The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q3LRZ3 (AXLP1_CAEEL)
Protein
Axin-like protein 1
Gene
axl-1
Organism
Caenorhabditis elegans
Status
Functioni
Works in parallel with pry-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Shown to have a role in excretory cell development.
1 PublicationMiscellaneous
Reporter transgenes fail to show detectable expression indicating that axl-1 may be expressed at low levels.
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
GO - Biological processi
- axon guidance Source: UniProtKB
- cell development Source: UniProtKB
- negative regulation of canonical Wnt signaling pathway Source: InterPro
- negative regulation of Wnt signaling pathway Source: UniProtKB
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein |
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
Reactomei | R-CEL-195253, Degradation of beta-catenin by the destruction complex R-CEL-196299, Beta-catenin phosphorylation cascade R-CEL-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane |
SignaLinki | Q3LRZ3 |
Names & Taxonomyi
Protein namesi | Recommended name: Axin-like protein 11 Publication |
Gene namesi | Name:axl-1Imported ORF Names:K02B12.4 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | K02B12.4a ; CE40260 ; WBGene00010497 ; axl-1 K02B12.4b ; CE40261 ; WBGene00010497 ; axl-1 |
Pathology & Biotechi
Disruption phenotypei
Worms exhibit defects in excretory cell development and axonal migration.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000347252 | 1 – 400 | Axin-like protein 1Add BLAST | 400 |
Proteomic databases
PaxDbi | Q3LRZ3 |
Expressioni
Gene expression databases
Bgeei | WBGene00010497, Expressed in multi-cellular organism and 4 other tissues |
Interactioni
Subunit structurei
Interacts with bar-1, dsh-2, gsk-3, and mig-5.
1 PublicationBinary interactionsi
Q3LRZ3
With | #Exp. | IntAct |
---|---|---|
gsk-3 [Q9U2Q9] | 4 | EBI-327368,EBI-330089 |
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 51582, 8 interactors |
IntActi | Q3LRZ3, 10 interactors |
STRINGi | 6239.K02B12.4b |
Structurei
3D structure databases
AlphaFoldDBi | Q3LRZ3 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 132 | RGSPROSITE-ProRule annotationAdd BLAST | 129 | |
Domaini | 305 – 392 | DIXPROSITE-ProRule annotationAdd BLAST | 88 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 190 – 233 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 278 – 306 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 194 – 210 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 278 – 299 | Polar residuesSequence analysisAdd BLAST | 22 |
Phylogenomic databases
eggNOGi | ENOG502TG1M, Eukaryota |
HOGENOMi | CLU_058688_0_0_1 |
InParanoidi | Q3LRZ3 |
OMAi | HMAMSTQ |
OrthoDBi | 1629042at2759 |
Family and domain databases
Gene3Di | 2.40.240.130, 1 hit |
InterProi | View protein in InterPro IPR043581, Axin-like IPR001158, DIX IPR038207, DIX_dom_sf IPR016137, RGS IPR036305, RGS_sf IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR46102, PTHR46102, 3 hits |
Pfami | View protein in Pfam PF00778, DIX, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50841, DIX, 1 hit PS50132, RGS, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform b1 Publication (identifier: Q3LRZ3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTMRSKFSID RVLHDTAFAK WCQKEESRNA DSITLYTSIL DFESKLKTGS
60 70 80 90 100
PSLSLLKLAR HIHRKYVSLN TGTCHVIGDS IRTKISTRVH EVLDGKPPYI
110 120 130 140 150
DLFDPLKQPL FQHLRSMHTE FSTTTADVNT TWEDASSTSS SNKGATIWFN
160 170 180 190 200
EDAIDKSSRH EIGQSTVTHE SEDDRFSFFN AVCTRLNSLQ ETKNSSETEE
210 220 230 240 250
HAESPRKEKS STPYGTDGFA PPPRSTQTNT LKVSNLPKRF ESLYKKKRQQ
260 270 280 290 300
VATSDSSGFG SNASDFWSFE RYGKSNQGTL ERPNRLFTGT NNGFSTLQPK
310 320 330 340 350
RRGSEAPKMT VELRYENDVP MVAKISANHA QSVTLRYFRH LFGLHYTDNC
360 370 380 390 400
RFFFKSTCED GSAQYQWTLL FHDDDILPVF QNRITAICRM CPPPEDHDLI
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_052860 | 1 – 69 | Missing in isoform a. 1 PublicationAdd BLAST | 69 | |
Alternative sequenceiVSP_052861 | 70 – 91 | NTGTC…TRVHE → MATMSRRWNYFTPHYNDEGS ID in isoform a. 1 PublicationAdd BLAST | 22 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ185512 mRNA Translation: ABA28304.1 Z75711 Genomic DNA Translation: CAK55175.1 Z75711 Genomic DNA Translation: CAK55176.1 |
RefSeqi | NP_001040671.1, NM_001047206.3 [Q3LRZ3-2] NP_001040672.1, NM_001047207.3 [Q3LRZ3-1] |
Genome annotation databases
EnsemblMetazoai | K02B12.4a.1; K02B12.4a.1; WBGene00010497 [Q3LRZ3-2] K02B12.4b.1; K02B12.4b.1; WBGene00010497 [Q3LRZ3-1] |
GeneIDi | 186869 |
KEGGi | cel:CELE_K02B12.4 |
UCSCi | K02B12.4b, c. elegans |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ185512 mRNA Translation: ABA28304.1 Z75711 Genomic DNA Translation: CAK55175.1 Z75711 Genomic DNA Translation: CAK55176.1 |
RefSeqi | NP_001040671.1, NM_001047206.3 [Q3LRZ3-2] NP_001040672.1, NM_001047207.3 [Q3LRZ3-1] |
3D structure databases
AlphaFoldDBi | Q3LRZ3 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 51582, 8 interactors |
IntActi | Q3LRZ3, 10 interactors |
STRINGi | 6239.K02B12.4b |
Proteomic databases
PaxDbi | Q3LRZ3 |
Genome annotation databases
EnsemblMetazoai | K02B12.4a.1; K02B12.4a.1; WBGene00010497 [Q3LRZ3-2] K02B12.4b.1; K02B12.4b.1; WBGene00010497 [Q3LRZ3-1] |
GeneIDi | 186869 |
KEGGi | cel:CELE_K02B12.4 |
UCSCi | K02B12.4b, c. elegans |
Organism-specific databases
CTDi | 186869 |
WormBasei | K02B12.4a ; CE40260 ; WBGene00010497 ; axl-1 K02B12.4b ; CE40261 ; WBGene00010497 ; axl-1 |
Phylogenomic databases
eggNOGi | ENOG502TG1M, Eukaryota |
HOGENOMi | CLU_058688_0_0_1 |
InParanoidi | Q3LRZ3 |
OMAi | HMAMSTQ |
OrthoDBi | 1629042at2759 |
Enzyme and pathway databases
Reactomei | R-CEL-195253, Degradation of beta-catenin by the destruction complex R-CEL-196299, Beta-catenin phosphorylation cascade R-CEL-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane |
SignaLinki | Q3LRZ3 |
Miscellaneous databases
PROi | PR:Q3LRZ3 |
Gene expression databases
Bgeei | WBGene00010497, Expressed in multi-cellular organism and 4 other tissues |
Family and domain databases
Gene3Di | 2.40.240.130, 1 hit |
InterProi | View protein in InterPro IPR043581, Axin-like IPR001158, DIX IPR038207, DIX_dom_sf IPR016137, RGS IPR036305, RGS_sf IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR46102, PTHR46102, 3 hits |
Pfami | View protein in Pfam PF00778, DIX, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50841, DIX, 1 hit PS50132, RGS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AXLP1_CAEEL | |
Accessioni | Q3LRZ3Primary (citable) accession number: Q3LRZ3 Secondary accession number(s): Q14V27 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | October 25, 2005 | |
Last modified: | May 25, 2022 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase