UniProtKB - Q3MIN7 (RGL3_HUMAN)
Protein
Ral guanine nucleotide dissociation stimulator-like 3
Gene
RGL3
Organism
Homo sapiens (Human)
Status
Functioni
Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity).By similarity
GO - Molecular functioni
- Ral guanyl-nucleotide exchange factor activity Source: Ensembl
GO - Biological processi
- positive regulation of GTPase activity Source: InterPro
- small GTPase mediated signal transduction Source: InterPro
Keywordsi
Molecular function | Guanine-nucleotide releasing factor |
Enzyme and pathway databases
PathwayCommonsi | Q3MIN7 |
Reactomei | R-HSA-5673001, RAF/MAP kinase cascade |
Names & Taxonomyi
Protein namesi | Recommended name: Ral guanine nucleotide dissociation stimulator-like 3Short name: RalGDS-like 3 |
Gene namesi | Name:RGL3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000205517.12 |
HGNCi | HGNC:30282, RGL3 |
MIMi | 616743, gene |
neXtProti | NX_Q3MIN7 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 57139 |
PharmGKBi | PA134979213 |
Miscellaneous databases
Pharosi | Q3MIN7, Tdark |
Polymorphism and mutation databases
BioMutai | RGL3 |
DMDMi | 296452877 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000306799 | 1 – 710 | Ral guanine nucleotide dissociation stimulator-like 3Add BLAST | 710 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 52 | PhosphoserineCombined sources | 1 | |
Modified residuei | 508 | PhosphoserineBy similarity | 1 | |
Modified residuei | 512 | PhosphoserineCombined sources | 1 | |
Modified residuei | 555 | PhosphoserineBy similarity | 1 | |
Modified residuei | 569 | PhosphoserineCombined sources | 1 | |
Modified residuei | 573 | PhosphoserineCombined sources | 1 | |
Modified residuei | 591 | PhosphoserineCombined sources | 1 | |
Modified residuei | 601 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q3MIN7 |
jPOSTi | Q3MIN7 |
MassIVEi | Q3MIN7 |
MaxQBi | Q3MIN7 |
PaxDbi | Q3MIN7 |
PeptideAtlasi | Q3MIN7 |
PRIDEi | Q3MIN7 |
ProteomicsDBi | 61789 [Q3MIN7-1] 6217 |
PTM databases
iPTMneti | Q3MIN7 |
PhosphoSitePlusi | Q3MIN7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000205517, Expressed in left lobe of thyroid gland and 151 other tissues |
ExpressionAtlasi | Q3MIN7, baseline and differential |
Genevisiblei | Q3MIN7, HS |
Organism-specific databases
HPAi | ENSG00000205517, Tissue enhanced (parathyroid gland, thyroid gland) |
Interactioni
Subunit structurei
Interacts with GTP-bound forms of RIT1, HRAS and MRAS.
By similarityBinary interactionsi
Hide detailsQ3MIN7
GO - Molecular functioni
- Ral guanyl-nucleotide exchange factor activity Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 121398, 6 interactors |
IntActi | Q3MIN7, 8 interactors |
STRINGi | 9606.ENSP00000377075 |
Miscellaneous databases
RNActi | Q3MIN7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 65 – 200 | N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST | 136 | |
Domaini | 247 – 505 | Ras-GEFPROSITE-ProRule annotationAdd BLAST | 259 | |
Domaini | 613 – 700 | Ras-associatingPROSITE-ProRule annotationAdd BLAST | 88 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 612 – 707 | Interaction with HRAS, MRAS and RIT1By similarityAdd BLAST | 96 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 231 – 234 | Poly-Glu | 4 | |
Compositional biasi | 537 – 607 | Pro-richAdd BLAST | 71 |
Domaini
The Ras-associating domain plays a central role in the activation of Ral-A GDP/GTP exchange activity.By similarity
Phylogenomic databases
eggNOGi | KOG3629, Eukaryota |
