UniProtKB - Q3KQU3 (MA7D1_HUMAN)
Protein
MAP7 domain-containing protein 1
Gene
MAP7D1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- microtubule cytoskeleton organization Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q3KQU3 |
Names & Taxonomyi
Protein namesi | Recommended name: MAP7 domain-containing protein 1Alternative name(s): Arginine/proline-rich coiled-coil domain-containing protein 1 Proline/arginine-rich coiled-coil domain-containing protein 1 |
Gene namesi | Name:MAP7D1 Synonyms:KIAA1187, PARCC1, RPRC1 ORF Names:PP2464 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25514, MAP7D1 |
neXtProti | NX_Q3KQU3 |
VEuPathDBi | HostDB:ENSG00000116871.15 |
Subcellular locationi
Cytoskeleton
- spindle 1 Publication
Cytoskeleton
- microtubule cytoskeleton Source: HPA
- spindle Source: UniProtKB-SubCell
Cytosol
- cytosol Source: HPA
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000116871 |
PharmGKBi | PA162394970 |
Miscellaneous databases
Pharosi | Q3KQU3, Tdark |
Genetic variation databases
BioMutai | MAP7D1 |
DMDMi | 121942584 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000306807 | 1 – 841 | MAP7 domain-containing protein 1Add BLAST | 841 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 47 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 51 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 70 | PhosphoserineCombined sources | 1 | |
Modified residuei | 86 | PhosphoserineCombined sources | 1 | |
Modified residuei | 93 | PhosphoserineCombined sources | 1 | |
Modified residuei | 97 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 113 | PhosphoserineCombined sources | 1 | |
Modified residuei | 116 | PhosphoserineCombined sources | 1 | |
Modified residuei | 118 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 123 | PhosphoserineCombined sources | 1 | |
Modified residuei | 125 | PhosphoserineCombined sources | 1 | |
Modified residuei | 254 | PhosphoserineCombined sources | 1 | |
Modified residuei | 273 | PhosphoserineCombined sources | 1 | |
Modified residuei | 313 | PhosphoserineCombined sources | 1 | |
Modified residuei | 366 | PhosphoserineCombined sources | 1 | |
Modified residuei | 399 | PhosphoserineCombined sources | 1 | |
Modified residuei | 442 | PhosphoserineCombined sources | 1 | |
Modified residuei | 446 | PhosphoserineCombined sources | 1 | |
Modified residuei | 452 | PhosphoserineCombined sources | 1 | |
Modified residuei | 454 | PhosphoserineCombined sources | 1 | |
Modified residuei | 460 | PhosphoserineCombined sources | 1 | |
Cross-linki | 462 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 479 | PhosphoserineBy similarity | 1 | |
Modified residuei | 496 | PhosphoserineBy similarity | 1 | |
Modified residuei | 544 | PhosphoserineCombined sources | 1 | |
Modified residuei | 548 | PhosphoserineCombined sources | 1 | |
Modified residuei | 552 | PhosphoserineCombined sources | 1 | |
Modified residuei | 554 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 742 | PhosphoserineCombined sources | 1 | |
Modified residuei | 753 | PhosphoserineCombined sources | 1 | |
Modified residuei | 813 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 816 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 834 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q3KQU3 |
jPOSTi | Q3KQU3 |
MassIVEi | Q3KQU3 |
MaxQBi | Q3KQU3 |
PaxDbi | Q3KQU3 |
PeptideAtlasi | Q3KQU3 |
PRIDEi | Q3KQU3 |
ProteomicsDBi | 61723 [Q3KQU3-1] 61724 [Q3KQU3-2] 61725 [Q3KQU3-3] 61726 [Q3KQU3-4] |
PTM databases
iPTMneti | Q3KQU3 |
PhosphoSitePlusi | Q3KQU3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000116871, Expressed in quadriceps femoris and 238 other tissues |
ExpressionAtlasi | Q3KQU3, baseline and differential |
Genevisiblei | Q3KQU3, HS |
Organism-specific databases
HPAi | ENSG00000116871, Tissue enhanced (skeletal) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120825, 76 interactors |
