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Protein

Protein LSM12 homolog

Gene

LSM12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • RNA metabolic process Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LSM12 homolog
Gene namesi
Name:LSM12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000161654.9
HGNCiHGNC:26407 LSM12
MIMi611793 gene
neXtProtiNX_Q3MHD2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161654
PharmGKBiPA142671502

Polymorphism and mutation databases

BioMutaiLSM12
DMDMi158705881

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00003051262 – 195Protein LSM12 homologAdd BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei75PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ3MHD2
MaxQBiQ3MHD2
PaxDbiQ3MHD2
PeptideAtlasiQ3MHD2
PRIDEiQ3MHD2
ProteomicsDBi61781
61782 [Q3MHD2-2]

PTM databases

iPTMnetiQ3MHD2
PhosphoSitePlusiQ3MHD2

Expressioni

Gene expression databases

BgeeiENSG00000161654 Expressed in 231 organ(s), highest expression level in gingival epithelium
CleanExiHS_LSM12
ExpressionAtlasiQ3MHD2 baseline and differential
GenevisibleiQ3MHD2 HS

Organism-specific databases

HPAiHPA051934

Interactioni

Protein-protein interaction databases

BioGridi125889, 30 interactors
IntActiQ3MHD2, 8 interactors
MINTiQ3MHD2
STRINGi9606.ENSP00000293406

Structurei

3D structure databases

ProteinModelPortaliQ3MHD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LSM12 family.Curated

Phylogenomic databases

eggNOGiKOG4401 Eukaryota
ENOG410Y6A1 LUCA
GeneTreeiENSGT00390000006956
HOGENOMiHOG000006611
HOVERGENiHBG057351
InParanoidiQ3MHD2
OMAiWEGANIR
PhylomeDBiQ3MHD2

Family and domain databases

InterProiView protein in InterPro
IPR019181 Anticodon-binding_dom
IPR039683 Lsm12-like
PANTHERiPTHR13542 PTHR13542, 1 hit
PfamiView protein in Pfam
PF09793 AD, 1 hit
SMARTiView protein in SMART
SM00995 AD, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3MHD2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPPGEYFS VGSQVSCRTC QEQRLQGEVV AFDYQSKMLA LKCPSSSGKP
60 70 80 90 100
NHADILLINL QYVSEVEIIN DRTETPPPLA SLNVSKLASK ARTEKEEKLS
110 120 130 140 150
QAYAISAGVS LEGQQLFQTI HKTIKDCKWQ EKNIVVMEEV VITPPYQVEN
160 170 180 190
CKGKEGSALS HVRKIVEKHF RDVESQKILQ RSQAQQPQKE AALSS
Length:195
Mass (Da):21,701
Last modified:October 2, 2007 - v2
Checksum:iBCEDE62DA43D86C7
GO
Isoform 2 (identifier: Q3MHD2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-42: K → ISPE

Note: No experimental confirmation available.
Show »
Length:198
Mass (Da):21,999
Checksum:iB955DE52C1730E8E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ELG9K7ELG9_HUMAN
Protein LSM12 homolog
LSM12
230Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03516677P → R1 PublicationCorresponds to variant dbSNP:rs17854322Ensembl.1
Natural variantiVAR_062209173V → L. Corresponds to variant dbSNP:rs59168537Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02824142K → ISPE in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055218 mRNA Translation: BAB70877.1
BC044587 mRNA Translation: AAH44587.1
BC105288 mRNA Translation: AAI05289.1
CCDSiCCDS11475.1 [Q3MHD2-1]
RefSeqiNP_689557.1, NM_152344.3 [Q3MHD2-1]
UniGeneiHs.355570

Genome annotation databases

EnsembliENST00000293406; ENSP00000293406; ENSG00000161654 [Q3MHD2-1]
ENST00000591247; ENSP00000466718; ENSG00000161654 [Q3MHD2-1]
GeneIDi124801
KEGGihsa:124801
UCSCiuc002iev.3 human [Q3MHD2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055218 mRNA Translation: BAB70877.1
BC044587 mRNA Translation: AAH44587.1
BC105288 mRNA Translation: AAI05289.1
CCDSiCCDS11475.1 [Q3MHD2-1]
RefSeqiNP_689557.1, NM_152344.3 [Q3MHD2-1]
UniGeneiHs.355570

3D structure databases

ProteinModelPortaliQ3MHD2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125889, 30 interactors
IntActiQ3MHD2, 8 interactors
MINTiQ3MHD2
STRINGi9606.ENSP00000293406

PTM databases

iPTMnetiQ3MHD2
PhosphoSitePlusiQ3MHD2

Polymorphism and mutation databases

BioMutaiLSM12
DMDMi158705881

Proteomic databases

EPDiQ3MHD2
MaxQBiQ3MHD2
PaxDbiQ3MHD2
PeptideAtlasiQ3MHD2
PRIDEiQ3MHD2
ProteomicsDBi61781
61782 [Q3MHD2-2]

Protocols and materials databases

DNASUi124801
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293406; ENSP00000293406; ENSG00000161654 [Q3MHD2-1]
ENST00000591247; ENSP00000466718; ENSG00000161654 [Q3MHD2-1]
GeneIDi124801
KEGGihsa:124801
UCSCiuc002iev.3 human [Q3MHD2-1]

Organism-specific databases

CTDi124801
EuPathDBiHostDB:ENSG00000161654.9
GeneCardsiLSM12
H-InvDBiHIX0034611
HGNCiHGNC:26407 LSM12
HPAiHPA051934
MIMi611793 gene
neXtProtiNX_Q3MHD2
OpenTargetsiENSG00000161654
PharmGKBiPA142671502
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4401 Eukaryota
ENOG410Y6A1 LUCA
GeneTreeiENSGT00390000006956
HOGENOMiHOG000006611
HOVERGENiHBG057351
InParanoidiQ3MHD2
OMAiWEGANIR
PhylomeDBiQ3MHD2

Miscellaneous databases

ChiTaRSiLSM12 human
GenomeRNAii124801
PROiPR:Q3MHD2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161654 Expressed in 231 organ(s), highest expression level in gingival epithelium
CleanExiHS_LSM12
ExpressionAtlasiQ3MHD2 baseline and differential
GenevisibleiQ3MHD2 HS

Family and domain databases

InterProiView protein in InterPro
IPR019181 Anticodon-binding_dom
IPR039683 Lsm12-like
PANTHERiPTHR13542 PTHR13542, 1 hit
PfamiView protein in Pfam
PF09793 AD, 1 hit
SMARTiView protein in SMART
SM00995 AD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLSM12_HUMAN
AccessioniPrimary (citable) accession number: Q3MHD2
Secondary accession number(s): Q86YB1, Q96NL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 7, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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