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UniProtKB - Q3LI73 (KR194_HUMAN)
Protein
Keratin-associated protein 19-4
Gene
KRTAP19-4
Organism
Homo sapiens (Human)
Status
Functioni
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Enzyme and pathway databases
PathwayCommonsi | Q3LI73 |
Reactomei | R-HSA-6805567, Keratinization |
SignaLinki | Q3LI73 |
Names & Taxonomyi
Protein namesi | Recommended name: Keratin-associated protein 19-4 |
Gene namesi | Name:KRTAP19-4 Synonyms:KAP19.4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18939, KRTAP19-4 |
neXtProti | NX_Q3LI73 |
VEuPathDBi | HostDB:ENSG00000186967 |
Subcellular locationi
Cytoskeleton
- intermediate filament Source: UniProtKB-KW
Cytosol
- cytosol Source: Reactome
Keywords - Cellular componenti
KeratinPathology & Biotechi
Organism-specific databases
PharmGKBi | PA134984740 |
Miscellaneous databases
Pharosi | Q3LI73, Tdark |
Genetic variation databases
BioMutai | KRTAP19-4 |
DMDMi | 88909170 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000223906 | 1 – 84 | Keratin-associated protein 19-4Add BLAST | 84 |
Proteomic databases
MassIVEi | Q3LI73 |
PaxDbi | Q3LI73 |
PeptideAtlasi | Q3LI73 |
PRIDEi | Q3LI73 |
PTM databases
iPTMneti | Q3LI73 |
PhosphoSitePlusi | Q3LI73 |
Expressioni
Gene expression databases
Bgeei | ENSG00000186967, Expressed in testis and 31 other tissues |
Organism-specific databases
HPAi | ENSG00000186967, Not detected |
Interactioni
Subunit structurei
Interacts with hair keratins.
By similarityBinary interactionsi
Q3LI73
With | #Exp. | IntAct |
---|---|---|
GPSM3 [Q9Y4H4] | 3 | EBI-12958461,EBI-347538 |
KLHL42 [Q9P2K6] | 3 | EBI-12958461,EBI-739890 |
LASP1 - isoform 2 [Q14847-2] | 3 | EBI-12958461,EBI-9088686 |
NOXA1 - isoform 2 [Q86UR1-2] | 3 | EBI-12958461,EBI-12025760 |
Protein-protein interaction databases
BioGRIDi | 130654, 12 interactors |
IntActi | Q3LI73, 4 interactors |
STRINGi | 9606.ENSP00000335567 |
Miscellaneous databases
RNActi | Q3LI73, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q3LI73 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the KRTAP type 19 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502TDP7, Eukaryota |
GeneTreei | ENSGT01030000235953 |
HOGENOMi | CLU_184630_1_0_1 |
OMAi | CHLSSYY |
OrthoDBi | 1638225at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR021743, KRTAP_type6/8/16/19/20/21 |
Pfami | View protein in Pfam PF11759, KRTAP, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3LI73-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSYYGSYYRG LGYGCGGFGG LGYGYGCGCG SFRRLGYGCG FGGNGYGYCR
60 70 80
PSCYGGYGFS ILLKSYPEDT ISEVIRRSFN LTKY
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053475 | 48 | Y → C1 PublicationCorresponds to variant dbSNP:rs2298437Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB096945 mRNA Translation: BAE46360.1 BC117197 mRNA Translation: AAI17198.1 BC117199 mRNA Translation: AAI17200.1 |
CCDSi | CCDS33534.1 |
RefSeqi | NP_853641.1, NM_181610.1 |
Genome annotation databases
Ensembli | ENST00000334058.3; ENSP00000335567.2; ENSG00000186967.7 |
GeneIDi | 337971 |
KEGGi | hsa:337971 |
MANE-Selecti | ENST00000334058.3; ENSP00000335567.2; NM_181610.3; NP_853641.1 |
UCSCi | uc011acz.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB096945 mRNA Translation: BAE46360.1 BC117197 mRNA Translation: AAI17198.1 BC117199 mRNA Translation: AAI17200.1 |
CCDSi | CCDS33534.1 |
RefSeqi | NP_853641.1, NM_181610.1 |
3D structure databases
AlphaFoldDBi | Q3LI73 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 130654, 12 interactors |
IntActi | Q3LI73, 4 interactors |
STRINGi | 9606.ENSP00000335567 |
PTM databases
iPTMneti | Q3LI73 |
PhosphoSitePlusi | Q3LI73 |
Genetic variation databases
BioMutai | KRTAP19-4 |
DMDMi | 88909170 |
Proteomic databases
MassIVEi | Q3LI73 |
PaxDbi | Q3LI73 |
PeptideAtlasi | Q3LI73 |
PRIDEi | Q3LI73 |
Protocols and materials databases
Antibodypediai | 34974, 7 antibodies from 3 providers |
DNASUi | 337971 |
Genome annotation databases
Ensembli | ENST00000334058.3; ENSP00000335567.2; ENSG00000186967.7 |
GeneIDi | 337971 |
KEGGi | hsa:337971 |
MANE-Selecti | ENST00000334058.3; ENSP00000335567.2; NM_181610.3; NP_853641.1 |
UCSCi | uc011acz.3, human |
Organism-specific databases
CTDi | 337971 |
GeneCardsi | KRTAP19-4 |
HGNCi | HGNC:18939, KRTAP19-4 |
HPAi | ENSG00000186967, Not detected |
neXtProti | NX_Q3LI73 |
PharmGKBi | PA134984740 |
VEuPathDBi | HostDB:ENSG00000186967 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TDP7, Eukaryota |
GeneTreei | ENSGT01030000235953 |
HOGENOMi | CLU_184630_1_0_1 |
OMAi | CHLSSYY |
OrthoDBi | 1638225at2759 |
Enzyme and pathway databases
PathwayCommonsi | Q3LI73 |
Reactomei | R-HSA-6805567, Keratinization |
SignaLinki | Q3LI73 |
Miscellaneous databases
BioGRID-ORCSi | 337971, 8 hits in 993 CRISPR screens |
GenomeRNAii | 337971 |
Pharosi | Q3LI73, Tdark |
PROi | PR:Q3LI73 |
RNActi | Q3LI73, protein |
Gene expression databases
Bgeei | ENSG00000186967, Expressed in testis and 31 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR021743, KRTAP_type6/8/16/19/20/21 |
Pfami | View protein in Pfam PF11759, KRTAP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KR194_HUMAN | |
Accessioni | Q3LI73Primary (citable) accession number: Q3LI73 Secondary accession number(s): Q17RT4, Q17RT6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2006 |
Last sequence update: | November 8, 2005 | |
Last modified: | May 25, 2022 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families