UniProtKB - Q3MIR4 (CC50B_HUMAN)
Protein
Cell cycle control protein 50B
Gene
TMEM30B
Organism
Homo sapiens (Human)
Status
Functioni
Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane.Curated1 Publication
GO - Molecular functioni
- aminophospholipid flippase activity Source: BHF-UCL
GO - Biological processi
- aminophospholipid transport Source: BHF-UCL
- phospholipid translocation Source: GO_Central
- positive regulation of protein exit from endoplasmic reticulum Source: UniProtKB
Keywordsi
Biological process | Lipid transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q3MIR4 |
Protein family/group databases
TCDBi | 8.A.27.1.6, the cdc50 p-type atpase lipid flippase subunit (cdc50) family |
Names & Taxonomyi
Protein namesi | Recommended name: Cell cycle control protein 50BAlternative name(s): P4-ATPase flippase complex beta subunit TMEM30B Transmembrane protein 30B |
Gene namesi | Name:TMEM30B Synonyms:CDC50B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000182107.6 |
HGNCi | HGNC:27254, TMEM30B |
MIMi | 611029, gene |
neXtProti | NX_Q3MIR4 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
Golgi apparatus
- Golgi apparatus Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 33 | CytoplasmicSequence analysisAdd BLAST | 33 | |
Transmembranei | 34 – 54 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 55 – 315 | Exoplasmic loopSequence analysisAdd BLAST | 261 | |
Transmembranei | 316 – 336 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 337 – 351 | CytoplasmicSequence analysisAdd BLAST | 15 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 161291 |
OpenTargetsi | ENSG00000182107 |
PharmGKBi | PA134993260 |
Miscellaneous databases
Pharosi | Q3MIR4, Tbio |
Polymorphism and mutation databases
BioMutai | TMEM30B |
DMDMi | 109819759 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000244474 | 1 – 351 | Cell cycle control protein 50BAdd BLAST | 351 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 75 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 213 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 286 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q3MIR4 |
MassIVEi | Q3MIR4 |
MaxQBi | Q3MIR4 |
PaxDbi | Q3MIR4 |
PeptideAtlasi | Q3MIR4 |
PRIDEi | Q3MIR4 |
ProteomicsDBi | 61791 |
PTM databases
GlyGeni | Q3MIR4, 3 sites |
iPTMneti | Q3MIR4 |
PhosphoSitePlusi | Q3MIR4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000182107, Expressed in colonic mucosa and 188 other tissues |
Genevisiblei | Q3MIR4, HS |
Organism-specific databases
HPAi | ENSG00000182107, Tissue enhanced (thyroid) |
Interactioni
Subunit structurei
Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (Probable).
Interacts with alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4.
Curated3 PublicationsBinary interactionsi
Hide detailsQ3MIR4
Protein-protein interaction databases
BioGRIDi | 127780, 88 interactors |
IntActi | Q3MIR4, 86 interactors |
STRINGi | 9606.ENSP00000450842 |
Miscellaneous databases
RNActi | Q3MIR4, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 344 – 349 | Poly-Asp | 6 |
Sequence similaritiesi
Belongs to the CDC50/LEM3 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2952, Eukaryota |
GeneTreei | ENSGT00390000004660 |
HOGENOMi | CLU_025025_1_0_1 |
InParanoidi | Q3MIR4 |
OMAi | FSNVSWM |
PhylomeDBi | Q3MIR4 |
TreeFami | TF300873 |
Family and domain databases
InterProi | View protein in InterPro IPR005045, CDC50/LEM3_fam IPR030352, TMEM30B |
PANTHERi | PTHR10926, PTHR10926, 1 hit PTHR10926:SF19, PTHR10926:SF19, 1 hit |
Pfami | View protein in Pfam PF03381, CDC50, 1 hit |
PIRSFi | PIRSF015840, DUF284_TM_euk, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3MIR4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTWSATARGA HQPDNTAFTQ QRLPAWQPLL SASIALPLFF CAGLAFIGLG
60 70 80 90 100
LGLYYSSNGI KELEYDYTGD PGTGNCSVCA AAGQGRALPP PCSCAWYFSL
110 120 130 140 150
PELFQGPVYL YYELTNFYQN NRRYGVSRDD AQLSGLPSAL RHPVNECAPY
160 170 180 190 200
QRSAAGLPIA PCGAIANSLF NDSFSLWHQR QPGGPYVEVP LDRSGIAWWT
210 220 230 240 250
DYHVKFRNPP LVNGSLALAF QGTAPPPNWR RPVYELSPDP NNTGFINQDF
260 270 280 290 300
VVWMRTAALP TFRKLYARIR QGNYSAGLPR GAYRVNITYN YPVRAFGGHK
310 320 330 340 350
LLIFSSISWM GGKNPFLGIA YLVVGSLCIL TGFVMLVVYI RYQDQDDDDE
E
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091169 mRNA Translation: BAG52296.1 CH471061 Genomic DNA Translation: EAW80799.1 BC101726 mRNA Translation: AAI01727.1 BC113559 mRNA Translation: AAI13560.1 |
CCDSi | CCDS32093.1 |
RefSeqi | NP_001017970.1, NM_001017970.2 |
Genome annotation databases
Ensembli | ENST00000555868; ENSP00000450842; ENSG00000182107 |
GeneIDi | 161291 |
KEGGi | hsa:161291 |
UCSCi | uc001xfl.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091169 mRNA Translation: BAG52296.1 CH471061 Genomic DNA Translation: EAW80799.1 BC101726 mRNA Translation: AAI01727.1 BC113559 mRNA Translation: AAI13560.1 |
CCDSi | CCDS32093.1 |
RefSeqi | NP_001017970.1, NM_001017970.2 |
3D structure databases
SMRi | Q3MIR4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127780, 88 interactors |
IntActi | Q3MIR4, 86 interactors |
STRINGi | 9606.ENSP00000450842 |
Protein family/group databases
TCDBi | 8.A.27.1.6, the cdc50 p-type atpase lipid flippase subunit (cdc50) family |
PTM databases
GlyGeni | Q3MIR4, 3 sites |
iPTMneti | Q3MIR4 |
PhosphoSitePlusi | Q3MIR4 |
Polymorphism and mutation databases
BioMutai | TMEM30B |
DMDMi | 109819759 |
Proteomic databases
jPOSTi | Q3MIR4 |
MassIVEi | Q3MIR4 |
MaxQBi | Q3MIR4 |
PaxDbi | Q3MIR4 |
PeptideAtlasi | Q3MIR4 |
PRIDEi | Q3MIR4 |
ProteomicsDBi | 61791 |
Protocols and materials databases
Antibodypediai | 24420, 116 antibodies |
Genome annotation databases
Ensembli | ENST00000555868; ENSP00000450842; ENSG00000182107 |
GeneIDi | 161291 |
KEGGi | hsa:161291 |
UCSCi | uc001xfl.4, human |
Organism-specific databases
CTDi | 161291 |
DisGeNETi | 161291 |
EuPathDBi | HostDB:ENSG00000182107.6 |
GeneCardsi | TMEM30B |
HGNCi | HGNC:27254, TMEM30B |
HPAi | ENSG00000182107, Tissue enhanced (thyroid) |
MIMi | 611029, gene |
neXtProti | NX_Q3MIR4 |
OpenTargetsi | ENSG00000182107 |
PharmGKBi | PA134993260 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2952, Eukaryota |
GeneTreei | ENSGT00390000004660 |
HOGENOMi | CLU_025025_1_0_1 |
InParanoidi | Q3MIR4 |
OMAi | FSNVSWM |
PhylomeDBi | Q3MIR4 |
TreeFami | TF300873 |
Enzyme and pathway databases
PathwayCommonsi | Q3MIR4 |
Miscellaneous databases
BioGRID-ORCSi | 161291, 4 hits in 841 CRISPR screens |
ChiTaRSi | TMEM30B, human |
GenomeRNAii | 161291 |
Pharosi | Q3MIR4, Tbio |
PROi | PR:Q3MIR4 |
RNActi | Q3MIR4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182107, Expressed in colonic mucosa and 188 other tissues |
Genevisiblei | Q3MIR4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR005045, CDC50/LEM3_fam IPR030352, TMEM30B |
PANTHERi | PTHR10926, PTHR10926, 1 hit PTHR10926:SF19, PTHR10926:SF19, 1 hit |
Pfami | View protein in Pfam PF03381, CDC50, 1 hit |
PIRSFi | PIRSF015840, DUF284_TM_euk, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CC50B_HUMAN | |
Accessioni | Q3MIR4Primary (citable) accession number: Q3MIR4 Secondary accession number(s): B3KR84, Q14D00 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | October 25, 2005 | |
Last modified: | December 2, 2020 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM