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Entry version 115 (12 Aug 2020)
Sequence version 1 (08 Nov 2005)
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Protein

Rho GTPase-activating protein 11B

Gene

ARHGAP11B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex (PubMed:25721503). Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis (PubMed:25721503). Does not possess GTPase activator activity (PubMed:25721503).1 Publication

Miscellaneous

When expressed in embryonic mouse neocortex, promotes basal progenitor generation and self-renewal, and can increase cortical plate area and induce gyrification.1 Publication
ARHGAP11B arose from partial duplication of ARHGAP11A on the human lineage after separation from the chimpanzee lineage, but before the divergence from Neandertals.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q3KRB8

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840, Rho GTPase cycle

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q3KRB8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 11BCurated
Alternative name(s):
Protein FAM7B1Curated
Rho-type GTPase-activating protein 11BCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGAP11BImported
Synonyms:FAM7B1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000187951.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15782, ARHGAP11B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616310, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q3KRB8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
89839

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134987257

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q3KRB8, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARHGAP11B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121942629

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003172911 – 267Rho GTPase-activating protein 11BAdd BLAST267

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3KRB8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q3KRB8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3KRB8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3KRB8

PeptideAtlas

More...
PeptideAtlasi
Q3KRB8

PRoteomics IDEntifications database

More...
PRIDEi
Q3KRB8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61744

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3KRB8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Specifically expressed in radial glia cells of cortical neural stem and progenitor cells (NPCs) during neocortex development. Preferentially expressed in apical and basal radial glia (PubMed:25721503). Not detected in cortical neurons and cortical plate (PubMed:25721503).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187951, Expressed in lung and 124 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000284906, Tissue enhanced (bone marrow, lymphoid tissue, testis)
ENSG00000285077, Tissue enhanced (esophagus, intestine, stomach)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124615, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q3KRB8, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000481934

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3KRB8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3KRB8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini49 – 250Rho-GAPPROSITE-ProRule annotationAdd BLAST202

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2710, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155312

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_048582_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3KRB8

KEGG Orthology (KO)

More...
KOi
K20635

Identification of Orthologs from Complete Genome Data

More...
OMAi
EREFYSG

Database of Orthologous Groups

More...
OrthoDBi
1169366at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3KRB8

TreeFam database of animal gene trees

More...
TreeFami
TF342052

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042869, ARHGAP11A/B
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom

The PANTHER Classification System

More...
PANTHERi
PTHR15670, PTHR15670, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00620, RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00324, RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50238, RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3KRB8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWDQRLVKLA LLQHLRAFYG IKVKGVRGQC DRRRHETAAT EIGGKIFGVP
60 70 80 90 100
FNALPHSAVP EYGHIPSFLV DACTSLEEHI HTEGLFRKSG SVIRLKALKN
110 120 130 140 150
KVDHGEGCLS SAPPCDIAGL LKQFFRELPE PILPADLHEA LLKAQQLGTE
160 170 180 190 200
EKNKAILLLS CLLADHTVHV LRYFFNFLRN VSLRSSENKM DSSNLAVIFA
210 220 230 240 250
PNLLQTSEGH EKMSSNAEKK GVYQTLSWKR YQPCWVLMVS VLLHHWKALK
260
KVNMKLLVNI REREDNV
Length:267
Mass (Da):30,251
Last modified:November 8, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6817B9B13951F4BA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC243687 Genomic DNA No translation available.
BC105788 mRNA Translation: AAI05789.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32185.1

NCBI Reference Sequences

More...
RefSeqi
NP_001034930.1, NM_001039841.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000428041; ENSP00000392760; ENSG00000285077

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
89839

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:89839

UCSC genome browser

More...
UCSCi
uc001zet.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC243687 Genomic DNA No translation available.
BC105788 mRNA Translation: AAI05789.1
CCDSiCCDS32185.1
RefSeqiNP_001034930.1, NM_001039841.1

3D structure databases

SMRiQ3KRB8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124615, 1 interactor
IntActiQ3KRB8, 16 interactors
STRINGi9606.ENSP00000481934

PTM databases

iPTMnetiQ3KRB8

Polymorphism and mutation databases

BioMutaiARHGAP11B
DMDMi121942629

Proteomic databases

jPOSTiQ3KRB8
MassIVEiQ3KRB8
MaxQBiQ3KRB8
PaxDbiQ3KRB8
PeptideAtlasiQ3KRB8
PRIDEiQ3KRB8
ProteomicsDBi61744

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
78623, 39 antibodies

Genome annotation databases

EnsembliENST00000428041; ENSP00000392760; ENSG00000285077
GeneIDi89839
KEGGihsa:89839
UCSCiuc001zet.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
89839
DisGeNETi89839
EuPathDBiHostDB:ENSG00000187951.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARHGAP11B
HGNCiHGNC:15782, ARHGAP11B
HPAiENSG00000284906, Tissue enhanced (bone marrow, lymphoid tissue, testis)
ENSG00000285077, Tissue enhanced (esophagus, intestine, stomach)
MIMi616310, gene
neXtProtiNX_Q3KRB8
PharmGKBiPA134987257

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2710, Eukaryota
GeneTreeiENSGT00940000155312
HOGENOMiCLU_048582_0_0_1
InParanoidiQ3KRB8
KOiK20635
OMAiEREFYSG
OrthoDBi1169366at2759
PhylomeDBiQ3KRB8
TreeFamiTF342052

Enzyme and pathway databases

PathwayCommonsiQ3KRB8
ReactomeiR-HSA-194840, Rho GTPase cycle
SIGNORiQ3KRB8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
89839, 106 hits in 829 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARHGAP11B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
89839
PharosiQ3KRB8, Tbio

Protein Ontology

More...
PROi
PR:Q3KRB8
RNActiQ3KRB8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000187951, Expressed in lung and 124 other tissues

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR042869, ARHGAP11A/B
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
PANTHERiPTHR15670, PTHR15670, 1 hit
PfamiView protein in Pfam
PF00620, RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324, RhoGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238, RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHGBB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3KRB8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 8, 2005
Last modified: August 12, 2020
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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