UniProtKB - Q3KPI0 (CEA21_HUMAN)
Protein
Carcinoembryonic antigen-related cell adhesion molecule 21
Gene
CEACAM21
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Carcinoembryonic antigen-related cell adhesion molecule 21 |
Gene namesi | Name:CEACAM21 ORF Names:UNQ3098/PRO10075 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28834 CEACAM21 |
MIMi | 618191 gene |
neXtProti | NX_Q3KPI0 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 35 – 240 | ExtracellularSequence analysisAdd BLAST | 206 | |
Transmembranei | 241 – 261 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 262 – 293 | CytoplasmicSequence analysisAdd BLAST | 32 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 90273 |
PharmGKBi | PA142672135 |
Miscellaneous databases
Pharosi | Q3KPI0 |
Polymorphism and mutation databases
BioMutai | CEACAM21 |
DMDMi | 156630480 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 34 | Sequence analysisAdd BLAST | 34 | |
ChainiPRO_0000297615 | 35 – 293 | Carcinoembryonic antigen-related cell adhesion molecule 21Add BLAST | 259 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 111 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 166 ↔ 214 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q3KPI0 |
PaxDbi | Q3KPI0 |
PeptideAtlasi | Q3KPI0 |
PRIDEi | Q3KPI0 |
ProteomicsDBi | 61718 [Q3KPI0-1] 61719 [Q3KPI0-2] 61720 [Q3KPI0-3] |
TopDownProteomicsi | Q3KPI0-2 [Q3KPI0-2] |
PTM databases
iPTMneti | Q3KPI0 |
PhosphoSitePlusi | Q3KPI0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000007129 Expressed in 93 organ(s), highest expression level in blood |
ExpressionAtlasi | Q3KPI0 baseline and differential |
Genevisiblei | Q3KPI0 HS |
Organism-specific databases
HPAi | HPA043411 |
Interactioni
Protein-protein interaction databases
BioGridi | 124686, 48 interactors |
IntActi | Q3KPI0, 33 interactors |
STRINGi | 9606.ENSP00000385739 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 147 – 231 | Ig-like C2-typeAdd BLAST | 85 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410J9PH Eukaryota ENOG4111D5D LUCA |
HOGENOMi | HOG000233417 |
InParanoidi | Q3KPI0 |
KOi | K06499 |
OrthoDBi | 998214at2759 |
PhylomeDBi | Q3KPI0 |
TreeFami | TF336859 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013106 Ig_V-set IPR013151 Immunoglobulin |
Pfami | View protein in Pfam PF00047 ig, 1 hit PF07686 V-set, 1 hit |
SMARTi | View protein in SMART SM00409 IG, 2 hits SM00408 IGc2, 1 hit |
SUPFAMi | SSF48726 SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835 IG_LIKE, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q3KPI0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGPPSACPHR ECIPWQGLLL TASLLTFWNA PTTAWLFIAS APFEVAEGEN
60 70 80 90 100
VHLSVVYLPE NLYSYGWYKG KTVEPNQLIA AYVIDTHVRT PGPAYSGRET
110 120 130 140 150
ISPSGDLHFQ NVTLEDTGYY TLQVTYRNSQ IEQASHHLRV YESVAQPSIQ
160 170 180 190 200
ASSTTVTEKG SVVLTCHTNN TGTSFQWIFN NQRLQVTKRM KLSWFNHMLT
210 220 230 240 250
IDPIRQEDAG EYQCEVSNPV SSNRSDPLKL TVKSDDNTLG ILIGVLVGSL
260 270 280 290
LVAALVCFLL LRKTGRASDQ SDFREQQPPA STPGHGPSDS SIS
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4J1W4 | A0A0B4J1W4_HUMAN | Carcinoembryonic antigen-related ce... | CEACAM21 | 165 | Annotation score: | ||
A0A0G2JSC8 | A0A0G2JSC8_HUMAN | Carcinoembryonic antigen-related ce... | CEACAM21 | 293 | Annotation score: | ||
A0A0J9YX60 | A0A0J9YX60_HUMAN | Carcinoembryonic antigen-related ce... | CEACAM21 | 95 | Annotation score: | ||
A0A0G2JS40 | A0A0G2JS40_HUMAN | Carcinoembryonic antigen-related ce... | CEACAM21 hCG_22317 | 191 | Annotation score: |
Sequence cautioni
The sequence AAC34569 differs from that shown. Reason: Erroneous gene model prediction.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034651 | 121 | T → N2 PublicationsCorresponds to variant dbSNP:rs714106Ensembl. | 1 | |
