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Protein

Keratin-associated protein 19-5

Gene

KRTAP19-5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 19-5
Gene namesi
Name:KRTAP19-5
Synonyms:KAP19.5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000186977.2
HGNCiHGNC:18940 KRTAP19-5
neXtProtiNX_Q3LI72

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134992782

Polymorphism and mutation databases

BioMutaiKRTAP19-5
DMDMi88909171

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002239071 – 72Keratin-associated protein 19-5Add BLAST72

Proteomic databases

PaxDbiQ3LI72
PeptideAtlasiQ3LI72
PRIDEiQ3LI72
ProteomicsDBi61770

PTM databases

iPTMnetiQ3LI72
PhosphoSitePlusiQ3LI72

Expressioni

Gene expression databases

BgeeiENSG00000186977 Expressed in 21 organ(s), highest expression level in skin of abdomen
CleanExiHS_KRTAP19-5

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi130655, 11 interactors
IntActiQ3LI72, 90 interactors
STRINGi9606.ENSP00000334985

Structurei

3D structure databases

ProteinModelPortaliQ3LI72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KRTAP type 19 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KCJM Eukaryota
ENOG4110NWA LUCA
GeneTreeiENSGT00730000112254
HOGENOMiHOG000113246
OMAiCRRPSHY

Family and domain databases

InterProiView protein in InterPro
IPR021743 KRTAP_type6/8/16/19/20/21
PfamiView protein in Pfam
PF11759 KRTAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q3LI72-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNYYGNYYGG LGYGYGGFDD LGYGYGCGCG SFRRLGYGGG YGGYGYGSGF
60 70
GGYGYRSCRP SCYGGYGFSG FY
Length:72
Mass (Da):7,624
Last modified:November 8, 2005 - v1
Checksum:iEEBDA9D9506BCCD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096946 mRNA Translation: BAE46361.1
BC100836 mRNA Translation: AAI00837.1
BC100837 mRNA Translation: AAI00838.1
BC100838 mRNA Translation: AAI00839.1
BC100839 mRNA Translation: AAI00840.1
BC113020 mRNA Translation: AAI13021.1
BC113021 mRNA Translation: AAI13022.1
CCDSiCCDS13597.1
RefSeqiNP_853642.1, NM_181611.1
UniGeneiHs.553694

Genome annotation databases

EnsembliENST00000334151; ENSP00000334985; ENSG00000186977
GeneIDi337972
KEGGihsa:337972
UCSCiuc011ada.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096946 mRNA Translation: BAE46361.1
BC100836 mRNA Translation: AAI00837.1
BC100837 mRNA Translation: AAI00838.1
BC100838 mRNA Translation: AAI00839.1
BC100839 mRNA Translation: AAI00840.1
BC113020 mRNA Translation: AAI13021.1
BC113021 mRNA Translation: AAI13022.1
CCDSiCCDS13597.1
RefSeqiNP_853642.1, NM_181611.1
UniGeneiHs.553694

3D structure databases

ProteinModelPortaliQ3LI72
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130655, 11 interactors
IntActiQ3LI72, 90 interactors
STRINGi9606.ENSP00000334985

PTM databases

iPTMnetiQ3LI72
PhosphoSitePlusiQ3LI72

Polymorphism and mutation databases

BioMutaiKRTAP19-5
DMDMi88909171

Proteomic databases

PaxDbiQ3LI72
PeptideAtlasiQ3LI72
PRIDEiQ3LI72
ProteomicsDBi61770

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334151; ENSP00000334985; ENSG00000186977
GeneIDi337972
KEGGihsa:337972
UCSCiuc011ada.3 human

Organism-specific databases

CTDi337972
EuPathDBiHostDB:ENSG00000186977.2
GeneCardsiKRTAP19-5
HGNCiHGNC:18940 KRTAP19-5
neXtProtiNX_Q3LI72
PharmGKBiPA134992782
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCJM Eukaryota
ENOG4110NWA LUCA
GeneTreeiENSGT00730000112254
HOGENOMiHOG000113246
OMAiCRRPSHY

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Miscellaneous databases

GenomeRNAii337972
PROiPR:Q3LI72

Gene expression databases

BgeeiENSG00000186977 Expressed in 21 organ(s), highest expression level in skin of abdomen
CleanExiHS_KRTAP19-5

Family and domain databases

InterProiView protein in InterPro
IPR021743 KRTAP_type6/8/16/19/20/21
PfamiView protein in Pfam
PF11759 KRTAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKR195_HUMAN
AccessioniPrimary (citable) accession number: Q3LI72
Secondary accession number(s): A4IF22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 8, 2005
Last modified: September 12, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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