Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q3LI64 (KRA61_HUMAN)

Entry version 90 (02 Dec 2020)
Sequence version 1 (08 Nov 2005)
Previous versions | rss
Add a publicationFeedback
Protein

Keratin-associated protein 6-1

Gene

KRTAP6-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q3LI64

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6805567, Keratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 6-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP6-1
Synonyms:C21orf103, KAP6.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000184724.5

Human Gene Nomenclature Database

More...HGNCi		HGNC:18931, KRTAP6-1

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q3LI64

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134988301

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q3LI64, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KRTAP6-1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002238981 – 71Keratin-associated protein 6-1Add BLAST71

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q3LI64

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q3LI64

PeptideAtlas

More...PeptideAtlasi		Q3LI64

PRoteomics IDEntifications database

More...PRIDEi		Q3LI64

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		61765

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q3LI64

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q3LI64

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000184724, Expressed in skin of abdomen and 10 other tissues

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000184724, Tissue enriched (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q3LI64
With#Exp.IntAct
ANAPC11 - isoform 2 [Q9NYG5-2]3EBI-12111050,EBI-12224467
APOBEC1 [P41238]3EBI-12111050,EBI-12819523
ARID5A [Q03989]3EBI-12111050,EBI-948603
BAHD1 [Q8TBE0]3EBI-12111050,EBI-742750
BHLHE40 [O14503]3EBI-12111050,EBI-711810
CAMK2A [Q9UQM7]3EBI-12111050,EBI-1383687
CAMK2G - isoform 5 [Q13555-5]3EBI-12111050,EBI-12020154
CATSPER1 [Q8NEC5]3EBI-12111050,EBI-744545
CCDC120 [Q96HB5]3EBI-12111050,EBI-744556
CCDC24 [Q8N4L8]3EBI-12111050,EBI-1104933
CDA [P32320]3EBI-12111050,EBI-9250559
CELF5 [Q8N6W0]5EBI-12111050,EBI-12139335
CREB5 - isoform 3 [Q02930-3]5EBI-12111050,EBI-10192698
CRYAB [P02511]3EBI-12111050,EBI-739060
CYSRT1 [A8MQ03]6EBI-12111050,EBI-3867333
DAZAP2 [Q15038]8EBI-12111050,EBI-724310
DTX2 [Q86UW9]3EBI-12111050,EBI-740376
EFEMP1 [Q12805]3EBI-12111050,EBI-536772
EVX2 [Q03828]3EBI-12111050,EBI-17280301
FCHO1 [A0A0C3SFZ9]3EBI-12111050,EBI-11977403
GLIS2 [Q9BZE0]3EBI-12111050,EBI-7251368
GLIS3 - isoform 2 [Q8NEA6-2]3EBI-12111050,EBI-12232117
GNE - isoform 2 [Q9Y223-2]3EBI-12111050,EBI-11975289
GPS2 [Q13227]3EBI-12111050,EBI-713355
GRN [P28799]3EBI-12111050,EBI-747754
HELT [A0A087WSW0]3EBI-12111050,EBI-12057631
HEY2 [Q9UBP5]3EBI-12111050,EBI-750630
HHEX [Q03014]3EBI-12111050,EBI-747421
HOXA1 [P49639]3EBI-12111050,EBI-740785
HOXC8 [P31273]3EBI-12111050,EBI-1752118
ITIH6 [Q6UXX5]3EBI-12111050,EBI-11028396
KPRP [Q5T749]3EBI-12111050,EBI-10981970
KRTAP11-1 [Q8IUC1]3EBI-12111050,EBI-1052037
KRTAP12-1 [P59990]3EBI-12111050,EBI-10210845
KRTAP12-3 [P60328]3EBI-12111050,EBI-11953334
KRTAP26-1 [Q6PEX3]3EBI-12111050,EBI-3957672
KRTAP3-1 [Q9BYR8]3EBI-12111050,EBI-9996449
KRTAP4-5 [Q9BYR2]3EBI-12111050,EBI-11993254
KRTAP6-2 [Q3LI66]3EBI-12111050,EBI-11962084
LONRF1 [Q17RB8]3EBI-12111050,EBI-2341787
MAGED1 [Q9Y5V3]3EBI-12111050,EBI-716006
MAP11 [Q8WVR3]3EBI-12111050,EBI-719893
MAPK1IP1L [Q8NDC0]3EBI-12111050,EBI-741424
MED25 [Q71SY5]3EBI-12111050,EBI-394558
MEIS2 - isoform 4 [O14770-4]3EBI-12111050,EBI-8025850
MGC50722 [Q8IVT4]3EBI-12111050,EBI-14086479
MYOZ3 [Q8TDC0]3EBI-12111050,EBI-5662487
NAF1 [Q96HR8]3EBI-12111050,EBI-2515597
NOTO [A8MTQ0]3EBI-12111050,EBI-17490746
NTAQ1 [Q96HA8]3EBI-12111050,EBI-741158
OLIG3 [Q7RTU3]3EBI-12111050,EBI-10225049
OSR2 - isoform 2 [Q8N2R0-2]3EBI-12111050,EBI-12850348
OTX1 [P32242]3EBI-12111050,EBI-740446
P4HA3 [Q7Z4N8]3EBI-12111050,EBI-10181968
PATZ1 - isoform 4 [Q9HBE1-4]3EBI-12111050,EBI-11022007
PDIA2 [Q13087]3EBI-12111050,EBI-1752525
PITX1 [P78337]3EBI-12111050,EBI-748265
PITX2 - isoform PTX2C [Q99697-2]3EBI-12111050,EBI-12138495
PLSCR3 [Q9NRY6]3EBI-12111050,EBI-750734
PLSCR4 [Q9NRQ2]4EBI-12111050,EBI-769257
POU1F1 [P28069]3EBI-12111050,EBI-8673859
POU4F2 [Q12837]3EBI-12111050,EBI-17236143
PRR13 [Q9NZ81]5EBI-12111050,EBI-740924
PRR35 [P0CG20]3EBI-12111050,EBI-11986293
RBPMS2 [Q6ZRY4]3EBI-12111050,EBI-11987469
RHOXF2 [Q9BQY4]5EBI-12111050,EBI-372094
SMARCC1 [Q92922]3EBI-12111050,EBI-355653
SMN2 [Q16637]3EBI-12111050,EBI-395421
SNRPB - isoform SM-B [P14678-2]3EBI-12111050,EBI-372475
TCF7L2 - isoform 10 [Q9NQB0-10]3EBI-12111050,EBI-11746252
TEKT3 [Q9BXF9]3EBI-12111050,EBI-8644516
TENT5B [Q96A09]3EBI-12111050,EBI-752030
TFAP2D [Q7Z6R9]3EBI-12111050,EBI-11952651
TLX3 [O43711]3EBI-12111050,EBI-3939165
TNIP1 [Q15025]3EBI-12111050,EBI-357849
TOLLIP [Q9H0E2]5EBI-12111050,EBI-74615
TRIP13 [Q15645]4EBI-12111050,EBI-358993
UNC5CL [Q8IV45]3EBI-12111050,EBI-12238241
VAC14 [Q08AM6]3EBI-12111050,EBI-2107455
VENTX [O95231]3EBI-12111050,EBI-10191303
VGLL3 - isoform 2 [A8MV65-2]3EBI-12111050,EBI-11957216
VPS37C [A5D8V6]3EBI-12111050,EBI-2559305
ZBTB32 [A0A0C4DGF1]5EBI-12111050,EBI-10188476
ZC3H10 [Q96K80]3EBI-12111050,EBI-742550
ZIC1 [Q15915]3EBI-12111050,EBI-11963196
ZNF414 [Q96IQ9]5EBI-12111050,EBI-744257

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		130649, 90 interactors

Protein interaction database and analysis system

More...IntActi		Q3LI64, 86 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000332690

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q3LI64, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 6 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502TF3E, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183372

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_182642_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		SGFANYY

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040313, KAP6

The PANTHER Classification System

More...PANTHERi		PTHR31678, PTHR31678, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3LI64-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGSYYGNYY GTPGYGFCGY GGLGYGYGGL GCGYGSCCGC GFRRLGCGYG 
        60         70 
YGSRSLCGYG YGCGSGSGYY Y
Length:71
Mass (Da):7,279
Last modified:November 8, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i233D648E50FB8858
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB096954 mRNA Translation: BAE46369.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13602.1

NCBI Reference Sequences

More...RefSeqi		NP_853633.1, NM_181602.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000329122; ENSP00000332690; ENSG00000184724

Database of genes from NCBI RefSeq genomes

More...GeneIDi		337966

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:337966

UCSC genome browser

More...UCSCi		uc002yop.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096954 mRNA Translation: BAE46369.1
CCDSiCCDS13602.1
RefSeqiNP_853633.1, NM_181602.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi130649, 90 interactors
IntActiQ3LI64, 86 interactors
STRINGi9606.ENSP00000332690

PTM databases

iPTMnetiQ3LI64
PhosphoSitePlusiQ3LI64

Polymorphism and mutation databases

BioMutaiKRTAP6-1

Proteomic databases

MassIVEiQ3LI64
PaxDbiQ3LI64
PeptideAtlasiQ3LI64
PRIDEiQ3LI64
ProteomicsDBi61765

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		337966

Genome annotation databases

EnsembliENST00000329122; ENSP00000332690; ENSG00000184724
GeneIDi337966
KEGGihsa:337966
UCSCiuc002yop.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		337966
EuPathDBiHostDB:ENSG00000184724.5

GeneCards: human genes, protein and diseases

More...GeneCardsi		KRTAP6-1
HGNCiHGNC:18931, KRTAP6-1
HPAiENSG00000184724, Tissue enriched (skin)
neXtProtiNX_Q3LI64
PharmGKBiPA134988301

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502TF3E, Eukaryota
GeneTreeiENSGT00950000183372
HOGENOMiCLU_182642_0_0_1
OMAiSGFANYY

Enzyme and pathway databases

PathwayCommonsiQ3LI64
ReactomeiR-HSA-6805567, Keratinization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		337966, 3 hits in 839 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		337966
PharosiQ3LI64, Tdark

Protein Ontology

More...PROi		PR:Q3LI64
RNActiQ3LI64, protein

Gene expression databases

BgeeiENSG00000184724, Expressed in skin of abdomen and 10 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR040313, KAP6
PANTHERiPTHR31678, PTHR31678, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKRA61_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3LI64
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 8, 2005
Last modified: December 2, 2020
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again