SLC10A6

Functionⁱ

Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner.1 Publication

GO - Molecular functionⁱ

bile acid:sodium symporter activity Source: Reactome
sodium-dependent organic anion transmembrane transporter activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

sodium-dependent organic anion transport Source: Ensembl
transmembrane transport Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ion transport, Sodium transport, Symport, Transport
Ligand	Sodium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds

Reactomeⁱ

R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds

Protein family/group databases

TCDBⁱ	2.A.28.1.4 the bile acid:na(+) symporter (bass) family

TCDBⁱ

2.A.28.1.4 the bile acid:na(+) symporter (bass) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Solute carrier family 10 member 6 Alternative name(s): Sodium-dependent organic anion transporter
Gene namesⁱ	Name:SLC10A6 Synonyms:SOAT
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000145283.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30603 SLC10A6
MIMⁱ	613366 gene
neXtProtⁱ	NX_Q3KNW5

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 29	ExtracellularSequence analysisAdd BLAST	29
Transmembraneⁱ	30 – 50	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	51 – 67	CytoplasmicSequence analysisAdd BLAST	17
Transmembraneⁱ	68 – 88	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	89 – 97	ExtracellularSequence analysis	9
Transmembraneⁱ	98 – 118	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	119 – 133	CytoplasmicSequence analysisAdd BLAST	15
Transmembraneⁱ	134 – 154	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	155 – 159	ExtracellularSequence analysis	5
Transmembraneⁱ	160 – 180	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	181 – 195	CytoplasmicSequence analysisAdd BLAST	15
Transmembraneⁱ	196 – 216	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	217 – 226	ExtracellularSequence analysis	10
Transmembraneⁱ	227 – 247	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	248 – 266	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	267 – 285	HelicalSequence analysisAdd BLAST	19
Topological domainⁱ	286 – 290	ExtracellularSequence analysis	5
Transmembraneⁱ	291 – 311	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	312 – 377	CytoplasmicSequence analysisAdd BLAST	66

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	345274
Open Targets More...OpenTargetsⁱ	ENSG00000145283
PharmGKBⁱ	PA142670910

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB05804 dehydroepiandrosterone sulfate DB02789 Pregnenolone

DrugBankⁱ

DB05804 dehydroepiandrosterone sulfate
DB02789 Pregnenolone

Polymorphism and mutation databases

BioMutaⁱ	SLC10A6
DMDMⁱ	160358735

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000309215	1 – 377	Solute carrier family 10 member 6Add BLAST		377

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	4	N-linked (GlcNAc...) asparagineSequence analysis		1
Glycosylationⁱ	157	N-linked (GlcNAc...) asparagineSequence analysis		1

Post-translational modificationⁱ

Glycosylated.1 Publication

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q3KNW5
PeptideAtlas More...PeptideAtlasⁱ	Q3KNW5
PRIDEⁱ	Q3KNW5
ProteomicsDBⁱ	61709

Expressionⁱ

Tissue specificityⁱ

Highly expressed in testis, placenta and pancreas. Moderately expressed in heart, lung and mammary gland. Weakly expressed in brain, colon, kidney, liver, ovary, prostate, small intestine, spleen and thymus.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000145283 Expressed in 70 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_SLC10A6

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA016662

HPAⁱ

HPA016662

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q3KNW5, 134 interactors
STRINGⁱ	9606.ENSP00000273905

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3KNW5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2718 Eukaryota COG0385 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074505
HOGENOMⁱ	HOG000234524
HOVERGENⁱ	HBG006537
InParanoidⁱ	Q3KNW5
KEGG Orthology (KO) More...KOⁱ	K14346
OMAⁱ	CLTIPVA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GT5
PhylomeDBⁱ	Q3KNW5
TreeFamⁱ	TF315811

Family and domain databases

Gene3Dⁱ	1.20.1530.20, 1 hit
InterProⁱ	View protein in InterPro IPR002657 BilAc:Na_symport/Acr3 IPR004710 Bilac:Na_transpt IPR038770 Na+/solute_symporter_sf IPR030203 SLC10A6
PANTHERⁱ	PTHR10361 PTHR10361, 1 hit PTHR10361:SF55 PTHR10361:SF55, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01758 SBF, 1 hit
TIGRFAMsⁱ	TIGR00841 bass, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3KNW5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRANCSSSSA CPANSSEEEL PVGLEVHGNL ELVFTVVSTV MMGLLMFSLG 
        60         70         80         90        100
CSVEIRKLWS HIRRPWGIAV GLLCQFGLMP FTAYLLAISF SLKPVQAIAV 
       110        120        130        140        150
LIMGCCPGGT ISNIFTFWVD GDMDLSISMT TCSTVAALGM MPLCIYLYTW 
       160        170        180        190        200
SWSLQQNLTI PYQNIGITLV CLTIPVAFGV YVNYRWPKQS KIILKIGAVV 
       210        220        230        240        250
GGVLLLVVAV AGVVLAKGSW NSDITLLTIS FIFPLIGHVT GFLLALFTHQ 
       260        270        280        290        300
SWQRCRTISL ETGAQNIQMC ITMLQLSFTA EHLVQMLSFP LAYGLFQLID 
       310        320        330        340        350
GFLIVAAYQT YKRRLKNKHG KKNSGCTEVC HTRKSTSSRE TNAFLEVNEE 
       360        370 
GAITPGPPGP MDCHRALEPV GHITSCE