IntActi | Q3KQU3, 71 interactors |
MINTi | Q3KQU3 |
STRINGi | 9606.ENSP00000362244 |
Miscellaneous databases
RNActi | Q3KQU3, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 128 – 222 | Sequence analysisAdd BLAST | 95 | |
Coiled coili | 412 – 441 | Sequence analysisAdd BLAST | 30 | |
Coiled coili | 593 – 721 | Sequence analysisAdd BLAST | 129 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 14 – 127 | Pro-richAdd BLAST | 114 | |
Compositional biasi | 467 – 589 | Pro-richAdd BLAST | 123 |
Sequence similaritiesi
Belongs to the MAP7 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QPJP, Eukaryota |
GeneTreei | ENSGT00950000182941 |
HOGENOMi | CLU_017315_2_0_1 |
InParanoidi | Q3KQU3 |
OMAi | QDRKEAT |
OrthoDBi | 738080at2759 |
PhylomeDBi | Q3KQU3 |
TreeFami | TF332273 |
Family and domain databases
InterProi | View protein in InterPro IPR008604, MAP7_fam |
Pfami | View protein in Pfam PF05672, MAP7, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q3KQU3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MESGPRAELG AGAPPAVVAR TPPEPRPSPE GDPSPPPPPM SALVPDTPPD
60 70 80 90 100
TPPAMKNATS SKQLPLEPES PSGQVGPRPA PPQEESPSSE AKSRGPTPPA
110 120 130 140 150
MGPRDARPPR RSSQPSPTAV PASDSPPTKQ EVKKAGERHK LAKERREERA
160 170 180 190 200
KYLAAKKAVW LEKEEKAKAL REKQLQERRR RLEEQRLKAE QRRAALEERQ
210 220 230 240 250
RQKLEKNKER YEAAIQRSVK KTWAEIRQQR WSWAGALHHS SPGHKTSGSR
260 270 280 290 300
CSVSAVNLPK HVDSIINKRL SKSSATLWNS PSRNRSLQLS AWESSIVDRL
310 320 330 340 350
MTPTLSFLAR SRSAVTLPRN GRDQGRGCDP GRGPTWGRAG ASLARGPQPD
360 370 380 390 400
RTHPSAAVPV CPRSASASPL TPCSVTRSVH RCAPAGERGE RRKPNAGGSP
410 420 430 440 450
APVRRRPEAS PVQKKEKKDK ERENEKEKSA LARERSLKKR QSLPASPRAR
460 470 480 490 500
LSASTASELS PKSKARPSSP STSWHRPASP CPSPGPGHTL PPKPPSPRGT
510 520 530 540 550
TASPKGRVRR KEEAKESPSA AGPEDKSQSK RRASNEKESA APASPAPSPA
560 570 580 590 600
PSPTPAPPQK EQPPAETPTD AAVLTSPPAP APPVTPSKPM AGTTDREEAT
610 620 630 640 650
RLLAEKRRQA REQREREEQE RRLQAERDKR MREEQLAREA EARAEREAEA
660 670 680 690 700
RRREEQEARE KAQAEQEEQE RLQKQKEEAE ARSREEAERQ RLEREKHFQQ
710 720 730 740 750
QEQERQERRK RLEEIMKRTR KSEVSETKQK QDSKEANANG SSPEPVKAVE
760 770 780 790 800
ARSPGLQKEA VQKEEPIPQE PQWSLPSKEL PASLVNGLQP LPAHQENGFS
810 820 830 840
TNGPSGDKSL SRTPETLLPF AEAEAFLKKA VVQSPQVTEV L
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YF21 | H0YF21_HUMAN | MAP7 domain-containing protein 1 | MAP7D1 | 248 | Annotation score: | ||
C9JIR3 | C9JIR3_HUMAN | MAP7 domain-containing protein 1 | MAP7D1 | 244 | Annotation score: | ||
E9PLH3 | E9PLH3_HUMAN | MAP7 domain-containing protein 1 | MAP7D1 | 140 | Annotation score: |
Sequence cautioni
The sequence AAG17244 differs from that shown. Reason: Frameshift.Curated
The sequence BAA86501 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 207 | N → S in AAG17244 (PubMed:15498874).Curated | 1 | |
Sequence conflicti | 794 | H → R in BAC04654 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035312 | 104 | R → W. Corresponds to variant dbSNP:rs2296266EnsemblClinVar. | 1 | |
Natural variantiVAR_053970 | 531 | R → S. Corresponds to variant dbSNP:rs12563354Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028483 | 1 – 454 | Missing in isoform 3. 1 PublicationAdd BLAST | 454 | |
Alternative sequenceiVSP_028484 | 247 – 283 | Missing in isoform 2. 2 PublicationsAdd BLAST | 37 | |
Alternative sequenceiVSP_028485 | 325 – 356 | Missing in isoform 4. 1 PublicationAdd BLAST | 32 | |
Alternative sequenceiVSP_028486 | 455 – 459 | TASEL → MNGPV in isoform 3. 1 Publication | 5 | |
Alternative sequenceiVSP_028487 | 570 – 578 | Missing in isoform 3. 1 Publication | 9 | |
