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Protein

Argininosuccinate lyase 2

Gene

argH2

Organism
Pseudomonas fluorescens (strain Pf0-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (arcB)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase 1 (argH1), Argininosuccinate lyase 2 (argH2)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciPFLU205922:G1G4S-5604-MONOMER
UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyase 2UniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASAL 2UniRule annotation
Alternative name(s):
Arginosuccinase 2UniRule annotation
Gene namesi
Name:argH2UniRule annotation
Ordered Locus Names:Pfl01_5489
OrganismiPseudomonas fluorescens (strain Pf0-1)
Taxonomic identifieri205922 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002704 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002407531 – 464Argininosuccinate lyase 2Add BLAST464

Proteomic databases

PRIDEiQ3K4S8

Interactioni

Protein-protein interaction databases

STRINGi205922.Pfl01_5489

Structurei

3D structure databases

ProteinModelPortaliQ3K4S8
SMRiQ3K4S8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK
OrthoDBiPOG091H026A

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 2 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q3K4S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTDKTNQSW GGRFSEPVDA FVARFTASVT FDQRLYRHDI MGSIAHATML
60 70 80 90 100
AKVGVLTDAE RDSIIDGLKT IQGEIEAGQF DWRVDLEDVH MNIEARLTDR
110 120 130 140 150
IGVTGKKLHT GRSRNDQVAT DIRLWLRDEI DLILSEITRL QKGLLEQAER
160 170 180 190 200
EAASIMPGFT HLQTAQPVTF GHHMLAWFEM LSRDYERLVD CRKRTNRMPL
210 220 230 240 250
GSAALAGTTY PIDREYTAQL LGFDAVGGNS LDNVSDRDFA IEFCSAASIA
260 270 280 290 300
MMHLSRFSEE LVLWTSAQFQ FIDLPDRFCT GSSIMPQKKN PDVPELVRGK
310 320 330 340 350
TGRVFGALMG LLTLMKGQPL AYNKDNQEDK EPLFDAADTL RDSLRAFADM
360 370 380 390 400
IPAIKPKHAI MREAALRGFS TATDLADYLV RRGLPFRDCH EIVGHAVKYG
410 420 430 440 450
VDTGKDLAEM SLEELRQFSD QIEQDVFAVL TLEGSVNARD HIGGTAPAQV
460
KAAVVRGQAL IASR
Length:464
Mass (Da):51,682
Last modified:November 8, 2005 - v1
Checksum:iAC00BE9F81D97D64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000094 Genomic DNA Translation: ABA77226.1
RefSeqiWP_011336517.1, NC_007492.2

Genome annotation databases

EnsemblBacteriaiABA77226; ABA77226; Pfl01_5489
KEGGipfo:Pfl01_5489

Similar proteinsi

Entry informationi

Entry nameiARLY2_PSEPF
AccessioniPrimary (citable) accession number: Q3K4S8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 8, 2005
Last modified: July 18, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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