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UniProtKB - Q3MHT3 (SOLH2_RAT)
Protein
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2
Gene
Sohlh2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Probable transcription factor, which may be involved in spermatogenesis and oogenesis.
By similarityGO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- identical protein binding Source: RGD
- protein heterodimerization activity Source: RGD
- protein homodimerization activity Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- cell differentiation Source: RGD
- oocyte differentiation Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- primary ovarian follicle growth Source: RGD
- regulation of gene expression Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- spermatogenesis Source: RGD
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Oogenesis, Spermatogenesis, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 |
Gene namesi | Name:Sohlh2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1589577, Sohlh2 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315702 | 1 – 462 | Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2Add BLAST | 462 |
Proteomic databases
PaxDbi | Q3MHT3 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000038091, Expressed in testis and 2 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: RGD
- protein heterodimerization activity Source: RGD
- protein homodimerization activity Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000049772 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 200 – 251 | bHLHPROSITE-ProRule annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 422 – 462 | DisorderedSequence analysisAdd BLAST | 41 |
Phylogenomic databases
eggNOGi | ENOG502S71C, Eukaryota |
GeneTreei | ENSGT00390000016050 |
HOGENOMi | CLU_056118_0_0_1 |
InParanoidi | Q3MHT3 |
OMAi | NIVVKYW |
OrthoDBi | 643083at2759 |
PhylomeDBi | Q3MHT3 |
TreeFami | TF336841 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032669, SOHLH2 |
PANTHERi | PTHR16223:SF16, PTHR16223:SF16, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q3MHT3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADRISTGEL GRRPGQGRVD LLLVGDATRY FLAGSVQKFF SSTAQITLTI
60 70 80 90 100
SNVKKVAALL AANSFDIIFL KVTSTLTAEE QEAVRLIRSG KKKNTHLLFA
110 120 130 140 150
FVIPEKLRGY ISDYGADISF NEPLTLEKVN TVINYWKTYF TNTDMGNTEL
160 170 180 190 200
PPECRLYFQT SCSELGGHFP TDLFLCSELL NNDTGLGLKA PLSSPERNKK
210 220 230 240 250
ASFLHSSKEK LRRERIKFCC EQLRTLLPYV KGRKSDVASV IEATVDYVKQ
260 270 280 290 300
VRESLSPAIM AQITESLQSN KRFSKRQMPI ELFLPCTATS QRGDAMLTSA
310 320 330 340 350
FSPVQEIQLL ADQGLNVYSM PAAGGPLEEA VRGQPGSVSE DLYKTRVPST
360 370 380 390 400
TLSLNSFHAV RYCSGPVSPH EAAARTNQNI SIYLPPTGPS VSSFTPQHCN
410 420 430 440 450
AMLCPTRPAS SSCLCTSGHE LPASSRTASS SIFRGFRESD SGHQASQQPT
460
GPSLQPQDSS YF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A8I6A1I4 | A0A8I6A1I4_RAT | Spermatogenesis- and oogenesis-spec... | Sohlh2 | 469 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC104697 mRNA Translation: AAI04698.1 |
RefSeqi | NP_001030133.1, NM_001034961.1 |
Genome annotation databases
Ensembli | ENSRNOT00000044424; ENSRNOP00000049772; ENSRNOG00000038091 |
GeneIDi | 619575 |
KEGGi | rno:619575 |
UCSCi | RGD:1589577, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC104697 mRNA Translation: AAI04698.1 |
RefSeqi | NP_001030133.1, NM_001034961.1 |
3D structure databases
AlphaFoldDBi | Q3MHT3 |
SMRi | Q3MHT3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000049772 |
Proteomic databases
PaxDbi | Q3MHT3 |
Genome annotation databases
Ensembli | ENSRNOT00000044424; ENSRNOP00000049772; ENSRNOG00000038091 |
GeneIDi | 619575 |
KEGGi | rno:619575 |
UCSCi | RGD:1589577, rat |
Organism-specific databases
CTDi | 54937 |
RGDi | 1589577, Sohlh2 |
Phylogenomic databases
eggNOGi | ENOG502S71C, Eukaryota |
GeneTreei | ENSGT00390000016050 |
HOGENOMi | CLU_056118_0_0_1 |
InParanoidi | Q3MHT3 |
OMAi | NIVVKYW |
OrthoDBi | 643083at2759 |
PhylomeDBi | Q3MHT3 |
TreeFami | TF336841 |
Miscellaneous databases
PROi | PR:Q3MHT3 |
Gene expression databases
Bgeei | ENSRNOG00000038091, Expressed in testis and 2 other tissues |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032669, SOHLH2 |
PANTHERi | PTHR16223:SF16, PTHR16223:SF16, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SOLH2_RAT | |
Accessioni | Q3MHT3Primary (citable) accession number: Q3MHT3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | October 25, 2005 | |
Last modified: | May 25, 2022 | |
This is version 98 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |