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Protein

Keratin-associated protein 21-3

Gene

KRTAP21-3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 21-3
Gene namesi
Name:KRTAP21-3
Synonyms:KAP21.3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000231068.1
HGNCiHGNC:34216 KRTAP21-3
neXtProtiNX_Q3LHN1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000231068
PharmGKBiPA165378419

Polymorphism and mutation databases

BioMutaiKRTAP21-3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003864481 – 58Keratin-associated protein 21-3Add BLAST58

Proteomic databases

PaxDbiQ3LHN1
PRIDEiQ3LHN1
ProteomicsDBi61756

Expressioni

Gene expression databases

BgeeiENSG00000231068

Organism-specific databases

HPAiHPA046554

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ3LHN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KCK1 Eukaryota
ENOG4110NVV LUCA
GeneTreeiENSGT00550000076392
HOGENOMiHOG000132480
InParanoidiQ3LHN1
OMAiSTHCGCN
OrthoDBiEOG091G1AY6

Sequencei

Sequence statusi: Complete.

Q3LHN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYFNYKSVCG SCGFGSCYGC GYGCIHSTHC GCNGYYGCYE NKYSVIDDLI

FFASKKCH
Length:58
Mass (Da):6,456
Last modified:November 8, 2005 - v1
Checksum:i61DA00333BEF8A45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB180042 mRNA Translation: BAE46381.1
CCDSiCCDS54481.1
RefSeqiNP_001157907.1, NM_001164435.1
UniGeneiHs.580877

Genome annotation databases

EnsembliENST00000444335; ENSP00000404517; ENSG00000231068
GeneIDi100288323
KEGGihsa:100288323
UCSCiuc021wii.1 human

Similar proteinsi

Entry informationi

Entry nameiKR213_HUMAN
AccessioniPrimary (citable) accession number: Q3LHN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: November 8, 2005
Last modified: June 20, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM

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