AT rich interactive domain 5A (Mrf1 like)

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• androgen receptor binding Source: RGD
• chromatin binding Source: RGD
• estrogen receptor binding Source: RGD
• identical protein binding Source: RGD
• retinoid X receptor binding Source: RGD
• RNA stem-loop binding Source: RGD
• sequence-specific DNA binding Source: RGD
• thyroid hormone receptor binding Source: RGD
• transcription corepressor activity Source: RGD
• transcription factor binding Source: RGD
• transcription regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular response to estrogen stimulus Source: RGD
• cellular response to lipopolysaccharide Source: RGD
• chondrocyte differentiation Source: RGD
• negative regulation of transcription by RNA polymerase II Source: RGD
• positive regulation of histone acetylation Source: RGD
• positive regulation of interferon-gamma production Source: RGD
• positive regulation of interleukin-17 production Source: RGD
• positive regulation of interleukin-6 production Source: RGD
• positive regulation of T-helper 17 type immune response Source: RGD
• positive regulation of T-helper 1 cell cytokine production Source: RGD
• positive regulation of transcription by RNA polymerase II Source: RGD
• positive regulation of tumor necrosis factor secretion Source: RGD
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• androgen receptor binding Source: RGD
• estrogen receptor binding Source: RGD
• identical protein binding Source: RGD
• retinoid X receptor binding Source: RGD
• thyroid hormone receptor binding Source: RGD
• transcription factor binding Source: RGD

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

Phylogenomic databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MAKELRGDDG ATEKLKKAKD SEERQADQTT SEKTKSDAPG QTQLPRQGSS 
        60         70         80         90        100
RDSTEQLGPV SGSSPPFLGA NSCPEAYKRL LASFYCKGAH GIMSPLAKKK 
       110        120        130        140        150
LLAQVSKAEA LQCQEEGCRH GARSPNKDLQ ESSQNPRGLA ENSEHQLTPP 
       160        170        180        190        200
EGLRAPGGST GVEAQVGPCP TAPTFLGRFH AYPTEVLKPV SQHPRDFFSS 
       210        220        230        240        250
LKDRVLLGPP GKEEGLTAKE SQLVWGGDAN RPSAFHKGST RKRSFYPKPK 
       260        270        280        290        300
ACWVSPMAKV PAESPGAPLP HPRSPGLSKK RGLEEEGYTH GGKKLKAVSP 
       310        320        330        340        350
FLKEVDARES EGKPAAPGLA VSCLLGPALG PTPPESYRGT MLRCPLNFTS 
       360        370        380        390        400
SADPLKGQAS LPFSPLVIPT FPAHLLATTG PSPMATSLMH FPPTPYDTVL 
       410        420        430 
RNRLGPASSA WHVPPVTTYA APHFFHLNTK L                     

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