Natural variantiVAR_034652 | 198 | M → V2 PublicationsCorresponds to variant dbSNP:rs2302188Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027303 | 142 – 293 | ESVAQ…DSSIS → GECSKFDSEISEDAAWPQDT FCWSLYPQSQWLSPPSKPAA PQSQRRAPWS in isoform 3. 1 PublicationAdd BLAST | 152 | |
Alternative sequenceiVSP_027304 | 234 – 235 | SD → Y in isoform 2. 1 Publication | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358084 mRNA Translation: AAQ88451.1 AC006129 Genomic DNA No translation available. AC005626 Genomic DNA Translation: AAC34569.1 Sequence problems. BC012001 mRNA Translation: AAH12001.1 BC106727 mRNA Translation: AAI06728.1 |
CCDSi | CCDS46086.1 [Q3KPI0-1] CCDS46087.1 [Q3KPI0-2] |
RefSeqi | NP_001091976.3, NM_001098506.3 NP_001275702.2, NM_001288773.2 NP_001277042.1, NM_001290113.1 NP_291021.4, NM_033543.5 XP_005278453.1, XM_005278396.4 XP_005278454.1, XM_005278397.3 |
Genome annotation databases
Ensembli | ENST00000187608; ENSP00000187608; ENSG00000007129 ENST00000401445; ENSP00000385739; ENSG00000007129 ENST00000457737; ENSP00000390697; ENSG00000007129 ENST00000611554; ENSP00000483598; ENSG00000278565 |
GeneIDi | 90273 |
KEGGi | hsa:90273 |
UCSCi | uc002ore.5 human [Q3KPI0-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358084 mRNA Translation: AAQ88451.1 AC006129 Genomic DNA No translation available. AC005626 Genomic DNA Translation: AAC34569.1 Sequence problems. BC012001 mRNA Translation: AAH12001.1 BC106727 mRNA Translation: AAI06728.1 |
CCDSi | CCDS46086.1 [Q3KPI0-1] CCDS46087.1 [Q3KPI0-2] |
RefSeqi | NP_001091976.3, NM_001098506.3 NP_001275702.2, NM_001288773.2 NP_001277042.1, NM_001290113.1 NP_291021.4, NM_033543.5 XP_005278453.1, XM_005278396.4 XP_005278454.1, XM_005278397.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 124686, 48 interactors |
IntActi | Q3KPI0, 33 interactors |
STRINGi | 9606.ENSP00000385739 |
PTM databases
iPTMneti | Q3KPI0 |
PhosphoSitePlusi | Q3KPI0 |
Polymorphism and mutation databases
BioMutai | CEACAM21 |
DMDMi | 156630480 |
Proteomic databases
MassIVEi | Q3KPI0 |
PaxDbi | Q3KPI0 |
PeptideAtlasi | Q3KPI0 |
PRIDEi | Q3KPI0 |
ProteomicsDBi | 61718 [Q3KPI0-1] 61719 [Q3KPI0-2] 61720 [Q3KPI0-3] |
TopDownProteomicsi | Q3KPI0-2 [Q3KPI0-2] |
Genome annotation databases
Ensembli | ENST00000187608; ENSP00000187608; ENSG00000007129 ENST00000401445; ENSP00000385739; ENSG00000007129 ENST00000457737; ENSP00000390697; ENSG00000007129 ENST00000611554; ENSP00000483598; ENSG00000278565 |
GeneIDi | 90273 |
KEGGi | hsa:90273 |
UCSCi | uc002ore.5 human [Q3KPI0-1] |
Organism-specific databases
CTDi | 90273 |
DisGeNETi | 90273 |
GeneCardsi | CEACAM21 |
HGNCi | HGNC:28834 CEACAM21 |
HPAi | HPA043411 |
MIMi | 618191 gene |
neXtProti | NX_Q3KPI0 |
PharmGKBi | PA142672135 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410J9PH Eukaryota ENOG4111D5D LUCA |
HOGENOMi | HOG000233417 |
InParanoidi | Q3KPI0 |
KOi | K06499 |
OrthoDBi | 998214at2759 |
PhylomeDBi | Q3KPI0 |
TreeFami | TF336859 |
Miscellaneous databases
ChiTaRSi | CEACAM21 human |
GenomeRNAii | 90273 |
Pharosi | Q3KPI0 |
PROi | PR:Q3KPI0 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000007129 Expressed in 93 organ(s), highest expression level in blood |
ExpressionAtlasi | Q3KPI0 baseline and differential |
Genevisiblei | Q3KPI0 HS |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013106 Ig_V-set IPR013151 Immunoglobulin |
Pfami | View protein in Pfam PF00047 ig, 1 hit PF07686 V-set, 1 hit |
SMARTi | View protein in SMART SM00409 IG, 2 hits SM00408 IGc2, 1 hit |
SUPFAMi | SSF48726 SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835 IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CEA21_HUMAN | |
Accessioni | Q3KPI0Primary (citable) accession number: Q3KPI0 Secondary accession number(s): B7WNQ6 Q96ER7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | August 21, 2007 | |
Last modified: | September 18, 2019 | |
This is version 126 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot