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UniProtKB - Q3KNW5 (SOAT_HUMAN)

Entry version 117 (07 Oct 2020)
Sequence version 2 (13 Nov 2007)
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Protein

Solute carrier family 10 member 6

Gene

SLC10A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q3KNW5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-425366, Transport of bile salts and organic acids, metal ions and amine compounds

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.28.1.4, the bile acid:na(+) symporter (bass) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 10 member 6
Alternative name(s):
Sodium-dependent organic anion transporter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC10A6
Synonyms:SOAT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000145283.7

Human Gene Nomenclature Database

More...HGNCi		HGNC:30603, SLC10A6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613366, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q3KNW5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Topological domaini51 – 67CytoplasmicSequence analysisAdd BLAST17
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Topological domaini89 – 97ExtracellularSequence analysis9
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 133CytoplasmicSequence analysisAdd BLAST15
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Topological domaini155 – 159ExtracellularSequence analysis5
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 195CytoplasmicSequence analysisAdd BLAST15
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 226ExtracellularSequence analysis10
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 266CytoplasmicSequence analysisAdd BLAST19
Transmembranei267 – 285HelicalSequence analysisAdd BLAST19
Topological domaini286 – 290ExtracellularSequence analysis5
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Topological domaini312 – 377CytoplasmicSequence analysisAdd BLAST66

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		345274

Open Targets

More...OpenTargetsi		ENSG00000145283

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142670910

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q3KNW5, Tdark

Chemistry databases

Drug and drug target database

More...DrugBanki		DB05804, Prasterone sulfate
DB02789, Pregnenolone

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC10A6

Domain mapping of disease mutations (DMDM)

More...DMDMi		160358735

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003092151 – 377Solute carrier family 10 member 6Add BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q3KNW5

PeptideAtlas

More...PeptideAtlasi		Q3KNW5

PRoteomics IDEntifications database

More...PRIDEi		Q3KNW5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		61709

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q3KNW5, 2 sites

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis, placenta and pancreas. Moderately expressed in heart, lung and mammary gland. Weakly expressed in brain, colon, kidney, liver, ovary, prostate, small intestine, spleen and thymus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000145283, Expressed in ectocervix and 89 other tissues

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000145283, Tissue enhanced (adipose tissue, breast, skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q3KNW5
With#Exp.IntAct
ACSL5 [Q9ULC5]3EBI-18159983,EBI-2876927
ANKRD46 - isoform 1 [Q86W74-2]3EBI-18159983,EBI-12109402
APOD [P05090]3EBI-18159983,EBI-715495
ARL6IP1 [Q15041]3EBI-18159983,EBI-714543
ARV1 [Q9H2C2]3EBI-18159983,EBI-11724186
ATP13A1 - isoform C [Q9HD20-3]3EBI-18159983,EBI-12069500
BMP10 [O95393]3EBI-18159983,EBI-3922513
BTN2A2 [Q8WVV5]3EBI-18159983,EBI-8648738
C11orf24 [Q96F05]3EBI-18159983,EBI-2836238
C2CD2L [O14523]3EBI-18159983,EBI-12822627
CCDC167 [Q9P0B6]3EBI-18159983,EBI-9083477
CCL4 [P13236]3EBI-18159983,EBI-2873970
CDIPT [O14735]3EBI-18159983,EBI-358858
CDS1 [Q92903]3EBI-18159983,EBI-13295305
CLDND2 [Q8NHS1]3EBI-18159983,EBI-11959453
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-18159983,EBI-11522780
CNIH1 [O95406]3EBI-18159983,EBI-12172273
COL4A5 - isoform 2 [P29400-2]3EBI-18159983,EBI-12211159
COMT [P21964]3EBI-18159983,EBI-372265
COX20 [Q5RI15]3EBI-18159983,EBI-2834035
CYB5B [O43169]3EBI-18159983,EBI-1058710
CYB5R3 [P00387]3EBI-18159983,EBI-1046040
CYP4F2 [P78329]3EBI-18159983,EBI-1752413
DERL1 [Q9BUN8]3EBI-18159983,EBI-398977
DGAT2L6 [Q6ZPD8]3EBI-18159983,EBI-12831978
EMC6 [Q9BV81]3EBI-18159983,EBI-2820492
ERG28 [Q9UKR5]3EBI-18159983,EBI-711490
FA2H [Q7L5A8]3EBI-18159983,EBI-11337888
FAM3C [Q92520]3EBI-18159983,EBI-2876774
FAXDC2 [Q96IV6]3EBI-18159983,EBI-12142299
FIS1 [Q9Y3D6]3EBI-18159983,EBI-3385283
FKBP8 [Q14318]3EBI-18159983,EBI-724839
FMO1 [Q01740]3EBI-18159983,EBI-12701460
FUNDC2 [Q9BWH2]3EBI-18159983,EBI-714482
FXYD3 - isoform 3 [Q14802-3]3EBI-18159983,EBI-12175685
FXYD6 [Q9H0Q3]3EBI-18159983,EBI-713304
GIMAP1 [Q8WWP7]3EBI-18159983,EBI-11991950
GJB6 [O95452]3EBI-18159983,EBI-13345609
GLB1 [P16278]3EBI-18159983,EBI-989638
GOLT1B [Q9Y3E0]3EBI-18159983,EBI-4402607
GOSR2 [O14653]3EBI-18159983,EBI-4401517
GPR151 [Q8TDV0]3EBI-18159983,EBI-11955647
GYPA [P02724]3EBI-18159983,EBI-702665
GYPC [P04921]3EBI-18159983,EBI-7797098
HTATIP2 - isoform 3 [Q9BUP3-3]3EBI-18159983,EBI-12937691
IGFBP5 [P24593]3EBI-18159983,EBI-720480
ITGAM [P11215]3EBI-18159983,EBI-2568251
LPAR3 [Q9UBY5]3EBI-18159983,EBI-12033434
LSS [P48449]3EBI-18159983,EBI-3930711
MALL [Q13021]3EBI-18159983,EBI-750078
MFSD5 [Q6N075]3EBI-18159983,EBI-3920969
MFSD6 [Q6ZSS7]3EBI-18159983,EBI-2858252
MGLL [A0A0C4DFN3]3EBI-18159983,EBI-12866138
MS4A1 [P11836]3EBI-18159983,EBI-2808234
NAT8 [Q9UHE5]3EBI-18159983,EBI-2863634
NEU1 [Q99519]3EBI-18159983,EBI-721517
NINJ2 [Q9NZG7]3EBI-18159983,EBI-10317425
NRM [Q8IXM6]3EBI-18159983,EBI-10262547
OR7D4 [Q8NG98]3EBI-18159983,EBI-18164026
ORMDL1 [Q9P0S3]3EBI-18159983,EBI-1054848
OSMR [Q99650]3EBI-18159983,EBI-2804080
PEX16 [Q9Y5Y5]3EBI-18159983,EBI-981985
PIP4P1 [Q86T03]3EBI-18159983,EBI-6164623
PIP4P2 [Q8N4L2]3EBI-18159983,EBI-2820617
PLLP [Q9Y342]3EBI-18159983,EBI-3919291
PLP1 - isoform DM-20 [P60201-2]3EBI-18159983,EBI-12188331
PNLIPRP1 [P54315]3EBI-18159983,EBI-8652812
PRAF2 [O60831]3EBI-18159983,EBI-2506064
PRRT2 [Q7Z6L0]3EBI-18159983,EBI-722696
PSEN1 - isoform 2 [P49768-2]3EBI-18159983,EBI-11047108
PSENEN [Q9NZ42]3EBI-18159983,EBI-998468
RNF24 - isoform 2 [Q9Y225-2]3EBI-18159983,EBI-13044680
RTP2 [Q5QGT7]3EBI-18159983,EBI-10244780
RUSF1 [Q96GQ5]3EBI-18159983,EBI-8636004
SACM1L [Q9NTJ5]3EBI-18159983,EBI-3917235
SCAMP4 [Q969E2]3EBI-18159983,EBI-4403649
SCAMP5 [Q8TAC9]3EBI-18159983,EBI-2695784
SCD [O00767]3EBI-18159983,EBI-2684237
SERP1 [Q9Y6X1]3EBI-18159983,EBI-10329948
SERP2 [Q8N6R1]3EBI-18159983,EBI-749270
SFT2D2 [O95562]3EBI-18159983,EBI-4402330
SFXN1 [Q9H9B4]3EBI-18159983,EBI-355861
SLC12A7 - isoform 2 [Q9Y666-2]3EBI-18159983,EBI-12854384
SLC25A46 [Q96AG3]3EBI-18159983,EBI-10281975
SLC30A2 [Q9BRI3]3EBI-18159983,EBI-8644112
SLC30A3 [Q99726]3EBI-18159983,EBI-10294651
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-18159983,EBI-17295964
SLC35G2 [Q8TBE7]3EBI-18159983,EBI-727304
SLC38A1 [Q9H2H9]3EBI-18159983,EBI-9978441
SLC39A6 - isoform 2 [Q13433-2]3EBI-18159983,EBI-12956703
SLC39A9 [Q9NUM3]3EBI-18159983,EBI-2823239
SLC41A1 [Q8IVJ1]3EBI-18159983,EBI-12266234
SLC66A2 [Q8N2U9]3EBI-18159983,EBI-3907610
SLC7A1 [P30825]3EBI-18159983,EBI-4289564
SMAGP [Q0VAQ4]3EBI-18159983,EBI-10226799
SMIM1 [B2RUZ4]3EBI-18159983,EBI-12188413
SNORC [Q6UX34]3EBI-18159983,EBI-11957067
STATH [P02808]3EBI-18159983,EBI-738687
STX12 [Q86Y82]3EBI-18159983,EBI-2691717
STX7 [O15400]3EBI-18159983,EBI-3221827
STX8 [Q9UNK0]3EBI-18159983,EBI-727240
SYNGR1 - isoform 1B [O43759-2]3EBI-18159983,EBI-12187159
SYNJ2BP [P57105]3EBI-18159983,EBI-1049004
TAP1 [Q03518]3EBI-18159983,EBI-747259
TECR [Q9NZ01]3EBI-18159983,EBI-2877718
TF [P02787]3EBI-18159983,EBI-714319
TM4SF4 [P48230]3EBI-18159983,EBI-8650934
TMEM107 [Q6UX40]3EBI-18159983,EBI-12845616
TMEM11 [P17152]3EBI-18159983,EBI-723946
TMEM120B [A0PK00]3EBI-18159983,EBI-10171534
TMEM128 - isoform 2 [Q5BJH2-2]3EBI-18159983,EBI-10694905
TMEM143 [Q96AN5]3EBI-18159983,EBI-13342951
TMEM14A [Q9Y6G1]3EBI-18159983,EBI-2800360
TMEM14C [Q9P0S9]3EBI-18159983,EBI-2339195
TMEM189-UBE2V1 [I3L0A0]3EBI-18159983,EBI-12213001
TMEM203 [Q969S6]3EBI-18159983,EBI-12274070
TMEM208 [Q9BTX3]3EBI-18159983,EBI-12876824
TMEM218 [A2RU14]3EBI-18159983,EBI-10173151
TMEM229B [Q8NBD8]3EBI-18159983,EBI-12195227
TMEM234 [Q8WY98]3EBI-18159983,EBI-8642211
TMEM239 - isoform 2 [Q8WW34-2]3EBI-18159983,EBI-11528917
TMEM242 [Q9NWH2]3EBI-18159983,EBI-10315004
TMEM252 [Q8N6L7]3EBI-18159983,EBI-8787626
TMEM262 [E9PQX1]3EBI-18159983,EBI-17180389
TMEM50B [P56557]3EBI-18159983,EBI-12366453
TMEM60 [Q9H2L4]3EBI-18159983,EBI-2852148
TMEM65 [Q6PI78]3EBI-18159983,EBI-6656213
TMEM86A [Q8N2M4]3EBI-18159983,EBI-12015604
TMEM86B [Q8N661]3EBI-18159983,EBI-2548832
TPRG1 [Q6ZUI0]3EBI-18159983,EBI-17249488
TREX1 - isoform 1 [Q9NSU2-1]3EBI-18159983,EBI-16746122
TSNARE1 [A0AVG3]3EBI-18159983,EBI-12003468
TSPAN2 [O60636]3EBI-18159983,EBI-3914288
TSPO2 [Q5TGU0]3EBI-18159983,EBI-12195249
TVP23B [Q9NYZ1]3EBI-18159983,EBI-11343401
UBE2J1 [Q9Y385]3EBI-18159983,EBI-988826
UNC50 [Q53HI1]3EBI-18159983,EBI-7601760
VAMP4 [O75379]3EBI-18159983,EBI-744953
YIPF1 [Q9Y548]3EBI-18159983,EBI-7850136
YIPF2 [Q9BWQ6]3EBI-18159983,EBI-751204
YIPF6 [Q96EC8]3EBI-18159983,EBI-751210
ZDHHC15 [Q96MV8]3EBI-18159983,EBI-12837904
ZFPL1 [O95159]3EBI-18159983,EBI-718439
Q96FB23EBI-18159983,EBI-2857623

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		131345, 146 interactors

Protein interaction database and analysis system

More...IntActi		Q3KNW5, 145 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000273905

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q3KNW5, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2718, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182808

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_034788_7_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q3KNW5

KEGG Orthology (KO)

More...KOi		K14346

Identification of Orthologs from Complete Genome Data

More...OMAi		MEIGIHN

Database of Orthologous Groups

More...OrthoDBi		1148347at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q3KNW5

TreeFam database of animal gene trees

More...TreeFami		TF315811

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1530.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002657, BilAc:Na_symport/Acr3
IPR004710, Bilac:Na_transpt
IPR038770, Na+/solute_symporter_sf
IPR030203, SLC10A6

The PANTHER Classification System

More...PANTHERi		PTHR10361, PTHR10361, 1 hit
PTHR10361:SF55, PTHR10361:SF55, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01758, SBF, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00841, bass, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3KNW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRANCSSSSA CPANSSEEEL PVGLEVHGNL ELVFTVVSTV MMGLLMFSLG 
        60         70         80         90        100
CSVEIRKLWS HIRRPWGIAV GLLCQFGLMP FTAYLLAISF SLKPVQAIAV 
       110        120        130        140        150
LIMGCCPGGT ISNIFTFWVD GDMDLSISMT TCSTVAALGM MPLCIYLYTW 
       160        170        180        190        200
SWSLQQNLTI PYQNIGITLV CLTIPVAFGV YVNYRWPKQS KIILKIGAVV 
       210        220        230        240        250
GGVLLLVVAV AGVVLAKGSW NSDITLLTIS FIFPLIGHVT GFLLALFTHQ 
       260        270        280        290        300
SWQRCRTISL ETGAQNIQMC ITMLQLSFTA EHLVQMLSFP LAYGLFQLID 
       310        320        330        340        350
GFLIVAAYQT YKRRLKNKHG KKNSGCTEVC HTRKSTSSRE TNAFLEVNEE 
       360        370 
GAITPGPPGP MDCHRALEPV GHITSCE
Length:377
Mass (Da):41,259
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA68B0F034B5BE83F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0369046S → F. Corresponds to variant dbSNP:rs17694522Ensembl.1
Natural variantiVAR_036905114I → V1 PublicationCorresponds to variant dbSNP:rs13106574Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
EF437223 mRNA Translation: ABO38126.1
AJ583502 mRNA Translation: CAE47477.1
CH471057 Genomic DNA Translation: EAX05969.1
BC107051 mRNA Translation: AAI07052.1
BC107052 mRNA Translation: AAI07053.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3614.1

NCBI Reference Sequences

More...RefSeqi		NP_932069.1, NM_197965.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000273905; ENSP00000273905; ENSG00000145283

Database of genes from NCBI RefSeq genomes

More...GeneIDi		345274

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:345274

UCSC genome browser

More...UCSCi		uc003hqd.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF437223 mRNA Translation: ABO38126.1
AJ583502 mRNA Translation: CAE47477.1
CH471057 Genomic DNA Translation: EAX05969.1
BC107051 mRNA Translation: AAI07052.1
BC107052 mRNA Translation: AAI07053.1
CCDSiCCDS3614.1
RefSeqiNP_932069.1, NM_197965.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi131345, 146 interactors
IntActiQ3KNW5, 145 interactors
STRINGi9606.ENSP00000273905

Chemistry databases

DrugBankiDB05804, Prasterone sulfate
DB02789, Pregnenolone

Protein family/group databases

TCDBi2.A.28.1.4, the bile acid:na(+) symporter (bass) family

PTM databases

GlyGeniQ3KNW5, 2 sites

Polymorphism and mutation databases

BioMutaiSLC10A6
DMDMi160358735

Proteomic databases

PaxDbiQ3KNW5
PeptideAtlasiQ3KNW5
PRIDEiQ3KNW5
ProteomicsDBi61709

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		14387, 41 antibodies

Genome annotation databases

EnsembliENST00000273905; ENSP00000273905; ENSG00000145283
GeneIDi345274
KEGGihsa:345274
UCSCiuc003hqd.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		345274
DisGeNETi345274
EuPathDBiHostDB:ENSG00000145283.7

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC10A6
HGNCiHGNC:30603, SLC10A6
HPAiENSG00000145283, Tissue enhanced (adipose tissue, breast, skin)
MIMi613366, gene
neXtProtiNX_Q3KNW5
OpenTargetsiENSG00000145283
PharmGKBiPA142670910

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2718, Eukaryota
GeneTreeiENSGT00950000182808
HOGENOMiCLU_034788_7_5_1
InParanoidiQ3KNW5
KOiK14346
OMAiMEIGIHN
OrthoDBi1148347at2759
PhylomeDBiQ3KNW5
TreeFamiTF315811

Enzyme and pathway databases

PathwayCommonsiQ3KNW5
ReactomeiR-HSA-425366, Transport of bile salts and organic acids, metal ions and amine compounds

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		345274, 5 hits in 864 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		345274
PharosiQ3KNW5, Tdark

Protein Ontology

More...PROi		PR:Q3KNW5
RNActiQ3KNW5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000145283, Expressed in ectocervix and 89 other tissues

Family and domain databases

Gene3Di1.20.1530.20, 1 hit
InterProiView protein in InterPro
IPR002657, BilAc:Na_symport/Acr3
IPR004710, Bilac:Na_transpt
IPR038770, Na+/solute_symporter_sf
IPR030203, SLC10A6
PANTHERiPTHR10361, PTHR10361, 1 hit
PTHR10361:SF55, PTHR10361:SF55, 1 hit
PfamiView protein in Pfam
PF01758, SBF, 1 hit
TIGRFAMsiTIGR00841, bass, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSOAT_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3KNW5
Secondary accession number(s): Q70EX7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: October 7, 2020
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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