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Protein

Probable cytosol aminopeptidase

Gene

pepA

Organism
Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / NCIMB 11848 / C-107)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.UniRule annotation

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi268Manganese 2UniRule annotation1
Metal bindingi273Manganese 1UniRule annotation1
Metal bindingi273Manganese 2UniRule annotation1
Active sitei280UniRule annotation1
Metal bindingi291Manganese 2UniRule annotation1
Metal bindingi350Manganese 1UniRule annotation1
Metal bindingi352Manganese 1UniRule annotation1
Metal bindingi352Manganese 2UniRule annotation1
Active sitei354UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosol aminopeptidaseUniRule annotation (EC:3.4.11.1UniRule annotation)
Alternative name(s):
Leucine aminopeptidaseUniRule annotation (EC:3.4.11.10UniRule annotation)
Short name:
LAPUniRule annotation
Leucyl aminopeptidaseUniRule annotation
Gene namesi
Name:pepAUniRule annotation
Ordered Locus Names:Noc_0289
OrganismiNitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / NCIMB 11848 / C-107)
Taxonomic identifieri323261 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeNitrosococcus
Proteomesi
  • UP000006838 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000199451 – 501Probable cytosol aminopeptidaseAdd BLAST501

Proteomic databases

PRIDEiQ3JEC8

Interactioni

Protein-protein interaction databases

STRINGi323261.Noc_0289

Structurei

3D structure databases

ProteinModelPortaliQ3JEC8
SMRiQ3JEC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZ6 Bacteria
COG0260 LUCA
HOGENOMiHOG000243132
KOiK01255
OMAiMKNTGPR
OrthoDBiPOG091H01BT

Family and domain databases

CDDicd00433 Peptidase_M17, 1 hit
HAMAPiMF_00181 Cytosol_peptidase_M17, 1 hit
InterProiView protein in InterPro
IPR011356 Leucine_aapep/pepB
IPR000819 Peptidase_M17_C
IPR023042 Peptidase_M17_leu_NH2_pept
IPR008283 Peptidase_M17_N
PANTHERiPTHR11963 PTHR11963, 1 hit
PfamiView protein in Pfam
PF00883 Peptidase_M17, 1 hit
PF02789 Peptidase_M17_N, 1 hit
PRINTSiPR00481 LAMNOPPTDASE
PROSITEiView protein in PROSITE
PS00631 CYTOSOL_AP, 1 hit

Sequencei

Sequence statusi: Complete.

Q3JEC8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNFHVTSGTP EKQRTAALVV GIYEDEKLSS YAQRIDKASE GYVSRLIKQG
60 70 80 90 100
DFTGKKGQAL LLFALPGVKA ERVLLMGCGQ KDKVTAKNLR QSWSGAVKAL
110 120 130 140 150
QACGATEAMI CPLEAKPKDE ELTQWARLIV ETAEQALYRY EHTKSKKESL
160 170 180 190 200
KKPLAKLTLL LDQRSQQPLA EQGIQQGQAI AKGVNLARDL GNLPGNICTP
210 220 230 240 250
TYLADEARRL AKEYKSLKAK ILEQAEMEKL GLGALLAVSR GSRQPPKLIT
260 270 280 290 300
LEYKGAPGKQ KPIVLVGKGL TFDAGGISIK PGERMDEMKY DMCGGAGVLG
310 320 330 340 350
TMQACAELEL PLNVIAVVPS SENLPDGAAN KPGDVLTSLS GQTIEVLNTD
360 370 380 390 400
AEGRLILCDA LTYSKRYRPD VVIDVATLTG ACVIALGAHA SGLLSNDQSL
410 420 430 440 450
AEHLLAAGQT SDDRAWQLPL WDDYQQQLDS NFADMANIGG RGAGTITAAC
460 470 480 490 500
FLARFTEEFR WAHLDIAGTA WLSGKEKGAT GRPVPLLTQY LIQRAQEAKT

S
Length:501
Mass (Da):54,021
Last modified:November 8, 2005 - v1
Checksum:iE0BB202610919653
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000127 Genomic DNA Translation: ABA56818.1
RefSeqiWP_002812011.1, NC_007484.1

Genome annotation databases

EnsemblBacteriaiABA56818; ABA56818; Noc_0289
KEGGinoc:Noc_0289

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000127 Genomic DNA Translation: ABA56818.1
RefSeqiWP_002812011.1, NC_007484.1

3D structure databases

ProteinModelPortaliQ3JEC8
SMRiQ3JEC8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi323261.Noc_0289

Proteomic databases

PRIDEiQ3JEC8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA56818; ABA56818; Noc_0289
KEGGinoc:Noc_0289

Phylogenomic databases

eggNOGiENOG4105BZ6 Bacteria
COG0260 LUCA
HOGENOMiHOG000243132
KOiK01255
OMAiMKNTGPR
OrthoDBiPOG091H01BT

Family and domain databases

CDDicd00433 Peptidase_M17, 1 hit
HAMAPiMF_00181 Cytosol_peptidase_M17, 1 hit
InterProiView protein in InterPro
IPR011356 Leucine_aapep/pepB
IPR000819 Peptidase_M17_C
IPR023042 Peptidase_M17_leu_NH2_pept
IPR008283 Peptidase_M17_N
PANTHERiPTHR11963 PTHR11963, 1 hit
PfamiView protein in Pfam
PF00883 Peptidase_M17, 1 hit
PF02789 Peptidase_M17_N, 1 hit
PRINTSiPR00481 LAMNOPPTDASE
PROSITEiView protein in PROSITE
PS00631 CYTOSOL_AP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAMPA_NITOC
AccessioniPrimary (citable) accession number: Q3JEC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 8, 2005
Last modified: October 10, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
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Main funding by: National Institutes of Health

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