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Protein

Triosephosphate isomerase

Gene

tpiA

Organism
Chlamydia trachomatis serovar A (strain ATCC VR-571B / DSM 19440 / HAR-13)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).UniRule annotation

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (tpiA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei118ElectrophileUniRule annotation1
Active sitei188Proton acceptorUniRule annotation1
Binding sitei194Substrate; via amide nitrogenUniRule annotation1
Binding sitei234SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciCTRA315277:G1G4F-357-MONOMER
UniPathwayi
UPA00109;UER00189

UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
Short name:
TIMUniRule annotation
Short name:
TPIUniRule annotation
Alternative name(s):
Triose-phosphate isomeraseUniRule annotation
Gene namesi
Name:tpiAUniRule annotation
Ordered Locus Names:CTA_0355
OrganismiChlamydia trachomatis serovar A (strain ATCC VR-571B / DSM 19440 / HAR-13)
Taxonomic identifieri315277 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000002532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003074441 – 274Triosephosphate isomeraseAdd BLAST274

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ3KM32
SMRiQ3KM32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni31 – 33Substrate bindingUniRule annotation3
Regioni255 – 256Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000226412
KOiK01803
OMAiLCVGEGL

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_B TIM_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR022896 TrioseP_Isoase_bac/euk
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
TIGRFAMsiTIGR00419 tim, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3KM32-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFTDKETHRK PFPTWAHLLH SEPSKQFVFG NWKMNKTLTE AQTFLKSFIS
60 70 80 90 100
SDILSNPQII TGIIPPFTLL SACQQAVSDS PIFLGAQTTH EADSGAFTGE
110 120 130 140 150
ISAPMLKDIG VDFVLIGHSE RRHIFHEQNP VLAEKAAAAI HSGMIPVLCI
160 170 180 190 200
GETLEEQESG ATQDILLNQL TIGLSKLPEQ ASFILAYEPV WAIGTGKVAH
210 220 230 240 250
PDLVQETHAF CRKTIASLFS KDIAERTPIL YGGSVKADDA RSLSLCPDVN
260 270
GLLVGGASLS SENFLSIIQQ VDIP
Length:274
Mass (Da):29,763
Last modified:November 8, 2005 - v1
Checksum:i751BB5F6CAF16EB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000051 Genomic DNA Translation: AAX50590.1
RefSeqiWP_011324683.1, NC_007429.1

Genome annotation databases

EnsemblBacteriaiAAX50590; AAX50590; CTA_0355
KEGGicta:CTA_0355

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000051 Genomic DNA Translation: AAX50590.1
RefSeqiWP_011324683.1, NC_007429.1

3D structure databases

ProteinModelPortaliQ3KM32
SMRiQ3KM32
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX50590; AAX50590; CTA_0355
KEGGicta:CTA_0355

Phylogenomic databases

HOGENOMiHOG000226412
KOiK01803
OMAiLCVGEGL

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00189

UPA00138

BioCyciCTRA315277:G1G4F-357-MONOMER

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_B TIM_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR022896 TrioseP_Isoase_bac/euk
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
TIGRFAMsiTIGR00419 tim, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPIS_CHLTA
AccessioniPrimary (citable) accession number: Q3KM32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 8, 2005
Last modified: April 25, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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