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UniProtKB - Q3MV19 (TRF6A_XENLA)
Protein
TNF receptor-associated factor 6-A
Gene
traf6-a
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation.
By similarityCatalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity EC:2.3.2.27
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarityView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 72 – 111 | RING-type; degeneratePROSITE-ProRule annotationAdd BLAST | 40 | |
Zinc fingeri | 148 – 204 | TRAF-type 1PROSITE-ProRule annotationAdd BLAST | 57 | |
Zinc fingeri | 205 – 261 | TRAF-type 2PROSITE-ProRule annotationAdd BLAST | 57 |
GO - Molecular functioni
- tumor necrosis factor receptor binding Source: InterPro
- ubiquitin-protein transferase activity Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- activation of NF-kappaB-inducing kinase activity Source: UniProtKB
- protein K63-linked ubiquitination Source: UniProtKB
- regulation of apoptotic process Source: InterPro
- regulation of I-kappaB kinase/NF-kappaB signaling Source: InterPro
Keywordsi
Molecular function | Transferase |
Biological process | Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: TNF receptor-associated factor 6-A (EC:2.3.2.27)Alternative name(s): E3 ubiquitin-protein ligase TRAF6 RING-type E3 ubiquitin transferase TRAF6-ACurated |
Gene namesi | Name:traf6-a |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-6254727, traf6.S |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cell cortex By similarity
- Lipid droplet By similarity
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cell cortex Source: UniProtKB-SubCell
- lipid droplet Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Lipid droplet, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000391613 | 1 – 556 | TNF receptor-associated factor 6-AAdd BLAST | 556 |
Expressioni
Tissue specificityi
Highly expressed in ovary and moderately expressed in kidney, spleen, stomach, colon and testis.1 Publication
Developmental stagei
First detected in the neurula stage and then increased during late tadpole stage.1 Publication
Interactioni
Subunit structurei
Homotrimer (By similarity). Homooligomer (By similarity).
Interacts with tifa (PubMed:16023795).
By similarity1 PublicationGO - Molecular functioni
- tumor necrosis factor receptor binding Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 384 – 533 | MATHPROSITE-ProRule annotationAdd BLAST | 150 |
Domaini
The MATH/TRAF domain binds to receptor cytoplasmic domains.By similarity
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 72 – 111 | RING-type; degeneratePROSITE-ProRule annotationAdd BLAST | 40 | |
Zinc fingeri | 148 – 204 | TRAF-type 1PROSITE-ProRule annotationAdd BLAST | 57 | |
Zinc fingeri | 205 – 261 | TRAF-type 2PROSITE-ProRule annotationAdd BLAST | 57 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
OMAi | WMQKNNQ |
OrthoDBi | 918518at2759 |
Family and domain databases
CDDi | cd03776, MATH_TRAF6, 1 hit |
Gene3Di | 2.60.210.10, 1 hit 3.30.40.10, 3 hits |
InterProi | View protein in InterPro IPR002083, MATH/TRAF_dom IPR043211, TNF_rcpt-assoc_TRAF IPR012227, TNF_rcpt-assoc_TRAF_met IPR008974, TRAF-like IPR027139, TRAF6 IPR037309, TRAF6_MATH IPR041310, TRAF6_Z2 IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS IPR001293, Znf_TRAF |
PANTHERi | PTHR10131, PTHR10131, 2 hits PTHR10131:SF131, PTHR10131:SF131, 2 hits |
Pfami | View protein in Pfam PF18048, TRAF6_Z2, 1 hit PF02176, zf-TRAF, 1 hit |
PIRSFi | PIRSF015614, TRAF, 1 hit |
SMARTi | View protein in SMART SM00061, MATH, 1 hit SM00184, RING, 2 hits |
PROSITEi | View protein in PROSITE PS50144, MATH, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit PS50145, ZF_TRAF, 2 hits |
i Sequence
Sequence statusi: Complete.
Q3MV19-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSILNPRTSL EAGDSEDACC AAMASVCCIN TKEDADSPSA GLPSGTTQNL
60 70 80 90 100
DVEEIQGYDV EFDPPLESKY ECPICLMALR EAVQTPCGHR FCKACILKSL
110 120 130 140 150
RNAGHKCPVD NEILMEKQLF PDNFAKREIL SLRVKCPNLG CTDTMELRHL
160 170 180 190 200
EHHLVQCQFA SVECSQCQGS FLKLLLDKHM EHECGRRRTF CDNCGLAMAY
210 220 230 240 250
EDKSGHELIC PMAYVTCDYC QTNLIREQMP AHYSMDCTMA PIPCMYCEFG
260 270 280 290 300
CREKMQRHNL AGHLQDFTQA HMRMMAQTLR SFSTTPTSHI SDISFCDPNQ
310 320 330 340 350
FEPVPLSVAP AHPSHMPSQQ DCSQETRNLR ETVEQLEGRL VRQDHQIREL
360 370 380 390 400
IAKMETQCTY VNELKHTIHS LEDKVADMDA HRCNGVFIWR IKGFSGLQKS
410 420 430 440 450
QEEEKPVVIH SPGFYTGDPG YKLCLRLHLQ LPSAQRCANY ISLFVHTMQG
460 470 480 490 500
DYDSLLPWPL QGTIRLSILD QSESTARQDQ VEVMDTKPDL LAFQRPTAPR
510 520 530 540 550
NPKGFGYVTF MHLNTLKQRQ YVKNDTLLVR CSVNIHLDLT SPRREGFQPR
SGEGTL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 162 | V → I in AAI08563 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB100960 mRNA Translation: BAE44508.1 BC108562 mRNA Translation: AAI08563.1 |
RefSeqi | NP_001089863.1, NM_001096394.1 |
Genome annotation databases
GeneIDi | 734929 |
KEGGi | xla:734929 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB100960 mRNA Translation: BAE44508.1 BC108562 mRNA Translation: AAI08563.1 |
RefSeqi | NP_001089863.1, NM_001096394.1 |
3D structure databases
AlphaFoldDBi | Q3MV19 |
SMRi | Q3MV19 |
ModBasei | Search... |
Protocols and materials databases
DNASUi | 734929 |
Genome annotation databases
GeneIDi | 734929 |
KEGGi | xla:734929 |
Organism-specific databases
CTDi | 734929 |
Xenbasei | XB-GENE-6254727, traf6.S |
Phylogenomic databases
OMAi | WMQKNNQ |
OrthoDBi | 918518at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Family and domain databases
CDDi | cd03776, MATH_TRAF6, 1 hit |
Gene3Di | 2.60.210.10, 1 hit 3.30.40.10, 3 hits |
InterProi | View protein in InterPro IPR002083, MATH/TRAF_dom IPR043211, TNF_rcpt-assoc_TRAF IPR012227, TNF_rcpt-assoc_TRAF_met IPR008974, TRAF-like IPR027139, TRAF6 IPR037309, TRAF6_MATH IPR041310, TRAF6_Z2 IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS IPR001293, Znf_TRAF |
PANTHERi | PTHR10131, PTHR10131, 2 hits PTHR10131:SF131, PTHR10131:SF131, 2 hits |
Pfami | View protein in Pfam PF18048, TRAF6_Z2, 1 hit PF02176, zf-TRAF, 1 hit |
PIRSFi | PIRSF015614, TRAF, 1 hit |
SMARTi | View protein in SMART SM00061, MATH, 1 hit SM00184, RING, 2 hits |
PROSITEi | View protein in PROSITE PS50144, MATH, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit PS50145, ZF_TRAF, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | TRF6A_XENLA | |
Accessioni | Q3MV19Primary (citable) accession number: Q3MV19 Secondary accession number(s): Q32NM4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 9, 2010 |
Last sequence update: | October 25, 2005 | |
Last modified: | May 25, 2022 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families