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UniProtKB - Q3KNW5 (SOAT_HUMAN)
Protein
Solute carrier family 10 member 6
Gene
SLC10A6
Organism
Homo sapiens (Human)
Status
Functioni
Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner.
1 PublicationGO - Molecular functioni
- bile acid:sodium symporter activity Source: GO_Central
- sodium-dependent organic anion transmembrane transporter activity Source: Ensembl
GO - Biological processi
- bile acid and bile salt transport Source: GO_Central
- sodium-dependent organic anion transport Source: Ensembl
- transmembrane transport Source: Reactome
Keywordsi
Biological process | Ion transport, Sodium transport, Symport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
PathwayCommonsi | Q3KNW5 |
Reactomei | R-HSA-425366, Transport of bile salts and organic acids, metal ions and amine compounds |
SignaLinki | Q3KNW5 |
Protein family/group databases
TCDBi | 2.A.28.1.4, the bile acid:na(+) symporter (bass) family |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 10 member 6Alternative name(s): Sodium-dependent organic anion transporter |
Gene namesi | Name:SLC10A6 Synonyms:SOAT |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30603, SLC10A6 |
MIMi | 613366, gene |
neXtProti | NX_Q3KNW5 |
VEuPathDBi | HostDB:ENSG00000145283 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 29 | ExtracellularSequence analysisAdd BLAST | 29 | |
Transmembranei | 30 – 50 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 51 – 67 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 68 – 88 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 89 – 97 | ExtracellularSequence analysis | 9 | |
Transmembranei | 98 – 118 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 119 – 133 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 134 – 154 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 155 – 159 | ExtracellularSequence analysis | 5 | |
Transmembranei | 160 – 180 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 181 – 195 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 196 – 216 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 217 – 226 | ExtracellularSequence analysis | 10 | |
Transmembranei | 227 – 247 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 248 – 266 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 267 – 285 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 286 – 290 | ExtracellularSequence analysis | 5 | |
Transmembranei | 291 – 311 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 312 – 377 | CytoplasmicSequence analysisAdd BLAST | 66 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 345274 |
OpenTargetsi | ENSG00000145283 |
PharmGKBi | PA142670910 |
Miscellaneous databases
Pharosi | Q3KNW5, Tdark |
Chemistry databases
DrugBanki | DB05804, Prasterone sulfate DB02789, Pregnenolone |
Genetic variation databases
BioMutai | SLC10A6 |
DMDMi | 160358735 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000309215 | 1 – 377 | Solute carrier family 10 member 6Add BLAST | 377 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 157 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Glycosylated.1 Publication
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q3KNW5 |
PeptideAtlasi | Q3KNW5 |
PRIDEi | Q3KNW5 |
PTM databases
GlyGeni | Q3KNW5, 2 sites |
Expressioni
Tissue specificityi
Highly expressed in testis, placenta and pancreas. Moderately expressed in heart, lung and mammary gland. Weakly expressed in brain, colon, kidney, liver, ovary, prostate, small intestine, spleen and thymus.1 Publication
Gene expression databases
Bgeei | ENSG00000145283, Expressed in ectocervix and 90 other tissues |
Organism-specific databases
HPAi | ENSG00000145283, Tissue enhanced (esophagus, skin) |
Interactioni
Binary interactionsi
Q3KNW5
Protein-protein interaction databases
BioGRIDi | 131345, 148 interactors |
IntActi | Q3KNW5, 145 interactors |
STRINGi | 9606.ENSP00000273905 |
Miscellaneous databases
RNActi | Q3KNW5, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2718, Eukaryota |
GeneTreei | ENSGT00950000182808 |
HOGENOMi | CLU_034788_7_5_1 |
InParanoidi | Q3KNW5 |
OMAi | KWPKQSK |
OrthoDBi | 1148347at2759 |
PhylomeDBi | Q3KNW5 |
TreeFami | TF315811 |
Family and domain databases
Gene3Di | 1.20.1530.20, 1 hit |
InterProi | View protein in InterPro IPR002657, BilAc:Na_symport/Acr3 IPR004710, Bilac:Na_transpt IPR038770, Na+/solute_symporter_sf IPR030203, SLC10A6 |
PANTHERi | PTHR10361, PTHR10361, 1 hit PTHR10361:SF55, PTHR10361:SF55, 1 hit |