Alternative sequenceiVSP_028488 | 729 | Missing in isoform 2, isoform 3 and isoform 4. 4 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB033013 mRNA Translation: BAA86501.2 Different initiation. AK001212 mRNA Translation: BAA91557.1 AK095939 mRNA Translation: BAC04654.1 CH471059 Genomic DNA Translation: EAX07381.1 CH471059 Genomic DNA Translation: EAX07382.1 BC027334 mRNA Translation: AAH27334.1 BC106053 mRNA Translation: AAI06054.1 AF218002 mRNA Translation: AAG17244.1 Frameshift. AL136547 mRNA Translation: CAB66482.2 CR457254 mRNA Translation: CAG33535.1 |
CCDSi | CCDS30673.1 [Q3KQU3-1] CCDS65492.1 [Q3KQU3-4] CCDS65493.1 [Q3KQU3-2] |
RefSeqi | NP_001273294.1, NM_001286365.1 [Q3KQU3-2] NP_001273295.1, NM_001286366.1 [Q3KQU3-4] NP_060537.3, NM_018067.4 [Q3KQU3-1] |
Genome annotation databases
Ensembli | ENST00000316156; ENSP00000320228; ENSG00000116871 [Q3KQU3-2] ENST00000373150; ENSP00000362243; ENSG00000116871 [Q3KQU3-4] ENST00000373151; ENSP00000362244; ENSG00000116871 [Q3KQU3-1] |
GeneIDi | 55700 |
KEGGi | hsa:55700 |
UCSCi | uc001bzz.5, human [Q3KQU3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB033013 mRNA Translation: BAA86501.2 Different initiation. AK001212 mRNA Translation: BAA91557.1 AK095939 mRNA Translation: BAC04654.1 CH471059 Genomic DNA Translation: EAX07381.1 CH471059 Genomic DNA Translation: EAX07382.1 BC027334 mRNA Translation: AAH27334.1 BC106053 mRNA Translation: AAI06054.1 AF218002 mRNA Translation: AAG17244.1 Frameshift. AL136547 mRNA Translation: CAB66482.2 CR457254 mRNA Translation: CAG33535.1 |
CCDSi | CCDS30673.1 [Q3KQU3-1] CCDS65492.1 [Q3KQU3-4] CCDS65493.1 [Q3KQU3-2] |
RefSeqi | NP_001273294.1, NM_001286365.1 [Q3KQU3-2] NP_001273295.1, NM_001286366.1 [Q3KQU3-4] NP_060537.3, NM_018067.4 [Q3KQU3-1] |
3D structure databases
SMRi | Q3KQU3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120825, 76 interactors |
IntActi | Q3KQU3, 71 interactors |
MINTi | Q3KQU3 |
STRINGi | 9606.ENSP00000362244 |
PTM databases
iPTMneti | Q3KQU3 |
PhosphoSitePlusi | Q3KQU3 |
Genetic variation databases
BioMutai | MAP7D1 |
DMDMi | 121942584 |
Proteomic databases
EPDi | Q3KQU3 |
jPOSTi | Q3KQU3 |
MassIVEi | Q3KQU3 |
MaxQBi | Q3KQU3 |
PaxDbi | Q3KQU3 |
PeptideAtlasi | Q3KQU3 |
PRIDEi | Q3KQU3 |
ProteomicsDBi | 61723 [Q3KQU3-1] 61724 [Q3KQU3-2] 61725 [Q3KQU3-3] 61726 [Q3KQU3-4] |
Protocols and materials databases
Antibodypediai | 31646, 69 antibodies |
Genome annotation databases
Ensembli | ENST00000316156; ENSP00000320228; ENSG00000116871 [Q3KQU3-2] ENST00000373150; ENSP00000362243; ENSG00000116871 [Q3KQU3-4] ENST00000373151; ENSP00000362244; ENSG00000116871 [Q3KQU3-1] |
GeneIDi | 55700 |
KEGGi | hsa:55700 |
UCSCi | uc001bzz.5, human [Q3KQU3-1] |
Organism-specific databases
CTDi | 55700 |
GeneCardsi | MAP7D1 |
HGNCi | HGNC:25514, MAP7D1 |
HPAi | ENSG00000116871, Tissue enhanced (skeletal) |
neXtProti | NX_Q3KQU3 |
OpenTargetsi | ENSG00000116871 |
PharmGKBi | PA162394970 |
VEuPathDBi | HostDB:ENSG00000116871.15 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPJP, Eukaryota |
GeneTreei | ENSGT00950000182941 |
HOGENOMi | CLU_017315_2_0_1 |
InParanoidi | Q3KQU3 |
OMAi | QDRKEAT |
OrthoDBi | 738080at2759 |
PhylomeDBi | Q3KQU3 |
TreeFami | TF332273 |
Enzyme and pathway databases
PathwayCommonsi | Q3KQU3 |
Miscellaneous databases
BioGRID-ORCSi | 55700, 14 hits in 1003 CRISPR screens |
ChiTaRSi | MAP7D1, human |
GenomeRNAii | 55700 |
Pharosi | Q3KQU3, Tdark |
PROi | PR:Q3KQU3 |
RNActi | Q3KQU3, protein |
Gene expression databases
Bgeei | ENSG00000116871, Expressed in quadriceps femoris and 238 other tissues |
ExpressionAtlasi | Q3KQU3, baseline and differential |
Genevisiblei | Q3KQU3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008604, MAP7_fam |
Pfami | View protein in Pfam PF05672, MAP7, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MA7D1_HUMAN | |
Accessioni | Q3KQU3Primary (citable) accession number: Q3KQU3 Secondary accession number(s): D3DPS4 Q9ULN3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | November 8, 2005 | |
Last modified: | April 7, 2021 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families