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Protein

Protein Aster-B

Gene

GRAMD1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.B.198.2.5 the membrane-anchored lipid-binding protein (lam) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Aster-BBy similarity
Alternative name(s):
GRAM domain-containing protein 1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GRAMD1B
Synonyms:KIAA1201
ORF Names:UNQ3032/PRO9834
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000023171.14

Human Gene Nomenclature Database

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HGNCi
HGNC:29214 GRAMD1B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q3KR37

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei623 – 643HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57476

Open Targets

More...
OpenTargetsi
ENSG00000023171

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671708

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121942617

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002874491 – 738Protein Aster-BAdd BLAST738

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei28PhosphoserineBy similarity1
Modified residuei30PhosphoserineCombined sources1
Modified residuei274PhosphoserineCombined sources1
Modified residuei389PhosphotyrosineCombined sources1
Modified residuei550PhosphoserineCombined sources1
Modified residuei581PhosphoserineCombined sources1
Modified residuei584PhosphothreonineBy similarity1
Modified residuei585PhosphothreonineCombined sources1
Modified residuei587PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3KR37

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3KR37

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3KR37

PeptideAtlas

More...
PeptideAtlasi
Q3KR37

PRoteomics IDEntifications database

More...
PRIDEi
Q3KR37

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61737
61738 [Q3KR37-2]
61739 [Q3KR37-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3KR37

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q3KR37

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000023171 Expressed in 206 organ(s), highest expression level in adrenal tissue

CleanEx database of gene expression profiles

More...
CleanExi
HS_GRAMD1B

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q3KR37 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3KR37 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA008557

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121546, 25 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000436500

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q3KR37

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3KR37

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini96 – 163GRAMSequence analysisAdd BLAST68
Domaini372 – 543VAStPROSITE-ProRule annotationAdd BLAST172

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

GRAM domain binds phosphatidylserine in the PM and mediates protein recruitment to endoplasmic reticulum-plasma membrane contact sites (EPCS) in response to excess cholesterol in the PM.By similarity
VASt (VAD1 Analog of StAR-related lipid transfer) domain, also known as ASTER (Greek for star) domain is a sterol-binding domain.By similarity

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1032 Eukaryota
ENOG410XRQQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156649

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294164

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG062004

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3KR37

Database of Orthologous Groups

More...
OrthoDBi
EOG091G051I

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3KR37

TreeFam database of animal gene trees

More...
TreeFami
TF327695

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004182 GRAM
IPR011993 PH-like_dom_sf
IPR031968 VASt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02893 GRAM, 1 hit
PF16016 VASt, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00568 GRAM, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51778 VAST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3KR37-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKGFKLSCTA SNSNRSTPAC SPILRKRSRS PTPQNQDGDT MVEKGSDHSS
60 70 80 90 100
DKSPSTPEQG VQRSCSSQSG RSGGKNSKKS QSWYNVLSPT YKQRNEDFRK
110 120 130 140 150
LFKQLPDTER LIVDYSCALQ RDILLQGRLY LSENWICFYS NIFRWETLLT
160 170 180 190 200
VRLKDICSMT KEKTARLIPN AIQVCTDSEK HFFTSFGARD RTYMMMFRLW
210 220 230 240 250
QNALLEKPLC PKELWHFVHQ CYGNELGLTS DDEDYVPPDD DFNTMGYCEE
260 270 280 290 300
IPVEENEVND SSSKSSIETK PDASPQLPKK SITNSTLTST GSSEAPVSFD
310 320 330 340 350
GLPLEEEALE GDGSLEKELA IDNIMGEKIE MIAPVNSPSL DFNDNEDIPT
360 370 380 390 400
ELSDSSDTHD EGEVQAFYED LSGRQYVNEV FNFSVDKLYD LLFTNSPFQR
410 420 430 440 450
DFMEQRRFSD IIFHPWKKEE NGNQSRVILY TITLTNPLAP KTATVRETQT
460 470 480 490 500
MYKASQESEC YVIDAEVLTH DVPYHDYFYT INRYTLTRVA RNKSRLRVST
510 520 530 540 550
ELRYRKQPWG LVKTFIEKNF WSGLEDYFRH LESELAKTES TYLAEMHRQS
560 570 580 590 600
PKEKASKTTT VRRRKRPHAH LRVPHLEEVM SPVTTPTDED VGHRIKHVAG
610 620 630 640 650
STQTRHIPED TPNGFHLQSV SKLLLVISCV ICFSLVLLVI LNMMLFYKLW
660 670 680 690 700
MLEYTTQTLT AWQGLRLQER LPQSQTEWAQ LLESQQKYHD TELQKWREII
710 720 730
KSSVMLLDQM KDSLINLQNG IRSRDYTSES EEKRNRYH
Length:738
Mass (Da):85,400
Last modified:November 8, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i96784D4504307393
GO
Isoform 2 (identifier: Q3KR37-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: Missing.

Note: No experimental confirmation available.
Show »
Length:698
Mass (Da):81,079
Checksum:i29D47C008D52509A
GO
Isoform 3 (identifier: Q3KR37-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-309: Missing.
     310-361: EGDGSLEKEL...LSDSSDTHDE → MPTSSAVLLR...CLLPDPLFCA
     631-634: Missing.

Note: No experimental confirmation available.
Show »
Length:425
Mass (Da):49,786
Checksum:iBDE9CC95661A6D4B
GO
Isoform 4 (identifier: Q3KR37-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-78: K → KSHKRLSK

Show »
Length:745
Mass (Da):86,237
Checksum:i8A3676F1CC5F873D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A024R3M2A0A024R3M2_HUMAN
GRAM domain-containing protein 1B
GRAMD1B hCG_39893
694Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KNL5J3KNL5_HUMAN
GRAM domain-containing protein 1B
GRAMD1B
738Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUD6A0A1B0GUD6_HUMAN
GRAM domain-containing protein 1B
GRAMD1B
877Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y5X2A0A2R8Y5X2_HUMAN
GRAM domain-containing protein 1B
GRAMD1B
702Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GWG7A0A1B0GWG7_HUMAN
GRAM domain-containing protein 1B
GRAMD1B
767Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRD6E9PRD6_HUMAN
GRAM domain-containing protein 1B
GRAMD1B
441Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXZ1A0A0J9YXZ1_HUMAN
GRAM domain-containing protein 1B
GRAMD1B
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YY71A0A0J9YY71_HUMAN
GRAM domain-containing protein 1B
GRAMD1B
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXF6A0A0J9YXF6_HUMAN
GRAM domain-containing protein 1B
GRAMD1B
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GVV0A0A1B0GVV0_HUMAN
GRAM domain-containing protein 1B
GRAMD1B
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86515 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti336N → H in BAG54507 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0254691 – 309Missing in isoform 3. 1 PublicationAdd BLAST309
Alternative sequenceiVSP_0254701 – 40Missing in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_05757378K → KSHKRLSK in isoform 4. 1
Alternative sequenceiVSP_025471310 – 361EGDGS…DTHDE → MPTSSAVLLRVLSIPLLTVL ILARDLSALGGCPWGPLPLR CHCLLPDPLFCA in isoform 3. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_025472631 – 634Missing in isoform 3. 1 Publication4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB033027 mRNA Translation: BAA86515.1 Different initiation.
AY358924 mRNA Translation: AAQ89283.1
AK127457 mRNA Translation: BAG54507.1
AP000841 Genomic DNA No translation available.
AP002765 Genomic DNA No translation available.
BC105741 mRNA Translation: AAI05742.1
BC105932 mRNA Translation: AAI05933.1
BC105931 mRNA Translation: AAI05932.1
BC107480 mRNA Translation: AAI07481.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53720.1 [Q3KR37-1]
CCDS66253.1 [Q3KR37-4]
CCDS66254.1 [Q3KR37-2]

NCBI Reference Sequences

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RefSeqi
NP_001273492.1, NM_001286563.1 [Q3KR37-4]
NP_001273493.1, NM_001286564.1 [Q3KR37-2]
NP_065767.1, NM_020716.2 [Q3KR37-1]
XP_016873536.1, XM_017018047.1 [Q3KR37-2]
XP_016873537.1, XM_017018048.1 [Q3KR37-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.144725
Hs.732509
Hs.738493

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000450171; ENSP00000388458; ENSG00000023171 [Q3KR37-3]
ENST00000456860; ENSP00000402457; ENSG00000023171 [Q3KR37-4]
ENST00000529432; ENSP00000432987; ENSG00000023171 [Q3KR37-2]
ENST00000529750; ENSP00000436500; ENSG00000023171 [Q3KR37-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57476

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:57476

UCSC genome browser

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UCSCi
uc001pyw.4 human
uc001pyx.4 human [Q3KR37-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033027 mRNA Translation: BAA86515.1 Different initiation.
AY358924 mRNA Translation: AAQ89283.1
AK127457 mRNA Translation: BAG54507.1
AP000841 Genomic DNA No translation available.
AP002765 Genomic DNA No translation available.
BC105741 mRNA Translation: AAI05742.1
BC105932 mRNA Translation: AAI05933.1
BC105931 mRNA Translation: AAI05932.1
BC107480 mRNA Translation: AAI07481.1
CCDSiCCDS53720.1 [Q3KR37-1]
CCDS66253.1 [Q3KR37-4]
CCDS66254.1 [Q3KR37-2]
RefSeqiNP_001273492.1, NM_001286563.1 [Q3KR37-4]
NP_001273493.1, NM_001286564.1 [Q3KR37-2]
NP_065767.1, NM_020716.2 [Q3KR37-1]
XP_016873536.1, XM_017018047.1 [Q3KR37-2]
XP_016873537.1, XM_017018048.1 [Q3KR37-2]
UniGeneiHs.144725
Hs.732509
Hs.738493

3D structure databases

ProteinModelPortaliQ3KR37
SMRiQ3KR37
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121546, 25 interactors
STRINGi9606.ENSP00000436500

Protein family/group databases

TCDBi9.B.198.2.5 the membrane-anchored lipid-binding protein (lam) family

PTM databases

iPTMnetiQ3KR37
PhosphoSitePlusiQ3KR37

Polymorphism and mutation databases

DMDMi121942617

Proteomic databases

EPDiQ3KR37
MaxQBiQ3KR37
PaxDbiQ3KR37
PeptideAtlasiQ3KR37
PRIDEiQ3KR37
ProteomicsDBi61737
61738 [Q3KR37-2]
61739 [Q3KR37-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000450171; ENSP00000388458; ENSG00000023171 [Q3KR37-3]
ENST00000456860; ENSP00000402457; ENSG00000023171 [Q3KR37-4]
ENST00000529432; ENSP00000432987; ENSG00000023171 [Q3KR37-2]
ENST00000529750; ENSP00000436500; ENSG00000023171 [Q3KR37-1]
GeneIDi57476
KEGGihsa:57476
UCSCiuc001pyw.4 human
uc001pyx.4 human [Q3KR37-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57476
DisGeNETi57476
EuPathDBiHostDB:ENSG00000023171.14

GeneCards: human genes, protein and diseases

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GeneCardsi
GRAMD1B
HGNCiHGNC:29214 GRAMD1B
HPAiHPA008557
neXtProtiNX_Q3KR37
OpenTargetsiENSG00000023171
PharmGKBiPA142671708

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1032 Eukaryota
ENOG410XRQQ LUCA
GeneTreeiENSGT00940000156649
HOGENOMiHOG000294164
HOVERGENiHBG062004
InParanoidiQ3KR37
OrthoDBiEOG091G051I
PhylomeDBiQ3KR37
TreeFamiTF327695

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GRAMD1B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57476

Protein Ontology

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PROi
PR:Q3KR37

Gene expression databases

BgeeiENSG00000023171 Expressed in 206 organ(s), highest expression level in adrenal tissue
CleanExiHS_GRAMD1B
ExpressionAtlasiQ3KR37 baseline and differential
GenevisibleiQ3KR37 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR004182 GRAM
IPR011993 PH-like_dom_sf
IPR031968 VASt
PfamiView protein in Pfam
PF02893 GRAM, 1 hit
PF16016 VASt, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 1 hit
PROSITEiView protein in PROSITE
PS51778 VAST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASTRB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3KR37
Secondary accession number(s): B3KXJ5
, E7EPH8, Q6UW85, Q9ULL9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: November 8, 2005
Last modified: December 5, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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