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Entry version 120 (02 Jun 2021)
Sequence version 2 (27 Jul 2011)
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Protein

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein

Gene

Prex2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8948751, Regulation of PTEN stability and activity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
Short name:
P-Rex2
Short name:
PtdIns(3,4,5)-dependent Rac exchanger 2
Alternative name(s):
DEP domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Prex2
Synonyms:Depdc2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1923385, Prex2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002867961 – 1598Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 proteinAdd BLAST1598

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3LAC4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3LAC4

PeptideAtlas

More...
PeptideAtlasi
Q3LAC4

PRoteomics IDEntifications database

More...
PRIDEi
Q3LAC4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
291652 [Q3LAC4-1]
291653 [Q3LAC4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3LAC4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3LAC4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000048960, Expressed in lung and 235 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3LAC4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAC1.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
224637, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q3LAC4, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000027056

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3LAC4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3LAC4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 206DHPROSITE-ProRule annotationAdd BLAST192
Domaini237 – 353PHPROSITE-ProRule annotationAdd BLAST117
Domaini382 – 456DEP 1PROSITE-ProRule annotationAdd BLAST75
Domaini483 – 558DEP 2PROSITE-ProRule annotationAdd BLAST76
Domaini584 – 663PDZ 1PROSITE-ProRule annotationAdd BLAST80
Domaini669 – 746PDZ 2PROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1573 – 1598DisorderedSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

PH domain confers substrate specificity and recognition. Able to discriminate between RAC1, RHOA, and CDC42 (By similarity).By similarity
DH domain alone was unable to confer substrate specificity and recognition.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3519, Eukaryota
KOG4428, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155894

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003935_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3LAC4

