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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF), Orotate phosphoribosyltransferase (pyrE)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei11SubstrateUniRule annotation1
Binding sitei32SubstrateUniRule annotation1
Active sitei61Proton donorUniRule annotation1
Binding sitei123SubstrateUniRule annotation1
Binding sitei185SubstrateUniRule annotation1
Binding sitei194SubstrateUniRule annotation1
Binding sitei214Substrate; via amide nitrogenUniRule annotation1
Binding sitei215SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

BioCyciAVAR240292:G7WH-8002-MONOMER
UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:Ava_0924
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeTrichormus
Proteomesi
  • UP000002533 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002418411 – 238Orotidine 5'-phosphate decarboxylaseAdd BLAST238

Proteomic databases

PRIDEiQ3MEN8

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi240292.Ava_0924

Structurei

3D structure databases

ProteinModelPortaliQ3MEN8
SMRiQ3MEN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni59 – 68Substrate bindingUniRule annotation10

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106EG9 Bacteria
COG0284 LUCA
HOGENOMiHOG000226070
KOiK01591
OMAiNFKIFLD
OrthoDBiPOG091H0256

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01200_B OMPdecase_type1_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR014732 OMPdecase
IPR018089 OMPdecase_AS
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR32119:SF2 PTHR32119:SF2, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR01740 pyrF, 1 hit
PROSITEiView protein in PROSITE
PS00156 OMPDECASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q3MEN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNNKIIVAL DVPDTESAIA LIDKLESVTF WKVGLELFTS SGPRILEVLK
60 70 80 90 100
SRQKRIFLDL KFHDIPNTVA GACRGAARYG VDLMTIHATS GRDALKAAKE
110 120 130 140 150
AVEEGAAQAG VKPSKLIAVT VLTSISARQL ALDLKIPVEL PEYALDMALM
160 170 180 190 200
AQEVGLDGAV CSPQEVAQLR QICGDDFVLV CPGVRPTWAE AKDQKRSLTP
210 220 230
SQAIQAGADY LVIGRPITAA AEPELAWKRI AQELTTVA
Length:238
Mass (Da):25,559
Last modified:October 25, 2005 - v1
Checksum:i7680DA6B03DE13D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000117 Genomic DNA Translation: ABA20548.1

Genome annotation databases

EnsemblBacteriaiABA20548; ABA20548; Ava_0924
KEGGiava:Ava_0924

Similar proteinsi

Entry informationi

Entry nameiPYRF_ANAVT
AccessioniPrimary (citable) accession number: Q3MEN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 25, 2005
Last modified: February 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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