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Protein

Collagen and calcium-binding EGF domain-containing protein 1

Gene

Ccbe1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processAngiogenesis
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen and calcium-binding EGF domain-containing protein 1
Alternative name(s):
Full of fluid protein homolog
Gene namesi
Name:Ccbe1
Synonyms:Kiaa1983
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2445053 Ccbe1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000027951736 – 408Collagen and calcium-binding EGF domain-containing protein 1Add BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi139 ↔ 151PROSITE-ProRule annotation
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi147 ↔ 160PROSITE-ProRule annotation
Disulfide bondi162 ↔ 175PROSITE-ProRule annotation
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ3MI99
PaxDbiQ3MI99
PeptideAtlasiQ3MI99
PRIDEiQ3MI99

PTM databases

iPTMnetiQ3MI99
PhosphoSitePlusiQ3MI99

Expressioni

Gene expression databases

BgeeiENSMUSG00000046318 Expressed in 92 organ(s), highest expression level in embryo
CleanExiMM_CCBE1
GenevisibleiQ3MI99 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052011

Structurei

3D structure databases

ProteinModelPortaliQ3MI99
SMRiQ3MI99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini135 – 176EGF-like; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini247 – 292Collagen-like 1Add BLAST46
Domaini302 – 335Collagen-like 2Add BLAST34

Sequence similaritiesi

Belongs to the CCBE1 family.Curated

Keywords - Domaini

Collagen, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IRWI Eukaryota
ENOG4111SKA LUCA
GeneTreeiENSGT00390000014907
HOGENOMiHOG000111400
HOVERGENiHBG081035
InParanoidiQ3MI99
KOiK19638
OMAiGRTCTKG
OrthoDBiEOG091G0FDT
PhylomeDBiQ3MI99
TreeFamiTF333138

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
PfamiView protein in Pfam
PF01391 Collagen, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS01187 EGF_CA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3MI99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPPPLPSRG GAAKRQLGKS LGPLLLLLAL GHTWTYREEP EDRDREVCSE
60 70 80 90 100
NKITTTKYPC LKSSGELTTC FRKKCCKGYK FVLGQCIPED YDICAQAPCE
110 120 130 140 150
QQCTDNFGRV LCTCYPGYRY DRERHQKRER PYCLDIDECA TSNTTLCAHI
160 170 180 190 200
CINTMGSYHC ECREGYILED DGRTCTRGDK YPNDTGHEEK SENEVKAGTC
210 220 230 240 250
CATCKEFSQM KQTVLQLKQK MALLPNNAAE LGKYVNGDKV LASNAYLPGP
260 270 280 290 300
PGLPGGQGPP GSPGPKGSPG FPGMPGPPGQ PGPRGSMGPM GPSPDLSHIK
310 320 330 340 350
QGRRGPVGPP GAPGRHGSKG ERGAPGPPGS PGPPGSFDFL LLVLADIRND
360 370 380 390 400
IAELQEKVFG HRTHSSAEDF PLPQEFSSYP ETLDFGSGDD YSRRTEARDP

EAPRNFYP
Length:408
Mass (Da):44,357
Last modified:May 5, 2009 - v2
Checksum:iE600004B6445EE88
GO

Sequence cautioni

The sequence BAD90476 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77K → E in BAD90476 (Ref. 2) Curated1
Sequence conflicti277P → L in AAI03804 (PubMed:15489334).Curated1
Sequence conflicti284R → Q in BAC25916 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028377 mRNA Translation: BAC25916.1
AK035153 mRNA Translation: BAC28962.1
AK039742 mRNA Translation: BAC30435.1
AK220435 mRNA Translation: BAD90476.1 Different initiation.
BC103803 mRNA Translation: AAI03804.1
BC152322 mRNA Translation: AAI52323.1
CCDSiCCDS29314.1
RefSeqiNP_848908.1, NM_178793.4
UniGeneiMm.442049

Genome annotation databases

EnsembliENSMUST00000061103; ENSMUSP00000052011; ENSMUSG00000046318
ENSMUST00000130300; ENSMUSP00000117636; ENSMUSG00000046318
GeneIDi320924
KEGGimmu:320924
UCSCiuc008ffr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028377 mRNA Translation: BAC25916.1
AK035153 mRNA Translation: BAC28962.1
AK039742 mRNA Translation: BAC30435.1
AK220435 mRNA Translation: BAD90476.1 Different initiation.
BC103803 mRNA Translation: AAI03804.1
BC152322 mRNA Translation: AAI52323.1
CCDSiCCDS29314.1
RefSeqiNP_848908.1, NM_178793.4
UniGeneiMm.442049

3D structure databases

ProteinModelPortaliQ3MI99
SMRiQ3MI99
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052011

PTM databases

iPTMnetiQ3MI99
PhosphoSitePlusiQ3MI99

Proteomic databases

MaxQBiQ3MI99
PaxDbiQ3MI99
PeptideAtlasiQ3MI99
PRIDEiQ3MI99

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061103; ENSMUSP00000052011; ENSMUSG00000046318
ENSMUST00000130300; ENSMUSP00000117636; ENSMUSG00000046318
GeneIDi320924
KEGGimmu:320924
UCSCiuc008ffr.1 mouse

Organism-specific databases

CTDi147372
MGIiMGI:2445053 Ccbe1
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IRWI Eukaryota
ENOG4111SKA LUCA
GeneTreeiENSGT00390000014907
HOGENOMiHOG000111400
HOVERGENiHBG081035
InParanoidiQ3MI99
KOiK19638
OMAiGRTCTKG
OrthoDBiEOG091G0FDT
PhylomeDBiQ3MI99
TreeFamiTF333138

Miscellaneous databases

PROiPR:Q3MI99
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046318 Expressed in 92 organ(s), highest expression level in embryo
CleanExiMM_CCBE1
GenevisibleiQ3MI99 MM

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
PfamiView protein in Pfam
PF01391 Collagen, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS01187 EGF_CA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCBE1_MOUSE
AccessioniPrimary (citable) accession number: Q3MI99
Secondary accession number(s): A7MCU5
, Q5DTT5, Q8BFW1, Q8BMT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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