Identification of Orthologs from Complete Genome Data

More...
OMAi
VRQYNQK

Database of Orthologous Groups

More...
OrthoDBi
24217at2759

TreeFam database of animal gene trees

More...
TreeFami
TF328639

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04439, DEP_1_P-Rex, 1 hit
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 2 hits
1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899, DBL_dom_sf
IPR000591, DEP_dom
IPR000219, DH-domain
IPR001331, GDS_CDC24_CS
IPR001478, PDZ
IPR036034, PDZ_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR037367, Rex2_DEP_1
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00610, DEP, 2 hits
PF00169, PH, 1 hit
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00049, DEP, 2 hits
SM00228, PDZ, 2 hits
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785, SSF46785, 2 hits
SSF48065, SSF48065, 1 hit
SSF50156, SSF50156, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50186, DEP, 2 hits
PS00741, DH_1, 1 hit
PS50010, DH_2, 1 hit
PS50106, PDZ, 2 hits
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3LAC4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDESAREVD KQLRLRVCVL SELQKTERDY VGTLEFLVSA FLHRMNQCAA
60 70 80 90 100
AKVDKNVTEE TVKMLFSNIE EILIVHKEFL KVVEECLYPE PSAQQEVGAC
110 120 130 140 150
FLHFKDKFRI YDEYCSNHEK AQKLLLELNK IRTIRTFLLN CMLLGGRKNT
160 170 180 190 200
DVPLEGYLVT PIQRICKYPL LLKELLKRTP RRHSDYTAVM EALQAMKAVC
210 220 230 240 250
SNINEAKRQM EKLEVLEEWQ AHIEGWEGSN ITDTCTEMLM CGVLMKISSG
260 270 280 290 300
NIQERVFFLF DNLLVYCKRK HRRLKNSKAS TDGYRYVFRG RINTEVMEVE
310 320 330 340 350
NVDDGTADFH SSGHIVVNGW KIHNTAKNKW FVCMAKSPEE KHEWFEAILK
360 370 380 390 400
ERERRKGLKL GMEQDTWVMI SEQGEKLYKM MCKQGNLIKD RKRKLTTFPK
410 420 430 440 450
CFLGSEFVSW LLEIGEIHRP EEGVHLGQAL LENGIIHHVT DKHQFKPEQM
460 470 480 490 500
LYRFRYDDGT FYPRSEMQDV ISKGVRLYCR LHSLFTPVVR DKDYHLRTYK
510 520 530 540 550
SVVMANKLID WLIAQGDCRT REEAMIFAVG LCDNGFMHHV LEKSEFKDEP
560 570 580 590 600
LLFRFFADEE MEGSNMKHRL MKHDLKVVEN VIAKSLLIKS NEGSYGFGLE
610 620 630 640 650
DKNKVPIIKL VEKGSNAEMA GMEVGKKIFA INGDLVFLRP FPEVDCFLKS
660 670 680 690 700
CLNSRKPLRV LVSTKPRETV KIPDSADGLG FQIRGFGPSV VHAVGRGTVA
710 720 730 740 750
AAAGLHPGQC IIKVNGINVS KETHASVIAH VTACRKYKRP MKQDSIQWVY
760 770 780 790 800
DSLESAQEDI QKSHSKPPGD GAGDAFECKV EDVIDKFNTM AIIDGKKEHV
810 820 830 840 850
SLTVDNVHLE YGVVYEYDST AGTKCNVVEK MVEPKGFFSL TAKILEALAK
860 870 880 890 900
SDEHFVQNCT SLNSLNEVIA TDLQSKFTSM CSERIEHVCH RISSYGRFSR
910 920 930 940 950
VLKNRAWPTF KQAKPKISPL HSSDFCPTNC HVNVMEVSYP KTSTSLGSAF
960 970 980 990 1000
GVQLDSRKHN SHDKENKSVE PGKLSPMVYI QHTITTMAAP SGLSLGHKDG
1010 1020 1030 1040 1050
HGLQYLLKEE DLETQDIYHK LLGKLQTALK EVEMSVCQID DLLSSITYSP
1060 1070 1080 1090 1100
KLERKTTECV TPMDSDNEKG ERNSKRVCFN VAGDEQEDSG HDTVSNRDSY
1110 1120 1130 1140 1150
SDCNSNRNSI ASFTSICSSQ CSSYFHSDEM DSGDELPISV RISHDKQDKI
1160 1170 1180 1190 1200
HTCLEQLFSQ IDSIINLLKG QAVIRAFEQT KYLTPGRGLQ EFQQEMEAKL
1210 1220 1230 1240 1250
SCPRRLRLHL KQDPWNLPSS IQALAQSIRK HAEEVKCRIL LALLEYSDSE
1260 1270 1280 1290 1300
TQLRRDMVFC QSLVATVCAF SEQLMAALNQ MFDNSKENEM ETCEASRRWL
1310 1320 1330 1340 1350
DQIANAGVLF HFQSLLSPNL KDEQAMLEDT LVALFDLEKV SFFFKPSEED
1360 1370 1380 1390 1400
PLVANVPLTY QVEGSRQALK VYFYMDSYHF EQLPQRLKNG GGFKIHPVLF
1410 1420 1430 1440 1450
SQALESMEGY CYRDNISVEE FQAQINTASL EKVKQYNQKL RAFYLDKSNS
1460 1470 1480 1490 1500
PPNTTSKAAY IDKLMKPLNA LDELYRLITS FIRSKRIAAC VNTPCSASGV
1510 1520 1530 1540 1550
GLLSVSSELC DRLGACHIIM CSSGVHRCTL SVTLEQTITL ARSHGLPPRY
1560 1570 1580 1590
IMQAMDVMRK QGARVQNTAK NLGVRDRTPQ SAPRLYKLCE PPPPVGEE
Length:1,598
Mass (Da):181,717
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC9507BC9CC5EAD6
GO
Isoform 2 (identifier: Q3LAC4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     698-734: TVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTAC → ETFFAAASRSAPAGPLALPCPTEGSPQSARNGPLSLK
     735-1598: Missing.

Show »
Length:734
Mass (Da):84,364
Checksum:iCE509293E946F278
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WRD8A0A087WRD8_MOUSE
Phosphatidylinositol 3,4,5-trisphos...
Prex2
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WRG8A0A087WRG8_MOUSE
Phosphatidylinositol 3,4,5-trisphos...
Prex2
15Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WRV5A0A087WRV5_MOUSE
Phosphatidylinositol 3,4,5-trisphos...
Prex2
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WS21A0A087WS21_MOUSE
Phosphatidylinositol 3,4,5-trisphos...
Prex2
24Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB31066 differs from that shown. Reason: Frameshift.Curated
The sequence BAE25059 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1166N → T in CAJ33348 (PubMed:15304343).Curated1
Sequence conflicti1176 – 1178AFE → PFD in CAJ33348 (PubMed:15304343).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_025164698 – 734TVAAA…HVTAC → ETFFAAASRSAPAGPLALPC PTEGSPQSARNGPLSLK in isoform 2. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_025165735 – 1598Missing in isoform 2. 1 PublicationAdd BLAST864

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AM109952 mRNA Translation: CAJ33348.1
AC102481 Genomic DNA No translation available.
AC102529 Genomic DNA No translation available.
AC102631 Genomic DNA No translation available.
AC164600 Genomic DNA No translation available.
AK018093 mRNA Translation: BAB31066.1 Sequence problems.
AK138884 mRNA Translation: BAE23811.1
AK142414 mRNA Translation: BAE25059.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS48217.1 [Q3LAC4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_083801.1, NM_029525.1 [Q3LAC4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000027056; ENSMUSP00000027056; ENSMUSG00000048960 [Q3LAC4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
109294

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:109294

UCSC genome browser

More...
UCSCi
uc007ahs.2, mouse [Q3LAC4-1]
uc007aht.1, mouse [Q3LAC4-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM109952 mRNA Translation: CAJ33348.1
AC102481 Genomic DNA No translation available.
AC102529 Genomic DNA No translation available.
AC102631 Genomic DNA No translation available.
AC164600 Genomic DNA No translation available.
AK018093 mRNA Translation: BAB31066.1 Sequence problems.
AK138884 mRNA Translation: BAE23811.1
AK142414 mRNA Translation: BAE25059.1 Different initiation.
CCDSiCCDS48217.1 [Q3LAC4-1]
RefSeqiNP_083801.1, NM_029525.1 [Q3LAC4-1]

3D structure databases

SMRiQ3LAC4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi224637, 10 interactors
IntActiQ3LAC4, 1 interactor
STRINGi10090.ENSMUSP00000027056

PTM databases

iPTMnetiQ3LAC4
PhosphoSitePlusiQ3LAC4

Proteomic databases

MaxQBiQ3LAC4
PaxDbiQ3LAC4
PeptideAtlasiQ3LAC4
PRIDEiQ3LAC4
ProteomicsDBi291652 [Q3LAC4-1]
291653 [Q3LAC4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
2764, 61 antibodies

The DNASU plasmid repository

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DNASUi
109294

Genome annotation databases

EnsembliENSMUST00000027056; ENSMUSP00000027056; ENSMUSG00000048960 [Q3LAC4-1]
GeneIDi109294
KEGGimmu:109294
UCSCiuc007ahs.2, mouse [Q3LAC4-1]
uc007aht.1, mouse [Q3LAC4-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
80243
MGIiMGI:1923385, Prex2

Phylogenomic databases

eggNOGiKOG3519, Eukaryota
KOG4428, Eukaryota
GeneTreeiENSGT00940000155894
HOGENOMiCLU_003935_0_0_1
InParanoidiQ3LAC4
OMAiVRQYNQK
OrthoDBi24217at2759
TreeFamiTF328639

Enzyme and pathway databases

ReactomeiR-MMU-8948751, Regulation of PTEN stability and activity

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
109294, 0 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Prex2, mouse

Protein Ontology

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PROi
PR:Q3LAC4
RNActiQ3LAC4, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000048960, Expressed in lung and 235 other tissues
GenevisibleiQ3LAC4, MM

Family and domain databases

CDDicd04439, DEP_1_P-Rex, 1 hit
cd00160, RhoGEF, 1 hit
Gene3Di1.10.10.10, 2 hits
1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 2 hits
InterProiView protein in InterPro
IPR035899, DBL_dom_sf
IPR000591, DEP_dom
IPR000219, DH-domain
IPR001331, GDS_CDC24_CS
IPR001478, PDZ
IPR036034, PDZ_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR037367, Rex2_DEP_1
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610, DEP, 2 hits
PF00169, PH, 1 hit
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00049, DEP, 2 hits
SM00228, PDZ, 2 hits
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SUPFAMiSSF46785, SSF46785, 2 hits
SSF48065, SSF48065, 1 hit
SSF50156, SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50186, DEP, 2 hits
PS00741, DH_1, 1 hit
PS50010, DH_2, 1 hit
PS50106, PDZ, 2 hits
PS50003, PH_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPREX2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3LAC4
Secondary accession number(s): E9QMG3
, Q3UQI2, Q3UU18, Q9CXD5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 27, 2011
Last modified: June 2, 2021
This is version 120 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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