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Protein

Keratin-associated protein 6-2

Gene

KRTAP6-2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 6-2
Gene namesi
Name:KRTAP6-2
Synonyms:KAP6.2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000186930.4
HGNCiHGNC:18932 KRTAP6-2
neXtProtiNX_Q3LI66

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134980095

Polymorphism and mutation databases

BioMutaiKRTAP6-2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002238991 – 62Keratin-associated protein 6-2Add BLAST62

Proteomic databases

PaxDbiQ3LI66
PRIDEiQ3LI66
ProteomicsDBi61766

PTM databases

iPTMnetiQ3LI66
PhosphoSitePlusiQ3LI66

Expressioni

Gene expression databases

BgeeiENSG00000186930 Expressed in 8 organ(s), highest expression level in adipose tissue
CleanExiHS_KRTAP6-2

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Binary interactionsi

Protein-protein interaction databases

IntActiQ3LI66, 196 interactors
STRINGi9606.ENSP00000334560

Structurei

3D structure databases

ProteinModelPortaliQ3LI66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KRTAP type 6 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00730000113256
OMAiNSCCHPS
OrthoDBiEOG09370K3D

Family and domain databases

InterProiView protein in InterPro
IPR021743 KRTAP_type6/8/16/19/20/21
PfamiView protein in Pfam
PF11759 KRTAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q3LI66-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGSYYGNYY GDHGYGCCGY EGLGYGYGSL RCGYSSCCGY GHGYGSRFFC
60
GCGYGCGSGY YY
Length:62
Mass (Da):6,654
Last modified:November 8, 2005 - v1
Checksum:i46DB5B92F0BEEBC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096952 mRNA Translation: BAE46367.1
CCDSiCCDS13600.1
RefSeqiNP_853635.1, NM_181604.1
UniGeneiHs.553690

Genome annotation databases

EnsembliENST00000334897; ENSP00000334560; ENSG00000186930
GeneIDi337967
KEGGihsa:337967
UCSCiuc011adc.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096952 mRNA Translation: BAE46367.1
CCDSiCCDS13600.1
RefSeqiNP_853635.1, NM_181604.1
UniGeneiHs.553690

3D structure databases

ProteinModelPortaliQ3LI66
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3LI66, 196 interactors
STRINGi9606.ENSP00000334560

PTM databases

iPTMnetiQ3LI66
PhosphoSitePlusiQ3LI66

Polymorphism and mutation databases

BioMutaiKRTAP6-2

Proteomic databases

PaxDbiQ3LI66
PRIDEiQ3LI66
ProteomicsDBi61766

Protocols and materials databases

DNASUi337967
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334897; ENSP00000334560; ENSG00000186930
GeneIDi337967
KEGGihsa:337967
UCSCiuc011adc.3 human

Organism-specific databases

CTDi337967
EuPathDBiHostDB:ENSG00000186930.4
GeneCardsiKRTAP6-2
HGNCiHGNC:18932 KRTAP6-2
neXtProtiNX_Q3LI66
PharmGKBiPA134980095
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00730000113256
OMAiNSCCHPS
OrthoDBiEOG09370K3D

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Miscellaneous databases

GenomeRNAii337967
PROiPR:Q3LI66

Gene expression databases

BgeeiENSG00000186930 Expressed in 8 organ(s), highest expression level in adipose tissue
CleanExiHS_KRTAP6-2

Family and domain databases

InterProiView protein in InterPro
IPR021743 KRTAP_type6/8/16/19/20/21
PfamiView protein in Pfam
PF11759 KRTAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKRA62_HUMAN
AccessioniPrimary (citable) accession number: Q3LI66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 8, 2005
Last modified: November 7, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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