UniProtKB - Q3MIX3 (ADCK5_HUMAN)

BLAST

>sp|Q3MIX3|ADCK5_HUMAN Uncharacterized aarF domain-containing protein kinase 5 OS=Homo sapiens OX=9606 GN=ADCK5 PE=1 SV=3
MWRPVQLCHFHSALLHSRQKPWPSPAVFFRRNVRGLPPRFSSPTPLWRKVLSTAVVGAPL
LLGARYVMAEAREKRRMRLVVDGMGRFGRSLKVGLQISLDYWWCTNVVLRGVEENSPGYL
EVMSACHQRAADALVAGAISNGGLYVKLGQGLCSFNHLLPPEYTRTLRVLEDRALKRGFQ
EVDELFLEDFQALPHELFQEFDYQPIAAASLAQVHRAKLHDGTSVAVKVQYIDLRDRFDG
DIHTLELLLRLVEVMHPSFGFSWVLQDLKGTLAQELDFENEGRNAERCARELAHFPYVVV
PRVHWDKSSKRVLTADFCAGCKVNDVEAIRSQGLAVHDIAEKLIKAFAEQIFYTGFIHSD
PHPGNVLVRKGPDGKAELVLLDHGLYQFLEEKDRAALCQLWRAIILRDDAAMRAHAAALG
VQDYLLFAEMLMQRPVRLGQLWGSHLLSREEAAYMVDMARERFEAVMAVLRELPRPMLLV
LRNINTVRAINVALGAPVDRYFLMAKRAVRGWSRLAGATYRGVYGTSLLRHAKVVWEMLK
FEVALRLETLAMRLTALLARALVHLSLVPPAEELYQYLET

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History
Entry version 112 (07 Nov 2018)
Sequence version 3 (12 Sep 2018)
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Protein

Uncharacterized aarF domain-containing protein kinase 5

Gene

ADCK5

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

GO - Molecular functionⁱ

protein serine/threonine kinase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase

Molecular function

Kinase, Serine/threonine-protein kinase, Transferase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Uncharacterized aarF domain-containing protein kinase 5 (EC:2.7.11.-)
Gene namesⁱ	Name:ADCK5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000173137.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21738 ADCK5
neXtProtⁱ	NX_Q3MIX3

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	50 – 67	HelicalSequence analysisAdd BLAST		18

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000173137
PharmGKBⁱ	PA134963849

Polymorphism and mutation databases

DMDMⁱ	121958055

DMDMⁱ

121958055

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000271800	1 – 580	Uncharacterized aarF domain-containing protein kinase 5Add BLAST		580

Proteomic databases

EPDⁱ	Q3MIX3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3MIX3
PaxDbⁱ	Q3MIX3
PeptideAtlas More...PeptideAtlasⁱ	Q3MIX3
PRIDEⁱ	Q3MIX3
ProteomicsDBⁱ	61799

PTM databases

iPTMnetⁱ	Q3MIX3
PhosphoSitePlusⁱ	Q3MIX3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000173137 Expressed in 117 organ(s), highest expression level in mucosa of transverse colon
CleanExⁱ	HS_ADCK5
ExpressionAtlasⁱ	Q3MIX3 baseline and differential
Genevisibleⁱ	Q3MIX3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA025692 HPA028679

HPAⁱ

HPA025692
HPA028679

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NOTCH2NL	Q7Z3S9	3	EBI-3923548,EBI-945833

With

Entry

#Exp.

IntAct

Notes

NOTCH2NL

Q7Z3S9

EBI-3923548,EBI-945833

Protein-protein interaction databases

BioGridⁱ	128442, 13 interactors
IntActⁱ	Q3MIX3, 27 interactors
Molecular INTeraction database More...MINTⁱ	Q3MIX3
STRINGⁱ	9606.ENSP00000310547

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3MIX3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	179 – 419	Protein kinaseAdd BLAST		241

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. ADCK protein kinase family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1235 Eukaryota COG0661 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074734
HOGENOMⁱ	HOG000240338
HOVERGENⁱ	HBG104406
InParanoidⁱ	Q3MIX3
KEGG Orthology (KO) More...KOⁱ	K08869
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G050X
PhylomeDBⁱ	Q3MIX3
TreeFamⁱ	TF354300

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR004147 UbiB_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03109 ABC1, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q3MIX3-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MWRPVQLCHF HSALLHSRQK PWPSPAVFFR RNVRGLPPRF SSPTPLWRKV 
        60         70         80         90        100
LSTAVVGAPL LLGARYVMAE AREKRRMRLV VDGMGRFGRS LKVGLQISLD 
       110        120        130        140        150
YWWCTNVVLR GVEENSPGYL EVMSACHQRA ADALVAGAIS NGGLYVKLGQ 
       160        170        180        190        200
GLCSFNHLLP PEYTRTLRVL EDRALKRGFQ EVDELFLEDF QALPHELFQE 
       210        220        230        240        250
FDYQPIAAAS LAQVHRAKLH DGTSVAVKVQ YIDLRDRFDG DIHTLELLLR 
       260        270        280        290        300
LVEVMHPSFG FSWVLQDLKG TLAQELDFEN EGRNAERCAR ELAHFPYVVV 
       310        320        330        340        350
PRVHWDKSSK RVLTADFCAG CKVNDVEAIR SQGLAVHDIA EKLIKAFAEQ 
       360        370        380        390        400
IFYTGFIHSD PHPGNVLVRK GPDGKAELVL LDHGLYQFLE EKDRAALCQL 
       410        420        430        440        450
WRAIILRDDA AMRAHAAALG VQDYLLFAEM LMQRPVRLGQ LWGSHLLSRE 
       460        470        480        490        500
EAAYMVDMAR ERFEAVMAVL RELPRPMLLV LRNINTVRAI NVALGAPVDR 
       510        520        530        540        550
YFLMAKRAVR GWSRLAGATY RGVYGTSLLR HAKVVWEMLK FEVALRLETL 
       560        570        580
AMRLTALLAR ALVHLSLVPP AEELYQYLET

Length:580

Mass (Da):65,828

Last modified:September 12, 2018 - v3

Checksum:ⁱACA0DB28B7B16F0C

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PLF3	E9PLF3_HUMAN	Uncharacterized aarF domain-contain... Uncharacterized aarF domain-containing protein kinase 5	ADCK5	115	Annotation score:
E9PJ20	E9PJ20_HUMAN	Uncharacterized aarF domain-contain... Uncharacterized aarF domain-containing protein kinase 5	ADCK5	129	Annotation score:
R4GN53	R4GN53_HUMAN	Uncharacterized aarF domain-contain... Uncharacterized aarF domain-containing protein kinase 5	ADCK5	87	Annotation score:

Sequence cautionⁱ

The sequence AAH31570 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	275	E → G in BAG52608 (PubMed:14702039).Curated	1
Sequence conflictⁱ	283	R → G in AAH85013 (PubMed:15489334).Curated	1
Sequence conflictⁱ	324 – 338	NDVEA…LAVHD → GGLVLCPLQCLSSPQ in AAH64345 (PubMed:15489334).CuratedAdd BLAST	15

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_029996	17	S → R1 PublicationCorresponds to variant dbSNP:rs6599528Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK092773 mRNA Translation: BAG52608.1 AC233992 Genomic DNA No translation available. BC031570 mRNA Translation: AAH31570.1 Different initiation. BC064345 mRNA Translation: AAH64345.1 BC085013 mRNA Translation: AAH85013.1 BC101659 mRNA Translation: AAI01660.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34965.2
NCBI Reference Sequences More...RefSeqⁱ	NP_777582.4, NM_174922.4
UniGeneⁱ	Hs.283374

Genome annotation databases

Ensemblⁱ	ENST00000308860; ENSP00000310547; ENSG00000173137 ENST00000645968; ENSP00000494807; ENSG00000285451
GeneIDⁱ	203054
KEGGⁱ	hsa:203054
UCSC genome browser More...UCSCⁱ	uc003zch.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q3MIX3	Uncharacterized protein		PANPA		585	UniRef90_Q3MIX3
Uncharacterized protein		CERAT		581
Uncharacterized protein		MANLE		581
Putative aarF domain-containing protein kinase 5 (Fragment)		MACMU		199
ADCK5 isoform 5		PONAB		580
+46

