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Entry version 151 (12 Aug 2020)
Sequence version 2 (25 Nov 2008)
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Protein

Chromodomain-helicase-DNA-binding protein 9

Gene

CHD9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi885 – 892ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q3L8U1

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1368082, RORA activates gene expression
R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-1989781, PPARA activates gene expression
R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168, Activation of gene expression by SREBF (SREBP)
R-HSA-381340, Transcriptional regulation of white adipocyte differentiation
R-HSA-400206, Regulation of lipid metabolism by PPARalpha
R-HSA-400253, Circadian Clock

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromodomain-helicase-DNA-binding protein 9 (EC:3.6.4.12)
Short name:
CHD-9
Alternative name(s):
ATP-dependent helicase CHD9
Chromatin-related mesenchymal modulator
Short name:
CReMM
Chromatin-remodeling factor CHROM1
Kismet homolog 2
PPAR-alpha-interacting complex protein 320 kDa
Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHD9
Synonyms:KIAA0308, KISH2, PRIC320
ORF Names:AD-013, x0008
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000177200.15

Human Gene Nomenclature Database

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HGNCi
HGNC:25701, CHD9

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q3L8U1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80205

Open Targets

More...
OpenTargetsi
ENSG00000177200

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394727

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q3L8U1, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CHD9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215273951

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002331721 – 2897Chromodomain-helicase-DNA-binding protein 9Add BLAST2897

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki197Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei499N6-acetyllysineCombined sources1
Modified residuei550PhosphoserineCombined sources1
Cross-linki596Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei611PhosphoserineCombined sources1
Modified residuei1468PhosphoserineCombined sources1
Modified residuei1472PhosphoserineCombined sources1
Cross-linki1588Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1738Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1903Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei2026PhosphoserineCombined sources1
Cross-linki2038Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei2058PhosphoserineCombined sources1
Modified residuei2059PhosphoserineCombined sources1
Cross-linki2074Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei2075PhosphoserineCombined sources1
Modified residuei2079PhosphoserineCombined sources1
Cross-linki2350Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2356Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2361Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2843Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine and tyrosine residues.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3L8U1

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q3L8U1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q3L8U1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3L8U1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3L8U1

PeptideAtlas

More...
PeptideAtlasi
Q3L8U1

PRoteomics IDEntifications database

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PRIDEi
Q3L8U1

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
61749 [Q3L8U1-1]
61750 [Q3L8U1-2]
61751 [Q3L8U1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3L8U1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q3L8U1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed at low levels. In bone marrow, expression is restricted to osteoprogenitor cells adjacent to mature osteoblasts.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000177200, Expressed in corpus callosum and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q3L8U1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q3L8U1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000177200, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PPARA. Probably interacts with ESR1 and NR1I3.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
123174, 41 interactors

Protein interaction database and analysis system

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IntActi
Q3L8U1, 26 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000457466

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3L8U1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q3L8U1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini690 – 761Chromo 1PROSITE-ProRule annotationAdd BLAST72
Domaini773 – 839Chromo 2PROSITE-ProRule annotationAdd BLAST67
Domaini872 – 1046Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST175
Domaini1186 – 1337Helicase C-terminalPROSITE-ProRule annotationAdd BLAST152

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2332 – 2481Binds A/T-rich DNAAdd BLAST150
Regioni2429 – 2436A.T hook-like8

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi868 – 872LXXLL motif 15
Motifi997 – 1000DEAH box4
Motifi1036 – 1040LXXLL motif 25
Motifi2031 – 2035LXXLL motif 35
Motifi2721 – 2725LXXLL motif 45
Motifi2793 – 2798LXXLL motif 56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi220 – 312Ser-richAdd BLAST93
Compositional biasi562 – 666Lys-richAdd BLAST105
Compositional biasi2128 – 2198Ser-richAdd BLAST71
Compositional biasi2639 – 2650Poly-AlaAdd BLAST12
Compositional biasi2785 – 2788Poly-Ala4
Compositional biasi2878 – 2888Poly-SerAdd BLAST11

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0384, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000155706

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_000315_5_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q3L8U1

KEGG Orthology (KO)

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KOi
K14438

Identification of Orthologs from Complete Genome Data

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OMAi
VKEEYDQ

Database of Orthologous Groups

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OrthoDBi
7181at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q3L8U1

TreeFam database of animal gene trees

More...
TreeFami
TF313572

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.28.130, 2 hits
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006576, BRK_domain
IPR037259, BRK_sf
IPR042850, CHD9
IPR016197, Chromo-like_dom_sf
IPR000953, Chromo/chromo_shadow_dom
IPR023780, Chromo_domain
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR038718, SNF2-like_sf
IPR000330, SNF2_N

The PANTHER Classification System

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PANTHERi
PTHR46850, PTHR46850, 2 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF07533, BRK, 2 hits
PF00385, Chromo, 2 hits
PF00271, Helicase_C, 1 hit
PF00176, SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00592, BRK, 2 hits
SM00298, CHROMO, 2 hits
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF160481, SSF160481, 2 hits
SSF52540, SSF52540, 2 hits
SSF54160, SSF54160, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50013, CHROMO_2, 2 hits
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3L8U1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTDPMMDFFD DANLFGETLE GLSDDAFVQP GPVSLVDELN LGAEFEPLHI
60 70 80 90 100
DSLNHVQGTP THQKMTDFEQ LNQFDSIKFH HVNQSFGSPA EHVLSPHSQF
110 120 130 140 150
NCSPIHPQNQ PNGLFPDVSD GSPMWGHQTA TTISNQNGSP FHQQGHSHSM
160 170 180 190 200
HQNKSFVAHH DFALFQANEQ QTQCTSLRSQ QNRNNLNPGQ NSLSQSKNFM
210 220 230 240 250
NVSGPHRVNV NHPPQMTNAS NSQQSISMQQ FSQTSNPSAH FHKCSSHQEG
260 270 280 290 300
NFNGPSPNMT SCSVSNSQQF SSHYSFSSNH ISPNSLLQSS AVLASNHTNQ
310 320 330 340 350
TLSDFTGSNS FSPHRGIKQE STQHILNPNT SLNSNNFQIL HSSHPQGNYS
360 370 380 390 400
NSKLSPVHMN FPDPVDSGTQ MGHFNDHVET NGFSSLEENL LHQVESQTEP
410 420 430 440 450
FTGLDPEDLL QEGLLPHFDE STFGQDNSSH ILDHDLDRQF TSHLVTRPSD
460 470 480 490 500
MAQTQLQSQA RSWHSSFSNH QHLHDRNHLC LQRQPPSSKK SDGSGTYTKL
510 520 530 540 550
QNTQVRVMSE KKQRKKVESE SKQEKANRII SEAIAKAKER GERNIPRVMS
560 570 580 590 600
PENFPTASVE GKEEKKGRRM KSKPKDKDSK KTKTCSKLKE KTKIGKLIIT
610 620 630 640 650
LGKKQKRKNE SSDEISDAEQ MPQHTLKDQD SQKRRSNRQI KRKKYAEDIE
660 670 680 690 700
GKQSEEEVKG SMKIKKNSAP LPGEQPLQLF VENPSEEDAA IVDKILSSRT
710 720 730 740 750
VKKEISPGVM IDTEEFFVKY KNYSYLHCEW ATEEQLLKDK RIQQKIKRFK
760 770 780 790 800
LRQAQRAHFF ADMEEEPFNP DYVEVDRVLE VSFCEDKDTG EPVIYYLVKW
810 820 830 840 850
CSLPYEDSTW ELKEDVDLAK IEEFEQLQAS RPDTRRLDRP PSNIWKKIDQ
860 870 880 890 900
SRDYKNGNQL REYQLEGLNW LLFNWYNRRN CILADEMGLG KTIQSITFLY
910 920 930 940 950
EILLTGIRGP FLIIAPLSTI ANWEREFRTW TDINVVVYHG SLISRQMIQQ
960 970 980 990 1000
YEMYFRDSQG RIIRGAYRFQ AIITTFEMIL GGCGELNAIE WRCVIIDEAH
1010 1020 1030 1040 1050
RLKNKNCKLL EGLKLMNLEH KVLLTGTPLQ NTVEELFSLL HFLEPLRFPS
1060 1070 1080 1090 1100
ESTFMQEFGD LKTEEQVQKL QAILKPMMLR RLKEDVEKKL APKEETIIEV
1110 1120 1130 1140 1150
ELTNIQKKYY RAILEKNFSF LSKGAGQTNV PNLVNTMMEL RKCCNHPYLI
1160 1170 1180 1190 1200
KGAEEKILGE FRDTYNPAAS DFHLQAMIQS AGKLVLIDKL LPKMKAGGHK
1210 1220 1230 1240 1250
VLIFSQMVRC LDILEDYLIH KRYLYERIDG RVRGNLRQAA IDRFSKPDSD
1260 1270 1280 1290 1300
RFVFLLCTRA GGLGINLTAA DTCIIFDSDW NPQNDLQAQA RCHRIGQNKA
1310 1320 1330 1340 1350
VKVYRLVTRN SYEREMFDRA SLKLGLDKAV LQSMSGRESN VGGIQQLSKK
1360 1370 1380 1390 1400
EIEDLLRRGA YGAIMEEEDE GSKFCEEDID QILLRRTKTI TIESEGRGST
1410 1420 1430 1440 1450
FAKASFVASG NRTDISLDDP NFWQKWAKKA EIDIEAISGR NSLVIDTPRI
1460 1470 1480 1490 1500
RKQTRPFSAT KDELAELSEA ESEGDEKPKL RRPCDRSNGY GRTECFRVEK
1510 1520 1530 1540 1550
NLLVYGWGRW REILSHGRFK RQLNEHDVEI ICRALLAYCL VHYRGDEKIK
1560 1570 1580 1590 1600
GFIWDLITPT EDGQTRELQN HLGLSAPVPR GRKGKKVKTQ TSSFDIQKAE
1610 1620 1630 1640 1650
WLRKYNPEQL LQDEGYKKHI KHHCNKVLLR VRMLYYLKQE VIGNECQKVF
1660 1670 1680 1690 1700
DGVDASDIDV WVPEPDHSEV PAEWWDFDAD KSLLIGVFKH GYEKYNTIRA
1710 1720 1730 1740 1750
DPALCFLERV GKPDEKAVAA EQRANDYMDG DVEDPEYKPA PAIFKDDIED
1760 1770 1780 1790 1800
DVSSPGDLVI ADGDGQLMEG DKVYWPTQSA LTTRLRRLIT AYQRTNKNRQ
1810 1820 1830 1840 1850
IQQIQPTFSV PTSVMQPIYE EATLNPKMAA KIERQQRWTR REEADFYRVV
1860 1870 1880 1890 1900
STFGVVFDPD RGQFDWTKFR AMARLHKKTD DSLEKYLYAF MSMCRRVCRL
1910 1920 1930 1940 1950
PSKEELVDPN IFIQPITEER ASRTLYRIEL LRKVREQALR HPQLFERLKL
1960 1970 1980 1990 2000
CHPNPDLPVW WECGPHDRDL LIGAAKHGVS RTDYHILRDP ELSFMAAQRN
2010 2020 2030 2040 2050
YSQSKMAHSR TSTPLLQQYQ VALSASPLTS LPRLLDAKGI ILEEMKVKSE
2060 2070 2080 2090 2100
NLKEEPQSSE EESMSSVETR TLIKSEPVSP KNGVLPQATG DQKSGGKCET
2110 2120 2130 2140 2150
DRRMVAARTE PLTPNPASKK PRVHKRGSES SSDSDSDSER SSCSSRSSSS
2160 2170 2180 2190 2200
SSSSSCSHSR SGSSSSSSSS CSSASSSSSS STSSSSSSSS SSSEESDSDE
2210 2220 2230 2240 2250
EEAQKRESTT HMKAYDEESV ASLSTTQDET QDSFQMNNGT PESAYILQGG
2260 2270 2280 2290 2300
YMLAASYWPK DRVMINRLDS ICQTVLKGKW PSARRSYDAN TVASFYTTKL
2310 2320 2330 2340 2350
LDSPGAATEY SDPSVPTPPG AGVKEEHDQS TQMSKVKKHV REKEFTVKIK
2360 2370 2380 2390 2400
DEGGLKLTFQ KQGLAQKRPF DGEDGALGQQ QYLTRLRELQ SASETSLVNF
2410 2420 2430 2440 2450
PKSIPVSGTS IQPTLGANGV ILDNQPIVKK RRGRRKNVEG VDIFFFNRNK
2460 2470 2480 2490 2500
PPNHVSLGLT SSQISTGINP ALSYTQPQGI PDTESPVPVI NLKDGTRLAG
2510 2520 2530 2540 2550
DDAPKRKDLE KWLKEHPGYV EDLGAFIPRM QLHEGRPKQK RHRCRNPNKL
2560 2570 2580 2590 2600
DVNSLTGEER VQLINRRNAR KVGGAFAPPL KDLCRFLKEN SEYGVAPEWG
2610 2620 2630 2640 2650
DVVKQSGFLP ESMYERILTG PVVREEVSRR GRRPKSGIAK ATAAAAAASA
2660 2670 2680 2690 2700
TSVSGNPLLA NGLLPGVDLT TLQALQQNLQ NLQSLQVTAG LMGMPTGLPS
2710 2720 2730 2740 2750
GGEAKNMAAM FPMLLSGMAG LPNLLGMGGL LTKPTESGTE DKKGSDSKES
2760 2770 2780 2790 2800
EGKTERTESQ SSENGGENSV SSSPSTSSTA ALNTAAAANP LALNPLLLSN
2810 2820 2830 2840 2850
ILYPGMLLTP GLNLHIPTLS QSNTFDVQNK NSDLGSSKSV EVKEEDSRIK
2860 2870 2880 2890
DQEDKGGTEP SPLNENSTDE GSEKADASSG SDSTSSSSED SDSSNED
Length:2,897
Mass (Da):326,022
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i91884A5E2F8ED183
GO
Isoform 2 (identifier: Q3L8U1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2336-2351: Missing.

Show »
Length:2,881
Mass (Da):324,055
Checksum:i5D325328A88F5E4E
GO
Isoform 3 (identifier: Q3L8U1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2206-2206: R → RA
     2336-2351: Missing.

Show »
Length:2,882
Mass (Da):324,127
Checksum:iE5E272E36C779BB6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BTW3H3BTW3_HUMAN
DNA helicase
CHD9
2,424Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WU44A0A087WU44_HUMAN
Chromodomain-helicase-DNA-binding p...
CHD9
963Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSP3H3BSP3_HUMAN
Chromodomain-helicase-DNA-binding p...
CHD9
632Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRU9H3BRU9_HUMAN
Chromodomain-helicase-DNA-binding p...
CHD9
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRH9J3KRH9_HUMAN
Chromodomain-helicase-DNA-binding p...
CHD9
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSW5J3KSW5_HUMAN
Chromodomain-helicase-DNA-binding p...
CHD9
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BV31H3BV31_HUMAN
Chromodomain-helicase-DNA-binding p...
CHD9
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L340I3L340_HUMAN
Chromodomain-helicase-DNA-binding p...
CHD9
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF24170 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAB14112 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti98 – 100SQF → PQL in AAT66509 (Ref. 3) Curated3
Sequence conflicti119S → P in AAT66509 (Ref. 3) Curated1
Sequence conflicti208V → A in AAT66509 (Ref. 3) Curated1
Sequence conflicti473L → I in AAT66509 (Ref. 3) Curated1
Sequence conflicti836R → C in ABD24032 (PubMed:16554032).Curated1
Sequence conflicti836R → C in BAA20767 (PubMed:9205841).Curated1
Sequence conflicti1072A → V in ABD24032 (PubMed:16554032).Curated1
Sequence conflicti1072A → V in BAB14112 (PubMed:14702039).Curated1
Sequence conflicti1122S → F in AAT66509 (Ref. 3) Curated1
Sequence conflicti1372S → P in AAT66509 (Ref. 3) Curated1
Sequence conflicti1442S → G in ABD24032 (PubMed:16554032).Curated1
Sequence conflicti1442S → G in BAB14112 (PubMed:14702039).Curated1
Sequence conflicti1724A → T in AAT66509 (Ref. 3) Curated1
Sequence conflicti1754S → L in AAT66509 (Ref. 3) Curated1
Sequence conflicti1867T → A in AAT66509 (Ref. 3) Curated1
Sequence conflicti2025A → V in AAT66509 (Ref. 3) Curated1
Sequence conflicti2069T → A in AAT66509 (Ref. 3) Curated1
Sequence conflicti2078V → G in AAT66509 (Ref. 3) Curated1
Sequence conflicti2189S → F in AAT66509 (Ref. 3) Curated1
Sequence conflicti2759S → N in AAT66509 (Ref. 3) Curated1
Sequence conflicti2776T → A in AAQ24287 (PubMed:16095617).Curated1
Sequence conflicti2776T → A in BAA20767 (PubMed:9205841).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0473552312D → E3 PublicationsCorresponds to variant dbSNP:rs6499548Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0180852206R → RA in isoform 3. 1 Publication1
Alternative sequenceiVSP_0180862336 – 2351Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY243500 mRNA Translation: AAQ24287.1
DQ333316 mRNA Translation: ABD24032.1
AY647157 mRNA Translation: AAT66509.1
AC007906 Genomic DNA No translation available.
AC079416 Genomic DNA No translation available.
BC140815 mRNA Translation: AAI40816.1
AB002306 mRNA Translation: BAA20767.3
AF150735 mRNA Translation: AAF24170.1 Sequence problems.
AK022582 mRNA Translation: BAB14112.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45485.1 [Q3L8U1-2]
CCDS76865.1 [Q3L8U1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001295248.1, NM_001308319.1 [Q3L8U1-1]
NP_079410.4, NM_025134.4 [Q3L8U1-2]
XP_005256229.1, XM_005256172.3
XP_016879210.1, XM_017023721.1 [Q3L8U1-1]
XP_016879211.1, XM_017023722.1 [Q3L8U1-3]
XP_016879212.1, XM_017023723.1 [Q3L8U1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000398510; ENSP00000381522; ENSG00000177200 [Q3L8U1-1]
ENST00000447540; ENSP00000396345; ENSG00000177200 [Q3L8U1-1]
ENST00000564845; ENSP00000455307; ENSG00000177200 [Q3L8U1-2]
ENST00000566029; ENSP00000457466; ENSG00000177200 [Q3L8U1-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80205

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80205

UCSC genome browser

More...
UCSCi
uc002egy.4, human [Q3L8U1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY243500 mRNA Translation: AAQ24287.1
DQ333316 mRNA Translation: ABD24032.1
AY647157 mRNA Translation: AAT66509.1
AC007906 Genomic DNA No translation available.
AC079416 Genomic DNA No translation available.
BC140815 mRNA Translation: AAI40816.1
AB002306 mRNA Translation: BAA20767.3
AF150735 mRNA Translation: AAF24170.1 Sequence problems.
AK022582 mRNA Translation: BAB14112.1 Different initiation.
CCDSiCCDS45485.1 [Q3L8U1-2]
CCDS76865.1 [Q3L8U1-1]
RefSeqiNP_001295248.1, NM_001308319.1 [Q3L8U1-1]
NP_079410.4, NM_025134.4 [Q3L8U1-2]
XP_005256229.1, XM_005256172.3
XP_016879210.1, XM_017023721.1 [Q3L8U1-1]
XP_016879211.1, XM_017023722.1 [Q3L8U1-3]
XP_016879212.1, XM_017023723.1 [Q3L8U1-2]

3D structure databases

SMRiQ3L8U1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123174, 41 interactors
IntActiQ3L8U1, 26 interactors
STRINGi9606.ENSP00000457466

PTM databases

iPTMnetiQ3L8U1
PhosphoSitePlusiQ3L8U1

Polymorphism and mutation databases

BioMutaiCHD9
DMDMi215273951

Proteomic databases

EPDiQ3L8U1
jPOSTiQ3L8U1
MassIVEiQ3L8U1
MaxQBiQ3L8U1
PaxDbiQ3L8U1
PeptideAtlasiQ3L8U1
PRIDEiQ3L8U1
ProteomicsDBi61749 [Q3L8U1-1]
61750 [Q3L8U1-2]
61751 [Q3L8U1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
28339, 61 antibodies

Genome annotation databases

EnsembliENST00000398510; ENSP00000381522; ENSG00000177200 [Q3L8U1-1]
ENST00000447540; ENSP00000396345; ENSG00000177200 [Q3L8U1-1]
ENST00000564845; ENSP00000455307; ENSG00000177200 [Q3L8U1-2]
ENST00000566029; ENSP00000457466; ENSG00000177200 [Q3L8U1-2]
GeneIDi80205
KEGGihsa:80205
UCSCiuc002egy.4, human [Q3L8U1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80205
DisGeNETi80205
EuPathDBiHostDB:ENSG00000177200.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CHD9
HGNCiHGNC:25701, CHD9
HPAiENSG00000177200, Low tissue specificity
neXtProtiNX_Q3L8U1
OpenTargetsiENSG00000177200
PharmGKBiPA128394727

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0384, Eukaryota
GeneTreeiENSGT00940000155706
HOGENOMiCLU_000315_5_1_1
InParanoidiQ3L8U1
KOiK14438
OMAiVKEEYDQ
OrthoDBi7181at2759
PhylomeDBiQ3L8U1
TreeFamiTF313572

Enzyme and pathway databases

PathwayCommonsiQ3L8U1
ReactomeiR-HSA-1368082, RORA activates gene expression
R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-1989781, PPARA activates gene expression
R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168, Activation of gene expression by SREBF (SREBP)
R-HSA-381340, Transcriptional regulation of white adipocyte differentiation
R-HSA-400206, Regulation of lipid metabolism by PPARalpha
R-HSA-400253, Circadian Clock

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
80205, 4 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CHD9, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CHD9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80205
PharosiQ3L8U1, Tbio

Protein Ontology

More...
PROi
PR:Q3L8U1
RNActiQ3L8U1, protein

Gene expression databases

BgeeiENSG00000177200, Expressed in corpus callosum and 250 other tissues
ExpressionAtlasiQ3L8U1, baseline and differential
GenevisibleiQ3L8U1, HS

Family and domain databases

Gene3Di2.20.28.130, 2 hits
3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR006576, BRK_domain
IPR037259, BRK_sf
IPR042850, CHD9
IPR016197, Chromo-like_dom_sf
IPR000953, Chromo/chromo_shadow_dom
IPR023780, Chromo_domain
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR038718, SNF2-like_sf
IPR000330, SNF2_N
PANTHERiPTHR46850, PTHR46850, 2 hits
PfamiView protein in Pfam
PF07533, BRK, 2 hits
PF00385, Chromo, 2 hits
PF00271, Helicase_C, 1 hit
PF00176, SNF2_N, 1 hit
SMARTiView protein in SMART
SM00592, BRK, 2 hits
SM00298, CHROMO, 2 hits
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF160481, SSF160481, 2 hits
SSF52540, SSF52540, 2 hits
SSF54160, SSF54160, 2 hits
PROSITEiView protein in PROSITE
PS50013, CHROMO_2, 2 hits
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHD9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3L8U1
Secondary accession number(s): B2RTU2
, B9ZVQ0, O15025, Q1WF12, Q6DTK9, Q9H9V7, Q9UHM2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 25, 2008
Last modified: August 12, 2020
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
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