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Entry version 88 (07 Oct 2020)
Sequence version 2 (14 Oct 2008)
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Protein

Keratin-associated protein 15-1

Gene

KRTAP15-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q3LI76

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567, Keratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 15-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP15-1
Synonyms:KAP15.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000186970.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18927, KRTAP15-1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q3LI76

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134911178

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q3LI76, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRTAP15-1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
209572640

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002239171 – 137Keratin-associated protein 15-1Add BLAST137

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q3LI76

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3LI76

PeptideAtlas

More...
PeptideAtlasi
Q3LI76

PRoteomics IDEntifications database

More...
PRIDEi
Q3LI76

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61772

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3LI76

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000186970, Not detected

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q3LI76
With#Exp.IntAct
ACY3 [Q96HD9]3EBI-11992140,EBI-3916242
ANKHD1 [Q8IWG5]3EBI-11992140,EBI-355540
ARID5A [Q03989]3EBI-11992140,EBI-948603
ASB13 - isoform 2 [Q8WXK3-2]3EBI-11992140,EBI-12015080
ATN1 [Q86V38]3EBI-11992140,EBI-11954292
C10orf55 [Q5SWW7]3EBI-11992140,EBI-12809220
CAMK2A [Q9UQM7]3EBI-11992140,EBI-1383687
CCDC24 [Q8N4L8]3EBI-11992140,EBI-1104933
CERCAM [Q5T4B2]3EBI-11992140,EBI-12261896
CYSRT1 [A8MQ03]3EBI-11992140,EBI-3867333
DAZAP2 [Q15038]5EBI-11992140,EBI-724310
DTX2 [Q86UW9]3EBI-11992140,EBI-740376
FCHO1 [A0A0C3SFZ9]3EBI-11992140,EBI-11977403
FOXD2 [O60548]3EBI-11992140,EBI-17282008
GEMIN4 [P57678]3EBI-11992140,EBI-356700
GRN [P28799]3EBI-11992140,EBI-747754
HOXA1 [P49639]7EBI-11992140,EBI-740785
HR [O43593]3EBI-11992140,EBI-2880706
INCA1 [Q0VD86]3EBI-11992140,EBI-6509505
INTS11 [Q5TA45]3EBI-11992140,EBI-748258
ITGB4 - isoform Beta-4A [P16144-2]3EBI-11992140,EBI-11051601
KPRP [Q5T749]3EBI-11992140,EBI-10981970
KRTAP10-8 [P60410]3EBI-11992140,EBI-10171774
KRTAP11-1 [Q8IUC1]3EBI-11992140,EBI-1052037
KRTAP12-1 [P59990]3EBI-11992140,EBI-10210845
KRTAP12-2 [P59991]3EBI-11992140,EBI-10176379
KRTAP13-2 [Q52LG2]3EBI-11992140,EBI-11953846
KRTAP19-1 [Q8IUB9]3EBI-11992140,EBI-12811111
KRTAP19-5 [Q3LI72]3EBI-11992140,EBI-1048945
KRTAP3-1 [Q9BYR8]3EBI-11992140,EBI-9996449
KRTAP3-2 [Q9BYR7]5EBI-11992140,EBI-751260
KRTAP3-3 [Q9BYR6]3EBI-11992140,EBI-3957694
KRTAP4-11 [Q9BYQ6]3EBI-11992140,EBI-10302392
KRTAP5-11 [Q6L8G4]3EBI-11992140,EBI-11993296
KRTAP5-3 [Q6L8H2]3EBI-11992140,EBI-11974251
KRTAP6-2 [Q3LI66]3EBI-11992140,EBI-11962084
KRTAP9-2 [Q9BYQ4]3EBI-11992140,EBI-1044640
NEU4 - isoform 2 [Q8WWR8-2]3EBI-11992140,EBI-10277551
NHLRC4 [P0CG21]3EBI-11992140,EBI-12868744
NOXA1 - isoform 2 [Q86UR1-2]3EBI-11992140,EBI-12025760
OTX1 [P32242]3EBI-11992140,EBI-740446
PATZ1 - isoform 4 [Q9HBE1-4]5EBI-11992140,EBI-11022007
PEF1 [Q9UBV8]3EBI-11992140,EBI-724639
PITX2 - isoform PTX2C [Q99697-2]3EBI-11992140,EBI-12138495
PLSCR3 [Q9NRY6]3EBI-11992140,EBI-750734
POU1F1 [P28069]3EBI-11992140,EBI-8673859
POU2AF1 [Q16633]3EBI-11992140,EBI-943588
PRR13 [Q9NZ81]3EBI-11992140,EBI-740924
PSMB1 [P20618]3EBI-11992140,EBI-372273
RBPMS - isoform C [Q93062-3]6EBI-11992140,EBI-740343
RHOXF2 [Q9BQY4]3EBI-11992140,EBI-372094
RIN1 [Q13671]3EBI-11992140,EBI-366017
RNF208 [Q9H0X6]3EBI-11992140,EBI-751555
SLC15A2 [Q16348]3EBI-11992140,EBI-12806032
SMUG1 - isoform 2 [Q53HV7-2]3EBI-11992140,EBI-12275818
SOX14 [O95416]3EBI-11992140,EBI-9087806
SPAG8 - isoform 2 [Q99932-2]3EBI-11992140,EBI-11959123
TEKT3 [Q9BXF9]3EBI-11992140,EBI-8644516
TEKT5 [Q96M29]3EBI-11992140,EBI-10239812
TFAP2D [Q7Z6R9]3EBI-11992140,EBI-11952651
TLE3 - isoform 4 [Q04726-4]3EBI-11992140,EBI-12014388
TOLLIP [Q9H0E2]3EBI-11992140,EBI-74615
UBAP2 [Q5T6F2]3EBI-11992140,EBI-2514383
UFSP1 [Q6NVU6]3EBI-11992140,EBI-12068150
VAC14 [Q08AM6]3EBI-11992140,EBI-2107455
VGLL3 - isoform 2 [A8MV65-2]3EBI-11992140,EBI-11957216
VPS37C [A5D8V6]3EBI-11992140,EBI-2559305
VWCE [Q96DN2]3EBI-11992140,EBI-2850497
WDR25 - isoform 2 [Q64LD2-2]3EBI-11992140,EBI-12032042
ZBTB32 [A0A0C4DGF1]3EBI-11992140,EBI-10188476
ZIC1 [Q15915]3EBI-11992140,EBI-11963196

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
129062, 72 interactors

Protein interaction database and analysis system

More...
IntActi
Q3LI76, 71 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000334866

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3LI76, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PMG family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502TD2Y, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162109

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_111618_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3LI76

Identification of Orthologs from Complete Genome Data

More...
OMAi
IYSPNTC

Database of Orthologous Groups

More...
OrthoDBi
1292816at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3LI76

TreeFam database of animal gene trees

More...
TreeFami
TF337331

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007951, KRTAP_PMG

The PANTHER Classification System

More...
PANTHERi
PTHR19051, PTHR19051, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05287, PMG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3LI76-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYNCSSGNF SSCCFGSYLR YPVSTYNLFY PSNAIYSPNT CQLGSSLYNG
60 70 80 90 100
CQETYCEPTS CQTSCTLARS YQTSCYCPKN SIFCSPRQTN YIRSLGCGNT
110 120 130
GLGSLGCGST GFQSLDCGSS FYHPTTFSSR NFQATCY
Length:137
Mass (Da):14,979
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C68B00CDF87837D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04701943L → M2 PublicationsCorresponds to variant dbSNP:rs2832873Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB096942 mRNA Translation: BAE46357.1
BC104927 mRNA Translation: AAI04928.1
BC104925 mRNA Translation: AAI04926.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13593.1

NCBI Reference Sequences

More...
RefSeqi
NP_853654.1, NM_181623.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334067; ENSP00000334866; ENSG00000186970

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
254950

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:254950

UCSC genome browser

More...
UCSCi
uc002yod.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096942 mRNA Translation: BAE46357.1
BC104927 mRNA Translation: AAI04928.1
BC104925 mRNA Translation: AAI04926.1
CCDSiCCDS13593.1
RefSeqiNP_853654.1, NM_181623.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi129062, 72 interactors
IntActiQ3LI76, 71 interactors
STRINGi9606.ENSP00000334866

PTM databases

PhosphoSitePlusiQ3LI76

Polymorphism and mutation databases

BioMutaiKRTAP15-1
DMDMi209572640

Proteomic databases

MassIVEiQ3LI76
PaxDbiQ3LI76
PeptideAtlasiQ3LI76
PRIDEiQ3LI76
ProteomicsDBi61772

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
6633, 7 antibodies

Genome annotation databases

EnsembliENST00000334067; ENSP00000334866; ENSG00000186970
GeneIDi254950
KEGGihsa:254950
UCSCiuc002yod.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
254950
EuPathDBiHostDB:ENSG00000186970.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRTAP15-1
HGNCiHGNC:18927, KRTAP15-1
HPAiENSG00000186970, Not detected
neXtProtiNX_Q3LI76
PharmGKBiPA134911178

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502TD2Y, Eukaryota
GeneTreeiENSGT00940000162109
HOGENOMiCLU_111618_0_0_1
InParanoidiQ3LI76
OMAiIYSPNTC
OrthoDBi1292816at2759
PhylomeDBiQ3LI76
TreeFamiTF337331

Enzyme and pathway databases

PathwayCommonsiQ3LI76
ReactomeiR-HSA-6805567, Keratinization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
254950, 16 hits in 862 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
254950
PharosiQ3LI76, Tdark

Protein Ontology

More...
PROi
PR:Q3LI76
RNActiQ3LI76, protein

Family and domain databases

InterProiView protein in InterPro
IPR007951, KRTAP_PMG
PANTHERiPTHR19051, PTHR19051, 1 hit
PfamiView protein in Pfam
PF05287, PMG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKR151_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3LI76
Secondary accession number(s): Q2M3F4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: October 14, 2008
Last modified: October 7, 2020
This is version 88 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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