UniProtKB - Q3LIE5 (ADPRM_HUMAN)
Protein
Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
Gene
ADPRM
Organism
Homo sapiens (Human)
Status
Functioni
Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity).By similarity
Catalytic activityi
Cofactori
Mg2+By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 25 | Zinc 1By similarity | 1 | |
Metal bindingi | 27 | Zinc 1By similarity | 1 | |
Metal bindingi | 74 | Zinc 1By similarity | 1 | |
Metal bindingi | 74 | Zinc 2By similarity | 1 | |
Metal bindingi | 110 | Zinc 2By similarity | 1 | |
Metal bindingi | 241 | Zinc 2By similarity | 1 | |
Metal bindingi | 278 | Zinc 2By similarity | 1 | |
Metal bindingi | 280 | Zinc 1By similarity | 1 |
GO - Molecular functioni
- 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity Source: GO_Central
- ADP-ribose diphosphatase activity Source: GO_Central
- CDP-glycerol diphosphatase activity Source: GO_Central
- manganese ion binding Source: GO_Central
GO - Biological processi
- nucleobase-containing small molecule catabolic process Source: Reactome
Keywordsi
Molecular function | Hydrolase |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q3LIE5 |
Reactomei | R-HSA-2393930, Phosphate bond hydrolysis by NUDT proteins |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ADPRM Synonyms:C17orf48 ORF Names:MDS006, Nbla03831 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000170222.11 |
HGNCi | HGNC:30925, ADPRM |
neXtProti | NX_Q3LIE5 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 56985 |
OpenTargetsi | ENSG00000170222 |
PharmGKBi | PA142672231 |
Miscellaneous databases
Pharosi | Q3LIE5, Tdark |
Polymorphism and mutation databases
BioMutai | ADPRM |
DMDMi | 121942723 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000286567 | 1 – 342 | Manganese-dependent ADP-ribose/CDP-alcohol diphosphataseAdd BLAST | 342 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
MassIVEi | Q3LIE5 |
PaxDbi | Q3LIE5 |
PeptideAtlasi | Q3LIE5 |
PRIDEi | Q3LIE5 |
ProteomicsDBi | 61776 [Q3LIE5-1] 61777 [Q3LIE5-3] |
PTM databases
iPTMneti | Q3LIE5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000170222, Expressed in prostate gland and 200 other tissues |
ExpressionAtlasi | Q3LIE5, baseline and differential |
Genevisiblei | Q3LIE5, HS |
Organism-specific databases
HPAi | ENSG00000170222, Low tissue specificity |
Interactioni
Subunit structurei
Monomer.
By similarityProtein-protein interaction databases
BioGRIDi | 121302, 4 interactors |
STRINGi | 9606.ENSP00000369099 |
Miscellaneous databases
RNActi | Q3LIE5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the ADPRibase-Mn family.Curated
Phylogenomic databases
eggNOGi | ENOG502QUQW, Eukaryota |
GeneTreei | ENSGT00390000014667 |
HOGENOMi | CLU_039893_0_0_1 |
InParanoidi | Q3LIE5 |
OMAi | QGAIEHW |
PhylomeDBi | Q3LIE5 |
TreeFami | TF331229 |
Family and domain databases
CDDi | cd07396, MPP_Nbla03831, 1 hit |
Gene3Di | 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like IPR041869, MPP_ADPRM |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q3LIE5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDDKPNPEAL SDSSERLFSF GVIADVQFAD LEDGFNFQGT RRRYYRHSLL
60 70 80 90 100
HLQGAIEDWN NESSMPCCVL QLGDIIDGYN AQYNASKKSL ELVMDMFKRL
110 120 130 140 150
KVPVHHTWGN HEFYNFSREY LTHSKLNTKF LEDQIVHHPE TMPSEDYYAY
160 170 180 190 200
HFVPFPKFRF ILLDAYDLSV LGVDQSSPKY EQCMKILREH NPNTELNSPQ
210 220 230 240 250
GLSEPQFVQF NGGFSQEQLN WLNEVLTFSD TNQEKVVIVS HLPIYPDASD
260 270 280 290 300
NVCLAWNYRD ALAVIWSHEC VVCFFAGHTH DGGYSEDPFG VYHVNLEGVI
310 320 330 340
ETAPDSQAFG TVHVYPDKMM LKGRGRVPDR IMNYKKERAF HC
Isoform 2 (identifier: Q3LIE5-3) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
202-205: LSEP → ELFL
206-342: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketV9GYR6 | V9GYR6_HUMAN | Manganese-dependent ADP-ribose/CDP-... | ADPRM | 294 | Annotation score: |
Sequence cautioni
The sequence AAF87317 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 113 | F → S in BAF85318 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 202 | L → F in AAF87317 (PubMed:12880961).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032125 | 92 | L → R. Corresponds to variant dbSNP:rs34940296Ensembl. | 1 | |
Natural variantiVAR_032126 | 337 | E → G. Corresponds to variant dbSNP:rs406446Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025092 | 202 – 205 | LSEP → ELFL in isoform 2. 2 Publications | 4 | |
Alternative sequenceiVSP_025093 | 206 – 342 | Missing in isoform 2. 2 PublicationsAdd BLAST | 137 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB073393 mRNA Translation: BAE45723.1 AK292629 mRNA Translation: BAF85318.1 CH471108 Genomic DNA Translation: EAW89995.1 CH471108 Genomic DNA Translation: EAW89996.1 BC001294 mRNA Translation: AAH01294.1 BC070155 mRNA Translation: AAH70155.1 AF168715 mRNA Translation: AAF87317.1 Frameshift. |
CCDSi | CCDS11159.2 [Q3LIE5-1] |
RefSeqi | NP_064618.3, NM_020233.4 [Q3LIE5-1] |
Genome annotation databases
Ensembli | ENST00000379774; ENSP00000369099; ENSG00000170222 [Q3LIE5-1] ENST00000468843; ENSP00000431622; ENSG00000170222 [Q3LIE5-3] |
GeneIDi | 56985 |
KEGGi | hsa:56985 |
UCSCi | uc060bgm.1, human [Q3LIE5-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB073393 mRNA Translation: BAE45723.1 AK292629 mRNA Translation: BAF85318.1 CH471108 Genomic DNA Translation: EAW89995.1 CH471108 Genomic DNA Translation: EAW89996.1 BC001294 mRNA Translation: AAH01294.1 BC070155 mRNA Translation: AAH70155.1 AF168715 mRNA Translation: AAF87317.1 Frameshift. |
CCDSi | CCDS11159.2 [Q3LIE5-1] |
RefSeqi | NP_064618.3, NM_020233.4 [Q3LIE5-1] |
3D structure databases
SMRi | Q3LIE5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121302, 4 interactors |
STRINGi | 9606.ENSP00000369099 |
PTM databases
iPTMneti | Q3LIE5 |
Polymorphism and mutation databases
BioMutai | ADPRM |
DMDMi | 121942723 |
Proteomic databases
MassIVEi | Q3LIE5 |
PaxDbi | Q3LIE5 |
PeptideAtlasi | Q3LIE5 |
PRIDEi | Q3LIE5 |
ProteomicsDBi | 61776 [Q3LIE5-1] 61777 [Q3LIE5-3] |
Protocols and materials databases
Antibodypediai | 12941, 63 antibodies |
DNASUi | 56985 |
Genome annotation databases
Ensembli | ENST00000379774; ENSP00000369099; ENSG00000170222 [Q3LIE5-1] ENST00000468843; ENSP00000431622; ENSG00000170222 [Q3LIE5-3] |
GeneIDi | 56985 |
KEGGi | hsa:56985 |
UCSCi | uc060bgm.1, human [Q3LIE5-1] |
Organism-specific databases
CTDi | 56985 |
DisGeNETi | 56985 |
EuPathDBi | HostDB:ENSG00000170222.11 |
GeneCardsi | ADPRM |
HGNCi | HGNC:30925, ADPRM |
HPAi | ENSG00000170222, Low tissue specificity |
neXtProti | NX_Q3LIE5 |
OpenTargetsi | ENSG00000170222 |
PharmGKBi | PA142672231 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUQW, Eukaryota |
GeneTreei | ENSGT00390000014667 |
HOGENOMi | CLU_039893_0_0_1 |
InParanoidi | Q3LIE5 |
OMAi | QGAIEHW |
PhylomeDBi | Q3LIE5 |
TreeFami | TF331229 |
Enzyme and pathway databases
PathwayCommonsi | Q3LIE5 |
Reactomei | R-HSA-2393930, Phosphate bond hydrolysis by NUDT proteins |
Miscellaneous databases
BioGRID-ORCSi | 56985, 7 hits in 841 CRISPR screens |
ChiTaRSi | ADPRM, human |
GenomeRNAii | 56985 |
Pharosi | Q3LIE5, Tdark |
PROi | PR:Q3LIE5 |
RNActi | Q3LIE5, protein |
Gene expression databases
Bgeei | ENSG00000170222, Expressed in prostate gland and 200 other tissues |
ExpressionAtlasi | Q3LIE5, baseline and differential |
Genevisiblei | Q3LIE5, HS |
Family and domain databases
CDDi | cd07396, MPP_Nbla03831, 1 hit |
Gene3Di | 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like IPR041869, MPP_ADPRM |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADPRM_HUMAN | |
Accessioni | Q3LIE5Primary (citable) accession number: Q3LIE5 Secondary accession number(s): A8K9B4 Q9NRU8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | November 8, 2005 | |
Last modified: | December 2, 2020 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations