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Entry version 118 (11 Dec 2019)
Sequence version 2 (18 May 2010)
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Protein

WD repeat-containing protein 72

Gene

WDR72

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a major role in formation of tooth enamel (PubMed:19853237, PubMed:25008349). Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane.By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBiomineralization

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q3MJ13

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein 72
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR72
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000166415.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26790 WDR72

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613214 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q3MJ13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Amelogenesis imperfecta, hypomaturation type, 2A3 (AI2A3)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.
Related information in OMIM

Keywords - Diseasei

Amelogenesis imperfecta

Organism-specific databases

DisGeNET

More...
DisGeNETi
256764

MalaCards human disease database

More...
MalaCardsi
WDR72
MIMi613211 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000166415

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
100033 Hypomaturation amelogenesis imperfecta

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670587

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q3MJ13 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WDR72

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296453027

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002414471 – 1102WD repeat-containing protein 72Add BLAST1102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1081PhosphoserineBy similarity1
Modified residuei1083PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3MJ13

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q3MJ13

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q3MJ13

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3MJ13

PeptideAtlas

More...
PeptideAtlasi
Q3MJ13

PRoteomics IDEntifications database

More...
PRIDEi
Q3MJ13

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61800

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3MJ13

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3MJ13

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166415 Expressed in 105 organ(s), highest expression level in kidney epithelium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3MJ13 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3MJ13 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA048212
HPA057410
HPA059819

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q3MJ13, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379619

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3MJ13 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati15 – 54WD 1Add BLAST40
Repeati60 – 102WD 2Add BLAST43
Repeati160 – 197WD 3Add BLAST38
Repeati318 – 362WD 4Add BLAST45
Repeati402 – 441WD 5Add BLAST40
Repeati459 – 504WD 6Add BLAST46
Repeati507 – 552WD 7Add BLAST46
Repeati555 – 594WD 8Add BLAST40

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ISIU Eukaryota
ENOG411264G LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160298

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168573

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3MJ13

Database of Orthologous Groups

More...
OrthoDBi
84170at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3MJ13

TreeFam database of animal gene trees

More...
TreeFami
TF313196

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q3MJ13-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTSLQAVAL WGQKAPPHSI TAIMITDDQR TIVTGSQEGQ LCLWNLSHEL
60 70 80 90 100
KISAKELLFG HSASVTCLAR ARDFSKQPYI VSAAENGEMC VWNVTNGQCM
110 120 130 140 150
EKATLPYRHT AICYYHCSFR MTGEGWLLCC GEYQDVLIID AKTLAVVHSF
160 170 180 190 200
RSSQFPDWIN CMCIVHSMRI QEDSLLVVSV AGELKVWDLS SSINSIQEKQ
210 220 230 240 250
DVYEKESKFL ESLNCQTIRF CTYTERLLLV VFSKCWKVYD YCDFSLLLTE
260 270 280 290 300
VSRNGQFFAG GEVIAAHRIL IWTEDGHSYI YQLLNSGLSK SIYPADGRVL
310 320 330 340 350
KETIYPHLLC STSVQENKEQ SRPFVMGYMN ERKEPFYKVL FSGEVSGRIT
360 370 380 390 400
LWHIPDVPVS KFDGSPREIP VTATWTLQDN FDKHDTMSQS IIDYFSGLKD
410 420 430 440 450
GAGTAVVTSS EYIPSLDKLI CGCEDGTIII TQALNAAKAR LLEGGSLVKD
460 470 480 490 500
SPPHKVLKGH HQSVTSLLYP HGLSSKLDQS WMLSGDLDSC VILWDIFTEE
510 520 530 540 550
ILHKFFLEAG PVTSLLMSPE KFKLRGEQII CCVCGDHSVA LLHLEGKSCL
560 570 580 590 600
LHARKHLFPV RMIKWHPVEN FLIVGCADDS VYIWEIETGT LERHETGERA
610 620 630 640 650
RIILNCCDDS QLVKSVLPIA SETLKHKSIE QRSSSPYQLG PLPCPGLQVE
660 670 680 690 700
SSCKVTDAKF CPRPFNVLPV KTKWSNVGFH ILLFDLENLV ELLLPTPLSD
710 720 730 740 750
VDSSSSFYGG EVLRRAKSTV EKKTLTLRKS KTACGPLSAE ALAKPITESL
760 770 780 790 800
AQGDNTIKFS EENDGIKRQK KMKISKKMQP KPSRKVDASL TIDTAKLFLS
810 820 830 840 850
CLLPWGVDKD LDYLCIKHLN ILKLQGPISL GISLNEDNFS LMLPGWDLCN
860 870 880 890 900
SGMIKDYSGV NLFSRKVLDL SDKYTATLPN QVGIPRGLEN NCDSLRESDT
910 920 930 940 950
IVYLLSRLFL VNKLVNMPLE LACRVGSSFR MESIHNKMRG AGNDILNMSS
960 970 980 990 1000
FYSCLRNGKN ESHVPEADLS LLKLISCWRD QSVQVTEAIQ AVLLAEVQQH
1010 1020 1030 1040 1050
MKSLGKIPVN SQPVSMAENG NCEMKQMLPK LEWTEELELQ CVRNTLPLQT
1060 1070 1080 1090 1100
PVSPVKHDSN SNSANFQDVE DMPDRCALEE SESPGEPRHH SWIAKVCPCK

