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Protein

Zinc finger protein 528

Gene

ZNF528

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri213 – 235C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri241 – 263C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri269 – 291C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 319C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 528
Gene namesi
Name:ZNF528
Synonyms:KIAA1827
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167555.13
HGNCiHGNC:29384 ZNF528
MIMi615580 gene
neXtProtiNX_Q3MIS6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167555
PharmGKBiPA134869369

Polymorphism and mutation databases

BioMutaiZNF528
DMDMi121942828

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804181 – 628Zinc finger protein 528Add BLAST628

Proteomic databases

EPDiQ3MIS6
MaxQBiQ3MIS6
PaxDbiQ3MIS6
PeptideAtlasiQ3MIS6
PRIDEiQ3MIS6
ProteomicsDBi61792
61793 [Q3MIS6-2]

PTM databases

iPTMnetiQ3MIS6
PhosphoSitePlusiQ3MIS6

Expressioni

Gene expression databases

BgeeiENSG00000167555
CleanExiHS_ZNF528
ExpressionAtlasiQ3MIS6 baseline and differential
GenevisibleiQ3MIS6 HS

Interactioni

Protein-protein interaction databases

BioGridi124076, 1 interactor
STRINGi9606.ENSP00000353652

Structurei

3D structure databases

ProteinModelPortaliQ3MIS6
SMRiQ3MIS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri213 – 235C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri241 – 263C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri269 – 291C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 319C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149104
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ3MIS6
KOiK09228
OMAiKISGCKH
OrthoDBiEOG091G02KC
PhylomeDBiQ3MIS6
TreeFamiTF341892

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 15 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3MIS6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALTQGPLKF MDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLGIC
60 70 80 90 100
LPDLSVTSML EQKRDPWTLQ SEEKIANDPD GRECIKGVNT ERSSKLGSNA
110 120 130 140 150
GNKPCKNQLG FTFQLHLSDL QLFQAERKIS GCKHFEKPVS DNSSVSPLEK
160 170 180 190 200
ISSSVKSHLL NKYRNNFDHA PLLPQEQKAH IREKAYKCNE HGQVFRASAS
210 220 230 240 250
LTNQVIHNAD NPYKCSECGK VFSCSSKLVI HRRMHTGEKP YKCHECGKLF
260 270 280 290 300
SSNSNLSQHQ RIHTGEKPYK CHECDKVFRS SSKLAQHQRI HTGEKPYKCH
310 320 330 340 350
ECDKVFNQIA HLVRHQKIHT GEKPYSCNKC GKVFSRHSYL AEHQTVHTGE
360 370 380 390 400
KPYKCEECGK AFSVRSSLIT HQLIHTGRKP YKCKECDKVF GRKCFLTSHQ
410 420 430 440 450
RIHTRERPYG CSQCGKIFSQ KSDLIRHRKT HTDEKPYKCN KCGTAFREFS
460 470 480 490 500
DLTAHFLIHS GEKPYECKEC GKVFRYKSSL TSHHRIHTGE KPYKCNRCGK
510 520 530 540 550
VFSRSSNLVC HQKIHTGEKP YKCNQCGKVF NQASYLTRHQ IIHTGERPYR
560 570 580 590 600
CSKCGKAFRG CSGLTAHLAI HTEKKSHECK ECGKIFTQKS SLTNHHRIHI
610 620
GEKPYKCTLC SKVFSHNSDL AQHQRVHS
Length:628
Mass (Da):72,138
Last modified:October 25, 2005 - v1
Checksum:iBB8704D4A354ED11
GO
Isoform 2 (identifier: Q3MIS6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-233: Missing.

Show »
Length:395
Mass (Da):45,715
Checksum:i04D697F0F7C21732
GO

Sequence cautioni

The sequence BAB47456 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti297Y → H in CAD89949 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052858419S → N. Corresponds to variant dbSNP:rs324109Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0236621 – 233Missing in isoform 2. 2 PublicationsAdd BLAST233

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056552 mRNA Translation: BAG51746.1
AL832630 mRNA Translation: CAD89949.1
CH471135 Genomic DNA Translation: EAW72078.1
BC101712 mRNA Translation: AAI01713.1
BC111950 mRNA Translation: AAI11951.1
AB058730 mRNA Translation: BAB47456.1 Different initiation.
CCDSiCCDS33091.1 [Q3MIS6-1]
RefSeqiNP_115799.2, NM_032423.2 [Q3MIS6-1]
UniGeneiHs.662043

Genome annotation databases

EnsembliENST00000360465; ENSP00000353652; ENSG00000167555 [Q3MIS6-1]
GeneIDi84436
KEGGihsa:84436
UCSCiuc002pzh.3 human [Q3MIS6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN528_HUMAN
AccessioniPrimary (citable) accession number: Q3MIS6
Secondary accession number(s): B3KPN4, Q86T88, Q96JK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 25, 2005
Last modified: June 20, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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