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Protein

Innate immunity activator protein

Gene

INAVA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity, Innate immunity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Innate immunity activator proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INAVAImported
Synonyms:C1orf106
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000163362.10

Human Gene Nomenclature Database

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HGNCi
HGNC:25599 INAVA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618051 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q3KP66

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Genetic variations in INAVA are associated with an increased risk of inflammatory bowel disease. A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology which is subdivided into Crohn disease and ulcerative colitis phenotypes.3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi164 – 170PKVRRRI → AAAAAAA: No effect on nuclear translocation upon induction by MDP. Abolishes nuclear translocation upon induction by MDP and slightly decreases NOD2-induced AP-1 and NF-kappaB activation and IL6 secretion; when associated with 335-A--A-338 and 423-A--A-426. 1 Publication7
Mutagenesisi246S → A: Decreases interaction with YWHAQ, cellular signaling pathway activation and cytokine secretion. 1 Publication1
Mutagenesisi335 – 338KPRK → AAAA: No effect on nuclear translocation upon induction by MDP. Abolishes nuclear translocation upon induction by MDP and slightly decreases NOD2-induced AP-1 and NF-kappaB activation and IL6 secretion; when associated with 164-A--A-170 and 423-A--A-426. 1 Publication4
Mutagenesisi340S → A: Decreases interaction with YWHAQ, cellular signaling pathway activation and cytokine secretion. 1 Publication1
Mutagenesisi423 – 426RRRP → AAAA: No effect on nuclear translocation upon induction by MDP. Abolishes nuclear translocation upon induction by MDP and slightly decreases NOD2-induced AP-1 and NF-kappaB activation and IL6 secretion; when associated with 164-A--A-170 and 335-A--A-338. 1 Publication4
Mutagenesisi616S → A: Decreases interaction with YWHAQ, cellular signaling pathway activation and cytokine secretion. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
55765

Open Targets

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OpenTargetsi
ENSG00000163362

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA142672490

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C1orf106

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373328

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002517291 – 663Innate immunity activator proteinAdd BLAST663

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q3KP66

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3KP66

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q3KP66

PeptideAtlas

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PeptideAtlasi
Q3KP66

PRoteomics IDEntifications database

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PRIDEi
Q3KP66

ProteomicsDB human proteome resource

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ProteomicsDBi
61715

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q3KP66

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q3KP66

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in intestinal myeloid-derived cells and expressed in monocyte-derived macrophages upon induction by PRR activation.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is induced by the component of peptidoglycan muramyl dipeptide (PubMed:28436939). Negatively regulated by microRNA-24 (miR-24) (PubMed:28436939).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000163362 Expressed in 143 organ(s), highest expression level in colonic mucosa

CleanEx database of gene expression profiles

More...
CleanExi
HS_C1orf106

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3KP66 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q3KP66 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027499
HPA027511

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with IRAK1, NOD2 and RIPK2; the interaction takes place upon PRR stimulation (PubMed:28436939). Interacts with YWHAQ/14-3-3T; the interaction increases upon PRR stimulation and is required for cellular signaling pathway activation and cytokine secretion (PubMed:28436939). Interacts (via N-terminal domain) with CYTH1 and CYTH2 (via their N-terminal domains) (PubMed:29420262). Interacts with FBXW11 and BTRC; associates with SCF E3 ubiquitin-protein ligase complexes (PubMed:29420262).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120883, 24 interactors

Protein interaction database and analysis system

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IntActi
Q3KP66, 26 interactors

Molecular INTeraction database

More...
MINTi
Q3KP66

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356311

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q3KP66

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q3KP66

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili118 – 147Sequence analysisAdd BLAST30

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi164 – 170Nuclear localization signal (NLS) 11 Publication7
Motifi332 – 338Nuclear localization signal (NLS) 21 Publication7
Motifi422 – 428Nuclear localization signal (NLS) 31 Publication7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi282 – 357Pro-richAdd BLAST76

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3529 Eukaryota
ENOG410XQFP LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154102

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000233699

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG080963

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q3KP66

Identification of Orthologs from Complete Genome Data

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OMAi
SPWKESS

Database of Orthologous Groups

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OrthoDBi
EOG091G0784

Database for complete collections of gene phylogenies

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PhylomeDBi
Q3KP66

TreeFam database of animal gene trees

More...
TreeFami
TF328984

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR021774 DUF3338
IPR039106 INAVA

