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Protein

Kelch domain-containing protein 2

Gene

Klhdc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch domain-containing protein 2
Gene namesi
Name:Klhdc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1306504 Klhdc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002289941 – 406Kelch domain-containing protein 2Add BLAST406

Proteomic databases

PaxDbiQ3KRE6

Expressioni

Gene expression databases

BgeeiENSRNOG00000004474 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ3KRE6 RN

Interactioni

Subunit structurei

Directly interacts with CREB3, but not with CREB1, ATF4, ATF6, JUN, FOS, CEBPA.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006223

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 89Kelch 1Add BLAST47
Repeati102 – 155Kelch 2Add BLAST54
Repeati157 – 202Kelch 3Add BLAST46
Repeati229 – 278Kelch 4Add BLAST50
Repeati280 – 329Kelch 5Add BLAST50
Repeati331 – 377Kelch 6Add BLAST47

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG0379 Eukaryota
ENOG410Y5WM LUCA
GeneTreeiENSGT00760000119086
HOGENOMiHOG000006587
HOVERGENiHBG067471
InParanoidiQ3KRE6
OMAiCATVGNK
OrthoDBiEOG091G06BF
PhylomeDBiQ3KRE6
TreeFamiTF314081

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR015915 Kelch-typ_b-propeller
SUPFAMiSSF117281 SSF117281, 2 hits

Sequencei

Sequence statusi: Complete.

Q3KRE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADGNEDARA EDMPGPAFEG YEAMELACPA ERSGHVAVSD GRHMFVWGGY
60 70 80 90 100
KSNQVRGLYD FYLPREELWI YNMETGRWKK INTEGDVPPS MSGSCAVCVD
110 120 130 140 150
RVLYLFGGHH SRGNTNKFYM LDSRSADRVL QWERIDCQGI PPSSKDKLGV
160 170 180 190 200
WVYKNKLIFF GGYGYLPEDK VLGTFEFDET SFWNSSHPRG WNDHVHILDT
210 220 230 240 250
ETFAWSQPIT TGKAPSPRAA HACATVGNKG FVFGGRYRDA RMNDLHYLNL
260 270 280 290 300
DTWEWNELIP QGICPVGRSW HSLTPVSSDH LFLFGGFTTE KQPLSDAWTY
310 320 330 340 350
CISKNEWIQF NHPYVEKPRL WHTACASDEG EVIVFGGCAN NLLVHHRAAH
360 370 380 390 400
SNEVLIFSVQ PKSLVRLSLE AVICFKEMLA NSWSCLPKHL LHSVNQRFGS

NNTSGS
Length:406
Mass (Da):45,926
Last modified:November 8, 2005 - v1
Checksum:iF06F8452B63BE0D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105756 mRNA Translation: AAI05757.1
RefSeqiNP_001029305.1, NM_001034133.1
UniGeneiRn.129179

Genome annotation databases

EnsembliENSRNOT00000006223; ENSRNOP00000006223; ENSRNOG00000004474
GeneIDi299113
KEGGirno:299113
UCSCiRGD:1306504 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105756 mRNA Translation: AAI05757.1
RefSeqiNP_001029305.1, NM_001034133.1
UniGeneiRn.129179

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006223

Proteomic databases

PaxDbiQ3KRE6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006223; ENSRNOP00000006223; ENSRNOG00000004474
GeneIDi299113
KEGGirno:299113
UCSCiRGD:1306504 rat

Organism-specific databases

CTDi23588
RGDi1306504 Klhdc2

Phylogenomic databases

eggNOGiKOG0379 Eukaryota
ENOG410Y5WM LUCA
GeneTreeiENSGT00760000119086
HOGENOMiHOG000006587
HOVERGENiHBG067471
InParanoidiQ3KRE6
OMAiCATVGNK
OrthoDBiEOG091G06BF
PhylomeDBiQ3KRE6
TreeFamiTF314081

Miscellaneous databases

PROiPR:Q3KRE6

Gene expression databases

BgeeiENSRNOG00000004474 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ3KRE6 RN

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR015915 Kelch-typ_b-propeller
SUPFAMiSSF117281 SSF117281, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKLDC2_RAT
AccessioniPrimary (citable) accession number: Q3KRE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 8, 2005
Last modified: September 12, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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