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Entry version 86 (12 Aug 2020)
Sequence version 1 (08 Nov 2005)
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Protein

Keratin-associated protein 6-2

Gene

KRTAP6-2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q3LI66

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6805567, Keratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 6-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP6-2
Synonyms:KAP6.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000186930.4

Human Gene Nomenclature Database

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HGNCi
HGNC:18932, KRTAP6-2

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q3LI66

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134980095

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q3LI66, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
KRTAP6-2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002238991 – 62Keratin-associated protein 6-2Add BLAST62

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q3LI66

PRoteomics IDEntifications database

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PRIDEi
Q3LI66

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
61766

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q3LI66

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q3LI66

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000186930, Expressed in lung and 13 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000186930, Not detected

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q3LI66
With#Exp.IntAct
ADAM12 - isoform 4 [O43184-4]3EBI-11962084,EBI-12006944
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-11962084,EBI-10173507
ANAPC11 - isoform 2 [Q9NYG5-2]3EBI-11962084,EBI-12224467
ANKS1A [Q49AR9]3EBI-11962084,EBI-11954519
ANXA11 [P50995]3EBI-11962084,EBI-715243
APOBEC1 [P41238]3EBI-11962084,EBI-12819523
AQP1 [P29972]3EBI-11962084,EBI-745213
ARID5A [Q03989]3EBI-11962084,EBI-948603
ATG9A - isoform 3 [Q7Z3C6-3]5EBI-11962084,EBI-12006308
ATN1 [Q86V38]3EBI-11962084,EBI-11954292
ATPAF2 [Q8N5M1]3EBI-11962084,EBI-1166928
BEX2 [Q9BXY8]3EBI-11962084,EBI-745073
BHLHE40 [O14503]3EBI-11962084,EBI-711810
C10orf55 [Q5SWW7]3EBI-11962084,EBI-12809220
C1orf94 [Q6P1W5]3EBI-11962084,EBI-946029
C20orf85 [Q9H1P6]3EBI-11962084,EBI-12155483
C6orf15 [Q6UXA7]3EBI-11962084,EBI-11990870
CAMK2A [Q9UQM7]3EBI-11962084,EBI-1383687
CAMK2B - isoform 2 [Q13554-3]3EBI-11962084,EBI-11523526
CASC3 [O15234]5EBI-11962084,EBI-299118
CATSPER1 [Q8NEC5]3EBI-11962084,EBI-744545
CCDC120 [Q96HB5]3EBI-11962084,EBI-744556
CCDC17 - isoform 2 [Q96LX7-5]3EBI-11962084,EBI-12165781
CCER1 [Q8TC90]3EBI-11962084,EBI-746041
CCNK - isoform 2 [O75909-2]5EBI-11962084,EBI-12010594
CELF5 [Q8N6W0]3EBI-11962084,EBI-12139335
CERCAM [Q5T4B2]3EBI-11962084,EBI-12261896
CERK [Q8TCT0]3EBI-11962084,EBI-10274247
CFP [P27918]5EBI-11962084,EBI-9038570
CHIC2 [Q9UKJ5]3EBI-11962084,EBI-741528
COL8A1 [P27658]5EBI-11962084,EBI-747133
CREB5 - isoform 3 [Q02930-3]5EBI-11962084,EBI-10192698
CTRC [Q99895]3EBI-11962084,EBI-10295404
CYSRT1 [A8MQ03]8EBI-11962084,EBI-3867333
DAZAP2 [Q15038]3EBI-11962084,EBI-724310
DHRS1 [Q96LJ7]3EBI-11962084,EBI-746300
DMRT3 [Q9NQL9]3EBI-11962084,EBI-9679045
ENKD1 [Q9H0I2]3EBI-11962084,EBI-744099
ESR2 - isoform 3 [Q92731-3]3EBI-11962084,EBI-12259414
FAAP20 - isoform 4 [Q6NZ36-4]3EBI-11962084,EBI-12013806
FAM166B - isoform 2 [A8MTA8-2]3EBI-11962084,EBI-12160437
FAM168A - isoform 2 [Q92567-2]5EBI-11962084,EBI-11978259
FAM214B [Q7L5A3]3EBI-11962084,EBI-745689
FAM83A [Q86UY5]5EBI-11962084,EBI-1384254
FOXD2 [O60548]3EBI-11962084,EBI-17282008
FOXD4L1 [Q9NU39]3EBI-11962084,EBI-11320806
FOXD4L3 [Q6VB84]3EBI-11962084,EBI-11961494
FOXP3 [Q9BZS1]3EBI-11962084,EBI-983719
FRS3 [O43559]5EBI-11962084,EBI-725515
GALT [P07902]3EBI-11962084,EBI-750827
GATA3 - isoform 2 [P23771-2]3EBI-11962084,EBI-6672518
GCM2 [O75603]3EBI-11962084,EBI-10188645
GLIS2 [Q9BZE0]5EBI-11962084,EBI-7251368
GLYCTK [Q8IVS8]5EBI-11962084,EBI-748515
GNE - isoform 2 [Q9Y223-2]3EBI-11962084,EBI-11975289
GPS2 [Q13227]5EBI-11962084,EBI-713355
GRINA [Q7Z429]3EBI-11962084,EBI-2832909
GRN [P28799]3EBI-11962084,EBI-747754
GSTP1 [P09211]3EBI-11962084,EBI-353467
HAPLN2 [Q9GZV7]3EBI-11962084,EBI-11956675
HELT [A0A087WSW0]5EBI-11962084,EBI-12057631
HEY1 [Q9Y5J3]3EBI-11962084,EBI-7231130
HEY2 [Q9UBP5]3EBI-11962084,EBI-750630
HEYL [Q9NQ87]3EBI-11962084,EBI-751092
HHEX [Q03014]3EBI-11962084,EBI-747421
HOXA1 [P49639]3EBI-11962084,EBI-740785
HOXB9 [P17482]3EBI-11962084,EBI-745290
HOXC8 [P31273]3EBI-11962084,EBI-1752118
HOXC9 [P31274]3EBI-11962084,EBI-1779423
HSF4 - isoform HSF4A [Q9ULV5-2]3EBI-11962084,EBI-12056251
HYAL2 [Q12891]3EBI-11962084,EBI-2806068
IGFN1 - isoform 5 [Q86VF2-5]3EBI-11962084,EBI-11955401
INCA1 [Q0VD86]5EBI-11962084,EBI-6509505
INO80B [Q9C086]3EBI-11962084,EBI-715611
ITGB4 - isoform Beta-4A [P16144-2]3EBI-11962084,EBI-11051601
KLHL38 [Q2WGJ6]3EBI-11962084,EBI-6426443
KPRP [Q5T749]3EBI-11962084,EBI-10981970
KRT83 [P78385]3EBI-11962084,EBI-10221390
KRTAP11-1 [Q8IUC1]3EBI-11962084,EBI-1052037
KRTAP12-1 [P59990]3EBI-11962084,EBI-10210845
KRTAP12-2 [P59991]6EBI-11962084,EBI-10176379
KRTAP12-3 [P60328]3EBI-11962084,EBI-11953334
KRTAP12-4 [P60329]3EBI-11962084,EBI-10176396
KRTAP15-1 [Q3LI76]3EBI-11962084,EBI-11992140
KRTAP19-5 [Q3LI72]3EBI-11962084,EBI-1048945
KRTAP26-1 [Q6PEX3]6EBI-11962084,EBI-3957672
KRTAP3-3 [Q9BYR6]3EBI-11962084,EBI-3957694
KRTAP4-11 [Q9BYQ6]3EBI-11962084,EBI-10302392
KRTAP4-12 [Q9BQ66]3EBI-11962084,EBI-739863
KRTAP6-1 [Q3LI64]3EBI-11962084,EBI-12111050
itself3EBI-11962084,EBI-11962084
LASP1 - isoform 2 [Q14847-2]3EBI-11962084,EBI-9088686
LCE2B [O14633]3EBI-11962084,EBI-11478468
LCE2D [Q5TA82]3EBI-11962084,EBI-10246750
LCE5A [Q5TCM9]3EBI-11962084,EBI-11955689
LETM1 [O95202]3EBI-11962084,EBI-1052895
LGALS9C [Q6DKI2]3EBI-11962084,EBI-9088829
LRFN4 [Q6PJG9]3EBI-11962084,EBI-7910762
LRRC41 [Q15345]3EBI-11962084,EBI-721408
LYVE1 [Q9Y5Y7]3EBI-11962084,EBI-10329546
MEIS2 - isoform 4 [O14770-4]5EBI-11962084,EBI-8025850
MKRN3 [Q13064]3EBI-11962084,EBI-2340269
NAF1 [Q96HR8]3EBI-11962084,EBI-2515597
NDUFA9 [Q16795]3EBI-11962084,EBI-1045087
NEU4 - isoform 2 [Q8WWR8-2]3EBI-11962084,EBI-10277551
NFKBID [Q8NI38]3EBI-11962084,EBI-10271199
NID2 [Q8IV28]3EBI-11962084,EBI-10261509
NPBWR2 [P48146]3EBI-11962084,EBI-10210114
NR1D2 [Q6NSM0]5EBI-11962084,EBI-10250949
NSD1 - isoform 2 [Q96L73-2]3EBI-11962084,EBI-11110981
OLIG3 [Q7RTU3]3EBI-11962084,EBI-10225049
OTX1 [P32242]3EBI-11962084,EBI-740446
PATL1 [Q86TB9]3EBI-11962084,EBI-2562092
PATZ1 - isoform 4 [Q9HBE1-4]3EBI-11962084,EBI-11022007
PAX3 - isoform Pax3E [P23760-8]3EBI-11962084,EBI-12105196
PDP1 [Q9P0J1]3EBI-11962084,EBI-2861634
PHLDA1 [A2BDE7]3EBI-11962084,EBI-14084211
PITX1 [P78337]5EBI-11962084,EBI-748265
PKD2 [Q13563]3EBI-11962084,EBI-7813714
PLEKHN1 - isoform 3 [Q494U1-3]3EBI-11962084,EBI-12014286
PLSCR4 [Q9NRQ2]3EBI-11962084,EBI-769257
POGZ [Q7Z3K3]5EBI-11962084,EBI-1389308
POU5F2 [Q8N7G0]3EBI-11962084,EBI-12849044
PPP1R32 - isoform 2 [Q7Z5V6-2]5EBI-11962084,EBI-12000762
PRR13 [Q9NZ81]6EBI-11962084,EBI-740924
PRR3 [P79522]3EBI-11962084,EBI-2803328
PRR30 [Q53SZ7]3EBI-11962084,EBI-12360827
PRR35 [P0CG20]5EBI-11962084,EBI-11986293
RASD1 [Q9Y272]3EBI-11962084,EBI-740818
RBFOX2 - isoform 10 [O43251-10]3EBI-11962084,EBI-11963050
RBPMS2 [Q6ZRY4]3EBI-11962084,EBI-11987469
RERE [Q9P2R6]3EBI-11962084,EBI-948076
RHOXF2 [Q9BQY4]3EBI-11962084,EBI-372094
RNF38 [Q9H0F5]3EBI-11962084,EBI-2341200
ROR2 [Q01974]3EBI-11962084,EBI-6422642
RTP5 [Q14D33]3EBI-11962084,EBI-10217913
RUNX1T1 - isoform MTG8A [Q06455-2]3EBI-11962084,EBI-11984663
RUSC1 [Q9BVN2]5EBI-11962084,EBI-6257312
SAMD7 [Q7Z3H4]5EBI-11962084,EBI-12148649
SHARPIN - isoform 2 [Q9H0F6-2]3EBI-11962084,EBI-9843813
SIAH3 [Q8IW03]3EBI-11962084,EBI-12880872
SMAP2 [Q8WU79]3EBI-11962084,EBI-2822515
SMARCC1 [Q92922]3EBI-11962084,EBI-355653
SMN2 [Q16637]5EBI-11962084,EBI-395421
SMUG1 - isoform 2 [Q53HV7-2]3EBI-11962084,EBI-12275818
SNRPB - isoform SM-B [P14678-2]3EBI-11962084,EBI-372475
SNRPC [P09234]5EBI-11962084,EBI-766589
SPAG8 - isoform 2 [Q99932-2]5EBI-11962084,EBI-11959123
SPATA8 [Q6RVD6]3EBI-11962084,EBI-8635958
TBX6 [O95947]5EBI-11962084,EBI-2824328
TCF7L2 - isoform 10 [Q9NQB0-10]5EBI-11962084,EBI-11746252
TEKT3 [Q9BXF9]3EBI-11962084,EBI-8644516
TEKT4 [Q8WW24]5EBI-11962084,EBI-750487
TEKT5 [Q96M29]3EBI-11962084,EBI-10239812
TENT5B [Q96A09]3EBI-11962084,EBI-752030
TENT5D [Q8NEK8]5EBI-11962084,EBI-744726
TEPSIN [Q96N21]3EBI-11962084,EBI-11139477
TEX37 [Q96LM6]4EBI-11962084,EBI-743976
TFAP2D [Q7Z6R9]5EBI-11962084,EBI-11952651
TLE5 - isoform 2 [Q08117-2]3EBI-11962084,EBI-11741437
TLX2 [O43763]3EBI-11962084,EBI-6101484
TLX3 [O43711]5EBI-11962084,EBI-3939165
TNIP1 [Q15025]6EBI-11962084,EBI-357849
TOLLIP [Q9H0E2]5EBI-11962084,EBI-74615
TPRX1 - isoform 2 [Q8N7U7-2]3EBI-11962084,EBI-14115717
TRIP13 [Q15645]3EBI-11962084,EBI-358993
TSGA10IP [Q3SY00]3EBI-11962084,EBI-10241197
TSPAN4 [O14817]3EBI-11962084,EBI-8652667
TSPYL6 [Q8N831]3EBI-11962084,EBI-12023322
VAC14 [Q08AM6]3EBI-11962084,EBI-2107455
VENTX [O95231]5EBI-11962084,EBI-10191303
VGLL3 - isoform 2 [A8MV65-2]3EBI-11962084,EBI-11957216
VPS37C [A5D8V6]5EBI-11962084,EBI-2559305
ZBTB32 [A0A0C4DGF1]3EBI-11962084,EBI-10188476
ZC3H10 [Q96K80]3EBI-11962084,EBI-742550
ZIC1 [Q15915]3EBI-11962084,EBI-11963196
ZNF414 [Q96IQ9]5EBI-11962084,EBI-744257
ZNF503 [Q96F45]5EBI-11962084,EBI-8832437
ZNF581 [Q9P0T4]3EBI-11962084,EBI-745520
ZNF683 [Q8IZ20]3EBI-11962084,EBI-12005952
ZNF843 [Q8N446]3EBI-11962084,EBI-6428016

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q3LI66, 180 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000334560

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3LI66, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 6 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502TBSA, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00950000183416

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_182642_0_0_1

Identification of Orthologs from Complete Genome Data

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OMAi
CGFRRLA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040313, KAP6
IPR021743, KRTAP_type6/8/16/19/20/21

The PANTHER Classification System

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PANTHERi
PTHR31678, PTHR31678, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11759, KRTAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3LI66-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGSYYGNYY GDHGYGCCGY EGLGYGYGSL RCGYSSCCGY GHGYGSRFFC
60
GCGYGCGSGY YY
Length:62
Mass (Da):6,654
Last modified:November 8, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46DB5B92F0BEEBC4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB096952 mRNA Translation: BAE46367.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13600.1

NCBI Reference Sequences

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RefSeqi
NP_853635.1, NM_181604.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000334897; ENSP00000334560; ENSG00000186930

Database of genes from NCBI RefSeq genomes

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GeneIDi
337967

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:337967

UCSC genome browser

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UCSCi
uc011adc.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096952 mRNA Translation: BAE46367.1
CCDSiCCDS13600.1
RefSeqiNP_853635.1, NM_181604.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ3LI66, 180 interactors
STRINGi9606.ENSP00000334560

PTM databases

iPTMnetiQ3LI66
PhosphoSitePlusiQ3LI66

Polymorphism and mutation databases

BioMutaiKRTAP6-2

Proteomic databases

PaxDbiQ3LI66
PRIDEiQ3LI66
ProteomicsDBi61766

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
337967

Genome annotation databases

EnsembliENST00000334897; ENSP00000334560; ENSG00000186930
GeneIDi337967
KEGGihsa:337967
UCSCiuc011adc.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
337967
EuPathDBiHostDB:ENSG00000186930.4

GeneCards: human genes, protein and diseases

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GeneCardsi
KRTAP6-2
HGNCiHGNC:18932, KRTAP6-2
HPAiENSG00000186930, Not detected
neXtProtiNX_Q3LI66
PharmGKBiPA134980095

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502TBSA, Eukaryota
GeneTreeiENSGT00950000183416
HOGENOMiCLU_182642_0_0_1
OMAiCGFRRLA

Enzyme and pathway databases

PathwayCommonsiQ3LI66
ReactomeiR-HSA-6805567, Keratinization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
337967, 4 hits in 869 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
337967
PharosiQ3LI66, Tdark

Protein Ontology

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PROi
PR:Q3LI66
RNActiQ3LI66, protein

Gene expression databases

BgeeiENSG00000186930, Expressed in lung and 13 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR040313, KAP6
IPR021743, KRTAP_type6/8/16/19/20/21
PANTHERiPTHR31678, PTHR31678, 1 hit
PfamiView protein in Pfam
PF11759, KRTAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKRA62_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3LI66
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 8, 2005
Last modified: August 12, 2020
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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