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Protein

Zinc finger protein SNAI3

Gene

SNAI3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3' (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 174C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri183 – 205C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri209 – 231C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri237 – 259C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 287C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ3KNW1

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein SNAI3
Alternative name(s):
Protein snail homolog 3
Zinc finger protein 293
Gene namesi
Name:SNAI3
Synonyms:ZNF293
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000185669.5
HGNCiHGNC:18411 SNAI3
MIMi612741 gene
neXtProtiNX_Q3KNW1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi333929
OpenTargetsiENSG00000185669
PharmGKBiPA134988226

Polymorphism and mutation databases

BioMutaiSNAI3
DMDMi121942538

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003300371 – 292Zinc finger protein SNAI3Add BLAST292

Proteomic databases

EPDiQ3KNW1
PaxDbiQ3KNW1
PeptideAtlasiQ3KNW1
PRIDEiQ3KNW1
ProteomicsDBi61707

PTM databases

iPTMnetiQ3KNW1
PhosphoSitePlusiQ3KNW1

Expressioni

Gene expression databases

BgeeiENSG00000185669 Expressed in 93 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_SNAI3
GenevisibleiQ3KNW1 HS

Organism-specific databases

HPAiHPA071127

Interactioni

Protein-protein interaction databases

BioGridi130614, 6 interactors
IntActiQ3KNW1, 3 interactors
STRINGi9606.ENSP00000327968

Structurei

3D structure databases

ProteinModelPortaliQ3KNW1
SMRiQ3KNW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 20SNAG domainBy similarityAdd BLAST20

Domaini

Binds E-box via C2H2-type zinc finger domain.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 174C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri183 – 205C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri209 – 231C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri237 – 259C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 287C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2462 Eukaryota
ENOG41106JS LUCA
GeneTreeiENSGT00390000011027
HOGENOMiHOG000261665
HOVERGENiHBG007477
InParanoidiQ3KNW1
KOiK09217
OMAiEINGACS
OrthoDBiEOG091G0Q0V
PhylomeDBiQ3KNW1
TreeFamiTF315515

Family and domain databases

InterProiView protein in InterPro
IPR002355 Cu_oxidase_Cu_BS
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequencei

Sequence statusi: Complete.

Q3KNW1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRSFLVKTH SSHRVPNYRR LETQREINGA CSACGGLVVP LLPRDKEAPS
60 70 80 90 100
VPGDLPQPWD RSSAVACISL PLLPRIEEAL GASGLDALEV SEVDPRASRA
110 120 130 140 150
AIVPLKDSLN HLNLPPLLVL PTRWSPTLGP DRHGAPEKLL GAERMPRAPG
160 170 180 190 200
GFECFHCHKP YHTLAGLARH RQLHCHLQVG RVFTCKYCDK EYTSLGALKM
210 220 230 240 250
HIRTHTLPCT CKICGKAFSR PWLLQGHVRT HTGEKPYACS HCSRAFADRS
260 270 280 290
NLRAHLQTHS DAKKYRCRRC TKTFSRMSLL ARHEESGCCP GP
Length:292
Mass (Da):32,474
Last modified:November 8, 2005 - v1
Checksum:iCF9853C07029621F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471184 Genomic DNA Translation: EAW66765.1
BC041461 mRNA Translation: AAH41461.1
BC107058 mRNA Translation: AAI07059.1
CCDSiCCDS32505.1
RefSeqiNP_840101.1, NM_178310.3
UniGeneiHs.673548

Genome annotation databases

EnsembliENST00000332281; ENSP00000327968; ENSG00000185669
GeneIDi333929
KEGGihsa:333929
UCSCiuc002flj.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471184 Genomic DNA Translation: EAW66765.1
BC041461 mRNA Translation: AAH41461.1
BC107058 mRNA Translation: AAI07059.1
CCDSiCCDS32505.1
RefSeqiNP_840101.1, NM_178310.3
UniGeneiHs.673548

3D structure databases

ProteinModelPortaliQ3KNW1
SMRiQ3KNW1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130614, 6 interactors
IntActiQ3KNW1, 3 interactors
STRINGi9606.ENSP00000327968

PTM databases

iPTMnetiQ3KNW1
PhosphoSitePlusiQ3KNW1

Polymorphism and mutation databases

BioMutaiSNAI3
DMDMi121942538

Proteomic databases

EPDiQ3KNW1
PaxDbiQ3KNW1
PeptideAtlasiQ3KNW1
PRIDEiQ3KNW1
ProteomicsDBi61707

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332281; ENSP00000327968; ENSG00000185669
GeneIDi333929
KEGGihsa:333929
UCSCiuc002flj.4 human

Organism-specific databases

CTDi333929
DisGeNETi333929
EuPathDBiHostDB:ENSG00000185669.5
GeneCardsiSNAI3
HGNCiHGNC:18411 SNAI3
HPAiHPA071127
MIMi612741 gene
neXtProtiNX_Q3KNW1
OpenTargetsiENSG00000185669
PharmGKBiPA134988226
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2462 Eukaryota
ENOG41106JS LUCA
GeneTreeiENSGT00390000011027
HOGENOMiHOG000261665
HOVERGENiHBG007477
InParanoidiQ3KNW1
KOiK09217
OMAiEINGACS
OrthoDBiEOG091G0Q0V
PhylomeDBiQ3KNW1
TreeFamiTF315515

Enzyme and pathway databases

SIGNORiQ3KNW1

Miscellaneous databases

GenomeRNAii333929
PROiPR:Q3KNW1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185669 Expressed in 93 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_SNAI3
GenevisibleiQ3KNW1 HS

Family and domain databases

InterProiView protein in InterPro
IPR002355 Cu_oxidase_Cu_BS
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSNAI3_HUMAN
AccessioniPrimary (citable) accession number: Q3KNW1
Secondary accession number(s): Q86SU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 8, 2005
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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