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UniProtKB - Q3LRZ3 (AXLP1_CAEEL)

Entry version 96 (25 May 2022)
Sequence version 1 (25 Oct 2005)
Previous versions | rss
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Protein

Axin-like protein 1

Gene

axl-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Works in parallel with pry-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Shown to have a role in excretory cell development.

1 Publication

Miscellaneous

Reporter transgenes fail to show detectable expression indicating that axl-1 may be expressed at low levels.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-CEL-195253, Degradation of beta-catenin by the destruction complex
R-CEL-196299, Beta-catenin phosphorylation cascade
R-CEL-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q3LRZ3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Axin-like protein 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:axl-1Imported
ORF Names:K02B12.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...WormBasei		K02B12.4a ; CE40260 ; WBGene00010497 ; axl-1
K02B12.4b ; CE40261 ; WBGene00010497 ; axl-1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Worms exhibit defects in excretory cell development and axonal migration.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003472521 – 400Axin-like protein 1Add BLAST400

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q3LRZ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		WBGene00010497, Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with bar-1, dsh-2, gsk-3, and mig-5.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		51582, 8 interactors

Protein interaction database and analysis system

More...IntActi		Q3LRZ3, 10 interactors

STRING: functional protein association networks

More...STRINGi		6239.K02B12.4b

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q3LRZ3

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 132RGSPROSITE-ProRule annotationAdd BLAST129
Domaini305 – 392DIXPROSITE-ProRule annotationAdd BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni190 – 233DisorderedSequence analysisAdd BLAST44
Regioni278 – 306DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi194 – 210Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi278 – 299Polar residuesSequence analysisAdd BLAST22

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502TG1M, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_058688_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q3LRZ3

Identification of Orthologs from Complete Genome Data

More...OMAi		HMAMSTQ

Database of Orthologous Groups

More...OrthoDBi		1629042at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.240.130, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043581, Axin-like
IPR001158, DIX
IPR038207, DIX_dom_sf
IPR016137, RGS
IPR036305, RGS_sf
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...PANTHERi		PTHR46102, PTHR46102, 3 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00778, DIX, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48097, SSF48097, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50841, DIX, 1 hit
PS50132, RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform b1 Publication (identifier: Q3LRZ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTMRSKFSID RVLHDTAFAK WCQKEESRNA DSITLYTSIL DFESKLKTGS 
        60         70         80         90        100
PSLSLLKLAR HIHRKYVSLN TGTCHVIGDS IRTKISTRVH EVLDGKPPYI 
       110        120        130        140        150
DLFDPLKQPL FQHLRSMHTE FSTTTADVNT TWEDASSTSS SNKGATIWFN 
       160        170        180        190        200
EDAIDKSSRH EIGQSTVTHE SEDDRFSFFN AVCTRLNSLQ ETKNSSETEE 
       210        220        230        240        250
HAESPRKEKS STPYGTDGFA PPPRSTQTNT LKVSNLPKRF ESLYKKKRQQ 
       260        270        280        290        300
VATSDSSGFG SNASDFWSFE RYGKSNQGTL ERPNRLFTGT NNGFSTLQPK 
       310        320        330        340        350
RRGSEAPKMT VELRYENDVP MVAKISANHA QSVTLRYFRH LFGLHYTDNC 
       360        370        380        390        400
RFFFKSTCED GSAQYQWTLL FHDDDILPVF QNRITAICRM CPPPEDHDLI
Length:400
Mass (Da):45,588
Last modified:October 25, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C1E5CADC18D3B26
GO
Isoform a1 Publication (identifier: Q3LRZ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.
     70-91: NTGTCHVIGDSIRTKISTRVHE → MATMSRRWNYFTPHYNDEGSID

Show »
Length:331
Mass (Da):37,872
Checksum:iE5679FB02285D97E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0528601 – 69Missing in isoform a. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_05286170 – 91NTGTC…TRVHE → MATMSRRWNYFTPHYNDEGS ID in isoform a. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DQ185512 mRNA Translation: ABA28304.1
Z75711 Genomic DNA Translation: CAK55175.1
Z75711 Genomic DNA Translation: CAK55176.1

NCBI Reference Sequences

More...RefSeqi		NP_001040671.1, NM_001047206.3 [Q3LRZ3-2]
NP_001040672.1, NM_001047207.3 [Q3LRZ3-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		K02B12.4a.1; K02B12.4a.1; WBGene00010497 [Q3LRZ3-2]
K02B12.4b.1; K02B12.4b.1; WBGene00010497 [Q3LRZ3-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		186869

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		cel:CELE_K02B12.4

UCSC genome browser

More...UCSCi		K02B12.4b, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ185512 mRNA Translation: ABA28304.1
Z75711 Genomic DNA Translation: CAK55175.1
Z75711 Genomic DNA Translation: CAK55176.1
RefSeqiNP_001040671.1, NM_001047206.3 [Q3LRZ3-2]
NP_001040672.1, NM_001047207.3 [Q3LRZ3-1]

3D structure databases

AlphaFoldDBiQ3LRZ3
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi51582, 8 interactors
IntActiQ3LRZ3, 10 interactors
STRINGi6239.K02B12.4b

Proteomic databases

PaxDbiQ3LRZ3

Genome annotation databases

EnsemblMetazoaiK02B12.4a.1; K02B12.4a.1; WBGene00010497 [Q3LRZ3-2]
K02B12.4b.1; K02B12.4b.1; WBGene00010497 [Q3LRZ3-1]
GeneIDi186869
KEGGicel:CELE_K02B12.4
UCSCiK02B12.4b, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		186869
WormBaseiK02B12.4a ; CE40260 ; WBGene00010497 ; axl-1
K02B12.4b ; CE40261 ; WBGene00010497 ; axl-1

Phylogenomic databases

eggNOGiENOG502TG1M, Eukaryota
HOGENOMiCLU_058688_0_0_1
InParanoidiQ3LRZ3
OMAiHMAMSTQ
OrthoDBi1629042at2759

Enzyme and pathway databases

ReactomeiR-CEL-195253, Degradation of beta-catenin by the destruction complex
R-CEL-196299, Beta-catenin phosphorylation cascade
R-CEL-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane
SignaLinkiQ3LRZ3

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q3LRZ3

Gene expression databases

BgeeiWBGene00010497, Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

Gene3Di2.40.240.130, 1 hit
InterProiView protein in InterPro
IPR043581, Axin-like
IPR001158, DIX
IPR038207, DIX_dom_sf
IPR016137, RGS
IPR036305, RGS_sf
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR46102, PTHR46102, 3 hits
PfamiView protein in Pfam
PF00778, DIX, 1 hit
SUPFAMiSSF48097, SSF48097, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50841, DIX, 1 hit
PS50132, RGS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAXLP1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3LRZ3
Secondary accession number(s): Q14V27
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 25, 2005
Last modified: May 25, 2022
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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