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UniProtKB - Q3MIX3 (ADCK5_HUMAN)
Protein
Uncharacterized aarF domain-containing protein kinase 5
Gene
ADCK5
Organism
Homo sapiens (Human)
Status
Functioni
The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
GO - Molecular functioni
- protein serine/threonine kinase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Enzyme and pathway databases
PathwayCommonsi | Q3MIX3 |
SignaLinki | Q3MIX3 |
SIGNORi | Q3MIX3 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ADCK5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21738, ADCK5 |
neXtProti | NX_Q3MIX3 |
VEuPathDBi | HostDB:ENSG00000173137 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 50 – 67 | HelicalSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000173137 |
PharmGKBi | PA134963849 |
Miscellaneous databases
Pharosi | Q3MIX3, Tdark |
Chemistry databases
ChEMBLi | CHEMBL4105886 |
Genetic variation databases
BioMutai | ADCK5 |
DMDMi | 121958055 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000271800 | 1 – 580 | Uncharacterized aarF domain-containing protein kinase 5Add BLAST | 580 |
Proteomic databases
EPDi | Q3MIX3 |
jPOSTi | Q3MIX3 |
MassIVEi | Q3MIX3 |
PaxDbi | Q3MIX3 |
PeptideAtlasi | Q3MIX3 |
PRIDEi | Q3MIX3 |
ProteomicsDBi | 61799 |
PTM databases
iPTMneti | Q3MIX3 |
PhosphoSitePlusi | Q3MIX3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000173137, Expressed in mucosa of transverse colon and 137 other tissues |
ExpressionAtlasi | Q3MIX3, baseline and differential |
Genevisiblei | Q3MIX3, HS |
Organism-specific databases
HPAi | ENSG00000173137, Low tissue specificity |
Interactioni
Binary interactionsi
Q3MIX3
With | #Exp. | IntAct |
---|---|---|
NOTCH2NLA [Q7Z3S9] | 4 | EBI-3923548,EBI-945833 |
Protein-protein interaction databases
BioGRIDi | 128442, 17 interactors |
IntActi | Q3MIX3, 31 interactors |
MINTi | Q3MIX3 |
STRINGi | 9606.ENSP00000310547 |
Miscellaneous databases
RNActi | Q3MIX3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 179 – 419 | Protein kinaseAdd BLAST | 241 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1235, Eukaryota |
GeneTreei | ENSGT00940000159821 |
HOGENOMi | CLU_006533_2_6_1 |
InParanoidi | Q3MIX3 |
OMAi | RPWRGGW |
OrthoDBi | 790106at2759 |
PhylomeDBi | Q3MIX3 |
TreeFami | TF354300 |
Family and domain databases
CDDi | cd13969, ADCK1-like, 1 hit |
InterProi | View protein in InterPro IPR004147, ABC1_dom IPR045307, ADCK1_dom IPR011009, Kinase-like_dom_sf |
Pfami | View protein in Pfam PF03109, ABC1, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q3MIX3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWRPVQLCHF HSALLHSRQK PWPSPAVFFR RNVRGLPPRF SSPTPLWRKV
60 70 80 90 100
LSTAVVGAPL LLGARYVMAE AREKRRMRLV VDGMGRFGRS LKVGLQISLD
110 120 130 140 150
YWWCTNVVLR GVEENSPGYL EVMSACHQRA ADALVAGAIS NGGLYVKLGQ
160 170 180 190 200
GLCSFNHLLP PEYTRTLRVL EDRALKRGFQ EVDELFLEDF QALPHELFQE
210 220 230 240 250
FDYQPIAAAS LAQVHRAKLH DGTSVAVKVQ YIDLRDRFDG DIHTLELLLR
260 270 280 290 300
LVEVMHPSFG FSWVLQDLKG TLAQELDFEN EGRNAERCAR ELAHFPYVVV
310 320 330 340 350
PRVHWDKSSK RVLTADFCAG CKVNDVEAIR SQGLAVHDIA EKLIKAFAEQ
360 370 380 390 400
IFYTGFIHSD PHPGNVLVRK GPDGKAELVL LDHGLYQFLE EKDRAALCQL
410 420 430 440 450
WRAIILRDDA AMRAHAAALG VQDYLLFAEM LMQRPVRLGQ LWGSHLLSRE
460 470 480 490 500
EAAYMVDMAR ERFEAVMAVL RELPRPMLLV LRNINTVRAI NVALGAPVDR
510 520 530 540 550
YFLMAKRAVR GWSRLAGATY RGVYGTSLLR HAKVVWEMLK FEVALRLETL
560 570 580
AMRLTALLAR ALVHLSLVPP AEELYQYLET
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PLF3 | E9PLF3_HUMAN | Uncharacterized aarF domain-contain... | ADCK5 | 115 | Annotation score: | ||
E9PJ20 | E9PJ20_HUMAN | Uncharacterized aarF domain-contain... | ADCK5 | 129 | Annotation score: | ||
R4GN53 | R4GN53_HUMAN | Uncharacterized aarF domain-contain... | ADCK5 | 87 | Annotation score: |
Sequence cautioni
The sequence AAH31570 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 275 | E → G in BAG52608 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 283 | R → G in AAH85013 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 324 – 338 | NDVEA…LAVHD → GGLVLCPLQCLSSPQ in AAH64345 (PubMed:15489334).CuratedAdd BLAST | 15 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029996 | 17 | S → R1 PublicationCorresponds to variant dbSNP:rs6599528Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK092773 mRNA Translation: BAG52608.1 AC233992 Genomic DNA No translation available. BC031570 mRNA Translation: AAH31570.1 Different initiation. BC064345 mRNA Translation: AAH64345.1 BC085013 mRNA Translation: AAH85013.1 BC101659 mRNA Translation: AAI01660.1 |
CCDSi | CCDS34965.2 |
RefSeqi | NP_777582.4, NM_174922.4 |
Genome annotation databases
Ensembli | ENST00000308860; ENSP00000310547; ENSG00000173137 ENST00000645968; ENSP00000494807; ENSG00000285451 |
GeneIDi | 203054 |
KEGGi | hsa:203054 |
MANE-Selecti | ENST00000308860.11; ENSP00000310547.6; NM_174922.5; NP_777582.4 |
UCSCi | uc003zch.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK092773 mRNA Translation: BAG52608.1 AC233992 Genomic DNA No translation available. BC031570 mRNA Translation: AAH31570.1 Different initiation. BC064345 mRNA Translation: AAH64345.1 BC085013 mRNA Translation: AAH85013.1 BC101659 mRNA Translation: AAI01660.1 |
CCDSi | CCDS34965.2 |
RefSeqi | NP_777582.4, NM_174922.4 |
3D structure databases
SMRi | Q3MIX3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128442, 17 interactors |
IntActi | Q3MIX3, 31 interactors |
MINTi | Q3MIX3 |
STRINGi | 9606.ENSP00000310547 |
Chemistry databases
ChEMBLi | CHEMBL4105886 |
PTM databases
iPTMneti | Q3MIX3 |
PhosphoSitePlusi | Q3MIX3 |
Genetic variation databases
BioMutai | ADCK5 |
DMDMi | 121958055 |
Proteomic databases
EPDi | Q3MIX3 |
jPOSTi | Q3MIX3 |
MassIVEi | Q3MIX3 |
PaxDbi | Q3MIX3 |
PeptideAtlasi | Q3MIX3 |
PRIDEi | Q3MIX3 |
ProteomicsDBi | 61799 |
Protocols and materials databases
Antibodypediai | 28478, 188 antibodies from 31 providers |
DNASUi | 203054 |
Genome annotation databases
Ensembli | ENST00000308860; ENSP00000310547; ENSG00000173137 ENST00000645968; ENSP00000494807; ENSG00000285451 |
GeneIDi | 203054 |
KEGGi | hsa:203054 |
MANE-Selecti | ENST00000308860.11; ENSP00000310547.6; NM_174922.5; NP_777582.4 |
UCSCi | uc003zch.5, human |
Organism-specific databases
CTDi | 203054 |
GeneCardsi | ADCK5 |
HGNCi | HGNC:21738, ADCK5 |
HPAi | ENSG00000173137, Low tissue specificity |
neXtProti | NX_Q3MIX3 |
OpenTargetsi | ENSG00000173137 |
PharmGKBi | PA134963849 |
VEuPathDBi | HostDB:ENSG00000173137 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1235, Eukaryota |
GeneTreei | ENSGT00940000159821 |
HOGENOMi | CLU_006533_2_6_1 |
InParanoidi | Q3MIX3 |
OMAi | RPWRGGW |
OrthoDBi | 790106at2759 |
PhylomeDBi | Q3MIX3 |
TreeFami | TF354300 |
Enzyme and pathway databases
PathwayCommonsi | Q3MIX3 |
SignaLinki | Q3MIX3 |
SIGNORi | Q3MIX3 |
Miscellaneous databases
BioGRID-ORCSi | 203054, 8 hits in 1078 CRISPR screens |
ChiTaRSi | ADCK5, human |
GenomeRNAii | 203054 |
Pharosi | Q3MIX3, Tdark |
PROi | PR:Q3MIX3 |
RNActi | Q3MIX3, protein |
Gene expression databases
Bgeei | ENSG00000173137, Expressed in mucosa of transverse colon and 137 other tissues |
ExpressionAtlasi | Q3MIX3, baseline and differential |
Genevisiblei | Q3MIX3, HS |
Family and domain databases
CDDi | cd13969, ADCK1-like, 1 hit |
InterProi | View protein in InterPro IPR004147, ABC1_dom IPR045307, ADCK1_dom IPR011009, Kinase-like_dom_sf |
Pfami | View protein in Pfam PF03109, ABC1, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ADCK5_HUMAN | |
Accessioni | Q3MIX3Primary (citable) accession number: Q3MIX3 Secondary accession number(s): B3KS46 Q8N5V3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | September 12, 2018 | |
Last modified: | February 23, 2022 | |
This is version 131 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families