Pfami | View protein in Pfam PF01758, SBF, 1 hit |
TIGRFAMsi | TIGR00841, bass, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3KNW5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRANCSSSSA CPANSSEEEL PVGLEVHGNL ELVFTVVSTV MMGLLMFSLG
60 70 80 90 100
CSVEIRKLWS HIRRPWGIAV GLLCQFGLMP FTAYLLAISF SLKPVQAIAV
110 120 130 140 150
LIMGCCPGGT ISNIFTFWVD GDMDLSISMT TCSTVAALGM MPLCIYLYTW
160 170 180 190 200
SWSLQQNLTI PYQNIGITLV CLTIPVAFGV YVNYRWPKQS KIILKIGAVV
210 220 230 240 250
GGVLLLVVAV AGVVLAKGSW NSDITLLTIS FIFPLIGHVT GFLLALFTHQ
260 270 280 290 300
SWQRCRTISL ETGAQNIQMC ITMLQLSFTA EHLVQMLSFP LAYGLFQLID
310 320 330 340 350
GFLIVAAYQT YKRRLKNKHG KKNSGCTEVC HTRKSTSSRE TNAFLEVNEE
360 370
GAITPGPPGP MDCHRALEPV GHITSCE
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036904 | 6 | S → F. Corresponds to variant dbSNP:rs17694522Ensembl. | 1 | |
Natural variantiVAR_036905 | 114 | I → V1 PublicationCorresponds to variant dbSNP:rs13106574Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF437223 mRNA Translation: ABO38126.1 AJ583502 mRNA Translation: CAE47477.1 CH471057 Genomic DNA Translation: EAX05969.1 BC107051 mRNA Translation: AAI07052.1 BC107052 mRNA Translation: AAI07053.1 |
CCDSi | CCDS3614.1 |
RefSeqi | NP_932069.1, NM_197965.2 |
Genome annotation databases
Ensembli | ENST00000273905.7; ENSP00000273905.6; ENSG00000145283.8 |
GeneIDi | 345274 |
KEGGi | hsa:345274 |
MANE-Selecti | ENST00000273905.7; ENSP00000273905.6; NM_197965.3; NP_932069.1 |
UCSCi | uc003hqd.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF437223 mRNA Translation: ABO38126.1 AJ583502 mRNA Translation: CAE47477.1 CH471057 Genomic DNA Translation: EAX05969.1 BC107051 mRNA Translation: AAI07052.1 BC107052 mRNA Translation: AAI07053.1 |
CCDSi | CCDS3614.1 |
RefSeqi | NP_932069.1, NM_197965.2 |
3D structure databases
AlphaFoldDBi | Q3KNW5 |
SMRi | Q3KNW5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131345, 148 interactors |
IntActi | Q3KNW5, 145 interactors |
STRINGi | 9606.ENSP00000273905 |
Chemistry databases
DrugBanki | DB05804, Prasterone sulfate DB02789, Pregnenolone |
Protein family/group databases
TCDBi | 2.A.28.1.4, the bile acid:na(+) symporter (bass) family |
PTM databases
GlyGeni | Q3KNW5, 2 sites |
Genetic variation databases
BioMutai | SLC10A6 |
DMDMi | 160358735 |
Proteomic databases
PaxDbi | Q3KNW5 |
PeptideAtlasi | Q3KNW5 |
PRIDEi | Q3KNW5 |
Protocols and materials databases
Antibodypediai | 14387, 46 antibodies from 13 providers |
DNASUi | 345274 |
Genome annotation databases
Ensembli | ENST00000273905.7; ENSP00000273905.6; ENSG00000145283.8 |
GeneIDi | 345274 |
KEGGi | hsa:345274 |
MANE-Selecti | ENST00000273905.7; ENSP00000273905.6; NM_197965.3; NP_932069.1 |
UCSCi | uc003hqd.2, human |
Organism-specific databases
CTDi | 345274 |
DisGeNETi | 345274 |
GeneCardsi | SLC10A6 |
HGNCi | HGNC:30603, SLC10A6 |
HPAi | ENSG00000145283, Tissue enhanced (esophagus, skin) |
MIMi | 613366, gene |
neXtProti | NX_Q3KNW5 |
OpenTargetsi | ENSG00000145283 |
PharmGKBi | PA142670910 |
VEuPathDBi | HostDB:ENSG00000145283 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2718, Eukaryota |
GeneTreei | ENSGT00950000182808 |
HOGENOMi | CLU_034788_7_5_1 |
InParanoidi | Q3KNW5 |
OMAi | KWPKQSK |
OrthoDBi | 1148347at2759 |
PhylomeDBi | Q3KNW5 |
TreeFami | TF315811 |
Enzyme and pathway databases
PathwayCommonsi | Q3KNW5 |
Reactomei | R-HSA-425366, Transport of bile salts and organic acids, metal ions and amine compounds |
SignaLinki | Q3KNW5 |
Miscellaneous databases
BioGRID-ORCSi | 345274, 7 hits in 1061 CRISPR screens |
GenomeRNAii | 345274 |
Pharosi | Q3KNW5, Tdark |
PROi | PR:Q3KNW5 |
RNActi | Q3KNW5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000145283, Expressed in ectocervix and 90 other tissues |
Family and domain databases
Gene3Di | 1.20.1530.20, 1 hit |
InterProi | View protein in InterPro IPR002657, BilAc:Na_symport/Acr3 IPR004710, Bilac:Na_transpt IPR038770, Na+/solute_symporter_sf IPR030203, SLC10A6 |
PANTHERi | PTHR10361, PTHR10361, 1 hit PTHR10361:SF55, PTHR10361:SF55, 1 hit |
Pfami | View protein in Pfam PF01758, SBF, 1 hit |
TIGRFAMsi | TIGR00841, bass, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SOAT_HUMAN | |
Accessioni | Q3KNW5Primary (citable) accession number: Q3KNW5 Secondary accession number(s): Q70EX7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | November 13, 2007 | |
Last modified: | May 25, 2022 | |
This is version 124 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families