Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q3MII6 (TBC25_HUMAN)

Entry version 123 (07 Apr 2021)
Sequence version 2 (18 May 2010)
Previous versions | rss
Add a publicationFeedback
Protein

TBC1 domain family member 25

Gene

TBC1D25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
Biological processAutophagy

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q3MII6

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8854214, TBC/RABGAPs

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q3MII6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TBC1 domain family member 25
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TBC1D25
Synonyms:OATL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:8092, TBC1D25

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		311240, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q3MII6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000068354.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi134 – 135ED → AA: Severely affects interaction with GABARAP. Does not localize at autophagosomes. 1 Publication2
Mutagenesisi136W → A: Abolishes interaction with GABARAP. Does not localize at autophagosomes. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		4943

Open Targets

More...OpenTargetsi		ENSG00000068354

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162405201

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q3MII6, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TBC1D25

Domain mapping of disease mutations (DMDM)

More...DMDMi		296452922

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002885081 – 688TBC1 domain family member 25Add BLAST688

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei140PhosphoserineBy similarity1
Modified residuei160PhosphothreonineBy similarity1
Modified residuei506PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q3MII6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q3MII6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q3MII6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q3MII6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q3MII6

PeptideAtlas

More...PeptideAtlasi		Q3MII6

PRoteomics IDEntifications database

More...PRIDEi		Q3MII6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		61786 [Q3MII6-1]
61787 [Q3MII6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q3MII6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q3MII6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000068354, Expressed in heart left ventricle and 169 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q3MII6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q3MII6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000068354, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminus) with MAP1LC3B, GABARAP and GABARAPL2.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110997, 52 interactors

Protein interaction database and analysis system

More...IntActi		Q3MII6, 17 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000365962

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q3MII6, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini228 – 434Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST207

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 28Poly-Ala7
Compositional biasi29 – 34Poly-Glu6
Compositional biasi494 – 499Poly-Gly6
Compositional biasi559 – 564Poly-Ser6

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2197, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159173

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004382_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q3MII6

Identification of Orthologs from Complete Genome Data

More...OMAi		VKVKKCD

Database of Orthologous Groups

More...OrthoDBi		1495285at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q3MII6

TreeFam database of animal gene trees

More...TreeFami		TF323518

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000195, Rab-GTPase-TBC_dom
IPR035969, Rab-GTPase_TBC_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00566, RabGAP-TBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00164, TBC, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47923, SSF47923, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50086, TBC_RABGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3MII6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATASGASDL SGSGAPPPGV GAQAAAAAEE EEREVVRVRV KKCESFLPPE 
        60         70         80         90        100
FRSFAVDPQI TSLDVLQHIL IRAFDLSGKK NFGISYLGRD RLGQEVYLSL 
       110        120        130        140        150
LSDWDLSTAF ATASKPYLQL RVDIRPSEDS PLLEDWDIIS PKDVIGSDVL 
       160        170        180        190        200
LAEKRSSLTT AALPFTQSIL TQVGRTLSKV QQVLSWSYGE DVKPFKPPLS 
       210        220        230        240        250
DAEFHTYLNH EGQLSRPEEL RLRIYHGGVE PSLRKVVWRY LLNVYPDGLT 
       260        270        280        290        300
GRERMDYMKR KSREYEQLKS EWAQRANPED LEFIRSTVLK DVLRTDRAHP 
       310        320        330        340        350
YYAGPEDGPH LRALHDLLTT YAVTHPQVSY CQGMSDLASP ILAVMDHEGH 
       360        370        380        390        400
AFVCFCGIMK RLAANFHPDG RAMATKFAHL KLLLRHADPD FYQYLQEAGA 
       410        420        430        440        450
DDLFFCYRWL LLELKREFAF DDALRMLEVT WSSLPPDPPE HEVELVGPPS 
       460        470        480        490        500
QVADAGFGGH RGWPVRQRHM LRPAGGGGST FEDAVDHLAT ASQGPGGGGR 
       510        520        530        540        550
LLRQASLDGL QQLRDNMGSR RDPLVQLPHP AALISSKSLS EPLLNSPDPL 
       560        570        580        590        600
LSSFSHPDSP SSSSPPSTQE ASPTGDMAVG SPLMQEVGSP KDPGKSLPPV 
       610        620        630        640        650
PPMGLPPPQE FGRGNPFMLF LCLAILLEHR DHIMRNGLDY NELAMHFDRL 
       660        670        680 
VRKHHLGRVL RRARALFADY LQSEVWDSEE GAEATAAS
Length:688
Mass (Da):76,327
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B070FE11D78D0A4
GO
Isoform 2 (identifier: Q3MII6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-100: KKNFGISYLGRDRLGQEVYLSL → PIARRLGHNQPQRCHWLRRVAG
     101-688: Missing.

Show »
Length:100
Mass (Da):10,757
Checksum:i552B53E4E93159B6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JMI8C9JMI8_HUMAN
TBC1 domain family member 25
TBC1D25
230Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti455A → T in AAI01818 (PubMed:15489334).Curated1
Sequence conflicti455A → T in AAI01820 (PubMed:15489334).Curated1
Sequence conflicti455A → T in AAI25089 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057345277N → S1 PublicationCorresponds to variant dbSNP:rs2293948Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02570379 – 100KKNFG…VYLSL → PIARRLGHNQPQRCHWLRRV AG in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_025704101 – 688Missing in isoform 2. 1 PublicationAdd BLAST588

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC115618 Genomic DNA No translation available.
AF196969 Genomic DNA No translation available.
BC026050 mRNA Translation: AAH26050.1
BC101817 mRNA Translation: AAI01818.1
BC101819 mRNA Translation: AAI01820.1
BC125088 mRNA Translation: AAI25089.1
BC125089 mRNA Translation: AAI25090.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35242.1 [Q3MII6-1]

NCBI Reference Sequences

More...RefSeqi		NP_001335191.1, NM_001348262.1
NP_002527.1, NM_002536.3 [Q3MII6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000376771; ENSP00000365962; ENSG00000068354 [Q3MII6-1]
ENST00000481090; ENSP00000476787; ENSG00000068354 [Q3MII6-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4943

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4943

UCSC genome browser

More...UCSCi		uc004dka.2, human [Q3MII6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115618 Genomic DNA No translation available.
AF196969 Genomic DNA No translation available.
BC026050 mRNA Translation: AAH26050.1
BC101817 mRNA Translation: AAI01818.1
BC101819 mRNA Translation: AAI01820.1
BC125088 mRNA Translation: AAI25089.1
BC125089 mRNA Translation: AAI25090.2
CCDSiCCDS35242.1 [Q3MII6-1]
RefSeqiNP_001335191.1, NM_001348262.1
NP_002527.1, NM_002536.3 [Q3MII6-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi110997, 52 interactors
IntActiQ3MII6, 17 interactors
STRINGi9606.ENSP00000365962

PTM databases

iPTMnetiQ3MII6
PhosphoSitePlusiQ3MII6

Genetic variation databases

BioMutaiTBC1D25
DMDMi296452922

Proteomic databases

EPDiQ3MII6
jPOSTiQ3MII6
MassIVEiQ3MII6
MaxQBiQ3MII6
PaxDbiQ3MII6
PeptideAtlasiQ3MII6
PRIDEiQ3MII6
ProteomicsDBi61786 [Q3MII6-1]
61787 [Q3MII6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		54837, 40 antibodies

Genome annotation databases

EnsembliENST00000376771; ENSP00000365962; ENSG00000068354 [Q3MII6-1]
ENST00000481090; ENSP00000476787; ENSG00000068354 [Q3MII6-2]
GeneIDi4943
KEGGihsa:4943
UCSCiuc004dka.2, human [Q3MII6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4943
DisGeNETi4943

GeneCards: human genes, protein and diseases

More...GeneCardsi		TBC1D25
HGNCiHGNC:8092, TBC1D25
HPAiENSG00000068354, Low tissue specificity
MIMi311240, gene
neXtProtiNX_Q3MII6
OpenTargetsiENSG00000068354
PharmGKBiPA162405201
VEuPathDBiHostDB:ENSG00000068354.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2197, Eukaryota
GeneTreeiENSGT00940000159173
HOGENOMiCLU_004382_1_0_1
InParanoidiQ3MII6
OMAiVKVKKCD
OrthoDBi1495285at2759
PhylomeDBiQ3MII6
TreeFamiTF323518

Enzyme and pathway databases

PathwayCommonsiQ3MII6
ReactomeiR-HSA-8854214, TBC/RABGAPs
SIGNORiQ3MII6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4943, 3 hits in 622 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TBC1D25, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4943
PharosiQ3MII6, Tbio

Protein Ontology

More...PROi		PR:Q3MII6
RNActiQ3MII6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000068354, Expressed in heart left ventricle and 169 other tissues
ExpressionAtlasiQ3MII6, baseline and differential
GenevisibleiQ3MII6, HS

Family and domain databases

InterProiView protein in InterPro
IPR000195, Rab-GTPase-TBC_dom
IPR035969, Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566, RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164, TBC, 1 hit
SUPFAMiSSF47923, SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086, TBC_RABGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBC25_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3MII6
Secondary accession number(s): Q08AN9, Q3MII4, Q8TAR9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 18, 2010
Last modified: April 7, 2021
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again