ
310 320 330 340 350
CKADRDGAES DASSCDPAPG RDSLHSPLST EPSPLRLHRS NREEKFGADS
360 370 380 390 400
DQELDRREVR TARSHSPVGH RSPPSSPRLE DRGKDKNTPE KKSESPESRK
410 420 430 440 450
DGGDNVFSRS LEKDKGESRR KEDSKSDPEC GSLSKETFAP LMVQTDSPPH
460 470 480 490 500
LSASHLQSLA LSGLHGQQFF NPLNAAQPLF IHPGQFTMGP GAFSAMGMGH
510 520 530 540 550
LLASMTGASA LDNGSLSSVQ GATGAATFPF HLSQHMLASQ GIPMPAFGGL
560 570 580 590 600
FPYPYTYMAA AAAAASAMPA TSAATTMPRN PFLSSTRPRL RFNPYQIPVG
610 620 630 640 650
IPPSTNLLTT GLSASLNPGS ESSKPGSSRE SSPIPDTPGH KRSHSNSLSP
660 670 680
KASMKDSINE LQNIQRLVSG LESQREVSPG RETPK
Length:685
Mass (Da):74,951
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC00BBEF198085A0C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7C9T7F7C9T7_XENTR
Exocyst complex component 3
nkrf
748Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q28C35Q28C35_XENTR
NFKB repressing factor
nkrf tbx2, TEgg058c19.1-001
791Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ124206 mRNA Translation: AAZ79651.1
BC135209 mRNA Translation: AAI35210.1

NCBI Reference Sequences

More...
RefSeqi
NP_001030291.1, NM_001035119.1
XP_017946799.1, XM_018091310.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
619588

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xtr:619588

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ124206 mRNA Translation: AAZ79651.1
BC135209 mRNA Translation: AAI35210.1
RefSeqiNP_001030291.1, NM_001035119.1
XP_017946799.1, XM_018091310.1

3D structure databases

SMRiQ3SA48
ModBaseiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000044410

Proteomic databases

PaxDbiQ3SA48
PRIDEiQ3SA48

Genome annotation databases

GeneIDi619588
KEGGixtr:619588

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6909
XenbaseiXB-GENE-1018115, tbx2

Phylogenomic databases

eggNOGiKOG3585, Eukaryota
HOGENOMiCLU_023038_1_0_1
InParanoidiQ3SA48
KOiK10176
OMAiEHHSNHK
OrthoDBi301173at2759
TreeFamiTF106341

Gene expression databases

BgeeiENSXETG00000020557, Expressed in mesonephros and 33 other tissues

Family and domain databases

CDDicd00182, TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967, p53-like_TF_DNA-bd
IPR036960, T-box_sf
IPR022582, TBX
IPR002070, TF_Brachyury
IPR001699, TF_T-box
IPR018186, TF_T-box_CS
PANTHERiPTHR11267, PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907, T-box, 1 hit
PF12598, TBX, 1 hit
PRINTSiPR00938, BRACHYURY
PR00937, TBOX
SMARTiView protein in SMART
SM00425, TBOX, 1 hit
SUPFAMiSSF49417, SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283, TBOX_1, 1 hit
PS01264, TBOX_2, 1 hit
PS50252, TBOX_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBX2_XENTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3SA48
Secondary accession number(s): A4IGQ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 11, 2005
Last modified: August 12, 2020
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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