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Protein
Submitted name:

MME protein

Gene

MME

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
MME proteinImported
Submitted name:
Membrane metallo-endopeptidase variant 2Imported
Submitted name:
NeprilysinImported
Gene namesi
Name:MMEImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000196549.10
HGNCiHGNC:7154 MME

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 52HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196549

Expressioni

Gene expression databases

BgeeiENSG00000196549 Expressed in 156 organ(s), highest expression level in metanephric glomerulus

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3624 Eukaryota
COG3590 LUCA
GeneTreeiENSGT00760000119162
HOGENOMiHOG000132465

Family and domain databases

InterProiView protein in InterPro
IPR029727 MME/CD10/NEP
IPR000718 Peptidase_M13
PANTHERiPTHR11733 PTHR11733, 1 hit
PTHR11733:SF114 PTHR11733:SF114, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q3KQS6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKSESQMDI TDINTPKPKK KQRWTPLEIS LSVLVLLLTI IAVTMIALYA
60 70 80
TYDDGICKSS DCIKSGMVAR AYNPRGRRIA
Length:80
Mass (Da):8,888
Last modified:November 8, 2005 - v1
Checksum:i830B278B830419E9
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P08473NEP_HUMAN
Neprilysin
MME EPN
750Annotation score:
C9IYX7C9IYX7_HUMAN
Neprilysin
MME
119Annotation score:
C9JR96C9JR96_HUMAN
Neprilysin
MME
233Annotation score:
C9J9X7C9J9X7_HUMAN
Neprilysin
MME
161Annotation score:
C9JDZ3C9JDZ3_HUMAN
Neprilysin
MME
93Annotation score:
A0A087WWM7A0A087WWM7_HUMAN
Neprilysin
MME
79Annotation score:
C9J7X4C9J7X4_HUMAN
Neprilysin
MME
15Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC106724 Genomic DNA No translation available.
AC117384 Genomic DNA No translation available.
KF457702 Genomic DNA No translation available.
BC106070 mRNA Translation: AAI06071.1
EU326307 Genomic DNA Translation: ACA05914.1
UniGeneiHs.307734

Genome annotation databases

EnsembliENST00000382989; ENSP00000372450; ENSG00000196549
ENST00000625667; ENSP00000485791; ENSG00000196549
UCSCiuc062pep.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC106724 Genomic DNA No translation available.
AC117384 Genomic DNA No translation available.
KF457702 Genomic DNA No translation available.
BC106070 mRNA Translation: AAI06071.1
EU326307 Genomic DNA Translation: ACA05914.1
UniGeneiHs.307734

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382989; ENSP00000372450; ENSG00000196549
ENST00000625667; ENSP00000485791; ENSG00000196549
UCSCiuc062pep.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000196549.10
HGNCiHGNC:7154 MME
OpenTargetsiENSG00000196549
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3624 Eukaryota
COG3590 LUCA
GeneTreeiENSGT00760000119162
HOGENOMiHOG000132465

Miscellaneous databases

ChiTaRSiMME human

Gene expression databases

BgeeiENSG00000196549 Expressed in 156 organ(s), highest expression level in metanephric glomerulus

Family and domain databases

InterProiView protein in InterPro
IPR029727 MME/CD10/NEP
IPR000718 Peptidase_M13
PANTHERiPTHR11733 PTHR11733, 1 hit
PTHR11733:SF114 PTHR11733:SF114, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ3KQS6_HUMAN
AccessioniPrimary (citable) accession number: Q3KQS6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: October 10, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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