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Protein

Uncharacterized aarF domain-containing protein kinase 5

Gene

ADCK5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized aarF domain-containing protein kinase 5 (EC:2.7.11.-)
Gene namesi
Name:ADCK5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000173137.11
HGNCiHGNC:21738 ADCK5
neXtProtiNX_Q3MIX3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei50 – 67HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173137
PharmGKBiPA134963849

Polymorphism and mutation databases

DMDMi121958055

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002718001 – 580Uncharacterized aarF domain-containing protein kinase 5Add BLAST580

Proteomic databases

EPDiQ3MIX3
MaxQBiQ3MIX3
PaxDbiQ3MIX3
PeptideAtlasiQ3MIX3
PRIDEiQ3MIX3
ProteomicsDBi61799

PTM databases

iPTMnetiQ3MIX3
PhosphoSitePlusiQ3MIX3

Expressioni

Gene expression databases

BgeeiENSG00000173137 Expressed in 117 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_ADCK5
ExpressionAtlasiQ3MIX3 baseline and differential
GenevisibleiQ3MIX3 HS

Organism-specific databases

HPAiHPA025692
HPA028679

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NOTCH2NLQ7Z3S93EBI-3923548,EBI-945833

Protein-protein interaction databases

BioGridi128442, 13 interactors
IntActiQ3MIX3, 27 interactors
MINTiQ3MIX3
STRINGi9606.ENSP00000310547

Structurei

3D structure databases

ProteinModelPortaliQ3MIX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 419Protein kinaseAdd BLAST241

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1235 Eukaryota
COG0661 LUCA
GeneTreeiENSGT00550000074734
HOGENOMiHOG000240338
HOVERGENiHBG104406
InParanoidiQ3MIX3
KOiK08869
OrthoDBiEOG091G050X
PhylomeDBiQ3MIX3
TreeFamiTF354300

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR004147 UbiB_dom
PfamiView protein in Pfam
PF03109 ABC1, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q3MIX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWRPVQLCHF HSALLHSRQK PWPSPAVFFR RNVRGLPPRF SSPTPLWRKV
60 70 80 90 100
LSTAVVGAPL LLGARYVMAE AREKRRMRLV VDGMGRFGRS LKVGLQISLD
110 120 130 140 150
YWWCTNVVLR GVEENSPGYL EVMSACHQRA ADALVAGAIS NGGLYVKLGQ
160 170 180 190 200
GLCSFNHLLP PEYTRTLRVL EDRALKRGFQ EVDELFLEDF QALPHELFQE
210 220 230 240 250
FDYQPIAAAS LAQVHRAKLH DGTSVAVKVQ YIDLRDRFDG DIHTLELLLR
260 270 280 290 300
LVEVMHPSFG FSWVLQDLKG TLAQELDFEN EGRNAERCAR ELAHFPYVVV
310 320 330 340 350
PRVHWDKSSK RVLTADFCAG CKVNDVEAIR SQGLAVHDIA EKLIKAFAEQ
360 370 380 390 400
IFYTGFIHSD PHPGNVLVRK GPDGKAELVL LDHGLYQFLE EKDRAALCQL
410 420 430 440 450
WRAIILRDDA AMRAHAAALG VQDYLLFAEM LMQRPVRLGQ LWGSHLLSRE
460 470 480 490 500
EAAYMVDMAR ERFEAVMAVL RELPRPMLLV LRNINTVRAI NVALGAPVDR
510 520 530 540 550
YFLMAKRAVR GWSRLAGATY RGVYGTSLLR HAKVVWEMLK FEVALRLETL
560 570 580
AMRLTALLAR ALVHLSLVPP AEELYQYLET
Length:580
Mass (Da):65,828
Last modified:September 12, 2018 - v3
Checksum:iACA0DB28B7B16F0C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PLF3E9PLF3_HUMAN
Uncharacterized aarF domain-contain...
ADCK5
115Annotation score:
E9PJ20E9PJ20_HUMAN
Uncharacterized aarF domain-contain...
ADCK5
129Annotation score:
R4GN53R4GN53_HUMAN
Uncharacterized aarF domain-contain...
ADCK5
87Annotation score:

Sequence cautioni

The sequence AAH31570 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti275E → G in BAG52608 (PubMed:14702039).Curated1
Sequence conflicti283R → G in AAH85013 (PubMed:15489334).Curated1
Sequence conflicti324 – 338NDVEA…LAVHD → GGLVLCPLQCLSSPQ in AAH64345 (PubMed:15489334).CuratedAdd BLAST15

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02999617S → R1 PublicationCorresponds to variant dbSNP:rs6599528Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092773 mRNA Translation: BAG52608.1
AC233992 Genomic DNA No translation available.
BC031570 mRNA Translation: AAH31570.1 Different initiation.
BC064345 mRNA Translation: AAH64345.1
BC085013 mRNA Translation: AAH85013.1
BC101659 mRNA Translation: AAI01660.1
CCDSiCCDS34965.2
RefSeqiNP_777582.4, NM_174922.4
UniGeneiHs.283374

Genome annotation databases

EnsembliENST00000308860; ENSP00000310547; ENSG00000173137
ENST00000645968; ENSP00000494807; ENSG00000285451
GeneIDi203054
KEGGihsa:203054
UCSCiuc003zch.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092773 mRNA Translation: BAG52608.1
AC233992 Genomic DNA No translation available.
BC031570 mRNA Translation: AAH31570.1 Different initiation.
BC064345 mRNA Translation: AAH64345.1
BC085013 mRNA Translation: AAH85013.1
BC101659 mRNA Translation: AAI01660.1
CCDSiCCDS34965.2
RefSeqiNP_777582.4, NM_174922.4
UniGeneiHs.283374

3D structure databases

ProteinModelPortaliQ3MIX3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128442, 13 interactors
IntActiQ3MIX3, 27 interactors
MINTiQ3MIX3
STRINGi9606.ENSP00000310547

PTM databases

iPTMnetiQ3MIX3
PhosphoSitePlusiQ3MIX3

Polymorphism and mutation databases

DMDMi121958055

Proteomic databases

EPDiQ3MIX3
MaxQBiQ3MIX3
PaxDbiQ3MIX3
PeptideAtlasiQ3MIX3
PRIDEiQ3MIX3
ProteomicsDBi61799

Protocols and materials databases

DNASUi203054
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308860; ENSP00000310547; ENSG00000173137
ENST00000645968; ENSP00000494807; ENSG00000285451
GeneIDi203054
KEGGihsa:203054
UCSCiuc003zch.5 human

Organism-specific databases

CTDi203054
EuPathDBiHostDB:ENSG00000173137.11
GeneCardsiADCK5
H-InvDBiHIX0201293
HGNCiHGNC:21738 ADCK5
HPAiHPA025692
HPA028679
neXtProtiNX_Q3MIX3
OpenTargetsiENSG00000173137
PharmGKBiPA134963849
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1235 Eukaryota
COG0661 LUCA
GeneTreeiENSGT00550000074734
HOGENOMiHOG000240338
HOVERGENiHBG104406
InParanoidiQ3MIX3
KOiK08869
OrthoDBiEOG091G050X
PhylomeDBiQ3MIX3
TreeFamiTF354300

Miscellaneous databases

ChiTaRSiADCK5 human
GenomeRNAii203054
PROiPR:Q3MIX3

Gene expression databases

BgeeiENSG00000173137 Expressed in 117 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_ADCK5
ExpressionAtlasiQ3MIX3 baseline and differential
GenevisibleiQ3MIX3 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR004147 UbiB_dom
PfamiView protein in Pfam
PF03109 ABC1, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADCK5_HUMAN
AccessioniPrimary (citable) accession number: Q3MIX3
Secondary accession number(s): B3KS46
, Q5U4P1, Q6P2S4, Q8N5V3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: September 12, 2018
Last modified: November 7, 2018
This is version 112 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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