InParanoidi | Q3MIN7 |
OrthoDBi | 940219at2759 |
PhylomeDBi | Q3MIN7 |
TreeFami | TF315204 |
Family and domain databases
CDDi | cd00155, RasGEF, 1 hit cd06224, REM, 1 hit |
Gene3Di | 1.10.840.10, 1 hit |
InterProi | View protein in InterPro IPR000159, RA_dom IPR008937, Ras-like_GEF IPR000651, Ras-like_Gua-exchang_fac_N IPR019804, Ras_G-nucl-exch_fac_CS IPR023578, Ras_GEF_dom_sf IPR001895, RASGEF_cat_dom IPR036964, RASGEF_cat_dom_sf IPR030750, RGL3 IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR23113, PTHR23113, 1 hit PTHR23113:SF220, PTHR23113:SF220, 1 hit |
Pfami | View protein in Pfam PF00788, RA, 1 hit PF00617, RasGEF, 1 hit PF00618, RasGEF_N, 1 hit |
SMARTi | View protein in SMART SM00314, RA, 1 hit SM00147, RasGEF, 1 hit SM00229, RasGEFN, 1 hit |
SUPFAMi | SSF48366, SSF48366, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50200, RA, 1 hit PS00720, RASGEF, 1 hit PS50009, RASGEF_CAT, 1 hit PS50212, RASGEF_NTER, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q3MIN7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MERTAGKELA LAPLQDWGEE TEDGAVYSVS LRRQRSQRRS PAEGPGGSQA
60 70 80 90 100
PSPIANTFLH YRTSKVRVLR AARLERLVGE LVFGDREQDP SFMPAFLATY
110 120 130 140 150
RTFVPTACLL GFLLPPMPPP PPPGVEIKKT AVQDLSFNKN LRAVVSVLGS
160 170 180 190 200
WLQDHPQDFR DPPAHSDLGS VRTFLGWAAP GSAEAQKAEK LLEDFLEEAE
210 220 230 240 250
REQEEEPPQV WTGPPRVAQT SDPDSSEACA EEEEGLMPQG PQLLDFSVDE
260 270 280 290 300
VAEQLTLIDL ELFSKVRLYE CLGSVWSQRD RPGAAGASPT VRATVAQFNT
310 320 330 340 350
VTGCVLGSVL GAPGLAAPQR AQRLEKWIRI AQRCRELRNF SSLRAILSAL
360 370 380 390 400
QSNPIYRLKR SWGAVSREPL STFRKLSQIF SDENNHLSSR EILFQEEATE
410 420 430 440 450
GSQEEDNTPG SLPSKPPPGP VPYLGTFLTD LVMLDTALPD MLEGDLINFE
460 470 480 490 500
KRRKEWEILA RIQQLQRRCQ SYTLSPHPPI LAALHAQNQL TEEQSYRLSR
510 520 530 540 550
VIEPPAASCP SSPRIRRRIS LTKRLSAKLA REKSSSPSGS PGDPSSPTSS
560 570 580 590 600
VSPGSPPSSP RSRDAPAGSP PASPGPQGPS TKLPLSLDLP SPRPFALPLG
610 620 630 640 650
SPRIPLPAQQ SSEARVIRVS IDNDHGNLYR SILLTSQDKA PSVVRRALQK
660 670 680 690 700
HNVPQPWACD YQLFQVLPGD RVLLIPDNAN VFYAMSPVAP RDFMLRRKEG
710
TRNTLSVSPS
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MRX4 | A0A0A0MRX4_HUMAN | Ral guanine nucleotide dissociation... | RGL3 | 710 | Annotation score: | ||
K7EIS7 | K7EIS7_HUMAN | Ral guanine nucleotide dissociation... | RGL3 | 176 | Annotation score: | ||
H3BN42 | H3BN42_HUMAN | Ral guanine nucleotide dissociation... | RGL3 | 250 | Annotation score: | ||
H3BQS8 | H3BQS8_HUMAN | Ral guanine nucleotide dissociation... | RGL3 | 181 | Annotation score: | ||
H3BRW0 | H3BRW0_HUMAN | Ral guanine nucleotide dissociation... | RGL3 | 167 | Annotation score: | ||
K7EMV7 | K7EMV7_HUMAN | Ral guanine nucleotide dissociation... | RGL3 | 77 | Annotation score: |
Sequence cautioni
The sequence AAH14426 differs from that shown. Reason: Frameshift.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035298 | 162 | P → H1 PublicationCorresponds to variant dbSNP:rs167479Ensembl. | 1 | |
Natural variantiVAR_035299 | 164 | A → V1 PublicationCorresponds to variant dbSNP:rs160838Ensembl. | 1 | |
Natural variantiVAR_035300 | 615 | R → C. Corresponds to variant dbSNP:rs2291516Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045369 | 549 | S → SSLCISP in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC024575 Genomic DNA No translation available. BC014426 mRNA Translation: AAH14426.1 Frameshift. BC101756 mRNA Translation: AAI01757.1 BC111958 mRNA Translation: AAI11959.1 BC143530 mRNA Translation: AAI43531.1 |
