UniProtKB - Q3MHW9 (NB5R1_BOVIN)
Protein
NADH-cytochrome b5 reductase 1
Gene
CYB5R1
Organism
Bos taurus (Bovine)
Status
Functioni
NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.By similarity
Catalytic activityi
- EC:1.6.2.2
Cofactori
FADBy similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 136 – 166 | FADBy similarityAdd BLAST | 31 | |
Nucleotide bindingi | 175 – 210 | FADBy similarityAdd BLAST | 36 |
GO - Molecular functioni
- cytochrome-b5 reductase activity, acting on NAD(P)H Source: UniProtKB-EC
- FAD binding Source: GO_Central
GO - Biological processi
- sterol biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism |
Ligand | FAD, Flavoprotein, NAD |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CYB5R1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:97257, CYB5R1 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 8 – 28 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287544 | 1 – 305 | NADH-cytochrome b5 reductase 1Add BLAST | 305 |
Proteomic databases
PaxDbi | Q3MHW9 |
PRIDEi | Q3MHW9 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 156 | FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST | 113 |
Sequence similaritiesi
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0534, Eukaryota |
GeneTreei | ENSGT00940000160784 |
InParanoidi | Q3MHW9 |
OrthoDBi | 1311668at2759 |
Family and domain databases
Gene3Di | 3.40.50.80, 1 hit |
InterProi | View protein in InterPro IPR001834, CBR-like IPR008333, Cbr1-like_FAD-bd_dom IPR017927, FAD-bd_FR_type IPR001709, Flavoprot_Pyr_Nucl_cyt_Rdtase IPR039261, FNR_nucleotide-bd IPR001433, OxRdtase_FAD/NAD-bd IPR017938, Riboflavin_synthase-like_b-brl |
Pfami | View protein in Pfam PF00970, FAD_binding_6, 1 hit PF00175, NAD_binding_1, 1 hit |
PRINTSi | PR00406, CYTB5RDTASE PR00371, FPNCR |
SUPFAMi | SSF52343, SSF52343, 1 hit SSF63380, SSF63380, 1 hit |
PROSITEi | View protein in PROSITE PS51384, FAD_FR, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3MHW9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLQPSPVLL ASLGVGLLTL LGVALGAYLV RRSRRPPVTL LDPNEKYQLR
60 70 80 90 100
LLDKTTVNHN TKRFRFALPT AHHVLGLPVG KHVYLSARID GSLVIRPYTP
110 120 130 140 150
VTSDEDQGYV DLVIKVYLKG VHPKFPEGGK MSQYLDSLKI GDVVEFRGPS
160 170 180 190 200
GLLTYAGKGK FNIQPNKKAP PEARVARNLG MIAGGTGITP MLQLIRAILK
210 220 230 240 250
DPEDPTQCFL LFANQTEKDI ILREDLEELQ ARHPGRFKLW FTLDHPPEGW
260 270 280 290 300
AYSKGFVSVD MIREHLPAPG EDVLLLLCGP PPMVQLACHP SLDKLGYSPK
MRFTY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC104584 mRNA Translation: AAI04585.1 |
RefSeqi | NP_001029690.1, NM_001034518.1 |
Genome annotation databases
Ensembli | ENSBTAT00000026548; ENSBTAP00000026548; ENSBTAG00000019927 |
GeneIDi | 516287 |
KEGGi | bta:516287 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC104584 mRNA Translation: AAI04585.1 |
RefSeqi | NP_001029690.1, NM_001034518.1 |
3D structure databases
SMRi | Q3MHW9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000026548 |
Proteomic databases
PaxDbi | Q3MHW9 |
PRIDEi | Q3MHW9 |
Genome annotation databases
Ensembli | ENSBTAT00000026548; ENSBTAP00000026548; ENSBTAG00000019927 |
GeneIDi | 516287 |
KEGGi | bta:516287 |
Organism-specific databases
CTDi | 51706 |
VGNCi | VGNC:97257, CYB5R1 |
Phylogenomic databases
eggNOGi | KOG0534, Eukaryota |
GeneTreei | ENSGT00940000160784 |
InParanoidi | Q3MHW9 |
OrthoDBi | 1311668at2759 |
Gene expression databases
ExpressionAtlasi | Q3MHW9, baseline and differential |
Family and domain databases
Gene3Di | 3.40.50.80, 1 hit |
InterProi | View protein in InterPro IPR001834, CBR-like IPR008333, Cbr1-like_FAD-bd_dom IPR017927, FAD-bd_FR_type IPR001709, Flavoprot_Pyr_Nucl_cyt_Rdtase IPR039261, FNR_nucleotide-bd IPR001433, OxRdtase_FAD/NAD-bd IPR017938, Riboflavin_synthase-like_b-brl |
Pfami | View protein in Pfam PF00970, FAD_binding_6, 1 hit PF00175, NAD_binding_1, 1 hit |
PRINTSi | PR00406, CYTB5RDTASE PR00371, FPNCR |
SUPFAMi | SSF52343, SSF52343, 1 hit SSF63380, SSF63380, 1 hit |
PROSITEi | View protein in PROSITE PS51384, FAD_FR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NB5R1_BOVIN | |
Accessioni | Q3MHW9Primary (citable) accession number: Q3MHW9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | October 25, 2005 | |
Last modified: | December 2, 2020 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families