The PANTHER Classification System

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PANTHERi
PTHR16093:SF4 PTHR16093:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11819 DUF3338, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3KP66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLQMPKLNEI PPGRAGRREA RGEGRWPGQT GPEAARLEWR AQGQAGGARA
60 70 80 90 100
PWDSWGSSRL PTQPGPGWSR CPPSLLCALS FQKSTMESKD EVSDTDSGII
110 120 130 140 150
LQSGPDSPVS PMKELTHAVH KQQRALEARL EACLEELRRL CLREAELTGT
160 170 180 190 200
LPAEYPLKPG EKAPKVRRRI GAAYKLDDWA LHREDPLSSL ERQLALQLQI
210 220 230 240 250
TEAARRLCLE ENLSRQARRQ RKHSMLQEEK KLQELQRCLV ERRRNSEPPP
260 270 280 290 300
AAALPLGREL SASDDSSLSD GLLLEEEESQ VPKPPPESPA PPSRPLPPQT
310 320 330 340 350
LEGLQPTGPE AGSPERAPVQ NSPWKETSLD HPYEKPRKSS EPWSESSSPA
360 370 380 390 400
TTPQDGPSAS SLWLLEPASY HVVPIRGVPG QWQGRTSAPA TPEIQGRRGQ
410 420 430 440 450
SQSLRVDSFR AGPEGRGRSA FPRRRPTHYT VTVPDSCFPA TKPPLPHAAC
460 470 480 490 500
HSCSEDSGSD VSSISHPTSP GSSSPDISFL QPLSPPKTHR HRGAWVPAGS
510 520 530 540 550
RELVAHHPKL LLPPGYFPAG RYVVVAESPL PPGEWELRRA APGPAYEEEG
560 570 580 590 600
TPLRYQRLVP SRSRIVRTPS LKDSPAGRGL SKAAVSEELK WWHERARLRS
610 620 630 640 650
TRPHSLDRQG AFRVRSLPLG REGFGRALGP RAQVPTVCVL RRSPDGAPVQ
660
VFVPEKGEII SQV
Length:663
Mass (Da):72,914
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i77EB3D76DC55EF8A
GO
Isoform 2 (identifier: Q3KP66-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:578
Mass (Da):63,695
Checksum:i92B58F00B878C9B5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JAT8C9JAT8_HUMAN
Innate immunity activator protein
INAVA
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PK29E9PK29_HUMAN
Innate immunity activator protein
INAVA
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91771 differs from that shown. Unlikely isoform. Aberrant splice sites.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti641R → W in BAA91892 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080249333Y → F Found in patients with inflammatory bowel disease; unknown pathological significance; decreases protein stability. 2 PublicationsCorresponds to variant dbSNP:rs41313912Ensembl.1
Natural variantiVAR_030835538R → C2 PublicationsCorresponds to variant dbSNP:rs296520Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0460481 – 85Missing in isoform 2. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK001583 mRNA Translation: BAA91771.1 Sequence problems.
AK001763 mRNA Translation: BAA91892.1
AK303885 mRNA Translation: BAG64821.1
AK316510 mRNA Translation: BAH14881.1
AC099756 Genomic DNA No translation available.
BC106877 mRNA Translation: AAI06878.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS44292.1 [Q3KP66-3]

NCBI Reference Sequences

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RefSeqi
NP_001136041.1, NM_001142569.2 [Q3KP66-3]
NP_060735.3, NM_018265.3
XP_011508056.1, XM_011509754.2 [Q3KP66-3]
XP_011508057.1, XM_011509755.1 [Q3KP66-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.518997

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367342; ENSP00000356311; ENSG00000163362 [Q3KP66-1]
ENST00000413687; ENSP00000392105; ENSG00000163362 [Q3KP66-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55765

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55765

UCSC genome browser

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UCSCi
uc010ppm.3 human [Q3KP66-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001583 mRNA Translation: BAA91771.1 Sequence problems.
AK001763 mRNA Translation: BAA91892.1
AK303885 mRNA Translation: BAG64821.1
AK316510 mRNA Translation: BAH14881.1
AC099756 Genomic DNA No translation available.
BC106877 mRNA Translation: AAI06878.1
CCDSiCCDS44292.1 [Q3KP66-3]
RefSeqiNP_001136041.1, NM_001142569.2 [Q3KP66-3]
NP_060735.3, NM_018265.3
XP_011508056.1, XM_011509754.2 [Q3KP66-3]
XP_011508057.1, XM_011509755.1 [Q3KP66-3]
UniGeneiHs.518997

3D structure databases

ProteinModelPortaliQ3KP66
SMRiQ3KP66
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120883, 24 interactors
IntActiQ3KP66, 26 interactors
MINTiQ3KP66
STRINGi9606.ENSP00000356311

PTM databases

iPTMnetiQ3KP66
PhosphoSitePlusiQ3KP66

Polymorphism and mutation databases

BioMutaiC1orf106
DMDMi317373328

Proteomic databases

EPDiQ3KP66
MaxQBiQ3KP66
PaxDbiQ3KP66
PeptideAtlasiQ3KP66
PRIDEiQ3KP66
ProteomicsDBi61715

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367342; ENSP00000356311; ENSG00000163362 [Q3KP66-1]
ENST00000413687; ENSP00000392105; ENSG00000163362 [Q3KP66-3]
GeneIDi55765
KEGGihsa:55765
UCSCiuc010ppm.3 human [Q3KP66-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55765
DisGeNETi55765
EuPathDBiHostDB:ENSG00000163362.10

GeneCards: human genes, protein and diseases

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GeneCardsi
INAVA
HGNCiHGNC:25599 INAVA
HPAiHPA027499
HPA027511
MIMi618051 gene
neXtProtiNX_Q3KP66
OpenTargetsiENSG00000163362
PharmGKBiPA142672490

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3529 Eukaryota
ENOG410XQFP LUCA
GeneTreeiENSGT00940000154102
HOGENOMiHOG000233699
HOVERGENiHBG080963
InParanoidiQ3KP66
OMAiSPWKESS
OrthoDBiEOG091G0784
PhylomeDBiQ3KP66
TreeFamiTF328984

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
C1orf106 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55765

Protein Ontology

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PROi
PR:Q3KP66

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163362 Expressed in 143 organ(s), highest expression level in colonic mucosa
CleanExiHS_C1orf106
ExpressionAtlasiQ3KP66 baseline and differential
GenevisibleiQ3KP66 HS

Family and domain databases

InterProiView protein in InterPro
IPR021774 DUF3338
IPR039106 INAVA
PANTHERiPTHR16093:SF4 PTHR16093:SF4, 1 hit
PfamiView protein in Pfam
PF11819 DUF3338, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINAVA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3KP66
Secondary accession number(s): B4E1K9
, E9PFY0, Q9NV65, Q9NVI0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: January 11, 2011
Last modified: December 5, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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