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UniProtKB - Q3MIN7 (RGL3_HUMAN)

Entry version 137 (02 Dec 2020)
Sequence version 2 (18 May 2010)
Previous versions | rss
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Protein

Ral guanine nucleotide dissociation stimulator-like 3

Gene

RGL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q3MIN7

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5673001, RAF/MAP kinase cascade

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ral guanine nucleotide dissociation stimulator-like 3
Short name:
RalGDS-like 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RGL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000205517.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:30282, RGL3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616743, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q3MIN7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		57139

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134979213

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q3MIN7, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RGL3

Domain mapping of disease mutations (DMDM)

More...DMDMi		296452877

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003067991 – 710Ral guanine nucleotide dissociation stimulator-like 3Add BLAST710

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei52PhosphoserineCombined sources1
Modified residuei508PhosphoserineBy similarity1
Modified residuei512PhosphoserineCombined sources1
Modified residuei555PhosphoserineBy similarity1
Modified residuei569PhosphoserineCombined sources1
Modified residuei573PhosphoserineCombined sources1
Modified residuei591PhosphoserineCombined sources1
Modified residuei601PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q3MIN7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q3MIN7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q3MIN7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q3MIN7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q3MIN7

PeptideAtlas

More...PeptideAtlasi		Q3MIN7

PRoteomics IDEntifications database

More...PRIDEi		Q3MIN7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		61789 [Q3MIN7-1]
6217

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q3MIN7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q3MIN7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000205517, Expressed in left lobe of thyroid gland and 151 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q3MIN7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q3MIN7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000205517, Tissue enhanced (parathyroid gland, thyroid gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GTP-bound forms of RIT1, HRAS and MRAS.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121398, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q3MIN7, 8 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000377075

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q3MIN7, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini65 – 200N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST136
Domaini247 – 505Ras-GEFPROSITE-ProRule annotationAdd BLAST259
Domaini613 – 700Ras-associatingPROSITE-ProRule annotationAdd BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni612 – 707Interaction with HRAS, MRAS and RIT1By similarityAdd BLAST96

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi231 – 234Poly-Glu4
Compositional biasi537 – 607Pro-richAdd BLAST71

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Ras-associating domain plays a central role in the activation of Ral-A GDP/GTP exchange activity.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3629, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q3MIN7

Database of Orthologous Groups

More...OrthoDBi		940219at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q3MIN7

TreeFam database of animal gene trees

More...TreeFami		TF315204

Family and domain databases

Conserved Domains Database

More...CDDi		cd00155, RasGEF, 1 hit
cd06224, REM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.840.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000159, RA_dom
IPR008937, Ras-like_GEF
IPR000651, Ras-like_Gua-exchang_fac_N
IPR019804, Ras_G-nucl-exch_fac_CS
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR036964, RASGEF_cat_dom_sf
IPR030750, RGL3
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...PANTHERi		PTHR23113, PTHR23113, 1 hit
PTHR23113:SF220, PTHR23113:SF220, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00788, RA, 1 hit
PF00617, RasGEF, 1 hit
PF00618, RasGEF_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00314, RA, 1 hit
SM00147, RasGEF, 1 hit
SM00229, RasGEFN, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48366, SSF48366, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50200, RA, 1 hit
PS00720, RASGEF, 1 hit
PS50009, RASGEF_CAT, 1 hit
PS50212, RASGEF_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3MIN7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERTAGKELA LAPLQDWGEE TEDGAVYSVS LRRQRSQRRS PAEGPGGSQA 
        60         70         80         90        100
PSPIANTFLH YRTSKVRVLR AARLERLVGE LVFGDREQDP SFMPAFLATY 
       110        120        130        140        150
RTFVPTACLL GFLLPPMPPP PPPGVEIKKT AVQDLSFNKN LRAVVSVLGS 
       160        170        180        190        200
WLQDHPQDFR DPPAHSDLGS VRTFLGWAAP GSAEAQKAEK LLEDFLEEAE 
       210        220        230        240        250
REQEEEPPQV WTGPPRVAQT SDPDSSEACA EEEEGLMPQG PQLLDFSVDE 
       260        270        280        290        300
VAEQLTLIDL ELFSKVRLYE CLGSVWSQRD RPGAAGASPT VRATVAQFNT 
       310        320        330        340        350
VTGCVLGSVL GAPGLAAPQR AQRLEKWIRI AQRCRELRNF SSLRAILSAL 
       360        370        380        390        400
QSNPIYRLKR SWGAVSREPL STFRKLSQIF SDENNHLSSR EILFQEEATE 
       410        420        430        440        450
GSQEEDNTPG SLPSKPPPGP VPYLGTFLTD LVMLDTALPD MLEGDLINFE 
       460        470        480        490        500
KRRKEWEILA RIQQLQRRCQ SYTLSPHPPI LAALHAQNQL TEEQSYRLSR 
       510        520        530        540        550
VIEPPAASCP SSPRIRRRIS LTKRLSAKLA REKSSSPSGS PGDPSSPTSS 
       560        570        580        590        600
VSPGSPPSSP RSRDAPAGSP PASPGPQGPS TKLPLSLDLP SPRPFALPLG 
       610        620        630        640        650
SPRIPLPAQQ SSEARVIRVS IDNDHGNLYR SILLTSQDKA PSVVRRALQK 
       660        670        680        690        700
HNVPQPWACD YQLFQVLPGD RVLLIPDNAN VFYAMSPVAP RDFMLRRKEG 
       710
TRNTLSVSPS
Length:710
Mass (Da):78,079
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE36E9E66201D7F47
GO
Isoform 2 (identifier: Q3MIN7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     549-549: S → SSLCISP

Show »
Length:716
Mass (Da):78,680
Checksum:i82B4174DDE0AF933
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRX4A0A0A0MRX4_HUMAN
Ral guanine nucleotide dissociation...
RGL3
710Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIS7K7EIS7_HUMAN
Ral guanine nucleotide dissociation...
RGL3
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BN42H3BN42_HUMAN
Ral guanine nucleotide dissociation...
RGL3
250Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQS8H3BQS8_HUMAN
Ral guanine nucleotide dissociation...
RGL3
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRW0H3BRW0_HUMAN
Ral guanine nucleotide dissociation...
RGL3
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMV7K7EMV7_HUMAN
Ral guanine nucleotide dissociation...
RGL3
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH14426 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035298162P → H1 PublicationCorresponds to variant dbSNP:rs167479Ensembl.1
Natural variantiVAR_035299164A → V1 PublicationCorresponds to variant dbSNP:rs160838Ensembl.1
Natural variantiVAR_035300615R → C. Corresponds to variant dbSNP:rs2291516Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045369549S → SSLCISP in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC024575 Genomic DNA No translation available.
BC014426 mRNA Translation: AAH14426.1 Frameshift.
BC101756 mRNA Translation: AAI01757.1
BC111958 mRNA Translation: AAI11959.1
BC143530 mRNA Translation: AAI43531.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32910.1 [Q3MIN7-1]
CCDS54221.1 [Q3MIN7-2]

NCBI Reference Sequences

More...RefSeqi		NP_001030300.3, NM_001035223.3
NP_001155088.2, NM_001161616.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000393423; ENSP00000377075; ENSG00000205517

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57139

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57139

UCSC genome browser

More...UCSCi		uc002mro.3, human [Q3MIN7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024575 Genomic DNA No translation available.
BC014426 mRNA Translation: AAH14426.1 Frameshift.
BC101756 mRNA Translation: AAI01757.1
BC111958 mRNA Translation: AAI11959.1
BC143530 mRNA Translation: AAI43531.1
CCDSiCCDS32910.1 [Q3MIN7-1]
CCDS54221.1 [Q3MIN7-2]
RefSeqiNP_001030300.3, NM_001035223.3
NP_001155088.2, NM_001161616.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121398, 6 interactors
IntActiQ3MIN7, 8 interactors
STRINGi9606.ENSP00000377075

PTM databases

iPTMnetiQ3MIN7
PhosphoSitePlusiQ3MIN7

Polymorphism and mutation databases

BioMutaiRGL3
DMDMi296452877

Proteomic databases

EPDiQ3MIN7
jPOSTiQ3MIN7
MassIVEiQ3MIN7
MaxQBiQ3MIN7
PaxDbiQ3MIN7
PeptideAtlasiQ3MIN7
PRIDEiQ3MIN7
ProteomicsDBi61789 [Q3MIN7-1]
6217

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		52109, 34 antibodies

Genome annotation databases

EnsembliENST00000393423; ENSP00000377075; ENSG00000205517
GeneIDi57139
KEGGihsa:57139
UCSCiuc002mro.3, human [Q3MIN7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57139
DisGeNETi57139
EuPathDBiHostDB:ENSG00000205517.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		RGL3
HGNCiHGNC:30282, RGL3
HPAiENSG00000205517, Tissue enhanced (parathyroid gland, thyroid gland)
MIMi616743, gene
neXtProtiNX_Q3MIN7
PharmGKBiPA134979213

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3629, Eukaryota
InParanoidiQ3MIN7
OrthoDBi940219at2759
PhylomeDBiQ3MIN7
TreeFamiTF315204

Enzyme and pathway databases

PathwayCommonsiQ3MIN7
ReactomeiR-HSA-5673001, RAF/MAP kinase cascade

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57139, 4 hits in 845 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RGL3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57139
PharosiQ3MIN7, Tdark

Protein Ontology

More...PROi		PR:Q3MIN7
RNActiQ3MIN7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000205517, Expressed in left lobe of thyroid gland and 151 other tissues
ExpressionAtlasiQ3MIN7, baseline and differential
GenevisibleiQ3MIN7, HS

Family and domain databases

CDDicd00155, RasGEF, 1 hit
cd06224, REM, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR000159, RA_dom
IPR008937, Ras-like_GEF
IPR000651, Ras-like_Gua-exchang_fac_N
IPR019804, Ras_G-nucl-exch_fac_CS
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR036964, RASGEF_cat_dom_sf
IPR030750, RGL3
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR23113, PTHR23113, 1 hit
PTHR23113:SF220, PTHR23113:SF220, 1 hit
PfamiView protein in Pfam
PF00788, RA, 1 hit
PF00617, RasGEF, 1 hit
PF00618, RasGEF_N, 1 hit
SMARTiView protein in SMART
SM00314, RA, 1 hit
SM00147, RasGEF, 1 hit
SM00229, RasGEFN, 1 hit
SUPFAMiSSF48366, SSF48366, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200, RA, 1 hit
PS00720, RASGEF, 1 hit
PS50009, RASGEF_CAT, 1 hit
PS50212, RASGEF_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGL3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3MIN7
Secondary accession number(s): B5ME84, B7ZL22, Q0P6G0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 18, 2010
Last modified: December 2, 2020
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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