Length:377

Mass (Da):41,259

Last modified:November 13, 2007 - v2

Checksum:ⁱA68B0F034B5BE83F

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_036904	6	S → F. Corresponds to variant dbSNP:rs17694522Ensembl.		1
Natural variantⁱVAR_036905	114	I → V1 PublicationCorresponds to variant dbSNP:rs13106574Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF437223 mRNA Translation: ABO38126.1 AJ583502 mRNA Translation: CAE47477.1 CH471057 Genomic DNA Translation: EAX05969.1 BC107051 mRNA Translation: AAI07052.1 BC107052 mRNA Translation: AAI07053.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3614.1
NCBI Reference Sequences More...RefSeqⁱ	NP_932069.1, NM_197965.2
UniGeneⁱ	Hs.452996

Genome annotation databases

Ensemblⁱ	ENST00000273905; ENSP00000273905; ENSG00000145283
GeneIDⁱ	345274
KEGGⁱ	hsa:345274
UCSC genome browser More...UCSCⁱ	uc003hqd.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q3KNW5	SLC10A6 isoform 1		PANTR		377	UniRef90_Q3KNW5
Uncharacterized protein		PANPA		377
Solute carrier family 10 member 6		SAIBB		377
Uncharacterized protein		CALJA		377
Uncharacterized protein		MACMU		377
+16

Protein	Similar proteins		Species	Score	Length	Source
Q3KNW5	Solute carrier family 10 member 6		MOUSE		373	UniRef50_Q3KNW5
Solute carrier family 10 member 6		RAT		370
Solute carrier family 10 member 6		BOVIN		377
Uncharacterized protein		CALJA		377
Uncharacterized protein		MACNE		377
+99

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF437223 mRNA Translation: ABO38126.1 AJ583502 mRNA Translation: CAE47477.1 CH471057 Genomic DNA Translation: EAX05969.1 BC107051 mRNA Translation: AAI07052.1 BC107052 mRNA Translation: AAI07053.1
CCDSⁱ	CCDS3614.1
RefSeqⁱ	NP_932069.1, NM_197965.2
UniGeneⁱ	Hs.452996

3D structure databases

ProteinModelPortalⁱ	Q3KNW5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q3KNW5, 134 interactors
STRINGⁱ	9606.ENSP00000273905

Chemistry databases

DrugBankⁱ	DB05804 dehydroepiandrosterone sulfate DB02789 Pregnenolone

DrugBankⁱ

DB05804 dehydroepiandrosterone sulfate
DB02789 Pregnenolone

Protein family/group databases

TCDBⁱ	2.A.28.1.4 the bile acid:na(+) symporter (bass) family

TCDBⁱ

2.A.28.1.4 the bile acid:na(+) symporter (bass) family

Polymorphism and mutation databases

BioMutaⁱ	SLC10A6
DMDMⁱ	160358735

Proteomic databases

PaxDbⁱ	Q3KNW5
PeptideAtlasⁱ	Q3KNW5
PRIDEⁱ	Q3KNW5
ProteomicsDBⁱ	61709

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000273905; ENSP00000273905; ENSG00000145283
GeneIDⁱ	345274
KEGGⁱ	hsa:345274
UCSCⁱ	uc003hqd.2 human

Organism-specific databases

CTDⁱ	345274
DisGeNETⁱ	345274
EuPathDBⁱ	HostDB:ENSG00000145283.7
GeneCardsⁱ	SLC10A6
HGNCⁱ	HGNC:30603 SLC10A6
HPAⁱ	HPA016662
MIMⁱ	613366 gene
neXtProtⁱ	NX_Q3KNW5
OpenTargetsⁱ	ENSG00000145283
PharmGKBⁱ	PA142670910
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2718 Eukaryota COG0385 LUCA
GeneTreeⁱ	ENSGT00550000074505
HOGENOMⁱ	HOG000234524
HOVERGENⁱ	HBG006537
InParanoidⁱ	Q3KNW5
KOⁱ	K14346
OMAⁱ	CLTIPVA
OrthoDBⁱ	EOG091G0GT5
PhylomeDBⁱ	Q3KNW5
TreeFamⁱ	TF315811

Enzyme and pathway databases

Reactomeⁱ	R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds

Reactomeⁱ

R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds

Miscellaneous databases

GenomeRNAiⁱ	345274
Protein Ontology More...PROⁱ	PR:Q3KNW5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000145283 Expressed in 70 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_SLC10A6

Family and domain databases

Gene3Dⁱ	1.20.1530.20, 1 hit
InterProⁱ	View protein in InterPro IPR002657 BilAc:Na_symport/Acr3 IPR004710 Bilac:Na_transpt IPR038770 Na+/solute_symporter_sf IPR030203 SLC10A6
PANTHERⁱ	PTHR10361 PTHR10361, 1 hit PTHR10361:SF55 PTHR10361:SF55, 1 hit
Pfamⁱ	View protein in Pfam PF01758 SBF, 1 hit
TIGRFAMsⁱ	TIGR00841 bass, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SOAT_HUMAN
Accessionⁱ	Q3KNW5Primary (citable) accession number: Q3KNW5 Secondary accession number(s): Q70EX7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
	Last sequence update:	November 13, 2007
	Last modified:	September 12, 2018
	This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniRef

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UniProtKB - Q3KNW5 (SOAT_HUMAN)

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Solute carrier family 10 member 6

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