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UniProtKB - Q3LI64 (KRA61_HUMAN)
Protein
Keratin-associated protein 6-1
Gene
KRTAP6-1
Organism
Homo sapiens (Human)
Status
Functioni
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
GO - Biological processi
- keratinization Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q3LI64 |
Reactomei | R-HSA-6805567, Keratinization |
SignaLinki | Q3LI64 |
Names & Taxonomyi
Protein namesi | Recommended name: Keratin-associated protein 6-1 |
Gene namesi | Name:KRTAP6-1 Synonyms:C21orf103, KAP6.1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18931, KRTAP6-1 |
neXtProti | NX_Q3LI64 |
VEuPathDBi | HostDB:ENSG00000184724 |
Subcellular locationi
Cytoskeleton
- intermediate filament Source: UniProtKB-KW
Cytosol
- cytosol Source: UniProtKB
Keywords - Cellular componenti
KeratinPathology & Biotechi
Organism-specific databases
PharmGKBi | PA134988301 |
Miscellaneous databases
Pharosi | Q3LI64, Tdark |
Genetic variation databases
BioMutai | KRTAP6-1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000223898 | 1 – 71 | Keratin-associated protein 6-1Add BLAST | 71 |
Proteomic databases
MassIVEi | Q3LI64 |
PaxDbi | Q3LI64 |
PeptideAtlasi | Q3LI64 |
PRIDEi | Q3LI64 |
ProteomicsDBi | 61765 |
PTM databases
iPTMneti | Q3LI64 |
PhosphoSitePlusi | Q3LI64 |
Expressioni
Gene expression databases
Bgeei | ENSG00000184724, Expressed in skin of abdomen and 10 other tissues |
Organism-specific databases
HPAi | ENSG00000184724, Tissue enriched (skin) |
Interactioni
Subunit structurei
Interacts with hair keratins.
By similarityBinary interactionsi
Q3LI64
Protein-protein interaction databases
BioGRIDi | 130649, 101 interactors |
IntActi | Q3LI64, 86 interactors |
STRINGi | 9606.ENSP00000332690 |
Miscellaneous databases
RNActi | Q3LI64, protein |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the KRTAP type 6 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502TF3E, Eukaryota |
GeneTreei | ENSGT00950000183372 |
HOGENOMi | CLU_182642_0_0_1 |
OMAi | GSGYRCC |
Family and domain databases
InterProi | View protein in InterPro IPR040313, KAP6 |
PANTHERi | PTHR31678, PTHR31678, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3LI64-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCGSYYGNYY GTPGYGFCGY GGLGYGYGGL GCGYGSCCGC GFRRLGCGYG
60 70
YGSRSLCGYG YGCGSGSGYY Y
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB096954 mRNA Translation: BAE46369.1 |
CCDSi | CCDS13602.1 |
RefSeqi | NP_853633.1, NM_181602.1 |
Genome annotation databases
Ensembli | ENST00000329122; ENSP00000332690; ENSG00000184724 |
GeneIDi | 337966 |
KEGGi | hsa:337966 |
UCSCi | uc002yop.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB096954 mRNA Translation: BAE46369.1 |
CCDSi | CCDS13602.1 |
RefSeqi | NP_853633.1, NM_181602.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 130649, 101 interactors |
IntActi | Q3LI64, 86 interactors |
STRINGi | 9606.ENSP00000332690 |
PTM databases
iPTMneti | Q3LI64 |
PhosphoSitePlusi | Q3LI64 |
Genetic variation databases
BioMutai | KRTAP6-1 |
Proteomic databases
MassIVEi | Q3LI64 |
PaxDbi | Q3LI64 |
PeptideAtlasi | Q3LI64 |
PRIDEi | Q3LI64 |
ProteomicsDBi | 61765 |
Protocols and materials databases
DNASUi | 337966 |
Genome annotation databases
Ensembli | ENST00000329122; ENSP00000332690; ENSG00000184724 |
GeneIDi | 337966 |
KEGGi | hsa:337966 |
UCSCi | uc002yop.4, human |
Organism-specific databases
CTDi | 337966 |
GeneCardsi | KRTAP6-1 |
HGNCi | HGNC:18931, KRTAP6-1 |
HPAi | ENSG00000184724, Tissue enriched (skin) |
neXtProti | NX_Q3LI64 |
PharmGKBi | PA134988301 |
VEuPathDBi | HostDB:ENSG00000184724 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TF3E, Eukaryota |
GeneTreei | ENSGT00950000183372 |
HOGENOMi | CLU_182642_0_0_1 |
OMAi | GSGYRCC |
Enzyme and pathway databases
PathwayCommonsi | Q3LI64 |
Reactomei | R-HSA-6805567, Keratinization |
SignaLinki | Q3LI64 |
Miscellaneous databases
BioGRID-ORCSi | 337966, 5 hits in 1025 CRISPR screens |
GenomeRNAii | 337966 |
Pharosi | Q3LI64, Tdark |
PROi | PR:Q3LI64 |
RNActi | Q3LI64, protein |
Gene expression databases
Bgeei | ENSG00000184724, Expressed in skin of abdomen and 10 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR040313, KAP6 |
PANTHERi | PTHR31678, PTHR31678, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KRA61_HUMAN | |
Accessioni | Q3LI64Primary (citable) accession number: Q3LI64 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2006 |
Last sequence update: | November 8, 2005 | |
Last modified: | February 23, 2022 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families