VS
Length:1,102
Mass (Da):123,425
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C32B03612C1BE6C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WTC3A0A087WTC3_HUMAN
WD repeat-containing protein 72
WDR72
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKE0H0YKE0_HUMAN
WD repeat-containing protein 72
WDR72
1,112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLX4H0YLX4_HUMAN
WD repeat-containing protein 72
WDR72
1,099Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YN02H0YN02_HUMAN
WD repeat-containing protein 72
WDR72
775Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti41L → P in CAD97880 (PubMed:17974005).Curated1
Sequence conflicti183E → G in CAD97880 (PubMed:17974005).Curated1
Sequence conflicti306P → L in CAD97880 (PubMed:17974005).Curated1
Sequence conflicti306P → L in AAI01617 (PubMed:15489334).Curated1
Sequence conflicti306P → L in AAI01615 (PubMed:15489334).Curated1
Sequence conflicti610S → P in CAD97880 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060045100M → V3 PublicationsCorresponds to variant dbSNP:rs690346EnsemblClinVar.1
Natural variantiVAR_057633399K → Q. Corresponds to variant dbSNP:rs35258188EnsemblClinVar.1
Natural variantiVAR_057634479Q → H. Corresponds to variant dbSNP:rs34123953EnsemblClinVar.1
Natural variantiVAR_062106781K → E. Corresponds to variant dbSNP:rs60404950EnsemblClinVar.1
Natural variantiVAR_026837819L → F. Corresponds to variant dbSNP:rs17730281EnsemblClinVar.1
Natural variantiVAR_026838833S → A. Corresponds to variant dbSNP:rs16966320EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX537884 mRNA Translation: CAD97880.1
AC024061 Genomic DNA No translation available.
AC066611 Genomic DNA No translation available.
AC066614 Genomic DNA No translation available.
BC101616 mRNA Translation: AAI01617.1
BC101614 mRNA Translation: AAI01615.1
AK096055 mRNA Translation: BAC04689.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10151.1

NCBI Reference Sequences

More...
RefSeqi
NP_877435.3, NM_182758.3
XP_011519735.1, XM_011521433.2
XP_011519737.1, XM_011521435.2
XP_016877550.1, XM_017022061.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000360509; ENSP00000353699; ENSG00000166415
ENST00000396328; ENSP00000379619; ENSG00000166415

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
256764

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:256764

UCSC genome browser

More...
UCSCi
uc002acj.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537884 mRNA Translation: CAD97880.1
AC024061 Genomic DNA No translation available.
AC066611 Genomic DNA No translation available.
AC066614 Genomic DNA No translation available.
BC101616 mRNA Translation: AAI01617.1
BC101614 mRNA Translation: AAI01615.1
AK096055 mRNA Translation: BAC04689.1
CCDSiCCDS10151.1
RefSeqiNP_877435.3, NM_182758.3
XP_011519735.1, XM_011521433.2
XP_011519737.1, XM_011521435.2
XP_016877550.1, XM_017022061.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ3MJ13, 1 interactor
STRINGi9606.ENSP00000379619

PTM databases

iPTMnetiQ3MJ13
PhosphoSitePlusiQ3MJ13

Polymorphism and mutation databases

BioMutaiWDR72
DMDMi296453027

Proteomic databases

EPDiQ3MJ13
jPOSTiQ3MJ13
MassIVEiQ3MJ13
PaxDbiQ3MJ13
PeptideAtlasiQ3MJ13
PRIDEiQ3MJ13
ProteomicsDBi61800

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
256764

Genome annotation databases

EnsembliENST00000360509; ENSP00000353699; ENSG00000166415
ENST00000396328; ENSP00000379619; ENSG00000166415
GeneIDi256764
KEGGihsa:256764
UCSCiuc002acj.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
256764
DisGeNETi256764
EuPathDBiHostDB:ENSG00000166415.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WDR72
HGNCiHGNC:26790 WDR72
HPAiHPA048212
HPA057410
HPA059819
MalaCardsiWDR72
MIMi613211 phenotype
613214 gene
neXtProtiNX_Q3MJ13
OpenTargetsiENSG00000166415
Orphaneti100033 Hypomaturation amelogenesis imperfecta
PharmGKBiPA142670587

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ISIU Eukaryota
ENOG411264G LUCA
GeneTreeiENSGT00940000160298
HOGENOMiHOG000168573
InParanoidiQ3MJ13
OrthoDBi84170at2759
PhylomeDBiQ3MJ13
TreeFamiTF313196

Enzyme and pathway databases

SignaLinkiQ3MJ13

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
WDR72 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
WDR72

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
256764
PharosiQ3MJ13 Tbio

Protein Ontology

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PROi
PR:Q3MJ13
RNActiQ3MJ13 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000166415 Expressed in 105 organ(s), highest expression level in kidney epithelium
ExpressionAtlasiQ3MJ13 baseline and differential
GenevisibleiQ3MJ13 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR72_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3MJ13
Secondary accession number(s): Q7Z3I3, Q8N8X2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 18, 2010
Last modified: December 11, 2019
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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