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Protein

Lysosomal protective protein

Gene

CTSA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei177By similarity1
Active sitei399By similarity1
Active sitei456By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease

Enzyme and pathway databases

ReactomeiR-BTA-1660662 Glycosphingolipid metabolism
R-BTA-2132295 MHC class II antigen presentation
R-BTA-4085001 Sialic acid metabolism
R-BTA-6798695 Neutrophil degranulation

Protein family/group databases

ESTHERibovin-ppgb Carboxypeptidase_S10
MEROPSiS10.002

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal protective protein (EC:3.4.16.5)
Alternative name(s):
Cathepsin A
Cleaved into the following 2 chains:
Gene namesi
Name:CTSA
Synonyms:PPGB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Organism-specific databases

VGNCiVGNC:27812 CTSA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27By similarityAdd BLAST27
ChainiPRO_000023621928 – 479Lysosomal protective proteinAdd BLAST452
ChainiPRO_000023622028 – 325Lysosomal protective protein 32 kDa chainBy similarityAdd BLAST298
ChainiPRO_0000236221326 – 479Lysosomal protective protein 20 kDa chainBy similarityAdd BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi87 ↔ 361By similarity
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi239 ↔ 255By similarity
Disulfide bondi240 ↔ 245By similarity
Disulfide bondi280 ↔ 330By similarity
Glycosylationi332N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ3MI05
PRIDEiQ3MI05

Expressioni

Gene expression databases

BgeeiENSBTAG00000027337 Expressed in 9 organ(s), highest expression level in lung

Interactioni

Subunit structurei

Heterodimer of a 32 kDa chain and a 20 kDa chain; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000039003

Structurei

3D structure databases

ProteinModelPortaliQ3MI05
SMRiQ3MI05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
GeneTreeiENSGT00880000138014
HOGENOMiHOG000198295
HOVERGENiHBG053652
InParanoidiQ3MI05
KOiK13289
OMAiDPPCTNT
OrthoDBiEOG091G06AA
TreeFamiTF323769

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR033124 Ser_caboxypep_his_AS
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00560 CARBOXYPEPT_SER_HIS, 1 hit
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3MI05-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRAALWPPV LLLLQLLLLA CAPGGEGAHD QDEIRFLPGL AKQPSFRQYS
60 70 80 90 100
GYLKGSGSKR LHYWFVESQK DPKSSPVVLW LNGGPGCSSL DGLLTEHGPF
110 120 130 140 150
LIQPDGVTLE YNPYSWNLIA NVLYLESPAG VGFSYSDDKS YATNDTEVAQ
160 170 180 190 200
SNFEALKDFF CLFPEYKGNE LFLTGESYAG IYIPTLAVLV MQDPSMNLQG
210 220 230 240 250
LAVGNGLSSY EQNDNSLVYF AYYHGLLGNR LWSSLQTHCC SQNQCNFHDN
260 270 280 290 300
KEPECVANLQ EVSHIVASSG LNIYNLYAPC AGGVPSHVRH EKDTVVVQDL
310 320 330 340 350
GNIFTRLPLK RVWHQTLLRS GEKVHLDPPC TNTTAASNYL NDPHVRKALH
360 370 380 390 400
IPEQLPRWDL CNFLVNIQYR RLYQSMCSQY LKLLSAQKYR ILLYNGDVDM
410 420 430 440 450
ACNFMGDEWF VDSLNQKMEV QRRPWLVDYG ESGEQIAGFV KEFSHIAFLT
460 470
IKGAGHMVPT DKPQAALTMF SRFLNRQPY
Length:479
Mass (Da):53,980
Last modified:October 25, 2005 - v1
Checksum:iA37CC37D5C575FBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104495 mRNA Translation: AAI04496.1
RefSeqiNP_001030403.1, NM_001035326.1
UniGeneiBt.21410

Genome annotation databases

EnsembliENSBTAT00000039203; ENSBTAP00000039003; ENSBTAG00000027337
GeneIDi518169
KEGGibta:518169

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104495 mRNA Translation: AAI04496.1
RefSeqiNP_001030403.1, NM_001035326.1
UniGeneiBt.21410

3D structure databases

ProteinModelPortaliQ3MI05
SMRiQ3MI05
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000039003

Protein family/group databases

ESTHERibovin-ppgb Carboxypeptidase_S10
MEROPSiS10.002

Proteomic databases

PaxDbiQ3MI05
PRIDEiQ3MI05

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000039203; ENSBTAP00000039003; ENSBTAG00000027337
GeneIDi518169
KEGGibta:518169

Organism-specific databases

CTDi5476
VGNCiVGNC:27812 CTSA

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
GeneTreeiENSGT00880000138014
HOGENOMiHOG000198295
HOVERGENiHBG053652
InParanoidiQ3MI05
KOiK13289
OMAiDPPCTNT
OrthoDBiEOG091G06AA
TreeFamiTF323769

Enzyme and pathway databases

ReactomeiR-BTA-1660662 Glycosphingolipid metabolism
R-BTA-2132295 MHC class II antigen presentation
R-BTA-4085001 Sialic acid metabolism
R-BTA-6798695 Neutrophil degranulation

Gene expression databases

BgeeiENSBTAG00000027337 Expressed in 9 organ(s), highest expression level in lung

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR033124 Ser_caboxypep_his_AS
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00560 CARBOXYPEPT_SER_HIS, 1 hit
PS00131 CARBOXYPEPT_SER_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPGB_BOVIN
AccessioniPrimary (citable) accession number: Q3MI05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 25, 2005
Last modified: September 12, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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