Sohlh2

Functionⁱ

Probable transcription factor, which may be involved in spermatogenesis and oogenesis.By similarity

GO - Molecular functionⁱ

DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl
RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
oocyte differentiation Source: Ensembl
primary ovarian follicle growth Source: Ensembl
spermatogenesis Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Differentiation, Oogenesis, Spermatogenesis, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2
Gene namesⁱ	Name:Sohlh2
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 2

Organism-specific databases

Rat genome database More...RGDⁱ	1589577 Sohlh2

RGDⁱ

1589577 Sohlh2

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000315702	1 – 462	Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2Add BLAST		462

Proteomic databases

PaxDbⁱ	Q3MHT3
PRIDEⁱ	Q3MHT3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000038091 Expressed in 1 organ(s), highest expression level in testis

Bgeeⁱ

ENSRNOG00000038091 Expressed in 1 organ(s), highest expression level in testis

Interactionⁱ

GO - Molecular functionⁱ

protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000049772

STRINGⁱ

10116.ENSRNOP00000049772

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3MHT3
SMRⁱ	Q3MHT3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	200 – 251	bHLHPROSITE-ProRule annotationAdd BLAST		52

Phylogenomic databases

eggNOGⁱ	ENOG410IUEE Eukaryota ENOG410ZGUF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016050
HOGENOMⁱ	HOG000070147
HOVERGENⁱ	HBG103652
InParanoidⁱ	Q3MHT3
OMAⁱ	LPQHCNS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08ZT
PhylomeDBⁱ	Q3MHT3
TreeFamⁱ	TF336841

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032669 SOHLH2
PANTHERⁱ	PTHR16223:SF16 PTHR16223:SF16, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3MHT3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MADRISTGEL GRRPGQGRVD LLLVGDATRY FLAGSVQKFF SSTAQITLTI 
        60         70         80         90        100
SNVKKVAALL AANSFDIIFL KVTSTLTAEE QEAVRLIRSG KKKNTHLLFA 
       110        120        130        140        150
FVIPEKLRGY ISDYGADISF NEPLTLEKVN TVINYWKTYF TNTDMGNTEL 
       160        170        180        190        200
PPECRLYFQT SCSELGGHFP TDLFLCSELL NNDTGLGLKA PLSSPERNKK 
       210        220        230        240        250
ASFLHSSKEK LRRERIKFCC EQLRTLLPYV KGRKSDVASV IEATVDYVKQ 
       260        270        280        290        300
VRESLSPAIM AQITESLQSN KRFSKRQMPI ELFLPCTATS QRGDAMLTSA 
       310        320        330        340        350
FSPVQEIQLL ADQGLNVYSM PAAGGPLEEA VRGQPGSVSE DLYKTRVPST 
       360        370        380        390        400
TLSLNSFHAV RYCSGPVSPH EAAARTNQNI SIYLPPTGPS VSSFTPQHCN 
       410        420        430        440        450
AMLCPTRPAS SSCLCTSGHE LPASSRTASS SIFRGFRESD SGHQASQQPT 
       460 
GPSLQPQDSS YF

Length:462

Mass (Da):50,669

Last modified:October 25, 2005 - v1

Checksum:ⁱ589BADC7ED81958F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC104697 mRNA Translation: AAI04698.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001030133.1, NM_001034961.1
UniGeneⁱ	Rn.137450

Genome annotation databases

Ensemblⁱ	ENSRNOT00000044424; ENSRNOP00000049772; ENSRNOG00000038091
GeneIDⁱ	619575
KEGGⁱ	rno:619575
UCSC genome browser More...UCSCⁱ	RGD:1589577 rat

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q3MHT3	spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2		MESAU		466	UniRef50_Q3MHT3
spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2-like		TARSY		459
Uncharacterized protein		CANLF		426
spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2		LEPWE		426
spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2		NEOSC		426
+29

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC104697 mRNA Translation: AAI04698.1
RefSeqⁱ	NP_001030133.1, NM_001034961.1
UniGeneⁱ	Rn.137450

3D structure databases

ProteinModelPortalⁱ	Q3MHT3
SMRⁱ	Q3MHT3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000049772

STRINGⁱ

10116.ENSRNOP00000049772

Proteomic databases

PaxDbⁱ	Q3MHT3
PRIDEⁱ	Q3MHT3

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000044424; ENSRNOP00000049772; ENSRNOG00000038091
GeneIDⁱ	619575
KEGGⁱ	rno:619575
UCSCⁱ	RGD:1589577 rat

Organism-specific databases

CTDⁱ	54937
RGDⁱ	1589577 Sohlh2

Phylogenomic databases

eggNOGⁱ	ENOG410IUEE Eukaryota ENOG410ZGUF LUCA
GeneTreeⁱ	ENSGT00390000016050
HOGENOMⁱ	HOG000070147
HOVERGENⁱ	HBG103652
InParanoidⁱ	Q3MHT3
OMAⁱ	LPQHCNS
OrthoDBⁱ	EOG091G08ZT
PhylomeDBⁱ	Q3MHT3
TreeFamⁱ	TF336841

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q3MHT3

PROⁱ

PR:Q3MHT3

Gene expression databases

Bgeeⁱ	ENSRNOG00000038091 Expressed in 1 organ(s), highest expression level in testis

Bgeeⁱ

ENSRNOG00000038091 Expressed in 1 organ(s), highest expression level in testis

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032669 SOHLH2
PANTHERⁱ	PTHR16223:SF16 PTHR16223:SF16, 1 hit
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SOLH2_RAT
Accessionⁱ	Q3MHT3Primary (citable) accession number: Q3MHT3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	October 25, 2005
	Last modified:	November 7, 2018
	This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3MHT3 (SOLH2_RAT)

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Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