CCDSi | CCDS32910.1 [Q3MIN7-1] CCDS54221.1 [Q3MIN7-2] |
RefSeqi | NP_001030300.3, NM_001035223.3 NP_001155088.2, NM_001161616.2 |
Genome annotation databases
Ensembli | ENST00000393423; ENSP00000377075; ENSG00000205517 |
GeneIDi | 57139 |
KEGGi | hsa:57139 |
UCSCi | uc002mro.3, human [Q3MIN7-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC024575 Genomic DNA No translation available. BC014426 mRNA Translation: AAH14426.1 Frameshift. BC101756 mRNA Translation: AAI01757.1 BC111958 mRNA Translation: AAI11959.1 BC143530 mRNA Translation: AAI43531.1 |
CCDSi | CCDS32910.1 [Q3MIN7-1] CCDS54221.1 [Q3MIN7-2] |
RefSeqi | NP_001030300.3, NM_001035223.3 NP_001155088.2, NM_001161616.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121398, 6 interactors |
IntActi | Q3MIN7, 8 interactors |
STRINGi | 9606.ENSP00000377075 |
PTM databases
iPTMneti | Q3MIN7 |
PhosphoSitePlusi | Q3MIN7 |
Polymorphism and mutation databases
BioMutai | RGL3 |
DMDMi | 296452877 |
Proteomic databases
EPDi | Q3MIN7 |
jPOSTi | Q3MIN7 |
MassIVEi | Q3MIN7 |
MaxQBi | Q3MIN7 |
PaxDbi | Q3MIN7 |
PeptideAtlasi | Q3MIN7 |
PRIDEi | Q3MIN7 |
ProteomicsDBi | 61789 [Q3MIN7-1] 6217 |
Protocols and materials databases
Antibodypediai | 52109, 34 antibodies |
Genome annotation databases
Ensembli | ENST00000393423; ENSP00000377075; ENSG00000205517 |
GeneIDi | 57139 |
KEGGi | hsa:57139 |
UCSCi | uc002mro.3, human [Q3MIN7-1] |
Organism-specific databases
CTDi | 57139 |
DisGeNETi | 57139 |
EuPathDBi | HostDB:ENSG00000205517.12 |
GeneCardsi | RGL3 |
HGNCi | HGNC:30282, RGL3 |
HPAi | ENSG00000205517, Tissue enhanced (parathyroid gland, thyroid gland) |
MIMi | 616743, gene |
neXtProti | NX_Q3MIN7 |
PharmGKBi | PA134979213 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3629, Eukaryota |
InParanoidi | Q3MIN7 |
OrthoDBi | 940219at2759 |
PhylomeDBi | Q3MIN7 |
TreeFami | TF315204 |
Enzyme and pathway databases
PathwayCommonsi | Q3MIN7 |
Reactomei | R-HSA-5673001, RAF/MAP kinase cascade |
Miscellaneous databases
BioGRID-ORCSi | 57139, 4 hits in 845 CRISPR screens |
ChiTaRSi | RGL3, human |
GenomeRNAii | 57139 |
Pharosi | Q3MIN7, Tdark |
PROi | PR:Q3MIN7 |
RNActi | Q3MIN7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000205517, Expressed in left lobe of thyroid gland and 151 other tissues |
ExpressionAtlasi | Q3MIN7, baseline and differential |
Genevisiblei | Q3MIN7, HS |
Family and domain databases
CDDi | cd00155, RasGEF, 1 hit cd06224, REM, 1 hit |
Gene3Di | 1.10.840.10, 1 hit |
InterProi | View protein in InterPro IPR000159, RA_dom IPR008937, Ras-like_GEF IPR000651, Ras-like_Gua-exchang_fac_N IPR019804, Ras_G-nucl-exch_fac_CS IPR023578, Ras_GEF_dom_sf IPR001895, RASGEF_cat_dom IPR036964, RASGEF_cat_dom_sf IPR030750, RGL3 IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR23113, PTHR23113, 1 hit PTHR23113:SF220, PTHR23113:SF220, 1 hit |
Pfami | View protein in Pfam PF00788, RA, 1 hit PF00617, RasGEF, 1 hit PF00618, RasGEF_N, 1 hit |
SMARTi | View protein in SMART SM00314, RA, 1 hit SM00147, RasGEF, 1 hit SM00229, RasGEFN, 1 hit |
SUPFAMi | SSF48366, SSF48366, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50200, RA, 1 hit PS00720, RASGEF, 1 hit PS50009, RASGEF_CAT, 1 hit PS50212, RASGEF_NTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RGL3_HUMAN | |
Accessioni | Q3MIN7Primary (citable) accession number: Q3MIN7 Secondary accession number(s): B5ME84, B7ZL22, Q0P6G0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 137 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations