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Protein

Protein Wnt-7b

Gene

WNT7B

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Required for normal fusion of the chorion and the allantois during placenta development (By similarity). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity).By similarity

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • receptor ligand activity Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-GGA-3238698 WNT ligand biogenesis and trafficking

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-7b
Gene namesi
Name:WNT7B
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000039267425 – 349Protein Wnt-7bAdd BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi73 ↔ 84By similarity
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi123 ↔ 131By similarity
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi133 ↔ 152By similarity
Disulfide bondi200 ↔ 214By similarity
Disulfide bondi202 ↔ 209By similarity
Lipidationi206O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi294 ↔ 309By similarity
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi324 ↔ 339By similarity
Disulfide bondi326 ↔ 336By similarity
Disulfide bondi331 ↔ 332By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiQ3L254
PRIDEiQ3L254

Expressioni

Tissue specificityi

Expressed in differentiating lens fiber cells.1 Publication

Developmental stagei

Detected in the anterior parencephalon and secondary prosencephalon at stages 20 and 24. Expressed in the ventricular epithelium of the spinal cord at the latest stages.1 Publication

Gene expression databases

BgeeiENSGALG00000014235 Expressed in 2 organ(s), highest expression level in cerebellum

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000029875

Structurei

3D structure databases

SMRiQ3L254
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni238 – 266Intrinsically disordered linkerBy similarityAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi304 – 339Cys-richAdd BLAST36

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00760000118943
HOGENOMiHOG000039528
HOVERGENiHBG001595
InParanoidiQ3L254
KOiK00572
OMAiCCQVECE
OrthoDBiEOG091G0OFF
PhylomeDBiQ3L254
TreeFamiTF105310

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR013300 Wnt7
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01891 WNT7PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q3L254-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHRNFRKWIF YVFLCFGVIY VKLGALSSVV ALGANIICNK IPGLAPRQRA
60 70 80 90 100
ICQSRPDAII VIGEGAQMGI NECQYQFRYG RWNCSALGEK TVFGQELRVG
110 120 130 140 150
SREAAFTYAI TAAGVAHAVT AACSQGNLSN CGCDREKQGY YNQEEGWKWG
160 170 180 190 200
GCSADIRYGI EFSRRFVDAR EIKKNARRLM NLHNNEAGRK VLEERMKLEC
210 220 230 240 250
KCHGVSGSCT TKTCWTTLPK FREIGYILKE KYNAAVQVEV VRASRLRQPT
260 270 280 290 300
FLKIKQIKSY QKPMETDLVY IEKSPNYCEE DASTGSVGTQ GRLCNRTSPN
310 320 330 340
ADGCDMMCCG RGYNTHQYTK VWQCNCKFHW CCFVKCNTCS ERTEVFTCK
Length:349
Mass (Da):39,530
Last modified:November 8, 2005 - v1
Checksum:i7E65DDBB1F069B83
GO
Isoform 2 (identifier: Q3L254-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MHRNFRKWIFYVFLCFGVIYVKLG → MILFSSRSVLLSVYYPQIFLILTSGSYL

Note: Produced by alternative splicing.
Show »
Length:353
Mass (Da):39,705
Checksum:iD30A2978758CF46D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0388471 – 24MHRNF…YVKLG → MILFSSRSVLLSVYYPQIFL ILTSGSYL in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY753290 mRNA Translation: AAW81992.1
AY753291 mRNA Translation: AAW81993.1
RefSeqiNP_001032351.1, NM_001037274.1 [Q3L254-1]
NP_001165064.1, NM_001171593.1 [Q3L254-2]
UniGeneiGga.32583

Genome annotation databases

EnsembliENSGALT00000048993; ENSGALP00000046960; ENSGALG00000036255 [Q3L254-2]
ENSGALT00000050637; ENSGALP00000048489; ENSGALG00000036255 [Q3L254-1]
GeneIDi427937
KEGGigga:427937

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY753290 mRNA Translation: AAW81992.1
AY753291 mRNA Translation: AAW81993.1
RefSeqiNP_001032351.1, NM_001037274.1 [Q3L254-1]
NP_001165064.1, NM_001171593.1 [Q3L254-2]
UniGeneiGga.32583

3D structure databases

SMRiQ3L254
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000029875

Proteomic databases

PaxDbiQ3L254
PRIDEiQ3L254

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000048993; ENSGALP00000046960; ENSGALG00000036255 [Q3L254-2]
ENSGALT00000050637; ENSGALP00000048489; ENSGALG00000036255 [Q3L254-1]
GeneIDi427937
KEGGigga:427937

Organism-specific databases

CTDi7477

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00760000118943
HOGENOMiHOG000039528
HOVERGENiHBG001595
InParanoidiQ3L254
KOiK00572
OMAiCCQVECE
OrthoDBiEOG091G0OFF
PhylomeDBiQ3L254
TreeFamiTF105310

Enzyme and pathway databases

ReactomeiR-GGA-3238698 WNT ligand biogenesis and trafficking

Miscellaneous databases

PROiPR:Q3L254

Gene expression databases

BgeeiENSGALG00000014235 Expressed in 2 organ(s), highest expression level in cerebellum

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR013300 Wnt7
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01891 WNT7PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWNT7B_CHICK
AccessioniPrimary (citable) accession number: Q3L254
Secondary accession number(s): Q3L253
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: November 8, 2005
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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