Protein	Similar proteins		Species	Score	Length	Source
Q3MIX3	Uncharacterized aarF domain-containing protein kinase 5		MOUSE		582	UniRef50_Q3MIX3
Uncharacterized protein		PANPA		585
Uncharacterized protein		CERAT		581
Uncharacterized protein		MANLE		581
Putative aarF domain-containing protein kinase 5 (Fragment)		MACMU		199
+206

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK092773 mRNA Translation: BAG52608.1 AC233992 Genomic DNA No translation available. BC031570 mRNA Translation: AAH31570.1 Different initiation. BC064345 mRNA Translation: AAH64345.1 BC085013 mRNA Translation: AAH85013.1 BC101659 mRNA Translation: AAI01660.1
CCDSⁱ	CCDS34965.2
RefSeqⁱ	NP_777582.4, NM_174922.4
UniGeneⁱ	Hs.283374

3D structure databases

ProteinModelPortalⁱ	Q3MIX3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	128442, 13 interactors
IntActⁱ	Q3MIX3, 27 interactors
MINTⁱ	Q3MIX3
STRINGⁱ	9606.ENSP00000310547

PTM databases

iPTMnetⁱ	Q3MIX3
PhosphoSitePlusⁱ	Q3MIX3

Polymorphism and mutation databases

DMDMⁱ	121958055

DMDMⁱ

121958055

Proteomic databases

EPDⁱ	Q3MIX3
MaxQBⁱ	Q3MIX3
PaxDbⁱ	Q3MIX3
PeptideAtlasⁱ	Q3MIX3
PRIDEⁱ	Q3MIX3
ProteomicsDBⁱ	61799

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	203054
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000308860; ENSP00000310547; ENSG00000173137 ENST00000645968; ENSP00000494807; ENSG00000285451
GeneIDⁱ	203054
KEGGⁱ	hsa:203054
UCSCⁱ	uc003zch.5 human

Organism-specific databases

CTDⁱ	203054
EuPathDBⁱ	HostDB:ENSG00000173137.11
GeneCardsⁱ	ADCK5
H-InvDBⁱ	HIX0201293
HGNCⁱ	HGNC:21738 ADCK5
HPAⁱ	HPA025692 HPA028679
neXtProtⁱ	NX_Q3MIX3
OpenTargetsⁱ	ENSG00000173137
PharmGKBⁱ	PA134963849
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1235 Eukaryota COG0661 LUCA
GeneTreeⁱ	ENSGT00550000074734
HOGENOMⁱ	HOG000240338
HOVERGENⁱ	HBG104406
InParanoidⁱ	Q3MIX3
KOⁱ	K08869
OrthoDBⁱ	EOG091G050X
PhylomeDBⁱ	Q3MIX3
TreeFamⁱ	TF354300

Miscellaneous databases

ChiTaRSⁱ	ADCK5 human
GenomeRNAiⁱ	203054
Protein Ontology More...PROⁱ	PR:Q3MIX3

Gene expression databases

Bgeeⁱ	ENSG00000173137 Expressed in 117 organ(s), highest expression level in mucosa of transverse colon
CleanExⁱ	HS_ADCK5
ExpressionAtlasⁱ	Q3MIX3 baseline and differential
Genevisibleⁱ	Q3MIX3 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR004147 UbiB_dom
Pfamⁱ	View protein in Pfam PF03109 ABC1, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ADCK5_HUMAN
Accessionⁱ	Q3MIX3Primary (citable) accession number: Q3MIX3 Secondary accession number(s): B3KS46 , Q5U4P1, Q6P2S4, Q8N5V3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
	Last sequence update:	September 12, 2018
	Last modified:	November 7, 2018
	This is version 112 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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Supporting data

UniProtKB - Q3MIX3 (ADCK5_HUMAN)

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Uncharacterized aarF domain-containing protein kinase 5

ADCK5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