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Protein

Solute carrier family 10 member 6

Gene

SLC10A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds

Protein family/group databases

TCDBi2.A.28.1.4 the bile acid:na(+) symporter (bass) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 10 member 6
Alternative name(s):
Sodium-dependent organic anion transporter
Gene namesi
Name:SLC10A6
Synonyms:SOAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000145283.7
HGNCiHGNC:30603 SLC10A6
MIMi613366 gene
neXtProtiNX_Q3KNW5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Topological domaini51 – 67CytoplasmicSequence analysisAdd BLAST17
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Topological domaini89 – 97ExtracellularSequence analysis9
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 133CytoplasmicSequence analysisAdd BLAST15
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Topological domaini155 – 159ExtracellularSequence analysis5
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 195CytoplasmicSequence analysisAdd BLAST15
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 226ExtracellularSequence analysis10
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 266CytoplasmicSequence analysisAdd BLAST19
Transmembranei267 – 285HelicalSequence analysisAdd BLAST19
Topological domaini286 – 290ExtracellularSequence analysis5
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Topological domaini312 – 377CytoplasmicSequence analysisAdd BLAST66

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi345274
OpenTargetsiENSG00000145283
PharmGKBiPA142670910

Chemistry databases

DrugBankiDB05804 dehydroepiandrosterone sulfate
DB02789 Pregnenolone

Polymorphism and mutation databases

BioMutaiSLC10A6
DMDMi160358735

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003092151 – 377Solute carrier family 10 member 6Add BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3KNW5
PeptideAtlasiQ3KNW5
PRIDEiQ3KNW5
ProteomicsDBi61709

Expressioni

Tissue specificityi

Highly expressed in testis, placenta and pancreas. Moderately expressed in heart, lung and mammary gland. Weakly expressed in brain, colon, kidney, liver, ovary, prostate, small intestine, spleen and thymus.1 Publication

Gene expression databases

BgeeiENSG00000145283 Expressed in 70 organ(s), highest expression level in ectocervix
CleanExiHS_SLC10A6

Organism-specific databases

HPAiHPA016662

Interactioni

Protein-protein interaction databases

IntActiQ3KNW5, 134 interactors
STRINGi9606.ENSP00000273905

Structurei

3D structure databases

ProteinModelPortaliQ3KNW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2718 Eukaryota
COG0385 LUCA
GeneTreeiENSGT00550000074505
HOGENOMiHOG000234524
HOVERGENiHBG006537
InParanoidiQ3KNW5
KOiK14346
OMAiCLTIPVA
OrthoDBiEOG091G0GT5
PhylomeDBiQ3KNW5
TreeFamiTF315811

Family and domain databases

Gene3Di1.20.1530.20, 1 hit
InterProiView protein in InterPro
IPR002657 BilAc:Na_symport/Acr3
IPR004710 Bilac:Na_transpt
IPR038770 Na+/solute_symporter_sf
IPR030203 SLC10A6
PANTHERiPTHR10361 PTHR10361, 1 hit
PTHR10361:SF55 PTHR10361:SF55, 1 hit
PfamiView protein in Pfam
PF01758 SBF, 1 hit
TIGRFAMsiTIGR00841 bass, 1 hit

Sequencei

Sequence statusi: Complete.

Q3KNW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRANCSSSSA CPANSSEEEL PVGLEVHGNL ELVFTVVSTV MMGLLMFSLG
60 70 80 90 100
CSVEIRKLWS HIRRPWGIAV GLLCQFGLMP FTAYLLAISF SLKPVQAIAV
110 120 130 140 150
LIMGCCPGGT ISNIFTFWVD GDMDLSISMT TCSTVAALGM MPLCIYLYTW
160 170 180 190 200
SWSLQQNLTI PYQNIGITLV CLTIPVAFGV YVNYRWPKQS KIILKIGAVV
210 220 230 240 250
GGVLLLVVAV AGVVLAKGSW NSDITLLTIS FIFPLIGHVT GFLLALFTHQ
260 270 280 290 300
SWQRCRTISL ETGAQNIQMC ITMLQLSFTA EHLVQMLSFP LAYGLFQLID
310 320 330 340 350
GFLIVAAYQT YKRRLKNKHG KKNSGCTEVC HTRKSTSSRE TNAFLEVNEE
360 370
GAITPGPPGP MDCHRALEPV GHITSCE
Length:377
Mass (Da):41,259
Last modified:November 13, 2007 - v2
Checksum:iA68B0F034B5BE83F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0369046S → F. Corresponds to variant dbSNP:rs17694522Ensembl.1
Natural variantiVAR_036905114I → V1 PublicationCorresponds to variant dbSNP:rs13106574Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF437223 mRNA Translation: ABO38126.1
AJ583502 mRNA Translation: CAE47477.1
CH471057 Genomic DNA Translation: EAX05969.1
BC107051 mRNA Translation: AAI07052.1
BC107052 mRNA Translation: AAI07053.1
CCDSiCCDS3614.1
RefSeqiNP_932069.1, NM_197965.2
UniGeneiHs.452996

Genome annotation databases

EnsembliENST00000273905; ENSP00000273905; ENSG00000145283
GeneIDi345274
KEGGihsa:345274
UCSCiuc003hqd.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF437223 mRNA Translation: ABO38126.1
AJ583502 mRNA Translation: CAE47477.1
CH471057 Genomic DNA Translation: EAX05969.1
BC107051 mRNA Translation: AAI07052.1
BC107052 mRNA Translation: AAI07053.1
CCDSiCCDS3614.1
RefSeqiNP_932069.1, NM_197965.2
UniGeneiHs.452996

3D structure databases

ProteinModelPortaliQ3KNW5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3KNW5, 134 interactors
STRINGi9606.ENSP00000273905

Chemistry databases

DrugBankiDB05804 dehydroepiandrosterone sulfate
DB02789 Pregnenolone

Protein family/group databases

TCDBi2.A.28.1.4 the bile acid:na(+) symporter (bass) family

Polymorphism and mutation databases

BioMutaiSLC10A6
DMDMi160358735

Proteomic databases

PaxDbiQ3KNW5
PeptideAtlasiQ3KNW5
PRIDEiQ3KNW5
ProteomicsDBi61709

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273905; ENSP00000273905; ENSG00000145283
GeneIDi345274
KEGGihsa:345274
UCSCiuc003hqd.2 human

Organism-specific databases

CTDi345274
DisGeNETi345274
EuPathDBiHostDB:ENSG00000145283.7
GeneCardsiSLC10A6
HGNCiHGNC:30603 SLC10A6
HPAiHPA016662
MIMi613366 gene
neXtProtiNX_Q3KNW5
OpenTargetsiENSG00000145283
PharmGKBiPA142670910
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2718 Eukaryota
COG0385 LUCA
GeneTreeiENSGT00550000074505
HOGENOMiHOG000234524
HOVERGENiHBG006537
InParanoidiQ3KNW5
KOiK14346
OMAiCLTIPVA
OrthoDBiEOG091G0GT5
PhylomeDBiQ3KNW5
TreeFamiTF315811

Enzyme and pathway databases

ReactomeiR-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds

Miscellaneous databases

GenomeRNAii345274
PROiPR:Q3KNW5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145283 Expressed in 70 organ(s), highest expression level in ectocervix
CleanExiHS_SLC10A6

Family and domain databases

Gene3Di1.20.1530.20, 1 hit
InterProiView protein in InterPro
IPR002657 BilAc:Na_symport/Acr3
IPR004710 Bilac:Na_transpt
IPR038770 Na+/solute_symporter_sf
IPR030203 SLC10A6
PANTHERiPTHR10361 PTHR10361, 1 hit
PTHR10361:SF55 PTHR10361:SF55, 1 hit
PfamiView protein in Pfam
PF01758 SBF, 1 hit
TIGRFAMsiTIGR00841 bass, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOAT_HUMAN
AccessioniPrimary (citable) accession number: Q3KNW5
Secondary accession number(s): Q70EX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: September 12, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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