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UniProtKB - Q3KNW1 (SNAI3_HUMAN)
Protein
Zinc finger protein SNAI3
Gene
SNAI3
Organism
Homo sapiens (Human)
Status
Functioni
Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3' (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 152 – 174 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 183 – 205 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 209 – 231 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 237 – 259 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 265 – 287 | C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- copper ion binding Source: InterPro
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q3KNW1 |
SignaLinki | Q3KNW1 |
SIGNORi | Q3KNW1 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein SNAI3Alternative name(s): Protein snail homolog 3 Zinc finger protein 293 |
Gene namesi | Name:SNAI3 Synonyms:ZNF293 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18411, SNAI3 |
MIMi | 612741, gene |
neXtProti | NX_Q3KNW1 |
VEuPathDBi | HostDB:ENSG00000185669 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 333929 |
OpenTargetsi | ENSG00000185669 |
PharmGKBi | PA134988226 |
Miscellaneous databases
Pharosi | Q3KNW1, Tbio |
Genetic variation databases
BioMutai | SNAI3 |
DMDMi | 121942538 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000330037 | 1 – 292 | Zinc finger protein SNAI3Add BLAST | 292 |
Proteomic databases
EPDi | Q3KNW1 |
MassIVEi | Q3KNW1 |
PaxDbi | Q3KNW1 |
PeptideAtlasi | Q3KNW1 |
PRIDEi | Q3KNW1 |
ProteomicsDBi | 61707 |
PTM databases
iPTMneti | Q3KNW1 |
PhosphoSitePlusi | Q3KNW1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000185669, Expressed in skeletal muscle tissue of rectus abdominis and 122 other tissues |
Genevisiblei | Q3KNW1, HS |
Organism-specific databases
HPAi | ENSG00000185669, Tissue enriched (skeletal) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 130614, 33 interactors |
IntActi | Q3KNW1, 5 interactors |
STRINGi | 9606.ENSP00000327968 |
Miscellaneous databases
RNActi | Q3KNW1, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | SNAG domainBy similarityAdd BLAST | 20 |
Domaini
Binds E-box via C2H2-type zinc finger domain.By similarity
Sequence similaritiesi
Belongs to the snail C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 152 – 174 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 183 – 205 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 209 – 231 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 237 – 259 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 265 – 287 | C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2462, Eukaryota |
GeneTreei | ENSGT00940000154511 |
HOGENOMi | CLU_002678_42_3_1 |
InParanoidi | Q3KNW1 |
OMAi | PWDRSSA |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q3KNW1 |
TreeFami | TF315515 |
Family and domain databases
InterProi | View protein in InterPro IPR002355, Cu_oxidase_Cu_BS IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
i Sequence
Sequence statusi: Complete.
Q3KNW1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRSFLVKTH SSHRVPNYRR LETQREINGA CSACGGLVVP LLPRDKEAPS
60 70 80 90 100
VPGDLPQPWD RSSAVACISL PLLPRIEEAL GASGLDALEV SEVDPRASRA
110 120 130 140 150
AIVPLKDSLN HLNLPPLLVL PTRWSPTLGP DRHGAPEKLL GAERMPRAPG
160 170 180 190 200
GFECFHCHKP YHTLAGLARH RQLHCHLQVG RVFTCKYCDK EYTSLGALKM
210 220 230 240 250
HIRTHTLPCT CKICGKAFSR PWLLQGHVRT HTGEKPYACS HCSRAFADRS
260 270 280 290
NLRAHLQTHS DAKKYRCRRC TKTFSRMSLL ARHEESGCCP GP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471184 Genomic DNA Translation: EAW66765.1 BC041461 mRNA Translation: AAH41461.1 BC107058 mRNA Translation: AAI07059.1 |
CCDSi | CCDS32505.1 |
RefSeqi | NP_840101.1, NM_178310.3 |
Genome annotation databases
Ensembli | ENST00000332281.6; ENSP00000327968.5; ENSG00000185669.6 |
GeneIDi | 333929 |
KEGGi | hsa:333929 |
MANE-Selecti | ENST00000332281.6; ENSP00000327968.5; NM_178310.4; NP_840101.1 |
UCSCi | uc002flj.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471184 Genomic DNA Translation: EAW66765.1 BC041461 mRNA Translation: AAH41461.1 BC107058 mRNA Translation: AAI07059.1 |
CCDSi | CCDS32505.1 |
RefSeqi | NP_840101.1, NM_178310.3 |
3D structure databases
AlphaFoldDBi | Q3KNW1 |
SMRi | Q3KNW1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 130614, 33 interactors |
IntActi | Q3KNW1, 5 interactors |
STRINGi | 9606.ENSP00000327968 |
PTM databases
iPTMneti | Q3KNW1 |
PhosphoSitePlusi | Q3KNW1 |
Genetic variation databases
BioMutai | SNAI3 |
DMDMi | 121942538 |
Proteomic databases
EPDi | Q3KNW1 |
MassIVEi | Q3KNW1 |
PaxDbi | Q3KNW1 |
PeptideAtlasi | Q3KNW1 |
PRIDEi | Q3KNW1 |
ProteomicsDBi | 61707 |
Protocols and materials databases
Antibodypediai | 17289, 129 antibodies from 26 providers |
DNASUi | 333929 |
Genome annotation databases
Ensembli | ENST00000332281.6; ENSP00000327968.5; ENSG00000185669.6 |
GeneIDi | 333929 |
KEGGi | hsa:333929 |
MANE-Selecti | ENST00000332281.6; ENSP00000327968.5; NM_178310.4; NP_840101.1 |
UCSCi | uc002flj.4, human |
Organism-specific databases
CTDi | 333929 |
DisGeNETi | 333929 |
GeneCardsi | SNAI3 |
HGNCi | HGNC:18411, SNAI3 |
HPAi | ENSG00000185669, Tissue enriched (skeletal) |
MIMi | 612741, gene |
neXtProti | NX_Q3KNW1 |
OpenTargetsi | ENSG00000185669 |
PharmGKBi | PA134988226 |
VEuPathDBi | HostDB:ENSG00000185669 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2462, Eukaryota |
GeneTreei | ENSGT00940000154511 |
HOGENOMi | CLU_002678_42_3_1 |
InParanoidi | Q3KNW1 |
OMAi | PWDRSSA |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q3KNW1 |
TreeFami | TF315515 |
Enzyme and pathway databases
PathwayCommonsi | Q3KNW1 |
SignaLinki | Q3KNW1 |
SIGNORi | Q3KNW1 |
Miscellaneous databases
BioGRID-ORCSi | 333929, 9 hits in 1099 CRISPR screens |
GenomeRNAii | 333929 |
Pharosi | Q3KNW1, Tbio |
PROi | PR:Q3KNW1 |
RNActi | Q3KNW1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000185669, Expressed in skeletal muscle tissue of rectus abdominis and 122 other tissues |
Genevisiblei | Q3KNW1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR002355, Cu_oxidase_Cu_BS IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | SNAI3_HUMAN | |
Accessioni | Q3KNW1Primary (citable) accession number: Q3KNW1 Secondary accession number(s): Q86SU5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | November 8, 2005 | |
Last modified: | May 25, 2022 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families