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Protein
Submitted name:

Caspase 4, apoptosis-related cysteine peptidase

Gene

Casp4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • cysteine-type endopeptidase activity Source: InterPro
  • scaffold protein binding Source: RGD

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
  • apoptotic process Source: RGD
  • inflammatory response Source: RGD

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseSAAS annotation

Protein family/group databases

MEROPSiC14.012

Names & Taxonomyi

Protein namesi
Submitted name:
Caspase 4, apoptosis-related cysteine peptidaseImported
Gene namesi
Name:Casp4Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi621757 Casp4

Subcellular locationi

Expressioni

Gene expression databases

GenevisibleiQ3MHS1 RN

Interactioni

GO - Molecular functioni

  • scaffold protein binding Source: RGD

Structurei

3D structure databases

ProteinModelPortaliQ3MHS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 80CARDInterPro annotationAdd BLAST80
Domaini130 – 258CASPASE_P20InterPro annotationAdd BLAST129
Domaini286 – 371CASPASE_P10InterPro annotationAdd BLAST86

Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
HOGENOMiHOG000234399
HOVERGENiHBG076981
KOiK04394

Family and domain databases

CDDicd00032 CASc, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR029030 Caspase-like_dom_sf
IPR033139 Caspase_cys_AS
IPR016129 Caspase_his_AS
IPR011029 DEATH-like_dom_sf
IPR002138 Pept_C14_p10
IPR001309 Pept_C14_p20
IPR015917 Pept_C14A
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PRINTSiPR00376 IL1BCENZYME
SMARTiView protein in SMART
SM00114 CARD, 1 hit
SM00115 CASc, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52129 SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS01122 CASPASE_CYS, 1 hit
PS01121 CASPASE_HIS, 1 hit
PS50207 CASPASE_P10, 1 hit
PS50208 CASPASE_P20, 1 hit

Sequencei

Sequence statusi: Complete.

Q3MHS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENNHPDKP LKVLEELGKE FLTEYLEKLV QSNVLKLKEE EKQKFNNAER
60 70 80 90 100
SDKRWVFVDV LKRKHNQVGK MLLQTFLNVD SGSHHGEANL EMEEPEESVD
110 120 130 140 150
TLKLCSSEEF TRLCREKKQE IYPIKETNGR TRKALIICNT EFKHLSLRYG
160 170 180 190 200
ANIDISGMKG LLEELGYDVV VKEELTAEGM ESEMKDFAAL SEHQTSDSTF
210 220 230 240 250
LVLMSHGTLQ GLCGTMHSEA TPDVLLYDTI YQIFNNCHCP GLRDKPKVII
260 270 280 290 300
VQACRGGNPG EVWIRESSGA HSYRAVDLPR NMEADAVRMS HVEKDFIALY
310 320 330 340 350
STTPHHLSYR DKTRGSYFIS KLISCFRIHA CSCHLFDIFL KVQQSFEKAS
360 370
INSQMPTIDR ATLTRYFYLF PGN
Length:373
Mass (Da):42,714
Last modified:October 25, 2005 - v1
Checksum:i2FD9BDE1ACA48BF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104720 mRNA Translation: AAI04721.1
RefSeqiNP_446188.2, NM_053736.2
UniGeneiRn.16195

Genome annotation databases

GeneIDi114555
KEGGirno:114555

Similar proteinsi

Entry informationi

Entry nameiQ3MHS1_RAT
AccessioniPrimary (citable) accession number: Q3MHS1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 25, 2005
Last sequence update: October 25, 2005
Last modified: June 20, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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