SNAI3

Functionⁱ

Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3' (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	152 – 174	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	183 – 205	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	209 – 231	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	237 – 259	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	265 – 287	C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

copper ion binding Source: InterPro
DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA-binding transcription factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SIGNORⁱ	Q3KNW1

SIGNORⁱ

Q3KNW1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein SNAI3 Alternative name(s): Protein snail homolog 3 Zinc finger protein 293
Gene namesⁱ	Name:SNAI3 Synonyms:ZNF293
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000185669.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18411 SNAI3
MIMⁱ	612741 gene
neXtProtⁱ	NX_Q3KNW1

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	333929
Open Targets More...OpenTargetsⁱ	ENSG00000185669
PharmGKBⁱ	PA134988226

Polymorphism and mutation databases

BioMutaⁱ	SNAI3
DMDMⁱ	121942538

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000330037	1 – 292	Zinc finger protein SNAI3Add BLAST		292

Proteomic databases

EPDⁱ	Q3KNW1
PaxDbⁱ	Q3KNW1
PeptideAtlas More...PeptideAtlasⁱ	Q3KNW1
PRIDEⁱ	Q3KNW1
ProteomicsDBⁱ	61707

PTM databases

iPTMnetⁱ	Q3KNW1
PhosphoSitePlusⁱ	Q3KNW1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000185669 Expressed in 93 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExⁱ	HS_SNAI3
Genevisibleⁱ	Q3KNW1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA071127

HPAⁱ

HPA071127

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	130614, 6 interactors
IntActⁱ	Q3KNW1, 3 interactors
STRINGⁱ	9606.ENSP00000327968

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3KNW1
SMRⁱ	Q3KNW1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 20	SNAG domainBy similarityAdd BLAST		20

Domainⁱ

Binds E-box via C2H2-type zinc finger domain.By similarity

Sequence similaritiesⁱ

Belongs to the snail C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	152 – 174	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	183 – 205	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	209 – 231	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	237 – 259	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	265 – 287	C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG2462 Eukaryota ENOG41106JS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011027
HOGENOMⁱ	HOG000261665
HOVERGENⁱ	HBG007477
InParanoidⁱ	Q3KNW1
KEGG Orthology (KO) More...KOⁱ	K09217
OMAⁱ	EINGACS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Q0V
PhylomeDBⁱ	Q3KNW1
TreeFamⁱ	TF315515

Family and domain databases

InterProⁱ	View protein in InterPro IPR002355 Cu_oxidase_Cu_BS IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3KNW1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPRSFLVKTH SSHRVPNYRR LETQREINGA CSACGGLVVP LLPRDKEAPS 
        60         70         80         90        100
VPGDLPQPWD RSSAVACISL PLLPRIEEAL GASGLDALEV SEVDPRASRA 
       110        120        130        140        150
AIVPLKDSLN HLNLPPLLVL PTRWSPTLGP DRHGAPEKLL GAERMPRAPG 
       160        170        180        190        200
GFECFHCHKP YHTLAGLARH RQLHCHLQVG RVFTCKYCDK EYTSLGALKM 
       210        220        230        240        250
HIRTHTLPCT CKICGKAFSR PWLLQGHVRT HTGEKPYACS HCSRAFADRS 
       260        270        280        290 
NLRAHLQTHS DAKKYRCRRC TKTFSRMSLL ARHEESGCCP GP

Length:292

Mass (Da):32,474

Last modified:November 8, 2005 - v1

Checksum:ⁱCF9853C07029621F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471184 Genomic DNA Translation: EAW66765.1 BC041461 mRNA Translation: AAH41461.1 BC107058 mRNA Translation: AAI07059.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32505.1
NCBI Reference Sequences More...RefSeqⁱ	NP_840101.1, NM_178310.3
UniGeneⁱ	Hs.673548

Genome annotation databases

Ensemblⁱ	ENST00000332281; ENSP00000327968; ENSG00000185669
GeneIDⁱ	333929
KEGGⁱ	hsa:333929
UCSC genome browser More...UCSCⁱ	uc002flj.4 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q3KNW1	Uncharacterized protein		MANLE		292	UniRef90_Q3KNW1
SNAI3 isoform 1		PANTR		292
SNAI3 isoform 1		PONAB		292
Uncharacterized protein		PANPA		292
Uncharacterized protein		MACMU		292
+17

Protein	Similar proteins		Species	Score	Length	Source
Q3KNW1	Zinc finger protein SNAI3		MOUSE		287	UniRef50_Q9QY31
Snail family transcriptional repressor 3		MONDO		296
Zinc finger protein SNAI3		FUKDA		334
Snail family transcriptional repressor 3		RAT		287
Zinc finger protein SNAI3		CRIGR		195
+42

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471184 Genomic DNA Translation: EAW66765.1 BC041461 mRNA Translation: AAH41461.1 BC107058 mRNA Translation: AAI07059.1
CCDSⁱ	CCDS32505.1
RefSeqⁱ	NP_840101.1, NM_178310.3
UniGeneⁱ	Hs.673548

3D structure databases

ProteinModelPortalⁱ	Q3KNW1
SMRⁱ	Q3KNW1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	130614, 6 interactors
IntActⁱ	Q3KNW1, 3 interactors
STRINGⁱ	9606.ENSP00000327968

PTM databases

iPTMnetⁱ	Q3KNW1
PhosphoSitePlusⁱ	Q3KNW1

Polymorphism and mutation databases

BioMutaⁱ	SNAI3
DMDMⁱ	121942538

Proteomic databases

EPDⁱ	Q3KNW1
PaxDbⁱ	Q3KNW1
PeptideAtlasⁱ	Q3KNW1
PRIDEⁱ	Q3KNW1
ProteomicsDBⁱ	61707

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000332281; ENSP00000327968; ENSG00000185669
GeneIDⁱ	333929
KEGGⁱ	hsa:333929
UCSCⁱ	uc002flj.4 human

Organism-specific databases

CTDⁱ	333929
DisGeNETⁱ	333929
EuPathDBⁱ	HostDB:ENSG00000185669.5
GeneCardsⁱ	SNAI3
HGNCⁱ	HGNC:18411 SNAI3
HPAⁱ	HPA071127
MIMⁱ	612741 gene
neXtProtⁱ	NX_Q3KNW1
OpenTargetsⁱ	ENSG00000185669
PharmGKBⁱ	PA134988226
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2462 Eukaryota ENOG41106JS LUCA
GeneTreeⁱ	ENSGT00390000011027
HOGENOMⁱ	HOG000261665
HOVERGENⁱ	HBG007477
InParanoidⁱ	Q3KNW1
KOⁱ	K09217
OMAⁱ	EINGACS
OrthoDBⁱ	EOG091G0Q0V
PhylomeDBⁱ	Q3KNW1
TreeFamⁱ	TF315515

Enzyme and pathway databases

SIGNORⁱ	Q3KNW1

SIGNORⁱ

Q3KNW1

Miscellaneous databases

GenomeRNAiⁱ	333929
Protein Ontology More...PROⁱ	PR:Q3KNW1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000185669 Expressed in 93 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExⁱ	HS_SNAI3
Genevisibleⁱ	Q3KNW1 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR002355 Cu_oxidase_Cu_BS IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SNAI3_HUMAN
Accessionⁱ	Q3KNW1Primary (citable) accession number: Q3KNW1 Secondary accession number(s): Q86SU5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
	Last sequence update:	November 8, 2005
	Last modified:	November 7, 2018
	This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniParc

Help

UniRef

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Supporting data

UniProtKB - Q3KNW1 (SNAI3_HUMAN)

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Zinc finger protein SNAI3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