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Protein

Transmembrane and ubiquitin-like domain-containing protein 1

Gene

tmub1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). The membrane form is involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR. May be involved in centrosome assembly.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and ubiquitin-like domain-containing protein 1
Gene namesi
Name:tmub1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6255012 tmub1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003702531 – 308Transmembrane and ubiquitin-like domain-containing protein 1Add BLAST308

Structurei

3D structure databases

ProteinModelPortaliQ3KPV4
SMRiQ3KPV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 242Ubiquitin-likePROSITE-ProRule annotationAdd BLAST74

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3KPV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALIEGVGDE VTVLFALVLF FMVLMLAWVS THTTERAPTH WIRPEPAQGG
60 70 80 90 100
ASSNSQRDFH PGPSQTLTNA DPNSETVDSS DSTQSSREFQ NAGATPHSEV
110 120 130 140 150
AFSSSGSTVS TGGSVEYTGA AADSPPDGES HPNFTVSSRD PQAGASSSLR
160 170 180 190 200
YRGLGDGTTA QSAEEAGTIH LRLKFLNDTE RLVTVRLSDT IMYIKRTYFP
210 220 230 240 250
GQELRVRLIF QGQLLRDDSQ TVSSLQLRDG SVLHCHISQH ASVPGVGADQ
260 270 280 290 300
ANVPLNVGNL LVPLLFLIVM LLWYCQFQYP SLFTGTATAC LGGFTLLISA

IAFSSYHR
Length:308
Mass (Da):33,155
Last modified:November 8, 2005 - v1
Checksum:i8BB5E6D692FFEEDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC106532 mRNA Translation: AAI06533.1
RefSeqiNP_001089771.1, NM_001096302.1
UniGeneiXl.50424

Genome annotation databases

GeneIDi734835
KEGGixla:734835

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC106532 mRNA Translation: AAI06533.1
RefSeqiNP_001089771.1, NM_001096302.1
UniGeneiXl.50424

3D structure databases

ProteinModelPortaliQ3KPV4
SMRiQ3KPV4
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi734835
KEGGixla:734835

Organism-specific databases

CTDi734835
XenbaseiXB-GENE-6255012 tmub1

Family and domain databases

InterProiView protein in InterPro
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMUB1_XENLA
AccessioniPrimary (citable) accession number: Q3KPV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 8, 2005
Last modified: November 22, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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