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Protein

LIM and calponin homology domains-containing protein 1

Gene

limch1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Actin stress fibers-associated protein that activates non-muscle myosin IIa. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM and calponin homology domains-containing protein 1Curated
Gene namesi
Name:limch1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5950315 limch1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002936211 – 1083LIM and calponin homology domains-containing protein 1Add BLAST1083

Proteomic databases

PRIDEiQ3KQW7

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ3KQW7
SMRiQ3KQW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 138Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST118
Domaini1011 – 1077LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST67

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili356 – 424Sequence analysisAdd BLAST69
Coiled coili784 – 835Sequence analysisAdd BLAST52

Sequence similaritiesi

Belongs to the LIMCH1 family.Curated

Keywords - Domaini

Coiled coil, LIM domain

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001997 Calponin/LIMCH1
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR031865 DUF4757
IPR029980 LIMCH1
IPR003096 SM22_calponin
IPR001781 Znf_LIM
PANTHERiPTHR15551:SF3 PTHR15551:SF3, 1 hit
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF15949 DUF4757, 1 hit
PF00412 LIM, 1 hit
PRINTSiPR00889 CALPONIN
PR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00132 LIM, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3KQW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNAALQGE DIPQPQESPP DTACMEAQKW IEQVTGKSFG DRDFRTGLEN
60 70 80 90 100
GILLCELLNA IKPGLVKKIN RLPTPIAGLD NITLFLRGCK ELGLKESQLF
110 120 130 140 150
DPGDLQDTAN RTTGRTSDCN RKLRNVLVTV YWLGKAANGC SSFSGTNLDL
160 170 180 190 200
KEFEGLLAQI RKENEEIESP KRSIRDSGYI DCWDSERSDS LSPPRHGRDD
210 220 230 240 250
SFDSLDSFGS RSQQTPSPDV VLRGSSDGRG SDSESDLPHR RIPDVRKDDM
260 270 280 290 300
SARRVSFGEN KAFVPFNQYL PNKNNQTAYI PAPLRKKKAE REDYRKSWST
310 320 330 340 350
ATSPLGGERP FRSMSMCDMR YEEEGSMLPH SRAHHEHLQH VNSLLKEEDD
360 370 380 390 400
TWQDDLARWK TRRRSASQDL IKKEEERKKM ERLMSGDSEL SDRRKSIKTY
410 420 430 440 450
REIVEEKERR EKELHVAYKN AKTRGEAERI LKSYIEKFTI SEAVLEGLVM
460 470 480 490 500
PKILERSQSV EPSLLSSSED PNPLKYLRQQ SLPSPKYTST VEATVTPSSP
510 520 530 540 550
CESKSPTGLI SPSKNIISKT VPMLTAKPYS QPKNTQEVLK TFKVDGKVNL
560 570 580 590 600
NGVEEQKGKE SGSQTFAAPS LTRSQMFEGV ARVDAPVVET KQDVASIKLN
610 620 630 640 650
LARPNTLNSL HESNSLCEDR NHISQKDEPD SFVQEESVHS VEQLSEGNTQ
660 670 680 690 700
SNSTTQAVPA VSSIEIPPLT VNGKDTEDKR KVEAAELIMH WSLDSNYKEA
710 720 730 740 750
KKNSLPPLKS SENVEESSKI KENESSHKVQ LNITLQTRNA WRRSQFFLQS
760 770 780 790 800
VDTECTEKSP ALVPNLSSPN RSCTWDPEEE RKRQEKWQQE QERLLQERYQ
810 820 830 840 850
KEQEKLKEEW EKAQKEVEEE ERKYYEEERK IIEDTVVPLT LSPNSNVHFN
860 870 880 890 900
ISERNGNFIP VLPDHAKRDQ ENNNGQLMAE PNRVIKNEIH MHSNVTQQQI
910 920 930 940 950
LYAHERSMLA AEETQIKGKT EKWEAEPCNH VQSNECNTPT RLTLQAGCKQ
960 970 980 990 1000
VMLSESCDLG SPKTPVDENA VHHNMSSIIS TRGIDSKEET LNSSQSTSQC
1010 1020 1030 1040 1050
QSPNRSVSGK KLCSTCGLPL GKGAAMIIET LSLYFHIQCF KCGLCKGQLG
1060 1070 1080
DATTGTDVRI RNGLLNCNDC YVKSRTAGHP TPL
Length:1,083
Mass (Da):122,183
Last modified:November 8, 2005 - v1
Checksum:iAFEA1AB27ED89A1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC106026 mRNA Translation: AAI06027.1
RefSeqiNP_001089675.1, NM_001096206.1
UniGeneiXl.79231

Genome annotation databases

GeneIDi734736
KEGGixla:734736

Similar proteinsi

Entry informationi

Entry nameiLIMC1_XENLA
AccessioniPrimary (citable) accession number: Q3KQW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 8, 2005
Last modified: July 18, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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