UniProtKB - Q3KQZ1 (S2535_HUMAN)
Protein
Solute carrier family 25 member 35
Gene
SLC25A35
Organism
Homo sapiens (Human)
Status
Functioni
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | Q3KQZ1 |
Protein family/group databases
TCDBi | 2.A.29.15.2, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 25 member 35 |
Gene namesi | Name:SLC25A35 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:31921, SLC25A35 |
MIMi | 610818, gene |
neXtProti | NX_Q3KQZ1 |
VEuPathDBi | HostDB:ENSG00000125434.10 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 38 – 58 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 59 – 79 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 91 – 119 | Helical; Name=3Sequence analysisAdd BLAST | 29 | |
Transmembranei | 169 – 190 | Helical; Name=4Sequence analysisAdd BLAST | 22 | |
Transmembranei | 205 – 225 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 277 – 300 | Helical; Name=6Sequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Organism-specific databases
DisGeNETi | 399512 |
OpenTargetsi | ENSG00000125434 |
PharmGKBi | PA142670907 |
Miscellaneous databases
Pharosi | Q3KQZ1, Tdark |
Genetic variation databases
BioMutai | SLC25A35 |
DMDMi | 121942600 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000291794 | 1 – 300 | Solute carrier family 25 member 35Add BLAST | 300 |
Proteomic databases
EPDi | Q3KQZ1 |
jPOSTi | Q3KQZ1 |
MassIVEi | Q3KQZ1 |
MaxQBi | Q3KQZ1 |
PaxDbi | Q3KQZ1 |
PeptideAtlasi | Q3KQZ1 |
PRIDEi | Q3KQZ1 |
ProteomicsDBi | 61730 [Q3KQZ1-1] 61731 [Q3KQZ1-2] 61732 [Q3KQZ1-3] 61733 [Q3KQZ1-4] |
PTM databases
iPTMneti | Q3KQZ1 |
PhosphoSitePlusi | Q3KQZ1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000125434, Expressed in right testis and 165 other tissues |
Genevisiblei | Q3KQZ1, HS |
Organism-specific databases
HPAi | ENSG00000125434, Tissue enhanced (placenta) |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 134361, 9 interactors |
IntActi | Q3KQZ1, 5 interactors |
STRINGi | 9606.ENSP00000369407 |
Miscellaneous databases
RNActi | Q3KQZ1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 1 – 90 | Solcar 1Add BLAST | 90 | |
Repeati | 100 – 193 | Solcar 2Add BLAST | 94 | |
Repeati | 203 – 294 | Solcar 3Add BLAST | 92 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0755, Eukaryota |
GeneTreei | ENSGT00940000160771 |
HOGENOMi | CLU_015166_14_3_1 |
InParanoidi | Q3KQZ1 |
OMAi | VMSRMYN |
OrthoDBi | 1013743at2759 |
PhylomeDBi | Q3KQZ1 |
TreeFami | TF324506 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q3KQZ1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDFLMSGLAA CGACVFTNPL EVVKTRMQLQ GELQAPGTYQ RHYRNVFHAF
60 70 80 90 100
ITIGKVDGLA ALQKGLAPAL LYQFLMNGIR LGTYGLAEAG GYLHTAEGTH
110 120 130 140 150
SPARSAAAGA MAGVMGAYLG SPIYMVKTHL QAQAASEIAV GHQYKHQGMF
160 170 180 190 200
QALTEIGQKH GLVGLWRGAL GGLPRVIVGS STQLCTFSST KDLLSQWEIF
210 220 230 240 250
PPQSWKLALV AAMMSGIAVV LAMAPFDVAC TRLYNQPTDA QGKGLMYRGI
260 270 280 290 300
LDALLQTART EGIFGMYKGI GASYFRLGPH TILSLFFWDQ LRSLYYTDTK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 79 | I → V in AAR92153 (Ref. 1) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_026237 | 244 – 300 | GLMYR…YTDTK → NRVPKFSATSCSASAPLLGT KDVRIVKGQTGHQLFKVTQA PGCSPILLGTQS in isoform 4. 2 PublicationsAdd BLAST | 57 | |
Alternative sequenceiVSP_026238 | 265 – 268 | Missing in isoform 3. 1 Publication | 4 | |
Alternative sequenceiVSP_026239 | 269 – 300 | GIGAS…YTDTK → EPSPQVLSNIMQCFSAFTGD QRC in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 32 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY498866 mRNA Translation: AAR92153.1 AK097536 mRNA Translation: BAC05091.1 BC101329 mRNA Translation: AAI01330.2 BC101330 mRNA Translation: AAI01331.1 BC105995 mRNA Translation: AAI05996.1 |
CCDSi | CCDS11138.1 [Q3KQZ1-4] CCDS82067.1 [Q3KQZ1-1] |
RefSeqi | NP_001307799.1, NM_001320870.1 [Q3KQZ1-1] NP_001307800.1, NM_001320871.1 [Q3KQZ1-4] NP_001307801.1, NM_001320872.1 [Q3KQZ1-4] NP_958928.1, NM_201520.2 [Q3KQZ1-4] XP_011522148.1, XM_011523846.1 [Q3KQZ1-2] |
Genome annotation databases
Ensembli | ENST00000380067; ENSP00000369407; ENSG00000125434 [Q3KQZ1-4] ENST00000577745; ENSP00000464231; ENSG00000125434 [Q3KQZ1-1] ENST00000579192; ENSP00000462395; ENSG00000125434 [Q3KQZ1-4] ENST00000579681; ENSP00000464307; ENSG00000125434 [Q3KQZ1-3] ENST00000580340; ENSP00000464071; ENSG00000125434 [Q3KQZ1-4] ENST00000585311; ENSP00000464191; ENSG00000125434 [Q3KQZ1-2] |
GeneIDi | 399512 |
KEGGi | hsa:399512 |
UCSCi | uc002gkt.4, human [Q3KQZ1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY498866 mRNA Translation: AAR92153.1 AK097536 mRNA Translation: BAC05091.1 BC101329 mRNA Translation: AAI01330.2 BC101330 mRNA Translation: AAI01331.1 BC105995 mRNA Translation: AAI05996.1 |
CCDSi | CCDS11138.1 [Q3KQZ1-4] CCDS82067.1 [Q3KQZ1-1] |
RefSeqi | NP_001307799.1, NM_001320870.1 [Q3KQZ1-1] NP_001307800.1, NM_001320871.1 [Q3KQZ1-4] NP_001307801.1, NM_001320872.1 [Q3KQZ1-4] NP_958928.1, NM_201520.2 [Q3KQZ1-4] XP_011522148.1, XM_011523846.1 [Q3KQZ1-2] |
3D structure databases
SMRi | Q3KQZ1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 134361, 9 interactors |
IntActi | Q3KQZ1, 5 interactors |
STRINGi | 9606.ENSP00000369407 |
Protein family/group databases
TCDBi | 2.A.29.15.2, the mitochondrial carrier (mc) family |
PTM databases
iPTMneti | Q3KQZ1 |
PhosphoSitePlusi | Q3KQZ1 |
Genetic variation databases
BioMutai | SLC25A35 |
DMDMi | 121942600 |
Proteomic databases
EPDi | Q3KQZ1 |
jPOSTi | Q3KQZ1 |
MassIVEi | Q3KQZ1 |
MaxQBi | Q3KQZ1 |
PaxDbi | Q3KQZ1 |
PeptideAtlasi | Q3KQZ1 |
PRIDEi | Q3KQZ1 |
ProteomicsDBi | 61730 [Q3KQZ1-1] 61731 [Q3KQZ1-2] 61732 [Q3KQZ1-3] 61733 [Q3KQZ1-4] |
Protocols and materials databases
Antibodypediai | 24621, 63 antibodies |
Genome annotation databases
Ensembli | ENST00000380067; ENSP00000369407; ENSG00000125434 [Q3KQZ1-4] ENST00000577745; ENSP00000464231; ENSG00000125434 [Q3KQZ1-1] ENST00000579192; ENSP00000462395; ENSG00000125434 [Q3KQZ1-4] ENST00000579681; ENSP00000464307; ENSG00000125434 [Q3KQZ1-3] ENST00000580340; ENSP00000464071; ENSG00000125434 [Q3KQZ1-4] ENST00000585311; ENSP00000464191; ENSG00000125434 [Q3KQZ1-2] |
GeneIDi | 399512 |
KEGGi | hsa:399512 |
UCSCi | uc002gkt.4, human [Q3KQZ1-1] |
Organism-specific databases
CTDi | 399512 |
DisGeNETi | 399512 |
GeneCardsi | SLC25A35 |
HGNCi | HGNC:31921, SLC25A35 |
HPAi | ENSG00000125434, Tissue enhanced (placenta) |
MIMi | 610818, gene |
neXtProti | NX_Q3KQZ1 |
OpenTargetsi | ENSG00000125434 |
PharmGKBi | PA142670907 |
VEuPathDBi | HostDB:ENSG00000125434.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0755, Eukaryota |
GeneTreei | ENSGT00940000160771 |
HOGENOMi | CLU_015166_14_3_1 |
InParanoidi | Q3KQZ1 |
OMAi | VMSRMYN |
OrthoDBi | 1013743at2759 |
PhylomeDBi | Q3KQZ1 |
TreeFami | TF324506 |
Enzyme and pathway databases
PathwayCommonsi | Q3KQZ1 |
Miscellaneous databases
BioGRID-ORCSi | 399512, 4 hits in 877 CRISPR screens |
ChiTaRSi | SLC25A35, human |
GenomeRNAii | 399512 |
Pharosi | Q3KQZ1, Tdark |
PROi | PR:Q3KQZ1 |
RNActi | Q3KQZ1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125434, Expressed in right testis and 165 other tissues |
Genevisiblei | Q3KQZ1, HS |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S2535_HUMAN | |
Accessioni | Q3KQZ1Primary (citable) accession number: Q3KQZ1 Secondary accession number(s): Q494X5, Q6RGS3, Q8N7Y5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2007 |
Last sequence update: | November 8, 2005 | |
Last modified: | February 10, 2021 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families