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UniProtKB - Q3KNW1 (SNAI3_HUMAN)

Entry version 135 (22 Apr 2020)
Sequence version 1 (08 Nov 2005)
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Protein

Zinc finger protein SNAI3

Gene

SNAI3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3' (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri152 – 174C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri183 – 205C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri209 – 231C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri237 – 259C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 287C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q3KNW1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein SNAI3
Alternative name(s):
Protein snail homolog 3
Zinc finger protein 293
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNAI3
Synonyms:ZNF293
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18411 SNAI3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612741 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q3KNW1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		333929

Open Targets

More...OpenTargetsi		ENSG00000185669

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134988226

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q3KNW1 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SNAI3

Domain mapping of disease mutations (DMDM)

More...DMDMi		121942538

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003300371 – 292Zinc finger protein SNAI3Add BLAST292

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q3KNW1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q3KNW1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q3KNW1

PeptideAtlas

More...PeptideAtlasi		Q3KNW1

PRoteomics IDEntifications database

More...PRIDEi		Q3KNW1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		61707

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q3KNW1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q3KNW1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000185669 Expressed in skeletal muscle tissue of rectus abdominis and 92 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q3KNW1 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000185669 Tissue enhanced (blood, skeletal muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		130614, 8 interactors

Protein interaction database and analysis system

More...IntActi		Q3KNW1, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000327968

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q3KNW1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q3KNW1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20SNAG domainBy similarityAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Binds E-box via C2H2-type zinc finger domain.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the snail C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 174C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri183 – 205C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri209 – 231C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri237 – 259C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 287C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2462 Eukaryota
ENOG41106JS LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154511

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_42_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q3KNW1

KEGG Orthology (KO)

More...KOi		K09217

Identification of Orthologs from Complete Genome Data

More...OMAi		PWDRSSA

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q3KNW1

TreeFam database of animal gene trees

More...TreeFami		TF315515

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002355 Cu_oxidase_Cu_BS
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096 zf-C2H2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355 ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667 SSF57667, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3KNW1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRSFLVKTH SSHRVPNYRR LETQREINGA CSACGGLVVP LLPRDKEAPS 
        60         70         80         90        100
VPGDLPQPWD RSSAVACISL PLLPRIEEAL GASGLDALEV SEVDPRASRA 
       110        120        130        140        150
AIVPLKDSLN HLNLPPLLVL PTRWSPTLGP DRHGAPEKLL GAERMPRAPG 
       160        170        180        190        200
GFECFHCHKP YHTLAGLARH RQLHCHLQVG RVFTCKYCDK EYTSLGALKM 
       210        220        230        240        250
HIRTHTLPCT CKICGKAFSR PWLLQGHVRT HTGEKPYACS HCSRAFADRS 
       260        270        280        290 
NLRAHLQTHS DAKKYRCRRC TKTFSRMSLL ARHEESGCCP GP
Length:292
Mass (Da):32,474
Last modified:November 8, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF9853C07029621F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CH471184 Genomic DNA Translation: EAW66765.1
BC041461 mRNA Translation: AAH41461.1
BC107058 mRNA Translation: AAI07059.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32505.1

NCBI Reference Sequences

More...RefSeqi		NP_840101.1, NM_178310.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000332281; ENSP00000327968; ENSG00000185669

Database of genes from NCBI RefSeq genomes

More...GeneIDi		333929

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:333929

UCSC genome browser

More...UCSCi		uc002flj.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471184 Genomic DNA Translation: EAW66765.1
BC041461 mRNA Translation: AAH41461.1
BC107058 mRNA Translation: AAI07059.1
CCDSiCCDS32505.1
RefSeqiNP_840101.1, NM_178310.3

3D structure databases

SMRiQ3KNW1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi130614, 8 interactors
IntActiQ3KNW1, 5 interactors
STRINGi9606.ENSP00000327968

PTM databases

iPTMnetiQ3KNW1
PhosphoSitePlusiQ3KNW1

Polymorphism and mutation databases

BioMutaiSNAI3
DMDMi121942538

Proteomic databases

EPDiQ3KNW1
MassIVEiQ3KNW1
PaxDbiQ3KNW1
PeptideAtlasiQ3KNW1
PRIDEiQ3KNW1
ProteomicsDBi61707

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17289 119 antibodies

Genome annotation databases

EnsembliENST00000332281; ENSP00000327968; ENSG00000185669
GeneIDi333929
KEGGihsa:333929
UCSCiuc002flj.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		333929
DisGeNETi333929

GeneCards: human genes, protein and diseases

More...GeneCardsi		SNAI3
HGNCiHGNC:18411 SNAI3
HPAiENSG00000185669 Tissue enhanced (blood, skeletal muscle)
MIMi612741 gene
neXtProtiNX_Q3KNW1
OpenTargetsiENSG00000185669
PharmGKBiPA134988226

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2462 Eukaryota
ENOG41106JS LUCA
GeneTreeiENSGT00940000154511
HOGENOMiCLU_002678_42_3_1
InParanoidiQ3KNW1
KOiK09217
OMAiPWDRSSA
OrthoDBi1318335at2759
PhylomeDBiQ3KNW1
TreeFamiTF315515

Enzyme and pathway databases

SIGNORiQ3KNW1

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		333929
PharosiQ3KNW1 Tbio

Protein Ontology

More...PROi		PR:Q3KNW1
RNActiQ3KNW1 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000185669 Expressed in skeletal muscle tissue of rectus abdominis and 92 other tissues
GenevisibleiQ3KNW1 HS

Family and domain databases

InterProiView protein in InterPro
IPR002355 Cu_oxidase_Cu_BS
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSNAI3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3KNW1
Secondary accession number(s): Q86SU5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 8, 2005
Last modified: April 22, 2020
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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