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Protein
Submitted name:

PAX4 protein

Gene

PAX4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi160 – 219HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinSAAS annotation, DNA-bindingPROSITE-ProRule annotationSAAS annotation
Biological processTranscription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
PAX4 proteinImported
Submitted name:
Paired box protein Pax-4Imported
Gene namesi
Name:PAX4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106331.14
HGNCiHGNC:8618 PAX4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000106331

Expressioni

Gene expression databases

BgeeiENSG00000106331 Expressed in 14 organ(s), highest expression level in mucosa of transverse colon

Interactioni

Protein-protein interaction databases

IntActiQ3KNR5, 14 interactors
Q3KNR5, 14 interactors

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 121PairedInterPro annotationAdd BLAST121
Domaini158 – 218HomeoboxInterPro annotationAdd BLAST61

Keywords - Domaini

HomeoboxPROSITE-ProRule annotation, Paired boxSAAS annotation

Phylogenomic databases

eggNOGiKOG0849 Eukaryota
ENOG410XS01 LUCA
GeneTreeiENSGT00680000099553
HOVERGENiHBG009115

Family and domain databases

CDDicd00086 homeodomain, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001523 Paired_dom
IPR033559 Pax-4
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR24329:SF14 PTHR24329:SF14, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00292 PAX, 1 hit
PRINTSiPR00027 PAIREDBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00351 PAX, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS51057 PAIRED_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q3KNR5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAWSSKSWLC LIASSCPRDT LLPSAHHASP VPASHLTQVS NGCVSKILGR
60 70 80 90 100
YYRTGVLEPK GIGGSKPRLA TPPVVARIAQ LKGECPALFA WEIQRQLCAE
110 120 130 140 150
GLCTQDKTPS VSSINRVLRA LQEDQGLPCT RLRSPAVLAP AVLTPHSGSE
160 170 180 190 200
TPRGTHPGTG HRNRTIFSPS QAEALEKEFQ RGQYPDSVAR GKLATATSLP
210 220 230 240 250
EDTVRVWFSN RRAKWRRQEK LKWEMQLPGA SQGLTVPRVA PGIISAQGPT

VFMSRKY
Length:257
Mass (Da):28,051
Last modified:November 8, 2005 - v1
Checksum:iC663D83DC9315CFD
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O43316PAX4_HUMAN
Paired box protein Pax-4
PAX4
350Annotation score:
A0A0A0MRB6A0A0A0MRB6_HUMAN
Paired box protein Pax-4
PAX4
349Annotation score:
G3V4Q1G3V4Q1_HUMAN
Paired box protein Pax-4
PAX4
341Annotation score:
J3KPG0J3KPG0_HUMAN
Paired box protein Pax-4
PAX4
348Annotation score:
A0A1W2PPX4A0A1W2PPX4_HUMAN
Paired box protein Pax-4
PAX4
351Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073934 Genomic DNA No translation available.
BC107149 mRNA Translation: AAI07150.1
UniGeneiHs.129706

Genome annotation databases

EnsembliENST00000483494; ENSP00000473846; ENSG00000106331
ENST00000611453; ENSP00000477877; ENSG00000106331
UCSCiuc064hsg.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073934 Genomic DNA No translation available.
BC107149 mRNA Translation: AAI07150.1
UniGeneiHs.129706

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3KNR5, 14 interactors
Q3KNR5, 14 interactors

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000483494; ENSP00000473846; ENSG00000106331
ENST00000611453; ENSP00000477877; ENSG00000106331
UCSCiuc064hsg.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000106331.14
HGNCiHGNC:8618 PAX4
OpenTargetsiENSG00000106331
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0849 Eukaryota
ENOG410XS01 LUCA
GeneTreeiENSGT00680000099553
HOVERGENiHBG009115

Miscellaneous databases

ChiTaRSiPAX4 human

Gene expression databases

BgeeiENSG00000106331 Expressed in 14 organ(s), highest expression level in mucosa of transverse colon

Family and domain databases

CDDicd00086 homeodomain, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001523 Paired_dom
IPR033559 Pax-4
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR24329:SF14 PTHR24329:SF14, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00292 PAX, 1 hit
PRINTSiPR00027 PAIREDBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00351 PAX, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS51057 PAIRED_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ3KNR5_HUMAN
AccessioniPrimary (citable) accession number: Q3KNR5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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