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Entry version 97 (07 Oct 2020)
Sequence version 3 (30 Nov 2010)
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Protein

UPF0538 protein C2orf76

Gene

C2orf76

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q3KRA6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UPF0538 protein C2orf76
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C2orf76
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000186132.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27017, C2orf76

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q3KRA6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
130355

Open Targets

More...
OpenTargetsi
ENSG00000186132

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162379558

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q3KRA6, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C2orf76

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104243

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003258241 – 126UPF0538 protein C2orf76Add BLAST126

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3KRA6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3KRA6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q3KRA6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3KRA6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3KRA6

PeptideAtlas

More...
PeptideAtlasi
Q3KRA6

PRoteomics IDEntifications database

More...
PRIDEi
Q3KRA6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61740

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3KRA6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3KRA6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186132, Expressed in C1 segment of cervical spinal cord and 205 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3KRA6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3KRA6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000186132, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
126230, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q3KRA6, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000386302

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3KRA6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3KRA6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPF0538 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4147, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015352

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_117792_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3KRA6

Identification of Orthologs from Complete Genome Data

More...
OMAi
NLDHDDW

Database of Orthologous Groups

More...
OrthoDBi
1568647at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3KRA6

TreeFam database of animal gene trees

More...
TreeFami
TF300221

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018794, UPF0538

The PANTHER Classification System

More...
PANTHERi
PTHR18444, PTHR18444, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10209, DUF2340, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q3KRA6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPGEVTITV RLIRSFEHRN FKPVVYHGVN LDQTVKEFIV FLKQDIPLRT
60 70 80 90 100
NLPPPFRNYK YDALKIIHQA HKSKTNELVL SLEDDERLLL KEDSTLKAAG
110 120
IASETEIAFF CEEDYKNYKA NPISSW
Length:126
Mass (Da):14,609
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07E53B7EA8DD364A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JTA8C9JTA8_HUMAN
UPF0538 protein C2orf76
C2orf76
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03993146I → V2 PublicationsCorresponds to variant dbSNP:rs1132267Ensembl.1
Natural variantiVAR_039932116K → R2 PublicationsCorresponds to variant dbSNP:rs1052500Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC016736 Genomic DNA No translation available.
CH471103 Genomic DNA Translation: EAW95213.1
BC047365 mRNA Translation: AAH47365.1
BC105805 mRNA Translation: AAI05806.1
BC126395 mRNA Translation: AAI26396.1
BC126397 mRNA Translation: AAI26398.1
BC144012 mRNA Translation: AAI44013.1
BC171737 mRNA Translation: AAI71737.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42739.1

NCBI Reference Sequences

More...
RefSeqi
NP_001017927.2, NM_001017927.3
NP_001309258.1, NM_001322329.1
NP_001309259.1, NM_001322330.1
NP_001309260.1, NM_001322331.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334816; ENSP00000335041; ENSG00000186132
ENST00000409466; ENSP00000386302; ENSG00000186132
ENST00000409523; ENSP00000386714; ENSG00000186132
ENST00000409877; ENSP00000387234; ENSG00000186132

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
130355

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:130355

UCSC genome browser

More...
UCSCi
uc002tls.2, human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016736 Genomic DNA No translation available.
CH471103 Genomic DNA Translation: EAW95213.1
BC047365 mRNA Translation: AAH47365.1
BC105805 mRNA Translation: AAI05806.1
BC126395 mRNA Translation: AAI26396.1
BC126397 mRNA Translation: AAI26398.1
BC144012 mRNA Translation: AAI44013.1
BC171737 mRNA Translation: AAI71737.1
CCDSiCCDS42739.1
RefSeqiNP_001017927.2, NM_001017927.3
NP_001309258.1, NM_001322329.1
NP_001309259.1, NM_001322330.1
NP_001309260.1, NM_001322331.1

3D structure databases

SMRiQ3KRA6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126230, 2 interactors
IntActiQ3KRA6, 1 interactor
STRINGi9606.ENSP00000386302

PTM databases

iPTMnetiQ3KRA6
PhosphoSitePlusiQ3KRA6

Polymorphism and mutation databases

BioMutaiC2orf76
DMDMi313104243

Proteomic databases

EPDiQ3KRA6
jPOSTiQ3KRA6
MassIVEiQ3KRA6
MaxQBiQ3KRA6
PaxDbiQ3KRA6
PeptideAtlasiQ3KRA6
PRIDEiQ3KRA6
ProteomicsDBi61740

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
47996, 57 antibodies

The DNASU plasmid repository

More...
DNASUi
130355

Genome annotation databases

EnsembliENST00000334816; ENSP00000335041; ENSG00000186132
ENST00000409466; ENSP00000386302; ENSG00000186132
ENST00000409523; ENSP00000386714; ENSG00000186132
ENST00000409877; ENSP00000387234; ENSG00000186132
GeneIDi130355
KEGGihsa:130355
UCSCiuc002tls.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
130355
DisGeNETi130355
EuPathDBiHostDB:ENSG00000186132.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C2orf76
HGNCiHGNC:27017, C2orf76
HPAiENSG00000186132, Low tissue specificity
neXtProtiNX_Q3KRA6
OpenTargetsiENSG00000186132
PharmGKBiPA162379558

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4147, Eukaryota
GeneTreeiENSGT00390000015352
HOGENOMiCLU_117792_1_0_1
InParanoidiQ3KRA6
OMAiNLDHDDW
OrthoDBi1568647at2759
PhylomeDBiQ3KRA6
TreeFamiTF300221

Enzyme and pathway databases

PathwayCommonsiQ3KRA6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
130355, 38 hits in 845 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C2orf76, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
130355
PharosiQ3KRA6, Tdark

Protein Ontology

More...
PROi
PR:Q3KRA6
RNActiQ3KRA6, protein

Gene expression databases

BgeeiENSG00000186132, Expressed in C1 segment of cervical spinal cord and 205 other tissues
ExpressionAtlasiQ3KRA6, baseline and differential
GenevisibleiQ3KRA6, HS

Family and domain databases

InterProiView protein in InterPro
IPR018794, UPF0538
PANTHERiPTHR18444, PTHR18444, 1 hit
PfamiView protein in Pfam
PF10209, DUF2340, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCB076_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3KRA6
Secondary accession number(s): B7ZLS8, Q4VC35
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 30, 2010
Last modified: October 7, 2020
This is version 97 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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