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Entry version 107 (05 Jun 2019)
Sequence version 1 (25 Oct 2005)
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Protein

Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2

Gene

ITPRIPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27257 ITPRIPL2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q3MIP1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini39 – 43ExtracellularSequence analysis5
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Topological domaini65 – 535CytoplasmicSequence analysisAdd BLAST471

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000205730

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164721117

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ITPRIPL2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121942822

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 38Sequence analysisAdd BLAST38
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000033609339 – 535Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2Add BLAST497

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei139PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3MIP1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3MIP1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3MIP1

PeptideAtlas

More...
PeptideAtlasi
Q3MIP1

PRoteomics IDEntifications database

More...
PRIDEi
Q3MIP1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61790

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3MIP1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3MIP1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000205730 Expressed in 205 organ(s), highest expression level in visceral pleura

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3MIP1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042011

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127808, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q3MIP1, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000370849

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi324 – 330Poly-Pro7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ITPRIP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFXY Eukaryota
ENOG4111FAS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00960000186654

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060320

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3MIP1

Identification of Orthologs from Complete Genome Data

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OMAi
QRTQGFP

Database of Orthologous Groups

More...
OrthoDBi
835491at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3MIP1

TreeFam database of animal gene trees

More...
TreeFami
TF332277

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024798 IP3R-int-like_2
IPR026250 ITPRIP_fam
IPR024810 Mab-21_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10656:SF9 PTHR10656:SF9, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03281 Mab-21, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02107 INOS145TPRIP

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01265 Mab-21, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q3MIP1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVHYTLNLR VFWPLVTGLC TALVCLYHVL RGSGGARAEP ADGVDGGFPL
60 70 80 90 100
LKVAVLLLLS YVLLRCRHAV RQRFLPGSPR LEGHAAFSSR HFREPGLSIL
110 120 130 140 150
LESYYEHEVR LSPHVLGHSK AHVSRIVGEL VRAGRARGSP GLIPGGALAL
160 170 180 190 200
AFRGDFIQVG SAYEQHKIRR PDSFDVLVPL RLPPLVALEP RSLGEEPALA
210 220 230 240 250
PAFRGCFLCA LKAPPSPSGA SGGHWLRDCK PFADAFCVDV RGRRHLSATL
260 270 280 290 300
VLRWFQSHLQ RSLATVRYSL EGRCRVTLTP GGLEQPPTLH ILPCRTDYGC
310 320 330 340 350
CRLSMAVRLI PAVHLGDGVF LVAPPPPPLP SAPLLELPEG LRAEALWGVN
360 370 380 390 400
TARQEQKLLS WLQERAAPGA CYLKCLQLLK ALRDLGARGL DSAAATQWGR
410 420 430 440 450
ILSSYVLKTV LLAVLLRKGA PGQGWDEEHL GRCLEELVQF LRDCLLRRHT
460 470 480 490 500
LFHCVLGPGG AAAEVGPLPK ALREAAPVDL LAAFDGHARE LAAARLLSTW
510 520 530
QRLPQLLRAY GGPRYLARCP PPRSQRTQGF LEGEP
Length:535
Mass (Da):58,446
Last modified:October 25, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i000E9D653FD16284
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_043549237C → S. Corresponds to variant dbSNP:rs8051801Ensembl.1
Natural variantiVAR_043550522P → S. Corresponds to variant dbSNP:rs11074362Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471186 Genomic DNA Translation: EAW50272.1
BC101749 mRNA Translation: AAI01750.1
BC101751 mRNA Translation: AAI01752.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32395.1

NCBI Reference Sequences

More...
RefSeqi
NP_001030013.1, NM_001034841.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000381440; ENSP00000370849; ENSG00000205730

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
162073

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:162073

UCSC genome browser

More...
UCSCi
uc002dfu.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471186 Genomic DNA Translation: EAW50272.1
BC101749 mRNA Translation: AAI01750.1
BC101751 mRNA Translation: AAI01752.1
CCDSiCCDS32395.1
RefSeqiNP_001030013.1, NM_001034841.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi127808, 6 interactors
IntActiQ3MIP1, 4 interactors
STRINGi9606.ENSP00000370849

PTM databases

iPTMnetiQ3MIP1
PhosphoSitePlusiQ3MIP1

Polymorphism and mutation databases

BioMutaiITPRIPL2
DMDMi121942822

Proteomic databases

EPDiQ3MIP1
jPOSTiQ3MIP1
PaxDbiQ3MIP1
PeptideAtlasiQ3MIP1
PRIDEiQ3MIP1
ProteomicsDBi61790

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381440; ENSP00000370849; ENSG00000205730
GeneIDi162073
KEGGihsa:162073
UCSCiuc002dfu.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
162073

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ITPRIPL2
HGNCiHGNC:27257 ITPRIPL2
HPAiHPA042011
neXtProtiNX_Q3MIP1
OpenTargetsiENSG00000205730
PharmGKBiPA164721117

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFXY Eukaryota
ENOG4111FAS LUCA
GeneTreeiENSGT00960000186654
HOGENOMiHOG000060320
InParanoidiQ3MIP1
OMAiQRTQGFP
OrthoDBi835491at2759
PhylomeDBiQ3MIP1
TreeFamiTF332277

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ITPRIPL2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
162073

Protein Ontology

More...
PROi
PR:Q3MIP1

Gene expression databases

BgeeiENSG00000205730 Expressed in 205 organ(s), highest expression level in visceral pleura
GenevisibleiQ3MIP1 HS

Family and domain databases

InterProiView protein in InterPro
IPR024798 IP3R-int-like_2
IPR026250 ITPRIP_fam
IPR024810 Mab-21_dom
PANTHERiPTHR10656:SF9 PTHR10656:SF9, 1 hit
PfamiView protein in Pfam
PF03281 Mab-21, 1 hit
PRINTSiPR02107 INOS145TPRIP
SMARTiView protein in SMART
SM01265 Mab-21, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIPIL2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3MIP1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 25, 2005
Last modified: June 5, 2019
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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