Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 118 (12 Aug 2020)
Sequence version 1 (08 Nov 2005)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Guanine nucleotide-binding protein subunit gamma

Gene

Gng10

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransducerUniRule annotationARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-1296041, Activation of G protein gated Potassium channels
R-RNO-202040, G-protein activation
R-RNO-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-RNO-392170, ADP signalling through P2Y purinoceptor 12
R-RNO-392451, G beta:gamma signalling through PI3Kgamma
R-RNO-392851, Prostacyclin signalling through prostacyclin receptor
R-RNO-400042, Adrenaline,noradrenaline inhibits insulin secretion
R-RNO-4086398, Ca2+ pathway
R-RNO-416476, G alpha (q) signalling events
R-RNO-416482, G alpha (12/13) signalling events
R-RNO-418217, G beta:gamma signalling through PLC beta
R-RNO-418555, G alpha (s) signalling events
R-RNO-418592, ADP signalling through P2Y purinoceptor 1
R-RNO-418594, G alpha (i) signalling events
R-RNO-418597, G alpha (z) signalling events
R-RNO-420092, Glucagon-type ligand receptors
R-RNO-428930, Thromboxane signalling through TP receptor
R-RNO-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-RNO-456926, Thrombin signalling through proteinase activated receptors (PARs)
R-RNO-500657, Presynaptic function of Kainate receptors
R-RNO-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-RNO-8964315, G beta:gamma signalling through BTK
R-RNO-8964616, G beta:gamma signalling through CDC42
R-RNO-9009391, Extra-nuclear estrogen signaling
R-RNO-997272, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit gammaUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gng10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Rat genome database

More...
RGDi
621514, Gng10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membraneUniRule annotationARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Lipoprotein, MethylationARBA annotation, PrenylationARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000025040, Expressed in duodenum and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma.

UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000020707

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 68G protein gammaInterPro annotationAdd BLAST66

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G protein gamma family.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4119, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01000000214489

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_168377_3_0_1

KEGG Orthology (KO)

More...
KOi
K04545

Identification of Orthologs from Complete Genome Data

More...
OMAi
QNACKDE

Database of Orthologous Groups

More...
OrthoDBi
1581168at2759

TreeFam database of animal gene trees

More...
TreeFami
TF319909

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00068, GGL, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.260.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015898, G-protein_gamma-like_dom
IPR036284, GGL_sf
IPR001770, Gprotein-gamma

The PANTHER Classification System

More...
PANTHERi
PTHR13809, PTHR13809, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00631, G-gamma, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00321, GPROTEING

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00224, GGL, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48670, SSF48670, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50058, G_PROTEIN_GAMMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3KRE3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSGASVSAL QRLVEQLKLE AGVERIKVSQ AAAELQQYCI QNACKDALLL
60
GVPAGSNPFR EPRSCALL
Length:68
Mass (Da):7,229
Last modified:November 8, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFCE33C306AE7EE5A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07048386 Genomic DNA No translation available.
BC105759 mRNA Translation: AAI05760.1

NCBI Reference Sequences

More...
RefSeqi
NP_446112.1, NM_053660.2
XP_017448605.1, XM_017593116.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000020707; ENSRNOP00000020707; ENSRNOG00000025040

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
114119

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:114119

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07048386 Genomic DNA No translation available.
BC105759 mRNA Translation: AAI05760.1
RefSeqiNP_446112.1, NM_053660.2
XP_017448605.1, XM_017593116.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020707

Genome annotation databases

EnsembliENSRNOT00000020707; ENSRNOP00000020707; ENSRNOG00000025040
GeneIDi114119
KEGGirno:114119

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2790
RGDi621514, Gng10

Phylogenomic databases

eggNOGiKOG4119, Eukaryota
GeneTreeiENSGT01000000214489
HOGENOMiCLU_168377_3_0_1
KOiK04545
OMAiQNACKDE
OrthoDBi1581168at2759
TreeFamiTF319909

Enzyme and pathway databases

ReactomeiR-RNO-1296041, Activation of G protein gated Potassium channels
R-RNO-202040, G-protein activation
R-RNO-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-RNO-392170, ADP signalling through P2Y purinoceptor 12
R-RNO-392451, G beta:gamma signalling through PI3Kgamma
R-RNO-392851, Prostacyclin signalling through prostacyclin receptor
R-RNO-400042, Adrenaline,noradrenaline inhibits insulin secretion
R-RNO-4086398, Ca2+ pathway
R-RNO-416476, G alpha (q) signalling events
R-RNO-416482, G alpha (12/13) signalling events
R-RNO-418217, G beta:gamma signalling through PLC beta
R-RNO-418555, G alpha (s) signalling events
R-RNO-418592, ADP signalling through P2Y purinoceptor 1
R-RNO-418594, G alpha (i) signalling events
R-RNO-418597, G alpha (z) signalling events
R-RNO-420092, Glucagon-type ligand receptors
R-RNO-428930, Thromboxane signalling through TP receptor
R-RNO-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-RNO-456926, Thrombin signalling through proteinase activated receptors (PARs)
R-RNO-500657, Presynaptic function of Kainate receptors
R-RNO-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-RNO-8964315, G beta:gamma signalling through BTK
R-RNO-8964616, G beta:gamma signalling through CDC42
R-RNO-9009391, Extra-nuclear estrogen signaling
R-RNO-997272, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Gene expression databases

BgeeiENSRNOG00000025040, Expressed in duodenum and 21 other tissues

Family and domain databases

CDDicd00068, GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898, G-protein_gamma-like_dom
IPR036284, GGL_sf
IPR001770, Gprotein-gamma
PANTHERiPTHR13809, PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631, G-gamma, 1 hit
PRINTSiPR00321, GPROTEING
SMARTiView protein in SMART
SM00224, GGL, 1 hit
SUPFAMiSSF48670, SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058, G_PROTEIN_GAMMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ3KRE3_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3KRE3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: August 12, 2020
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again